The Karmukata of Svedana Karma: A Critical Analysis Mishra Gaurav, 1 Kumar Ashvini, 2 BA Lohith, 3 Sharma Swati. 4

Similar documents
Bhattacharyya Nirupam et al / Int. J. Res. Ayurveda Pharm. 4(5), Sep Oct Review Article.

World Journal of Pharmaceutical and Life Sciences WJPLS

International Journal of Health Sciences and Research ISSN:

International Journal of Applied Ayurved Research ISSN: AN OUTLOOK OF DETERMINATION OF RASAVAHASROTAS 1 Bhadiyadra Bharat L.

HOW XTC IMPROVED MINOXIDIL PENETRATION - 5 WAYS!

Impact factor: /ICV:

REFERENCE TO EMBRYOLOGY

Canine Myofunctional Therapy (Canine Massage)

REVIEW OF HRIDROGA WITH SPECIAL REFERENCE TO VEG-VIDHARAN HETU

Vertebrates. Vertebrate Characteristics. 444 Chapter 14

Review Article International Ayurvedic Medical Journal ISSN:

Your Dog & Massage Therapy

How it works. To name only a few, all of which can be treated using massage therapy.

Sthaulya has been learned. Symptoms of thesee two have been reviewed and compared. The difference be-

Phylum Echinodermata. Biology 11

Restore life and vitality in your dog. Feel the same results as an owner.

Ayurlog: National Journal of Research in Ayurved Science. Review on description of Seasons in Charakasamhita

Pain management: making the most of the latest options

FREQUENTLY ASKED QUESTIONS Pet Owners

Complementary therapies

PROPYLENE GLYCOL FREE MINOXIDIL TOPICAL FORMULATION FOR HAIR LOSS BASED ON PATENTED TECHNOLOGY

Restore life and vitality in your dog. Feel the same results as an owner.

Some important information about the fetus and the newborn puppy

Anatomical considerations on sira in Ayurveda with special reference to Sushruta Samhita

Lesson 7. References: Chapter 6: Chapter 12: Reading for Next Lesson: Chapter 6:

A Current Look at Navicular Syndrome. Patrick First, DVM

Burn Infection & Laboratory Diagnosis

INTRODUCTION TO WILDLIFE PHARMACOLOGY. Lisa Fosco Wildlife Rehabilitation Manager Toronto Wildlife Centre

Gastric Dilatation-Volvulus

CONCEPTUAL STUDY ON ROLE OF LIFESTYLE MODIFICATION IN THE MANAGEMENT OF OBESITY

Package leaflet: Information for the user

Nutritional support for healthy urinary tract function with stress relieving properties for cats

Mobility Issues and Arthritis

Start of new generation of NSAIDs?

VETERINARY MEDICINE-VM (VM)

SUMMARY OF PRODUCT CHARACTERISTICS

A A M J Anveshana Ayurveda Medical Journal

SUMMARY OF PRODUCT CHARACTERISTICS

World Journal of Pharmaceutical and Life Sciences WJPLS

VETERINARY BIOMEDICAL SCIENCES (VBSC)

Hurricane Animal Hospital 2120 Mount Vernon Road Hurricane, WV or

Summary of Product Characteristics

Frog Dissection Information Manuel

Metacam 1.5 mg/ml oral suspension for dogs

BREATHING WHICH IS NOT RESPIRATION

ON FORCE-FEEDING GEESE AND DUCKS (GAVAGE)

Name Class Date. After you read this section, you should be able to answer these questions:

Correlation of. Animal Science Biology & Technology, 3/E, by Dr. Robert Mikesell/ MeeCee Baker, 2011, ISBN 10: ; ISBN 13:

Feline Lower Urinary Tract Disease FLUTD

Indication for laser acupuncture, body and ear acupuncture treatment

SUMMARY OF PRODUCT CHARACTERISTICS

ANNEX I SUMMARY OF PRODUCT CHARACTERISTICS. Medicinal product no longer authorised

1. Hair 2. Mammary glands produce milk 3. Specialized teeth 4. 3 inner ear bones 5. Endothermic 6. Diaphragm 7. Sweat, oil and scent glands 8.

Course Curriculum for Master Degree Theriogenology & Artificial Insemination/Faculty of Veterinary Medicine

Just where it s needed.

SUMMARY OF PRODUCT CHARACTERISTICS. Excipients: Contains 4% w/w cetyl alcohol and 7% w/w propylene glycol.

Weekly Schedule of Neuroscience (2017/2018) Week 1

Dr. P. P. Doke. M.D., D.N.B., Ph.D., FIPHA. Professor, Department of Community Medicine, Bharati Vidyapeeth Medical College, Pune

Oral and intestinal candidiasis. As adjuvant treatment with other local nystatin preparations to prevent reinfection.

SUMMARY OF PRODUCT CHARACTERISTICS

Summary of Product Characteristics

Therapeutic apheresis in veterinary

5STEPS. Becca Tobin This Glee star plays the part of a bully, but in real life, this avid animal lover is anything but. Allergies.

Effects of Heat Stress on Reproduction in Lactating Dairy Cows

SUMMARY OF PRODUCT CHARACTERISTICS

Don t let arthritis slow down your dog!

DISSOCIATIVE ANESTHESIA

Jaipur Declaration on Antimicrobial Resistance

acupressure for joint conditions

Osmoregulation. 31 st Lecture Fri 03 April Chapter 26 & 27. Research Proposal Meetings 1

Osmoregulation Chapter 26 & 27

SUMMARY OF PRODUCT CHARACTERISTICS. 1. NAME OF THE VETERINARY MEDICINAL PRODUCT Emdocam 20 mg/ml solution for injection for cattle, pigs and horses

Clumber Spaniel Club Health Survey 2014 Summary of Results

A-l. Students shall examine the circulatory and respiratory systems of animals.

JOINT ARTICULATION DOG. Younger acting if not younger looking A PET OWNER S GUIDE. Helping dogs with joint disorders and osteoarthritis

Scientific Discussion post-authorisation update for Rheumocam extension X/007

Australian and New Zealand College of Veterinary Scientists. Fellowship Examination. Small Animal Surgery Paper 1

ANNEX I SUMMARY OF PRODUCT CHARACTERISTICS

Course Curriculum for Master Degree in Internal Medicine/ Faculty of Veterinary Medicine

Fishes, Amphibians, Reptiles

Author - Dr. Josie Traub-Dargatz

Weekly Schedule of Neuroscience (2018/2019) Week 1

Treatment of Respiratory Tract Infections Prof. Mohammad Alhumayyd Dr. Aliah Alshanwani

Metacam. The Only NSAID Approved for Cats in the US. John G. Pantalo, VMD Professional Services Veterinarian. Think easy. Think cat. Think METACAM.

Oral and intestinal candidiasis. As adjuvant treatment with other local nystatin preparations to prevent reinfection.

Nutritional support for healthy urinary tract function with stress relieving properties for cats

Copper-Storage Liver Disease Basics

Infection Control and Standard Precautions

Dry Eye Keratoconjunctivitis sicca (KCS)

Public Assessment Report Scientific discussion

SUMMARY OF PRODUCT CHARACTERISTICS

Materials and Methods: Anti-snake venom activities of Asparagus racernosus

Chapter 59 Wound Management Principles

Table of Contents. About the Author. Preface. Acknowledgments. Part One: Performing the Feline Physical Examination

American Association of Feline Practitioners American Animal Hospital Association

HUMAN PANTING? TIM AINGE & KATE MCKINNON

IACUC Policy on Humane Endpoints in Animal Use Proposals

4.5. Special precautions for use Special precautions to be taken by person administering the veterinary medicinal product to animals

Reproductive physiology and eggs

Course Syllabus. Offered by School of Veterinary Medicine With effect from Semester A 2017 /18

Transcription:

The Karmukata of Svedana Karma: A Critical Analysis Mishra Gaurav, 1 Kumar Ashvini, 2 BA Lohith, 3 Sharma Swati. 4 1 Post Graduate Scholar, 2 Professor, 3 Associate Professor and Head, Department of Panchakarma, 4 Post Graduate Scholar, Department of Dravyaguna, SDM college of Ayurveda, Hassan, Karnataka, India. A B S T R A C T Traditional approach to health care and cure has been the basic concept of Panchakarma. The Panchakarma is a branch of Ayurveda and one of the oldest health systems in the world with wide acceptance among large segments of the population. Svedana which is a major procedure of Panchakarma acts unanimously as Purvakarma, Pradhana Karma and Pashchat Karma, fight against diseases and becoming more successful in achieving Samyavastha. By its versatility it shows its effectiveness in the diseases of almost all the system by mostly causing vasodilatation and improved general circulation leading to healthy return in the condition. Svedana is considered as Bahirparimarjana Chikitsa and one among the Sad-Upakrama. Svedana which is a major procedure of Panchakarma and it is subdivided into Purvakarma, Pradhana Karma and Pashchat Karma. It is an independent Upakarma, as a Purvakarma measures generally done after Deepana, Pachana and Snehana, before administration of Shodhana treatment, Svedana is a process to induce sweating artificially in a patient who had already undergone Snehana may be or may not be. The heat is generated directly (Saagni) or indirectly (Niragni). Svedana liquefies the Doshas, clears the obstruction of channels of circulation and directs the Doshas to selective places from where they can be expelled easily. In the Vedic era the use of Natural remedies like sun-rays, fire were advocated as remedy in many disorders and mentioned as destroyers of Rakshas i.e. microbes. The current status of Svedana which indicate fluid perspiration from the body by sun light and exercise or the sweating which brought about in the body by contact of heat. Key words: Panchakarma, Shodhana, Svedana, Bahirparimarjana, Shadupakrama. INTRODUCTION Svedana is the procedure which relieves stiffness, heaviness and coldness of body and produces sweating. [1] Sveda (sweat) is a Mala (excretion) of the Medo Dhatu (adipose layer of tissues) produced in consequence to heat exposure. [2] Therapeutic Address for correspondence: Dr. Gaurav Mishra Post Graduate Scholar, Department of Panchakarma, SDM College of Ayurveda, Hassan. E-mail: drgauravmishra2349@gmail.com Submission Date : 05/04/2017 Accepted Date: 28/04/2017 Access this article online Quick Response Code Website: www.jaims.in DOI: 10.21760/jaims.v2i2.7723 production of Sveda via applying the variety of measures is known as Svedana Karma. It is one among the Shada-Upakrama [3] (six types of treatment modalities). It is foremost procedure of Panchakarma. It removes Stambha (stiffness), Gouravata (heaviness) and Sheetata (coldness) from body. Snehana produces Mriduta (softness), Klinnata (semiliquid) of the morbid Doshas [4] which are situated in the Koshtha (Amashaya/Pakvashaya i.e. Stomach/intestine), Dhatu (tissue system), Shakha (extremities), Srotas (channels). Thereafter Svedana liquefies these Doshas [5] These liquefies Doshas easily transforms into movable form and later on removed by Shodhana Karma (bio-purification) as oily and moist wood burned by Agni. Thus Svedana is useful just after Snehana Karma (therapy), both procedures helps to cause Utkleshana of Doshas. [6] Svedana should be applied according to the Doshas by the support of Journal of Ayurveda and Integrated Medical Sciences Mar - Apr 2017 Vol. 2 Issue 2 174

proper formulation if drug. The consequences of Svedana are determined on the basis of Vyadhis (disease), Ritu (season). It pacifies the Vata and Kapha Vyadhis, [7] encourage elimination of Purisha, Mutra and Retas accumulated in the body. Karmukata Karmukata of Svedana Karma can be discussed under 2 sub-headings, 1. Ayurvedic point of view A) Based on Mahabhuta B) Based on Karma A) Based on Mahabhuta [8] Guna s Mahabhuta Pramukha Karma Ushna Agni Utsahakara / Svedakara Teekshna Agni Dahapakakara / Shodhana/Srhavana Drava Jala Kledana / Syandana / Alodana Sukshma Akash, Vayu, Agni Vivaransheela / Anupraveshita Sara Vayu, Jala Anulomana / Prerana / Pravartana Sthira Prithavi Dharana / Stambhaka Rooksha Vayu, Agni Khara / Kaphahara Snigdha Jala, Prithavi B) Based on Karma [9] Mardava / Balakrita / Varnakrita Sveda Karma has 4 major actions over the body: Stambhaghnata Gouravaghnata Sheetaghnata Svedakarakata. 1. Stambhaghnata: Stambha means stiffness which is produced as a resultant of excess Sheeta Guna. Stambha also means obstruction or block. Therefore, Svedana not only relieves stiffness, but also clears blocking of passages (Srotorodha). Generally Srotas as a structural entity is Kapha Pradhana and its important function is Ayana or transport which is under the control of Vata. There by it is evident that there is a predominant influence of Vata and Kapha over the Srotas. [10] Similarly Svedana has the opposite qualities to that of Vata and Kapha, thereby producing a palliative effect on them and thus clears the Srotodushti or Sanga. In other words, application of heat increases the local circulation which renders contracted Lumina of the body to become smoother and wider. Thus relieves variety of obstructions. 2. Gouravaghnata: Heaviness of the body is being relieved by Svedana. By means of Svedana, the fluids in the body are being excreted through the Sveda (sweat) and hence the feeling of lightness in the body. Svedana stimulates the nerve endings and promotes muscle strength. 3. Sheetaghnata: Sheetaghnata has to be understood as the patient is relieved of the coldness existing prior by the Ushna Guna Pradhana Sveda Karma. 4. Svedakarakata: Svedana produces perspiration. This is a Mala (excretory product) where the wastes of all the layers of skin, muscles, nerves, Rasa, Rakta, and Meda etc. are mixed. Therefore, it is a mechanism of excreting the metabolic wastes in the body tissues. Apart from these major actions, Svedana also produces the following effects. a. Doshadraveekarana: Snehana performed prior to Svedana makes the Dosha Mridu and eradicates the Mala Sanga 11. The Svedana penetrates to each and every channel in the body and liquefies the Dosha. These liquefied Dosha has to be eliminated from the body means of Shodhana Karma. b. Vata Shamana: Sneha poorvaka Sveda pacifies the Vata Dosha, thereby curing the Purisha- Mutra-Shukra Sanga. By its properties opposite to that of Vata, it pacifies the Vata. [12] Journal of Ayurveda and Integrated Medical Sciences Mar - Apr 2017 Vol. 2 Issue 2 175

c. Gatra Vinamana: By application of oil and heat, even dry wood can be bent so similar effects may be expected from Svedana Karma. [13] It cures Harsha, Ruk, Ayama, Shopha, Stambha and Graha and produces Mardavata, thereby permitting normal flexible body movements. d. Agni Deepana: As Svedana is Ushna Guna Pradhana; it does the Ama Pachana there by promoting the Agni in the body. [14] e. Tvak Mardavata and Prasadana: Perspiration is dependent on skin, where in the hair follicles which are the Moola of Svedavahi Srotas is situated. [15] Due to sweating and excretion of wastes, the skin becomes soft and pleasant. f. Sroto Shuddhi: It is evident that there is a predominant influence of Vata and Kapha over the Srotas and Svedana has the opposite qualities to that of Vata and Kapha, thereby producing a palliative effect on them and thus clears the Srotodushti or Sanga. [16] g. Nidra-Tandra Nasha: Svedana pacifies Vata. Vata is responsible for the functions of Indriya wherein Nidra and Tandra are affecting. Svedana also pacifies Kapha thereby making the body light, and providing relaxation. Thus it prevents excessive sleep and drowsiness. [17] h. Sandhi Cheshtakara: Svedana relieves Stambha and Graha thereby promoting the Sandhi Cheshta. [18] i. Dosha Shodhana: The Dosha situated in the Dhatu, Koshtha and Shakha-Asthi and those Leena in the Srotas gets Kledana by Snehana and gets liquefied by the Svedana and comes to the Koshtha and get ready for elimination by means of Shodhana Karma. [19] 2. Modern point of view Physiological effect of heat [20] 1. Increased Metabolism - More heat in the superficial tissues that increase the metabolism which increased the demand of oxygen and nutrition which leads to increased output of waste products so there will be more removal of waste products from body and Feeling of lightness in body. 2. Increased Blood Supply - Removal of waste products is increased so there is more excretion of metabolites from walls of capillaries and arterioles which leads to vasodilatation. Because of vasodilatation there is a more blood supply ultimately which gives relax to the muscles and nerves these end up with lightness of body. Stimulation of superficial nerve endings can also cause a reflex dilatation of the arterioles. As a result of vasodilatation there is an increased flow of blood through the area so that the necessary oxygen and nutritive materials are supplied and waste products are removed. Physiology of Sweat There is two main types of sweat glands in our body eccrine and apocrine glands. Perspiration comes from small sweat glands (eccrine). These are small organs located in the skin. The eccrine glands are controlled by the sympathetic and parasympathetic nervous system and pre-optic area in hypothalamus. Due to certain stimuli (nervous or hormonal) they will secrete sweat which helps in thermal regulation. Physical effect of sudation Sudation stimulates the sensory nerve ending which produces relaxation and it relieves the muscular fatigue. In the meanwhile again it produces a hyperemic effect which causes arterioles to dilate because of this dilatation it achieves more circulation and relieves the muscular fatigue. Vasodilatation causes movements of the muscles thereby accelerating the blood supply and nutrition which relieves the muscular fatigue. Nourishment of cells and tissues [21] Because of heat there is a generation of temperature around the cell. This increased temperature causes diffusion of liquid substances from the cell membrane which leads to formation of lipoid vesicles these lipoid vesicles are expansion in the cell volume This Makes the blabbing of cell membrane inside. Due to temperature blabbing again increased these leads to Detachment of blebs from cell membrane lastly these Journal of Ayurveda and Integrated Medical Sciences Mar - Apr 2017 Vol. 2 Issue 2 176

blebs comes out from cell membrane and Provide nourishment to the tissue. Application of heat on that area creates generation of temperature gradient around the cell membrane which leads to the diffusion of liquid substances through the cell membrane this plays a key role in the formation of lipoid vesicles it causes an expansion in the cell volume this makes the blebbing of cell membrane inside. This blebbing is again increased by heat in particular direction. These blebs get detached from the cell membrane and remain there. After sometime these blebs comes out from membrane and spread further, thus providing nourishment to the tissues. DISCUSSION Hyperthermia Local increased in temperature during Svedana Karma has both therapeutic and physiological effect and very much effective in joint degenerative conditions. [22] a. It stimulates and increases local blood and lymphatic circulation and thereby improving local tissue metabolism. [23] b. During hyperthermia by modifying secretion of various inflammatory mediators it reduces inflammation. [24],[25] c. By physical effect of heat Hyperthermia relaxes local musculature and thereby reduces pain. d. A study has shown that hyperthermia increases the rate of trance dermal drug delivery and there by helpful during Abhyanga followed by Sveda for better trance dermal drug absorption. [26] Absorption of Drug Trance dermal drug delivery is the newly emerged system of drug delivery. This therapeutics is safe, efficacious and may improve patient treatment compliance. Pharmacologic considerations including avoiding first pass effect and biotransformation may also be important advantages of transdermal administration. The advantages of using transdermal drug delivery include bypassing the gastrointestinal tract and hepatic first pass biotransformation and metabolism, control of absorption and the availability of multiple sites for application. Avoiding the gastrointestinal environment which may significantly affect bioavailability would seem intuitive. The use of transdermal administration may also reduce hospitalization time and be utilized in home care. Mechanisms of Absorption [27] The skin has been referred to as the largest organ system accounting for a large proportion of the body s total surface area. Due to easy access and the ability to maintain applied formulations for prolonged periods of time, transdermal drug administration has become a dynamic area of investigation. Basically, the skin is composed of three layers consisting of the epidermis, dermis and sub dermal tissue. The epidermis in haired skin of the dog and cat is composed of four layers including the stratum corneum, stratum granulosum, stratum spinosum and the stratum basal. The cornified layer of the stratum corneum appears to provide the rate limiting step to transdermal drug absorption. Once thought to be a fairly inert layer, it is now known that this layer actively opposes absorption from outside and loss from within. Penetration of the skin depends on diffusion therefore the hydration of the skin will affect permeability. Absorption via the transdermal route primarily occurs by passive diffusion through the stratum corneum. [28] The rate of diffusion is dependent on the permeability coefficient of the drug, the applied concentration of the drug, the surface area of the skin exposed to the drug and the thickness of the epidermis (Fick s law of diffusion). Studies have revealed the fact that lipoidal barrier is very much suitable for penetration of drug molecule through stratum corneum. [29],[30],[31] On this basis we can assume that in the procedure, Taila may serve lipoidal barrier for the penetration of drug molecules of Bala and exerts immediate effect. Moreover heat applied during Valuka Svedana increases the rate of drug absorption. Modulation of Pain The precise mechanism of action in massage therapy is not known. It has been proposed that increased Journal of Ayurveda and Integrated Medical Sciences Mar - Apr 2017 Vol. 2 Issue 2 177

parasympathetic activity and a slowed-down physiological state may underpin the behavioural and physiological processes associated with massage. As discussed by Wright and Sluka, massage is thought to induce a variety of positive physiological effects that may contribute to tissue repair, pain modulation, relaxation, and improved mood. For example, these authors point to research showing that massage has beneficial effects on arterial and venous blood flow and oedema. In addition, they note that vigorous massage has been shown to increase local blood flow and cardiac stroke volume, as well as improve lymph drainage; massage also appears to have an anticoagulant effect. Finally, Wright and Sluka maintain that massage may activate segmental inhibitory mechanisms to suppress pain and that some techniques may activate descending pain inhibitory systems. CONCLUSION Svedana Karma is essential for doing any procedure in Panchakarma. Due to Poorvakarma like Snehana and Svedana, benefits and acceptance of the Pradhanakarma is improved. It makes changes in Vikrita Doshas to mobilize them without creating harm to the body. Poorvakarma helps to achieve best outcome from Pradhanakarma, in meantime body develops sensitivity to keep balance throughout the process of Pradhanakarma. Negligence of Poorvakarma makes complications as an unripe fruit get crushed during juice extraction whereas ripened fruit is best and juice can be easily extracted. It is one of the Poorvakarma and Pradhana Karma in Panchakarma. Svedana is very useful in Vata and Kapha, Amaja Diseases. Effective Clinical result can be obtained in disease conditions where in there is severe stiffness, pain, wasting of muscles, loss of muscle strength. Proper care to taken while administering Svedana to prevent Atisvinna Lakshanas. REFERENCES 1. Charaka, Dridhabala. Charaka Samhita of Agnivesa with 2013;p.120. 2. Charaka, Dridhabala. Charaka Samhita of Agnivesa with 2013;p.515. 3. Charaka, Dridhabala. Charaka Samhita of Agnivesa with 2013;120. 4. Charaka, Dridhabala. Charaka Samhita of Agnivesa with 2013;p.120. 5. Charaka, Dridhabala. Charaka Samhita of Agnivesa with 2013;p.180. 6. Charaka, Dridhabala. Charaka Samhita of Agnivesa with 2013;p180. 7. Charaka, Dridhabala. Charaka Samhita of Agnivesa with 2013;p.87. 8. Charaka, Dridhabala. Charaka Samhita of Agnivesa with 2013;p120. 9. Charaka, Dridhabala. Charaka Samhita of Agnivesa with 2013;p.120. 10. Charaka, Dridhabala. Charaka Samhita of Agnivesa with 2013;p.249. 11. Charaka, Dridhabala. Charaka Samhita of Agnivesa with 2013;p.678. 12. Charaka, Dridhabala. Charaka Samhita of Agnivesa with 2013;p.87. Journal of Ayurveda and Integrated Medical Sciences Mar - Apr 2017 Vol. 2 Issue 2 178

13. Charaka, Dridhabala. Charaka Samhita of Agnivesa with 2013;p.87. 14. Sushruth Samhita of Sushruth, Hindi tika Ayurveda 15. Sushruth Samhita of Sushruth, Hindi tika Ayurveda 16. Sushruth Samhita of Sushruth, Hindi tika Ayurveda 17. Sushruth Samhita of Sushruth, Hindi tika Ayurveda 18. Sushruth Samhita of Sushruth, Hindi tika Ayurveda 19. Sushruth Samhita of Sushruth, Hindi tika Ayurveda 20. Raj, P. Pritvi, Practical Management of Pain. Mosby. 2.000. ISBN 978-0-8151-2569-3. 21. Weinberger A, Fadilah R, Lev A, Shohami E, Pinkhas J. Treatment of articular effusions with local deep microwave hyperthermia. Clin Rheumatol. 1989 Dec;8(4):461-6. 22. H Shirota, M Goto, K Katayama. Application of adjuvant-induced local hyperthermia for evaluation of anti-inflammatory drugs. Journal of Pharmacology and Experimental Therapeutics December 1988, 247(3) 1158-1163. 23. H Shirota, M Goto, K Katayama. Application of adjuvant-induced local hyperthermia for evaluation of anti-inflammatory drugs. Journal of Pharmacology and Experimental Therapeutics December 1988, 247 (3) 1158-1163. 24. Brosseau L, Yonge KA, Welch V, Marchand S, Judd M, Wells GA, Tugwell P. Thermotherapy for treatment of osteoarthritis. Cochrane Database of Systematic Reviews 2003, Issue 4. Art. No.: CD004522. DOI: 10.1002/14651858.CD004522. 25. Otremski I, Erling G, Cohen Z, Newman RJ. The effect of hyperthermia (42.5 C) on zymosan-induced synovitis of the knee. Rheumatology. 1994 Aug 1;33(8):721-3. 26. Markovic M, Stuhlmeier KM. Short-term hyperthermia prevents activation of proinflammatory genes in fibroblast-like synoviocytes by blocking the activation of the transcription factor NF-κB. Journal of molecular medicine. 2006 Oct 1;84(10):821-32. 27. The Journal of Applied Research in Clinical and Experimental Therapeutics. Wade hull, MS, ZARS Heat- Enhanced Transdermal Drug Delivery: A Survey Paper. 28. The Journal of Applied Research in Clinical and Experimental Therapeutics, Wadehull,MS, ZARS Heat- Enhanced Transdermal Drug Delivery: A Survey Paper. 29. Dhruve K, Chaudhary A. Sneha kalpana- A probable pharmaceutical explanation. Aryvaidyan 2007;20:181-9. 30. Medina C, Santos M, Radomski A, Corrigan V, Radomski MW. Nanoparticles: Pharmacological and toxicological significance. Br J Pharmacol 2007;150:552-8. 31. Aarathi TS, Chaudhary A. Pharmaceutical standardization of Ksheerbala Taila - Shelf life study, M Pharma Ay. dissertation. Gujarat, India: Gujarat Ayurveda University; 2005. How to cite this article: Mishra Gaurav,Kumar Ashvini, BA Lohith, Sharma Swati. The Karmukata of Svedana Karma: A Critical Analysis. J Ayurveda Integr Med Sci 2017;2:174-179. http://dx.doi.org/10.21760/jaims.v2i2.7723 Source of Support: Nil, Conflict of Interest: None declared. ******************************* Journal of Ayurveda and Integrated Medical Sciences Mar - Apr 2017 Vol. 2 Issue 2 179