GLOBAL MARKETS FOR ANIMAL THERAPEUTICS AND DIAGNOSTICS

GLOBAL MARKETS FOR ANIMAL THERAPEUTICS AND DIAGNOSTICS HLC034D January 2015 Melissa Elder Project Analyst ISBN: 1-62296-028-9 BCC Research 49 Walnut Park, Building 2 Wellesley, MA 02481 USA 866-285-7215 (toll-free within the USA), or (+1) 781-489-7301 www.bccresearch.com information@bccresearch.com

TABLE OF CONTENTS CHAPTER 1 INTRODUCTION 2 STUDY GOALS AND OBJECTIVES 2 REASONS FOR DOING THE STUDY 2 INTENDED AUDIENCE 2 SCOPE OF REPORT 3 INFORMATION SOURCES 3 RELATED BCC RESEARCH REPORTS 3 ANALYST'S CREDENTIALS 4 BCC RESEARCH WEBSITE 4 DISCLAIMER 4 CHAPTER 2 SUMMARY 6 MARKET OVERVIEW 6 SUMMARY TABLE GLOBAL ANIMAL THERAPEUTICS AND DIAGNOSTICS MARKET BY MAJOR PRODUCT SEGMENT, SUMMARY FIGURE GLOBAL ANIMAL THERAPEUTICS AND DIAGNOSTICS MARKET BY MAJOR PRODUCT SEGMENT, LEADING MANUFACTURERS AND SUPPLIERS 7 7 7 CHAPTER 3 INDUSTRY OVERVIEW 10 ANIMAL ANATOMY AND PHYSIOLOGY 10 REPRODUCTIVE SYSTEM 11 TABLE 1 GESTATION PERIODS OF SELECT COMMON SPECIES 12 AVIAN ANATOMY 12 TABLE 2 LIFESPAN OF COMMON AVIAN SPECIES OF PETS 15 ANIMAL POPULATIONS IN THE UNITED STATES 15 COMPANION ANIMALS 15 TABLE 3 STATISTICS FOR COMPANION ANIMALS FOUND IN U.S. HOUSEHOLDS, 2011 AND 2014 (THOUSANDS) TABLE 4 ESTIMATED POPULATIONS OF COMPANION ANIMALS FOUND IN U.S. HOUSEHOLDS, 2014 (THOUSANDS) FOOD PRODUCTION ANIMALS 16 TABLE 5 REPORTED 2005, 2010 AND ESTIMATED 2014 POPULATION OF FOOD PRODUCTION ANIMALS IN THE UNITED STATES (THOUSANDS) U.S. Broiler Production 17 TABLE 6 TOP 20 LEADING BROILER PRODUCING STATES, 2013 (THOUSANDS) 17 ANIMAL POPULATIONS BY COUNTRY 18 DOGS 18 TABLE 7 DOG (CANINE) POPULATION BY SELECT COUNTRY, 2014 (THOUSANDS) 18 FIGURE 1 DOG (CANINE) POPULATION BY SELECT COUNTRY, 2014 (THOUSANDS) 19 CATS 19 TABLE 8 CAT (FELINE) POPULATION BY SELECT COUNTRY, 2014 (THOUSANDS) 19 FIGURE 2 CAT (FELINE) POPULATION BY COUNTRY, 2014 (THOUSANDS) 20 HORSES 20 TABLE 9 HORSE (EQUINE) POPULATION BY COUNTRY, 2014 (THOUSANDS) 21 FIGURE 3 HORSE (EQUINE) POPULATION BY COUNTRY, 2014 (THOUSANDS) 21 16 16 17

CATTLE 22 TABLE 10 CATTLE (BOVINE) POPULATION BY COUNTRY, 2014 (THOUSANDS) 22 FIGURE 4 CATTLE (BOVINE) POPULATION BY COUNTRY, 2014 (THOUSANDS) 22 SWINE 23 TABLE 11 PIG/HOG (SWINE) POPULATION BY COUNTRY, 2014 (THOUSANDS) 23 FIGURE 5 PIG/HOG (SWINE) POPULATION BY COUNTRY, 2014 (THOUSANDS) 24 SHEEP 24 TABLE 12 SHEEP POPULATION BY COUNTRY, 2014 (THOUSANDS) 24 FIGURE 6 SHEEP POPULATION BY COUNTRY, 2014 (THOUSANDS) 25 GOATS 25 TABLE 13 GOAT POPULATION BY COUNTRY, 2014 (THOUSANDS) 25 FIGURE 7 GOAT POPULATION BY COUNTRY, 2014 (THOUSANDS) 26 COMPANION ANIMAL DISEASES 26 INFECTIOUS DISEASES 27 Viruses 27 Adenovirus 27 Avian Influenza 28 Coronavirus 28 Distemper 28 Eastern Equine Encephalitis 29 Equine Viral Arteritis 29 Feline Calicivirus and Feline Herpes Virus 29 Feline Immunosuppressive Virus 29 Feline Infectious Peritonitis Virus 30 Feline Leukemia Virus 30 Infectious Hepatitis 31 Internal Papillomatosis of Parrots 31 Newcastle Disease 31 Pacheco's Disease 32 Parainfluenza Virus 32 Paramyxoviruses 32 Parvovirus 33 Polyomavirus 33 Poxviruses 34 Psittacine Beak and Feather Disease 35 Rabies 35 Reovirus 35 West Nile Virus 36 Bacteria 36 Black Tongue 36 Bordetella 36 Brucellosis 36 Campylobacteriosis 37 Chlamydia 37 Leptospirosis 38 Lyme Disease 38 Q Fever 38

Respiratory Mycoplasmosis 39 Spirochaetaceae 39 Tetanus 39 Allergy and Inflammatory Diseases 40 Allergies 40 Arthritis 40 Asthma 41 Dermatitis 41 Eosinophilic Granuloma Complex 41 Gout 42 Inflammatory Bowel Disease 42 Metabolic Diseases 42 Cushing's Syndrome 43 Diabetes Mellitus 43 Thyroid Disease 44 Pancreatitis 45 Metabolic Bone Disease in Birds 45 Parasitic Diseases 45 Ear Mites 45 Fleas 46 Heartworm 47 Hemotropic Mycoplasmas (formerly Hemobartonellosis) 48 Feline Scabies 48 Lice 48 Sarcoptic Mange 48 Worms 49 Urinary Diseases 49 Glomerulonephritis 50 Feline Lower Urinary Tract Disease 50 Other Diseases 51 Equine Protozoal Myelitis 51 Leptospirosis and Equine Recurrent Uveitis 51 Neoplastic Disease 52 Heart Disease 53 PRODUCTION ANIMAL DISEASES 53 INFECTIOUS DISEASES 53 Viruses and Prions 53 Avian Pneumovirus 54 Bovine Spongiform Encephalopathy 54 Bovine Viral Diarrhea (BVD) 55 Classical Swine Fever 56 Foot and Mouth Disease 56 Furunculosis 56 Infectious Pancreatic Necrosis 57 Marek's Disease 57 Pathogenic Avian Influenza 57 Q Fever 58

Vesicular Stomatitis 58 Bacteria 58 Anthrax 58 Blackleg 59 Conjunctivitis 59 Tetanus 59 OTHER DISEASES OF PRODUCTION ANIMALS 59 Ehrlichia Ruminantium (previously known as Heartwater) 59 Pneumonia 60 Pneumonia 60 Texas Cattle Fever 60 ZOONOTIC DISEASES 61 TABLE 14 COMMON EXAMPLES OF ZOONOTIC DISEASES 63 CHAPTER 4 ISSUES AFFECTING THE MARKET 65 ANTIBIOTIC USE AND RESISTANCE IN PRODUCTION ANIMALS 65 LOSING LIVESTOCK 65 THERAPEUTIC USE 66 TABLE 15 CURRENTLY APPROVED ANTIBIOTICS/ANTIMICROBIALS USED IN FOOD-PRODUCING ANIMALS IN THE UNITED STATES Resistance 67 TABLE 16 ANTIMICROBIAL DRUG USE AND SALES IN FOOD-PRODUCING ANIMALS, 2010 AND 2011 (ANNUAL TOTALS, KG*) Human Side Effects 69 Microbial Ecology 70 Agriculture and Food Research Initiative 70 Levels of Contaminated Meats in the U.S. 70 Movement for Lower Amounts of Antibiotics in Livestock Production 71 PROBIOTICS 71 LEGAL AND REGULATORY ISSUES 71 MINIMALLY AND HIGHLY REGULATED PRODUCTS 71 ANIMAL DRUG USER FEE ACT OF 2003 72 ANIMAL DRUG USER FEE AMENDMENTS OF 2008 (ADUFA II) 72 ANIMAL DRUG USER FEE AMENDMENTS OF 2013 (ADUFA III) 72 ADVANCES IN DRUG DELIVERY 73 TRANSDERMAL (SPRAY-ON) DRUGS 73 SUBLINGUAL (UNDER THE TONGUE) DRUGS 73 STERILIZATION METHODS 73 BIOTECHNOLOGY IN ANIMAL HEALTH 74 ANIMAL CLONING 74 ANIMAL OBESITY 75 CAUSES 75 WEIGHT REDUCTION 76 DEMAND IN THE VETERINARY SERVICE INDUSTRY 77 TABLE 17 ESTIMATED NUMBER OF VETERINARIAN PRACTICES IN THE UNITED STATES BY TYPE OF PRACTICE, 2013 (NO./%) TABLE 18 ESTIMATED NUMBER OF VETERINARIANS IN THE UNITED STATES BY GENDER AND YEAR, 2009-2013 66 68 77 78

FIGURE 8 ESTIMATED NUMBER OF VETERINARIANS IN THE UNITED STATES BY GENDER AND YEAR, 2009-2013 TRENDS IN COMPANION PET OWNERSHIP 79 ANIMAL HEALTH INSURANCE 80 TABLE 19 APPA NATIONAL PET OWNERS SURVEY: BASIC ANNUAL EXPENSES FOR DOGS AND CATS IN U.S., 2013 AND 2014 ($) TABLE 20 DOG INSURANCE PLAN COMPARISONS, UNITED STATES ($) 81 TABLE 21 CAT INSURANCE PLAN COMPARISONS, UNITED STATES 82 ADVANCED MEDICAL PROCEDURES 82 LIFE CYCLE APPROACH 84 INTERNATIONAL ISSUES AND TRENDS 84 LIVESTOCK 85 Swine Production Consolidation 85 BRAZIL 85 INDIA 85 CHINA 85 COMPANION ANIMALS AND VETERINARIANS 85 TABLE 22 NUMBER OF VETERINARIANS AND PARAVETERINARIAN ASSISTANTS, TOP 10 COUNTRIES, 2012 FIGURE 9 NUMBER OF VETERINARIANS AND PARAVETERINARIAN ASSISTANTS, TOP 10 COUNTRIES, 2012 IMPORTED PET FOOD PRODUCT CONCERNS 87 78 80 86 86 CHAPTER 5 ANIMAL VACCINES 89 OVERVIEW 89 PRODUCT DESCRIPTIONS 89 ACTIVE IMMUNITY 89 PASSIVE IMMUNITY 90 OTHER TYPES 90 COMPANION ANIMALS 90 VACCINE PROVIDERS 90 Boehringer Ingelheim/Vetmedica 90 Heska 91 Merck Animal Health 91 Merial 91 TARGET SPECIES 92 TABLE 23 COMPANION ANIMAL VACCINES BY TARGET SPECIES AND PROVIDERS 92 COMPANION ANIMAL VACCINES MARKET ANALYSIS 94 TABLE 24 GLOBAL MARKET FOR COMPANION ANIMAL VACCINES BY ANIMAL SPECIES, FIGURE 10 GLOBAL MARKET FOR COMPANION ANIMAL VACCINES BY ANIMAL SPECIES, GLOBAL MARKET ANALYSIS BY VACCINE TYPE 95 TABLE 25 GLOBAL MARKET FOR COMPANION ANIMAL VACCINES BY TYPE, FIGURE 11 GLOBAL REVENUES FOR COMPANION ANIMAL VACCINES BY TYPE, PRODUCTION ANIMALS 96 VACCINE PROVIDERS 96 94 94 95 95

Boehringer Ingelheim 96 Merck & Co. 96 Merial 97 Novartis 97 Zoetis 97 TARGET SPECIES 97 TABLE 26 PRODUCTION ANIMAL VACCINES BY TARGET SPECIES AND PROVIDERS 97 PRODUCTION ANIMAL VACCINE MARKET ANALYSIS 102 TABLE 27 GLOBAL MARKET FOR PRODUCTION ANIMAL VACCINES BY ANIMAL SPECIES, FIGURE 12 GLOBAL MARKET FOR PRODUCTIONANIMAL VACCINES BY ANIMAL SPECIES, MARKET ANALYSIS BY VACCINE TYPE 103 TABLE 28 GLOBAL MARKET FOR PRODUCTION ANIMAL VACCINES BY TYPE, FIGURE 13 GLOBAL MARKET FOR PRODUCTION ANIMAL VACCINES BY TYPE, GLOBAL MARKET ANALYSIS AND CONCLUSIONS 104 TABLE 29 GLOBAL MARKET FOR ANIMAL VACCINES BY ANIMAL GROUP, THROUGH FIGURE 14 GLOBAL MARKET FOR ANIMAL VACCINES BY ANIMAL GROUP, FIGURE 15 GLOBAL MARKET SHARES OF ANIMAL VACCINES BY ANIMAL GROUP, 2014 (%) GLOBAL MARKET BY GEOGRAPHICAL REGION 106 TABLE 30 GLOBAL MARKET FOR ANIMAL VACCINES BY REGION, THROUGH 2019 ($ FIGURE 16 GLOBAL MARKET FOR ANIMAL VACCINES BY REGION, 2012-2019 ($ FIGURE 17 GLOBAL MARKET SHARES OF ANIMAL VACCINES BY REGION, 2014 (%) 107 COMPETITIVE SUMMARY 108 TABLE 31 GLOBAL MARKET SHARES OF ANIMAL VACCINE SUPPLIERS BASED ON COMPETITOR REVENUES, 2014 ($ MILLIONS/%) FIGURE 18 GLOBAL MARKET SHARES OF ANIMAL VACCINE SUPPLIERS BASED ON COMPETITOR REVENUES, 2014 (%) 102 102 104 104 105 105 105 106 107 108 109 CHAPTER 6 ANIMAL PHARMACEUTICAL PRODUCTS 111 OVERVIEW 111 PRODUCT DESCRIPTIONS 111 ALLERGY AND RESPIRATORY DRUGS 111 Target Species and Providers 111 TABLE 32 ALLERGY AND RESPIRATORY DRUGS BY TARGET SPECIES AND PROVIDER 112 Allergy and Respiratory Market Analysis 112 TABLE 33 GLOBAL MARKET FOR ALLERGY AND RESPIRATORY PRODUCTS BY ANIMAL GROUP, FIGURE 19 GLOBAL MARKET FOR ALLERGY AND RESPIRATORY PRODUCTS BY ANIMAL GROUP, ANTI-INFECTIVES AND ANTIFUNGALS 113 Providers 114 Bayer 114 113 113

Boehringer Ingelheim 114 ECO 114 Elanco 114 Esteve 115 Merck Animal Health 115 Novartis 115 Zoetis (Pfizer) 116 Virbac 116 Target Species 117 TABLE 34 ANTI-INFECTIVES BY TARGET SPECIES AND PROVIDERS 117 Anti-Infectives Market Analysis 118 TABLE 35 GLOBAL MARKET FOR ANTI-INFECTIVES BY ANIMAL GROUP, THROUGH FIGURE 20 GLOBAL MARKET FOR ANTI-INFECTIVES BY ANIMAL GROUP, 2012-2019 ($ ANTI-INFLAMMATORIES AND ANALGESICS 120 Providers 120 Bayer 120 Boehringer Ingelheim 120 Esteve 120 Merck Animal Health 120 Novartis 121 Zoetis (Pfizer) 121 Target Species 121 TABLE 36 ANTI-INFLAMMATORIES AND ANALGESICS BY TARGET SPECIES AND PROVIDER Anti-Inflammatory Market Analysis 122 TABLE 37 GLOBAL MARKET FOR ANTI-INFLAMMATORIES AND ANALGESICS BY ANIMAL GROUP, FIGURE 21 GLOBAL MARKET FOR ANTI-INFLAMMATORIES AND ANALGESICS BY ANIMAL GROUP, 2012 METABOLIC DRUGS 123 Target Species and Providers 124 TABLE 38 METABOLIC DRUGS BY TARGET SPECIES AND PROVIDERS 124 Metabolic Drug Market Analysis 124 TABLE 39 GLOBAL MARKET FOR METABOLIC DRUGS BY ANIMAL GROUP, THROUGH FIGURE 22 GLOBAL MARKET FOR METABOLIC DRUGS BY ANIMAL GROUP, PARASITICIDES 125 Providers 126 Bayer 126 ECO 126 Elanco 126 Merck Animal Health 127 Merial 127 Novartis 128 Zoetis (Pfizer) 130 Virbac 130 119 119 121 122 123 125 125

Target Species 130 TABLE 40 PARASITICIDES BY TARGET SPECIES AND PROVIDERS 130 Parasiticide Market Analysis 132 TABLE 41 GLOBAL MARKET FOR PARASITICIDES BY ANIMAL GROUP, THROUGH FIGURE 23 GLOBAL MARKET FOR PARASITICIDES BY ANIMAL GROUP, 2012-2019 ($ OTHER PHARMACEUTICALS 134 Providers 134 HbO2 Therapeutics (OPK Biotech) 134 Elanco 134 Esteve 134 Merck Animal Health 134 Merial 135 Novartis 135 Virbac 135 Dental 135 Target Species 136 TABLE 42 OTHER PHARMACEUTICALS BY TARGET SPECIES AND PROVIDERS 136 Other Pharmaceuticals Market Analysis 136 TABLE 43 GLOBAL MARKET FOR OTHER PHARMACEUTICALS BY ANIMAL GROUP, FIGURE 24 GLOBAL MARKET FOR OTHER PHARMACEUTICALS BY ANIMAL GROUP, 2014- GLOBAL MARKET ANALYSIS AND CONCLUSIONS 137 TABLE 44 GLOBAL MARKET FOR ANIMAL PHARMACEUTICAL PRODUCTS BY TYPE, FIGURE 25 GLOBAL MARKET FOR ANIMAL PHARMACEUTICAL PRODUCTS BY TYPE, 2014- COMPANION ANIMAL VS. PRODUCTION ANIMAL MARKETS 139 TABLE 45 GLOBAL MARKET FOR ANIMAL PHARMACEUTICAL PRODUCTS BY ANIMAL GROUP, FIGURE 26 GLOBAL MARKET FOR ANIMAL PHARMACEUTICAL PRODUCTS BY ANIMAL GROUP, FIGURE 27 GLOBAL MARKET SHARES OF ANIMAL PHARMACEUTICAL PRODUCTS BY ANIMAL GROUP, 2014 (%) MARKETS BY GEOGRAPHICAL REGION 141 TABLE 46 GLOBAL MARKET FOR ANIMAL PHARMACEUTICALS BY REGION, FIGURE 28 GLOBAL MARKET FOR ANIMAL PHARMACEUTICALS BY REGION, 2014- FIGURE 29 GLOBAL MARKET SHARES OF ANIMAL PHARMACEUTICALS BY REGION, 2014 (%) COMPETITIVE SUMMARY 143 TABLE 47 GLOBAL MARKET SHARES OF ANIMAL PHARMACEUTICAL PRODUCT SUPPLIERS, 2014 (%/$ FIGURE 30 GLOBAL MARKET SHARES OF ANIMAL PHARMACEUTICAL PRODUCT SUPPLIERS BASED ON COMPETITOR REVENUES, 2014 (%) 133 133 137 137 138 138 139 140 140 141 141 142 144 144 CHAPTER 7 ANIMAL FEED ADDITIVES 146

OVERVIEW 146 PRODUCT DESCRIPTIONS 147 AMINO ACIDS 147 Providers 147 Adisseo 147 Ajinomoto 147 Evonik 147 Novus International 148 Target Species 148 TABLE 48 AMINO ACIDS BY TARGET SPECIES AND PROVIDERS 148 Amino Acid Market Analysis 149 TABLE 49 GLOBAL MARKET FOR AMINO ACIDS BY ANIMAL GROUP, THROUGH 2019 ($ FIGURE 31 GLOBAL MARKET FOR AMINO ACIDS BY ANIMAL GROUP, 2012-2019 ($ MEDICINAL ADDITIVES 150 Providers 150 Elanco 150 Merial 150 Novartis 150 Zoetis 151 Target Species 151 TABLE 50 MEDICINAL ADDITIVES BY TARGET SPECIES AND PROVIDERS 151 Medicinal Feed Additive Market Analysis 152 TABLE 51 GLOBAL MARKET FOR MEDICINAL FEED ADDITIVES BY ANIMAL GROUP, FIGURE 32 GLOBAL MARKET FOR MEDICINAL FEED ADDITIVES BY ANIMAL GROUP, NUTRITIONAL SUPPLEMENTS 154 Providers 154 Adisseo 154 BASF 154 Boehringer Ingelheim 154 DSM Nutritional Products 154 Esteve 155 Heska 155 Mosaic 155 Veterinary Products Laboratories 155 Virbac 155 Target Species 156 TABLE 52 NUTRITIONAL SUPPLEMENTS BY TARGET SPECIES AND PROVIDERS 156 Nutritional Supplement Market Analysis 156 TABLE 53 GLOBAL MARKET FOR NUTRITIONAL SUPPLEMENTS BY ANIMAL GROUP, FIGURE 33 GLOBAL MARKET FOR NUTRITIONAL SUPPLEMENTS BY ANIMAL GROUP, VITAMINS AND MINERALS 158 Providers 158 Adisseo 158 149 149 153 153 157 157

Beaphar 158 Church & Dwight Co. 158 DSM Nutritional Products 159 Merck Animal Health 159 Zoetis 159 Target Species 159 TABLE 54 VITAMINS AND MINERALS BY TARGET SPECIES AND PROVIDERS 159 Vitamin and Mineral Market Analysis 160 TABLE 55 GLOBAL MARKET FOR VITAMINS AND MINERALS BY ANIMAL GROUP, FIGURE 34 GLOBAL MARKET FOR VITAMINS AND MINERALS BY ANIMAL GROUP, GLOBAL MARKET ANALYSIS AND CONCLUSION 161 TABLE 56 GLOBAL MARKET FOR ANIMAL FEED ADDITIVE PRODUCTS BY TYPE, FIGURE 35 GLOBAL MARKET FOR ANIMAL FEED ADDITIVE PRODUCTS BY TYPE, COMPANION ANIMAL VS. PRODUCTION ANIMAL MARKETS 162 TABLE 57 GLOBAL MARKET FOR FEED ADDITIVES BY ANIMAL GROUP, THROUGH FIGURE 36 GLOBAL MARKET FOR FEED ADDITIVES BY ANIMAL GROUP, 2012-2019 ($ FIGURE 37 GLOBAL MARKET SHARES OF FEED ADDITIVES BY ANIMAL GROUP, 2014 (%) MARKETS BY GEOGRAPHICAL REGION 164 TABLE 58 GLOBAL MARKET FOR ANIMAL FEED ADDITIVES BY REGION, THROUGH FIGURE 38 GLOBAL MARKET FOR ANIMAL FEED ADDITIVES BY REGION, 2012-2019 ($ FIGURE 39 GLOBAL MARKET SHARES OF ANIMAL FEED ADDITIVES BY REGION, 2014 (%) COMPETITIVE SUMMARY 166 TABLE 59 GLOBAL MARKET SHARES OF SUPPLIERS OF ANIMAL FEED ADDITIVES, 2014 (%/$ FIGURE 40 GLOBAL MARKET SHARES OF SUPPLIERS OF ANIMAL FEED ADDITIVES, 2014 (%) 160 160 162 162 163 163 163 164 165 165 167 167 CHAPTER 8 ANIMAL DIAGNOSTICS 169 OVERVIEW 169 PRODUCT SEGMENTS 169 DIAGNOSTIC RAPID TESTING MARKET ANALYSIS 169 TABLE 60 GLOBAL MARKET FOR RAPID DIAGNOSTIC TESTS BY ANIMAL GROUP, FIGURE 41 GLOBAL MARKET FOR RAPID DIAGNOSTIC TESTS BY ANIMAL GROUP, Market Analysis of Rapid Diagnostics by Test Type 170 TABLE 61 GLOBAL MARKET FOR RAPID DIAGNOSTICS BY TEST TYPE (VETERINARY APPLICATIONS), FIGURE 42 GLOBAL MARKET FOR RAPID DIAGNOSTICS BY TEST TYPE (VETERINARY APPLICATIONS), 170 170 171 171

MARKET ANALYSIS OF DIAGNOSTIC ANALYZERS AND CONSUMABLES 172 TABLE 62 GLOBAL MARKET FOR DIAGNOSTIC ANALYZERS AND CONSUMABLES BY ANIMAL GROUP, FIGURE 43 GLOBAL MARKET FOR DIAGNOSTIC ANALYZERS AND CONSUMABLES BY ANIMAL GROUP, Market Analysis by Test Type 173 TABLE 63 GLOBAL MARKET FOR DIAGNOSTIC ANALYZERS AND CONSUMABLES BY TEST TYPE (VETERINARY APPLICATIONS), FIGURE 44 GLOBAL MARKET FOR DIAGNOSTIC ANALYZERS AND CONSUMABLES BY TEST TYPE (VETERINARY APPLICATIONS), MARKET ANALYSIS OF DIAGNOSTIC IMAGING EQUIPMENT 174 TABLE 64 GLOBAL MARKET FOR DIAGNOSTIC IMAGING EQUIPMENT AND RELATED MATERIALS BY ANIMAL GROUP, FIGURE 45 GLOBAL MARKET FOR DIAGNOSTIC IMAGING EQUIPMENT AND RELATED MATERIALS BY ANIMAL GROUP, PRODUCT PROVIDERS AND DESCRIPTIONS 175 HESKA 175 IDEXX 175 MERCK ANIMAL HEALTH 177 SYNBIOTICS 177 TARGET SPECIES 178 TABLE 65 DIAGNOSTICS BY TARGET SPECIES AND PROVIDERS 178 GLOBAL MARKET ANALYSIS AND CONCLUSION 181 TABLE 66 GLOBAL MARKET FOR ANIMAL DIAGNOSTICS BY TYPE, THROUGH 2019 ($ FIGURE 46 GLOBAL MARKET FOR ANIMAL DIAGNOSTICS BY TYPE, 2012-2019 ($ COMPANION ANIMAL VS. PRODUCTION ANIMAL MARKETS 182 TABLE 67 GLOBAL MARKET FOR ANIMAL DIAGNOSTIC PRODUCTS BY ANIMAL GROUP, FIGURE 47 GLOBAL MARKET FOR ANIMAL DIAGNOSTIC PRODUCTS BY ANIMAL GROUP, FIGURE 48 GLOBAL MARKET SHARES OF ANIMAL DIAGNOSTICS BY ANIMAL GROUP, 2014 (%) MARKETS BY GEOGRAPHICAL REGION 184 TABLE 68 GLOBAL MARKET FOR ANIMAL DIAGNOSTICS BY REGION, THROUGH FIGURE 49 GLOBAL MARKET FOR ANIMAL DIAGNOSTICS BY REGION, 2012-2019 ($ FIGURE 50 GLOBAL MARKET SHARES OF ANIMAL DIAGNOSTICS BY REGION, 2014 (%) COMPETITIVE SUMMARY 186 TABLE 69 GLOBAL MARKET SHARES OF ANIMAL DIAGNOSTICS SUPPLIERS BASED ON COMPETITOR REVENUES, 2014 (%/$ FIGURE 51 GLOBAL MARKET SHARES OF ANIMAL DIAGNOSTIC SUPPLIERS BASED ON COMPETITOR REVENUES, 2014 (%) 172 172 173 173 174 175 181 181 183 183 183 184 184 185 186 186 CHAPTER 9 MARKET SUMMARY 189 GLOBAL ANIMAL THERAPEUTICS AND DIAGNOSTICS MARKET ANALYSIS 189 TABLE 70 GLOBAL MARKET FOR ANIMAL THERAPEUTICS AND DIAGNOSTICS BY PRODUCT SEGMENT, 189

FIGURE 52 GLOBAL MARKET FOR ANIMAL THERAPEUTICS AND DIAGNOSTICS BY PRODUCT SEGMENT, MARKETS BY USE OR ANIMAL GROUP 190 TABLE 71 GLOBAL MARKET FOR ANIMAL THERAPEUTICS AND DIAGNOSTICS BY ANIMAL GROUP FIGURE 53 GLOBAL MARKET FOR ANIMAL THERAPEUTICS AND DIAGNOSTICS BY ANIMAL GROUP, FIGURE 54 GLOBAL MARKET SHARES OF ANIMAL THERAPEUTICS AND DIAGNOSTICS BY ANIMAL GROUP, 2014 (%) MARKETS BY WORLD REGION 192 TABLE 72 GLOBAL MARKET FOR ANIMAL THERAPEUTICS AND DIAGNOSTICS BY REGION, FIGURE 55 GLOBAL MARKET FOR ANIMAL THERAPEUTICS AND DIAGNOSTICS BY REGION, FIGURE 56 GLOBAL MARKET SHARES OF ANIMAL THERAPEUTICS AND DIAGNOSTICS BY REGION, 2014 (%) FIGURE 57 GLOBAL MARKET SHARES OF ANIMAL THERAPEUTICS AND DIAGNOSTICS BY SELECT COUNTRY, 2014 (%) INDUSTRY PARTICIPANTS BY TYPE 195 TABLE 73 MAJOR INDUSTRY PARTICIPATION BY ANIMAL HEALTH SUPPLIERS 195 COMPETITIVE ANALYSIS 196 TABLE 74 GLOBAL MARKET SHARES OF ANIMAL THERAPEUTICS AND DIAGNOSTICS BY MANUFACTURER REVENUES, 2014 ($ MILLIONS/%) FIGURE 58 GLOBAL MARKET SHARES OF ANIMAL THERAPEUTICS AND DIAGNOSTICS BY MANUFACTURER REVENUES, 2014 ($ COMPANY ACQUISITIONS AND STRATEGIES 199 PATENT ANALYSIS 200 OVERVIEW 200 PATENT PRODUCT SEGMENTS 201 Patents Filed by Year 201 TABLE 75 ANNUAL DISTRIBUTION OF U.S. PATENTS GRANTED ON ANIMAL HEALTH PRODUCTS, JAN. 1, 2000 TO SEPT. 1, 2014 (NO.) FIGURE 59 ANNUAL DISTRIBUTION OF U.S. PATENTS GRANTED ON ANIMAL HEALTH PRODUCTS, JAN. 1, 2000 TO SEPT. 1, 2014 (NO.) International Patents by Country 202 TABLE 76 DISTRIBUTION OF U.S. PATENTS ON ANIMAL HEALTH PRODUCTS BY PATENT HOLDER'S COUNTRY, JAN. 1, 2000 TO SEPT. 1, 2014 (NO.) FIGURE 60 DISTRIBUTION OF U.S. PATENTS ON ANIMAL HEALTH PRODUCTS BY PATENT HOLDER'S COUNTRY, JAN. 1, 2000 TO SEPT. 1, 2014 (NO.) Patents Issued by Patent Holder 204 TABLE 77 DISTRIBUTION OF U.S. PATENTS ON ANIMAL HEALTH PRODUCTS BY PATENT HOLDER, JAN. 1, 2000 TO SEPT. 1, 2014 (NO.) 189 191 191 191 193 193 193 194 197 198 201 202 203 203 204 CHAPTER 10 COMPANY PROFILES 207 OVERVIEW 207 TABLE 78 COMPETITOR MARKET POSITION IN ANIMAL THERAPEUTICS AND DIAGNOSTICS BY SEGMENT, 2014 ($ PROFILES 208 ABAXIS INC. 208 BASF ANIMAL NUTRITION (BASF SE) 209 208

BAYER ANIMAL HEALTH 210 BLUESTAR GROUP 210 BOEHRINGER INGELHEIM GMBH 211 Boehringer Ingelheim Corp. 211 Boehringer Ingelheim Vetmedica Inc. 211 DSM N.V. 212 DSM Nutritional Products Ltd. 212 ELANCO ANIMAL HEALTH 212 EVONIK INDUSTRIES AG 213 HESKA CORP. 214 IDEXX LABORATORIES INC. 214 MERCK & CO. INC. 215 MOSAIC CO. (THE) 216 NOVARTIS AG 216 Novartis Animal Health Inc. 216 NOVUS INTERNATIONAL INC. 217 SANOFI 217 Merial Ltd. 218 VIRBAC S.A. 218 ZOETIS INC. (PREVIOUSLY PFIZER ANIMAL HEALTH) 219 CHAPTER 11 APPENDICES 221 APPENDIX I: DIRECTORY OF LEADING MANUFACTURES AND AFFILIATED COMPANIES ABAXIS INC. 221 ACRUX LTD. 221 ADISSEO FRANCE S.A.S. 221 AJINOMOTO CO. LTD. 221 BASF ANIMAL NUTRITION (BASF SE) 222 BAYER AG 222 BEAPHAR B.V. 222 BLUESTAR GROUP-CHINA NATIONAL BLUESTAR CO. LTD. 222 BOEHRINGER INGELHEIM CORP. 222 BOEHRINGER INGELHEIM GMBH 222 BOEHRINGER INGELHEIM VETMEDICA INC. 223 DECHRA PHARMACEUTICALS PLC 223 DSM NUTRITIONAL PRODUCTS LTD. 223 ECO ANIMAL HEALTH 223 ELANCO ANIMAL HEALTH 223 ELI LILLY & CO. 223 ESTEVE 224 ESTEVE USA 224 EVONIK INDUSTRIES AG 224 HESKA CORP. 224 HUVEPHARMA 224 IDEXX LABORATORIES INC. 224 LUITPOLD ANIMAL HEALTH 225 MERCK & CO. INC. 225 221

MERIAL ANIMAL HEALTH LTD. 225 MINDRAY MEDICAL INTERNATIONAL LTD. 225 MOSAIC CO. (THE) 225 NOVARTIS AG 225 NOVARTIS ANIMAL HEALTH INC. 226 NOVUS INTERNATIONAL INC. 226 PHIBRO ANIMAL HEALTH CORP. 226 ROYAL DSM N.V. 226 SANOFI 226 VCA ANTECH INC. 226 VIRBAC S.A. 227 ZOETIS INC. (PREVIOUSLY PFIZER ANIMAL HEALTH) 227 APPENDIX II: DIRECTORY OF RELEVANT ASSOCIATIONS AND ORGANIZATIONS 227 AMERICAN ASSOCIATION OF FELINE PRACTITIONERS 227 AMERICAN HUMANE ASSOCIATION 227 AMERICAN PET PRODUCTS ASSOCIATION INC. 227 AMERICAN SOCIETY FOR THE PREVENTION OF CRUELTY TO ANIMALS 227 AMERICAN VETERINARY DISTRIBUTORS ASSOCIATION (AVDA) 228 AMERICAN VETERINARY MEDICAL ASSOCIATION 228 CANADIAN VETERINARY MEDICAL ASSOCIATION 228 HUMANE SOCIETY OF THE UNITED STATES 228 NATIONAL ANIMAL CONTROL ASSOCIATION 228 PET FOOD INSTITUTE 228 SOCIETY OF ANIMAL WELFARE ADMINISTRATORS 228 UNITED STATES DEPARTMENT OF AGRICULTURE 229 UNITED STATES FOOD AND DRUG ADMINISTRATION 229 U.S. POULTRY & EGG ASSOCIATION 229

LIST OF TABLES TABLE HEADING SUMMARY TABLE GLOBAL ANIMAL THERAPEUTICS AND DIAGNOSTICS MARKET BY MAJOR PRODUCT SEGMENT, TABLE 1 GESTATION PERIODS OF SELECT COMMON SPECIES 12 TABLE 2 LIFESPAN OF COMMON AVIAN SPECIES OF PETS 15 TABLE 3 STATISTICS FOR COMPANION ANIMALS FOUND IN U.S. HOUSEHOLDS, 2011 AND 2014 (THOUSANDS) TABLE 4 ESTIMATED POPULATIONS OF COMPANION ANIMALS FOUND IN U.S. HOUSEHOLDS, 2014 (THOUSANDS) TABLE 5 REPORTED 2005, 2010 AND ESTIMATED 2014 POPULATION OF FOOD PRODUCTION ANIMALS IN THE UNITED STATES (THOUSANDS) TABLE 6 TOP 20 LEADING BROILER PRODUCING STATES, 2013 (THOUSANDS) 17 TABLE 7 DOG (CANINE) POPULATION BY SELECT COUNTRY, 2014 (THOUSANDS) 18 TABLE 8 CAT (FELINE) POPULATION BY SELECT COUNTRY, 2014 (THOUSANDS) 19 TABLE 9 HORSE (EQUINE) POPULATION BY COUNTRY, 2014 (THOUSANDS) 21 TABLE 10 CATTLE (BOVINE) POPULATION BY COUNTRY, 2014 (THOUSANDS) 22 TABLE 11 PIG/HOG (SWINE) POPULATION BY COUNTRY, 2014 (THOUSANDS) 23 TABLE 12 SHEEP POPULATION BY COUNTRY, 2014 (THOUSANDS) 24 TABLE 13 GOAT POPULATION BY COUNTRY, 2014 (THOUSANDS) 25 TABLE 14 COMMON EXAMPLES OF ZOONOTIC DISEASES 63 TABLE 15 CURRENTLY APPROVED ANTIBIOTICS/ANTIMICROBIALS USED IN FOOD-PRODUCING ANIMALS IN THE UNITED STATES TABLE 16 ANTIMICROBIAL DRUG USE AND SALES IN FOOD-PRODUCING ANIMALS, 2010 AND 2011 (ANNUAL TOTALS, KG*) TABLE 17 ESTIMATED NUMBER OF VETERINARIAN PRACTICES IN THE UNITED STATES BY TYPE OF PRACTICE, 2013 (NO./%) TABLE 18 ESTIMATED NUMBER OF VETERINARIANS IN THE UNITED STATES BY GENDER AND YEAR, 2009-2013 TABLE 19 APPA NATIONAL PET OWNERS SURVEY: BASIC ANNUAL EXPENSES FOR DOGS AND CATS IN U.S., 2013 AND 2014 ($) TABLE 20 DOG INSURANCE PLAN COMPARISONS, UNITED STATES ($) 81 TABLE 21 CAT INSURANCE PLAN COMPARISONS, UNITED STATES 82 TABLE 22 NUMBER OF VETERINARIANS AND PARAVETERINARIAN ASSISTANTS, TOP 10 COUNTRIES, 2012 TABLE 23 COMPANION ANIMAL VACCINES BY TARGET SPECIES AND PROVIDERS 92 TABLE 24 GLOBAL MARKET FOR COMPANION ANIMAL VACCINES BY ANIMAL SPECIES, TABLE 25 GLOBAL MARKET FOR COMPANION ANIMAL VACCINES BY TYPE, THROUGH TABLE 26 PRODUCTION ANIMAL VACCINES BY TARGET SPECIES AND PROVIDERS 97 TABLE 27 GLOBAL MARKET FOR PRODUCTION ANIMAL VACCINES BY ANIMAL SPECIES, TABLE 28 GLOBAL MARKET FOR PRODUCTION ANIMAL VACCINES BY TYPE, TABLE 29 GLOBAL MARKET FOR ANIMAL VACCINES BY ANIMAL GROUP, THROUGH TABLE 30 GLOBAL MARKET FOR ANIMAL VACCINES BY REGION, THROUGH 2019 ($ TABLE 31 GLOBAL MARKET SHARES OF ANIMAL VACCINE SUPPLIERS BASED ON COMPETITOR REVENUES, 2014 ($ MILLIONS/%) TABLE 32 ALLERGY AND RESPIRATORY DRUGS BY TARGET SPECIES AND PROVIDER 112 7 16 16 17 66 68 77 78 80 86 94 95 102 104 105 106 108

TABLE HEADING TABLE 33 GLOBAL MARKET FOR ALLERGY AND RESPIRATORY PRODUCTS BY ANIMAL GROUP, TABLE 34 ANTI-INFECTIVES BY TARGET SPECIES AND PROVIDERS 117 TABLE 35 GLOBAL MARKET FOR ANTI-INFECTIVES BY ANIMAL GROUP, THROUGH TABLE 36 ANTI-INFLAMMATORIES AND ANALGESICS BY TARGET SPECIES AND PROVIDER TABLE 37 GLOBAL MARKET FOR ANTI-INFLAMMATORIES AND ANALGESICS BY ANIMAL GROUP, TABLE 38 METABOLIC DRUGS BY TARGET SPECIES AND PROVIDERS 124 TABLE 39 GLOBAL MARKET FOR METABOLIC DRUGS BY ANIMAL GROUP, THROUGH TABLE 40 PARASITICIDES BY TARGET SPECIES AND PROVIDERS 130 TABLE 41 GLOBAL MARKET FOR PARASITICIDES BY ANIMAL GROUP, THROUGH 2019 ($ TABLE 42 OTHER PHARMACEUTICALS BY TARGET SPECIES AND PROVIDERS 136 TABLE 43 GLOBAL MARKET FOR OTHER PHARMACEUTICALS BY ANIMAL GROUP, TABLE 44 GLOBAL MARKET FOR ANIMAL PHARMACEUTICAL PRODUCTS BY TYPE, TABLE 45 GLOBAL MARKET FOR ANIMAL PHARMACEUTICAL PRODUCTS BY ANIMAL GROUP, TABLE 46 GLOBAL MARKET FOR ANIMAL PHARMACEUTICALS BY REGION, THROUGH TABLE 47 GLOBAL MARKET SHARES OF ANIMAL PHARMACEUTICAL PRODUCT SUPPLIERS, 2014 (%/$ TABLE 48 AMINO ACIDS BY TARGET SPECIES AND PROVIDERS 148 TABLE 49 GLOBAL MARKET FOR AMINO ACIDS BY ANIMAL GROUP, THROUGH 2019 ($ TABLE 50 MEDICINAL ADDITIVES BY TARGET SPECIES AND PROVIDERS 151 TABLE 51 GLOBAL MARKET FOR MEDICINAL FEED ADDITIVES BY ANIMAL GROUP, TABLE 52 NUTRITIONAL SUPPLEMENTS BY TARGET SPECIES AND PROVIDERS 156 TABLE 53 GLOBAL MARKET FOR NUTRITIONAL SUPPLEMENTS BY ANIMAL GROUP, TABLE 54 VITAMINS AND MINERALS BY TARGET SPECIES AND PROVIDERS 159 TABLE 55 GLOBAL MARKET FOR VITAMINS AND MINERALS BY ANIMAL GROUP, TABLE 56 GLOBAL MARKET FOR ANIMAL FEED ADDITIVE PRODUCTS BY TYPE, TABLE 57 GLOBAL MARKET FOR FEED ADDITIVES BY ANIMAL GROUP, THROUGH TABLE 58 GLOBAL MARKET FOR ANIMAL FEED ADDITIVES BY REGION, THROUGH TABLE 59 GLOBAL MARKET SHARES OF SUPPLIERS OF ANIMAL FEED ADDITIVES, 2014 (%/$ TABLE 60 GLOBAL MARKET FOR RAPID DIAGNOSTIC TESTS BY ANIMAL GROUP, TABLE 61 GLOBAL MARKET FOR RAPID DIAGNOSTICS BY TEST TYPE (VETERINARY APPLICATIONS), TABLE 62 GLOBAL MARKET FOR DIAGNOSTIC ANALYZERS AND CONSUMABLES BY ANIMAL GROUP, 113 119 121 122 125 133 137 138 139 141 144 149 153 157 160 162 163 164 167 170 171 172

TABLE HEADING TABLE 63 GLOBAL MARKET FOR DIAGNOSTIC ANALYZERS AND CONSUMABLES BY TEST TYPE (VETERINARY APPLICATIONS), TABLE 64 GLOBAL MARKET FOR DIAGNOSTIC IMAGING EQUIPMENT AND RELATED MATERIALS BY ANIMAL GROUP, TABLE 65 DIAGNOSTICS BY TARGET SPECIES AND PROVIDERS 178 TABLE 66 GLOBAL MARKET FOR ANIMAL DIAGNOSTICS BY TYPE, THROUGH 2019 ($ TABLE 67 GLOBAL MARKET FOR ANIMAL DIAGNOSTIC PRODUCTS BY ANIMAL GROUP, TABLE 68 GLOBAL MARKET FOR ANIMAL DIAGNOSTICS BY REGION, THROUGH 2019 ($ TABLE 69 GLOBAL MARKET SHARES OF ANIMAL DIAGNOSTICS SUPPLIERS BASED ON COMPETITOR REVENUES, 2014 (%/$ TABLE 70 GLOBAL MARKET FOR ANIMAL THERAPEUTICS AND DIAGNOSTICS BY PRODUCT SEGMENT, TABLE 71 GLOBAL MARKET FOR ANIMAL THERAPEUTICS AND DIAGNOSTICS BY ANIMAL GROUP TABLE 72 GLOBAL MARKET FOR ANIMAL THERAPEUTICS AND DIAGNOSTICS BY REGION, TABLE 73 MAJOR INDUSTRY PARTICIPATION BY ANIMAL HEALTH SUPPLIERS 195 TABLE 74 GLOBAL MARKET SHARES OF ANIMAL THERAPEUTICS AND DIAGNOSTICS BY MANUFACTURER REVENUES, 2014 ($ MILLIONS/%) TABLE 75 ANNUAL DISTRIBUTION OF U.S. PATENTS GRANTED ON ANIMAL HEALTH PRODUCTS, JAN. 1, 2000 TO SEPT. 1, 2014 (NO.) TABLE 76 DISTRIBUTION OF U.S. PATENTS ON ANIMAL HEALTH PRODUCTS BY PATENT HOLDER'S COUNTRY, JAN. 1, 2000 TO SEPT. 1, 2014 (NO.) TABLE 77 DISTRIBUTION OF U.S. PATENTS ON ANIMAL HEALTH PRODUCTS BY PATENT HOLDER, JAN. 1, 2000 TO SEPT. 1, 2014 (NO.) TABLE 78 COMPETITOR MARKET POSITION IN ANIMAL THERAPEUTICS AND DIAGNOSTICS BY SEGMENT, 2014 ($ 173 174 181 183 184 186 189 191 193 197 201 203 204 208

LIST OF FIGURES FIGURE TITLE SUMMARY FIGURE GLOBAL ANIMAL THERAPEUTICS AND DIAGNOSTICS MARKET BY MAJOR PRODUCT SEGMENT, FIGURE 1 DOG (CANINE) POPULATION BY SELECT COUNTRY, 2014 (THOUSANDS) 19 FIGURE 2 CAT (FELINE) POPULATION BY COUNTRY, 2014 (THOUSANDS) 20 FIGURE 3 HORSE (EQUINE) POPULATION BY COUNTRY, 2014 (THOUSANDS) 21 FIGURE 4 CATTLE (BOVINE) POPULATION BY COUNTRY, 2014 (THOUSANDS) 22 FIGURE 5 PIG/HOG (SWINE) POPULATION BY COUNTRY, 2014 (THOUSANDS) 24 FIGURE 6 SHEEP POPULATION BY COUNTRY, 2014 (THOUSANDS) 25 FIGURE 7 GOAT POPULATION BY COUNTRY, 2014 (THOUSANDS) 26 FIGURE 8 ESTIMATED NUMBER OF VETERINARIANS IN THE UNITED STATES BY GENDER AND YEAR, 2009-2013 FIGURE 9 NUMBER OF VETERINARIANS AND PARAVETERINARIAN ASSISTANTS, TOP 10 COUNTRIES, 2012 FIGURE 10 GLOBAL MARKET FOR COMPANION ANIMAL VACCINES BY ANIMAL SPECIES, FIGURE 11 GLOBAL REVENUES FOR COMPANION ANIMAL VACCINES BY TYPE, FIGURE 12 GLOBAL MARKET FOR PRODUCTIONANIMAL VACCINES BY ANIMAL SPECIES, FIGURE 13 GLOBAL MARKET FOR PRODUCTION ANIMAL VACCINES BY TYPE, FIGURE 14 GLOBAL MARKET FOR ANIMAL VACCINES BY ANIMAL GROUP, 2012-2019 ($ FIGURE 15 GLOBAL MARKET SHARES OF ANIMAL VACCINES BY ANIMAL GROUP, 2014 (%) FIGURE 16 GLOBAL MARKET FOR ANIMAL VACCINES BY REGION, 2012-2019 ($ FIGURE 17 GLOBAL MARKET SHARES OF ANIMAL VACCINES BY REGION, 2014 (%) 107 FIGURE 18 GLOBAL MARKET SHARES OF ANIMAL VACCINE SUPPLIERS BASED ON COMPETITOR REVENUES, 2014 (%) FIGURE 19 GLOBAL MARKET FOR ALLERGY AND RESPIRATORY PRODUCTS BY ANIMAL GROUP, FIGURE 20 GLOBAL MARKET FOR ANTI-INFECTIVES BY ANIMAL GROUP, 2012-2019 ($ FIGURE 21 GLOBAL MARKET FOR ANTI-INFLAMMATORIES AND ANALGESICS BY ANIMAL GROUP, 2012 FIGURE 22 GLOBAL MARKET FOR METABOLIC DRUGS BY ANIMAL GROUP, 2012-2019 ($ FIGURE 23 GLOBAL MARKET FOR PARASITICIDES BY ANIMAL GROUP, 2012-2019 ($ FIGURE 24 GLOBAL MARKET FOR OTHER PHARMACEUTICALS BY ANIMAL GROUP, 2014- FIGURE 25 GLOBAL MARKET FOR ANIMAL PHARMACEUTICAL PRODUCTS BY TYPE, 2014- FIGURE 26 GLOBAL MARKET FOR ANIMAL PHARMACEUTICAL PRODUCTS BY ANIMAL GROUP, FIGURE 27 GLOBAL MARKET SHARES OF ANIMAL PHARMACEUTICAL PRODUCTS BY ANIMAL GROUP, 2014 (%) FIGURE 28 GLOBAL MARKET FOR ANIMAL PHARMACEUTICALS BY REGION, 2014-7 78 86 94 95 102 104 105 105 107 109 113 119 123 125 133 137 138 140 140 141

FIGURE TITLE FIGURE 29 GLOBAL MARKET SHARES OF ANIMAL PHARMACEUTICALS BY REGION, 2014 (%) FIGURE 30 GLOBAL MARKET SHARES OF ANIMAL PHARMACEUTICAL PRODUCT SUPPLIERS BASED ON COMPETITOR REVENUES, 2014 (%) FIGURE 31 GLOBAL MARKET FOR AMINO ACIDS BY ANIMAL GROUP, 2012-2019 ($ FIGURE 32 GLOBAL MARKET FOR MEDICINAL FEED ADDITIVES BY ANIMAL GROUP, FIGURE 33 GLOBAL MARKET FOR NUTRITIONAL SUPPLEMENTS BY ANIMAL GROUP, FIGURE 34 GLOBAL MARKET FOR VITAMINS AND MINERALS BY ANIMAL GROUP, FIGURE 35 GLOBAL MARKET FOR ANIMAL FEED ADDITIVE PRODUCTS BY TYPE, FIGURE 36 GLOBAL MARKET FOR FEED ADDITIVES BY ANIMAL GROUP, 2012-2019 ($ FIGURE 37 GLOBAL MARKET SHARES OF FEED ADDITIVES BY ANIMAL GROUP, 2014 (%) FIGURE 38 GLOBAL MARKET FOR ANIMAL FEED ADDITIVES BY REGION, 2012-2019 ($ FIGURE 39 GLOBAL MARKET SHARES OF ANIMAL FEED ADDITIVES BY REGION, 2014 (%) FIGURE 40 GLOBAL MARKET SHARES OF SUPPLIERS OF ANIMAL FEED ADDITIVES, 2014 (%) FIGURE 41 GLOBAL MARKET FOR RAPID DIAGNOSTIC TESTS BY ANIMAL GROUP, FIGURE 42 GLOBAL MARKET FOR RAPID DIAGNOSTICS BY TEST TYPE (VETERINARY APPLICATIONS), FIGURE 43 GLOBAL MARKET FOR DIAGNOSTIC ANALYZERS AND CONSUMABLES BY ANIMAL GROUP, FIGURE 44 GLOBAL MARKET FOR DIAGNOSTIC ANALYZERS AND CONSUMABLES BY TEST TYPE (VETERINARY APPLICATIONS), FIGURE 45 GLOBAL MARKET FOR DIAGNOSTIC IMAGING EQUIPMENT AND RELATED MATERIALS BY ANIMAL GROUP, FIGURE 46 GLOBAL MARKET FOR ANIMAL DIAGNOSTICS BY TYPE, 2012-2019 ($ FIGURE 47 GLOBAL MARKET FOR ANIMAL DIAGNOSTIC PRODUCTS BY ANIMAL GROUP, FIGURE 48 GLOBAL MARKET SHARES OF ANIMAL DIAGNOSTICS BY ANIMAL GROUP, 2014 (%) FIGURE 49 GLOBAL MARKET FOR ANIMAL DIAGNOSTICS BY REGION, 2012-2019 ($ FIGURE 50 GLOBAL MARKET SHARES OF ANIMAL DIAGNOSTICS BY REGION, 2014 (%) 185 FIGURE 51 GLOBAL MARKET SHARES OF ANIMAL DIAGNOSTIC SUPPLIERS BASED ON COMPETITOR REVENUES, 2014 (%) FIGURE 52 GLOBAL MARKET FOR ANIMAL THERAPEUTICS AND DIAGNOSTICS BY PRODUCT SEGMENT, FIGURE 53 GLOBAL MARKET FOR ANIMAL THERAPEUTICS AND DIAGNOSTICS BY ANIMAL GROUP, FIGURE 54 GLOBAL MARKET SHARES OF ANIMAL THERAPEUTICS AND DIAGNOSTICS BY ANIMAL GROUP, 2014 (%) 142 144 149 153 157 160 162 163 163 165 165 167 170 171 172 173 175 181 183 183 184 186 189 191 191

FIGURE TITLE FIGURE 55 GLOBAL MARKET FOR ANIMAL THERAPEUTICS AND DIAGNOSTICS BY REGION, FIGURE 56 GLOBAL MARKET SHARES OF ANIMAL THERAPEUTICS AND DIAGNOSTICS BY REGION, 2014 (%) FIGURE 57 GLOBAL MARKET SHARES OF ANIMAL THERAPEUTICS AND DIAGNOSTICS BY SELECT COUNTRY, 2014 (%) FIGURE 58 GLOBAL MARKET SHARES OF ANIMAL THERAPEUTICS AND DIAGNOSTICS BY MANUFACTURER REVENUES, 2014 ($ FIGURE 59 ANNUAL DISTRIBUTION OF U.S. PATENTS GRANTED ON ANIMAL HEALTH PRODUCTS, JAN. 1, 2000 TO SEPT. 1, 2014 (NO.) FIGURE 60 DISTRIBUTION OF U.S. PATENTS ON ANIMAL HEALTH PRODUCTS BY PATENT HOLDER'S COUNTRY, JAN. 1, 2000 TO SEPT. 1, 2014 (NO.) 193 193 194 198 202 203