INVIVOS 2018 PRICE LIST

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INVIVOS 2018 LIST

OUTBRED MICE MPF IcrTac:ICR 3-4 M 28.70 F 28.70 Common Name: ICR 5-6 M 33.35 F 33.35 7-8 M 36.20 F 36.20 9-10 M 40.00 F 40.00 Female with litter 128.35 Untimed Pregnant* 73.50 Time-mated female 105.85 Retired breeder 41.40 INBRED MICE RF 129S6/SvEvTac 3-4 M 53.50 F 57.10 Common Name: 129SvEv 5-6 M 60.80 F 63.45 7-8 M 69.00 F 71.70 9 M 73.15 F 75.65 10 M 84.45 F 88.50 Female with litter 336.05 Untimed Pregnant* 306.75 Time-mated female 704.90 Retired breeder (male) 84.45 Retired breeder (female) 88.50

INBRED MICE MPF BALB/cAnNTac 3-4 M 41.10 F 45.25 Common Name: BALB/cAn; BALB/c 5-6 M 48.85 F 50.10 7-8 M 55.45 F 56.05 9 M 59.60 F 58.90 10 M 81.95 F 68.95 Female with litter 279.95 Untimed Pregnant* 201.10 Time-mated female 284.20 Retired breeder (male) 83.60 Retired breeder (female) 62.05 RF BALB/cAnNTac 3-4 M 57.55 F 63.35 Common Name: BALB/cAn; BALB/c 5-6 M 68.35 F 70.15 7-8 M 77.60 F 78.50 9 M 83.40 F 82.50 10 M 114.70 F 96.50 Female with litter 326.55 Untimed Pregnant* 234.60 Time-mated female 331.55 Retired breeder (male) 117.00 Retired breeder (female) 86.90 MPF C3H/HeNTac 3-4 M 45.80 F 50.80 Common Name: C3H/HeN 5-6 M 50.55 F 53.50 7-9 M 57.10 F 59.65 Female with litter 253.30 Untimed Pregnant* 234.85 Retired breeder (male) 65.40 Retired breeder (female) 81.10 RF C3H/HeNTac 3-4 M 64.10 F 71.15 Common Name: C3H/HeN 5-6 M 70.75 F 74.90 7-9 M 79.95 F 83.50 Female with litter 354.65 Untimed Pregnant* 328.75 Retired breeder (male) 91.60 Retired breeder (female) 113.55

INBRED MICE MPF C57BL/6NTac 3-4 M 43.15 F 46.35 Common Name: C57BL/6N; Black 6N 5-6 M 51.10 F 51.50 7-9 M 57.50 F 56.65 10-12 M 77.90 F 77.00 Female with litter 336.55 Untimed Pregnant* 241.35 Time-mated female 341.05 Retired breeder 76.35 RF C57BL/6NTac 3-4 M 60.45 F 64.90 Common Name: C57BL/6N; Black 6N 5-6 M 71.50 F 72.10 7-9 M 80.50 F 79.35 10-12 M 109.10 F 107.85 Female with litter 462.00 Untimed Pregnant* 338.05 Time-mated female 487.20 Retired breeder 106.90 RF FVB/NTac 3-4 M 42.70 F 46.65 Common Name: FVB/N; FVB 5-6 M 50.50 F 54.70 7-9 M 60.55 F 64.95 10 M 72.50 F 86.70 Female with litter 381.00 Untimed Pregnant* 293.30 Time-mated female 446.00 Retired breeder (male) 60.45 Retired breeder (female) 72.25

IMMUNOCOMPROMISED MICE RF CrTac:NCr-Foxn1 nu 4 M 56.05 F 62.00 Common Name: NCr nude 5-6 M 67.20 F 74.70 7-9 M 72.90 F 81.05 Female with litter 466.00 Untimed Pregnant* 386.70 Retired breeder 84.65 Prices are for both homozygous and heterozygous RF C.Cg/AnNTac-Foxn1 nu NE9 4-8 M 157.50 F 157.50 Common Name: BALB/c nude 9-12 M 176.40 F 176.40 Untimed Pregnant* 1,131.85 Retired breeder 236.00 Prices are for both homozygous and heterozygous RF C.B-Igh-1 b /IcrTac-Prkdc scid 4 M 94.50 F 94.50 Common Name: CB17 scid 5-8 M 102.25 F 102.25 Female with litter 589.00 Untimed Pregnant* 455.20 Retired breeder 94.70 RF NOD/MrkBomTac-Prkdc scid 3-8 M 130.15 F 141.60 Common Name: NOD scid 9 M 142.95 F 150.40

OUTBRED RATS MPF NTac:SD 3 M 56.50 F 58.85 Common Name: Sprague Dawley / SD 4 M 72.40 F 75.90 5 M 86.75 F 93.70 6 M 107.05 F 104.70 7 M 125.20 F 118.30 8 M 131.85 F 128.55 9 M 149.65 F 134.35 10 M 169.85 F 141.05 11 M 201.25 F 151.65 12 M 216.30 F 170.65 Female with litter 244.70 Untimed Pregnant* 194.15 Time-mated female 237.50 Retired breeder (male) 154.40 Retired breeder (female) 141.45 OUTBRED RATS MPF HanTac:WH 3 M 50.85 F 58.50 Common Name: Wistar Han 4 M 69.65 F 78.50 5 M 89.30 F 93.45 6 M 102.65 F 105.00 7 M 112.20 F 117.95 8 M 133.55 F 126.85 9 M 149.55 F 138.90 10 M 163.00 F 165.30 Female with litter 272.50 Untimed Pregnant* 222.25 Time-mated female 273.45 Retired breeder 126.95

INBRED MICE FROM THE JACKSON LABORATORIES RF C57BL/6JInv 3-4 M 44.85 F 48.65 Common Name: B6; B6J; Black 6 5-6 M 53.05 F 53.65 7-9 M 59.10 F 58.85 10-12 M 82.70 F 82.40 Female with litter 395.95 Untimed Pregnant* 283.95 Time-mated female 384.55 Retired breeder 66.00 RF BALB/cJInv 3-4 M 40.90 F 47.20 Common Name: BALB/c; 5-6 M 47.90 F 52.00 7-8 M 55.50 F 58.40 9 M 57.60 F 62.30 10 M 61.10 F 71.10 Female with litter 395.25 Untimed Pregnant* 311.00 Time-mated female 381.05 Retired breeder (male) 84.85 Retired breeder (female) 64.90 RF CBA/JInv 3-4 M 56.65 F 61.90 Common Name: CBA Jackson 5-6 M 61.10 F 65.75 7-9 M 71.55 F 82.85 10-12 M 100.95 F 105.85 Female with litter Untimed Pregnant* Time-mated female Retired breeder RF NOD.Cg- Prkdc scid Il2rg tm1wjl /SzJInv 3-5 M 185.00** F 210.15** Common Name: NSG TM 6-8 M 189.00** F 214.05** 9-10 M 210.00** F 219.80** Female with litter Untimed Pregnant* Time-mated female Retired breeder ** Pricing shown is for Academic users only. Commercial users should enquire regarding price.

CONTRACT BREEDING AND OTHER SERVICES DESCRIPTION Husbandry / Breeding Services: Individually Ventilated Cages (IVC) Husbandry / Breeding Services: Small Gnotobiotic Isolator (15 cages maximum) Husbandry / Breeding Services: Large Gnotobiotic Isolator (50 cages maximum) Biospecimens Animal Identification $31.10 per cage per week $900.15 per week $1945.60 per week DELIVERY CONTAINERS DESCRIPTION TTC with clear high profile lid (without animals) 45.15 Plastic Dividers (High Lid) (each) 6.80 Gel Packs (each) 6.40 DELIVERY CHARGES & IMPORTATION PROCESSING FEE DESCRIPTION Shipping and Handling Mice and Rats (Per Transit Container) 40.00 Urgent Delivery Charge per trip (on top of the normal delivery charge per TTC ) 50.00 Importation Processing Fee 250.00

NOTES TO THE LIST IACUC Approval All purchases of animals and services from InVivos must be accompanied by an IACUC-approved protocol number. We are unable to process orders without an IACUC-approved protocol number. Prices All prices shown in this list are before Goods and Services Tax (GST). Prices in this list are effective from 1 January 2018. Prices in this list are only valid for the period up to 31 December 2018. InVivos reserves the right to change prices at any time. Delivery All animal orders are packed in filtered, plastic shipping containers within their Barrier Unit of origin. The shipping containers are called Taconic Transit Cages (TTC ) and are designed to provide the optimal shipping environment for today s sophisticated rats and mice. Your order will include a charge for the appropriate number of TTC. An additional charge will be added based on transport and delivery costs. Animal Health Status InVivos shall follow the health monitoring procedures and standards established by Taconic as their International Health Monitoring System (IHMS ) (see www.taconic.com) Murine Pathogen Free (MPF ) MPF rats and mice are monitored to verify that they do not harbor microorganisms that are known to be pathogenic under a variety of study conditions. MPF animals are free of Helicobacter sp. (H. bilis, H. hepaticus, H. rodentium, H. typhlonius, H. trogontum, H. muridarium*), Parvoviruses, Pasteurella pneumotropica and other pathogenic organisms. A description of the IHMS microbial monitoring procedures for MPF rodents may be found at www.taconic.com. Restricted Flora (RF ) RF animals harbor a wide variety of commensal microorganisms in their flora but the animals and their environment are intensively monitored to detect the presence of specific opportunistic bacteria that can be pathogenic in immunocompromised rodents. The animals are maintained in Barrier Units utilizing IVC technology to protect the animals from opportunistic organisms. The quality control laboratory screens monthly for 5 additional organisms that are not accepted in the RF colonies: Beta haemolytic Streptococcus species, Klebsiella pneumoniae and Klebsiella oxytoca, Pseudomonas aeruginosa, and Staphylococcus aureus. A description of the IHMS microbial monitoring procedures for the RF rodents may be found at www.taconic.com. TERMS AND CONDITIONS OF SALE* (a) The Goods are supplied to the Purchaser on an as-is basis without any warranties, representations or conditions. The Purchaser assumes the entire risk as to the quality and fitness of purpose of the Goods. (b) All warranties, representations or conditions including but not limited to those relating to fitness for purpose, merchantable or satisfactory quality, durability or mortality rate of the Goods, whether express or implied by statute or common law or otherwise are hereby excluded to the fullest extent permitted by law. (c) Except in respect of personal injury or death caused directly by the negligence of INVIVOS, in no event shall INVIVOS be liable to the Purchaser for any loss or damage including any indirect, special, incidental or consequential loss or damage (including loss of profits) arising out of or in connection with this Contract as a result of any breach of this Contract, tort (including negligence), breach of statutory duty or otherwise. (d) Purchasers agree and acknowledge the following terms of use: MODELS will be used for research purposes only MODELS and biological materials derived from them will not be distributed to third parties or used for commercial purposes *(This is a summarized version of the full legal document pending)