Histoplasmosis : Un update Ayako SANO Histoplasma capsulatum 1, 2 2008 58 http:www.pf.chiba-u.ac.jp 8 1 3 7 1 8 20,000 3 9 4 10, 11 deep-seated mycoses, systemic mycoses 3 0260-8673 1-8 -1 edical ycology Research Center, Chiba University (1-8-1, Inohana, Chuo-ku, Chiba, 260-8673, Chiba)
8 12 19 1 2 3 2 3 Aspergillus fumigatus Candida albicans Cladophialophora carrionii Cladophialophora bantiana Cryptococcus neoformans Exophiala dermatitidis onsecaea pedrosoi Sporothrix schenkii Blastomyces dermatitidis Coccidioides immitis Histoplasma capsulatumh. capsulatum var. capsulatum, H. capsulatum var. duboisii Histoplasma farciminosumhistoplasma capsulatum var. farciminosum Paracoccidioides brasiliensis Penicillium marneffei Aspergillus spp., Chaetomium spp., usarium spp., yrothecium spp., Penicillium spp. 2 1 2 3 4 5 6 7 8 b 1 c 4 1 2 3 4 5 6 7 8 e 1 17 24 67 a 72 84 78 47 59 4 3 8 2.6D 2.3SZ 5 4SH 12SZ d 8BT 13LR 4.75 H H H C, CL, H H, B C, CL, H, B H, B H, B H, IA H H, IH H, B H, B H, B C, H, B C, B H, B H, B H, IH 12Acta ed Okayama 11 : 347-364, 1957. 13 36 : 194, 1961. 14 59 : 256-257, 1984. 15J Dermatol 21 : 586-589, 1994. 16 93 : 387, 2004. 17Tropical edicine and Health 33 : 40, 2005. 18 22 : 92-96, 2008. 19 82588, 2008. 8Jpn Vet ed Sci 631229-31, 2001. 10Jpn J Vet Sci. 34333-339, 1972. 3J Vet ed Sci. 60863-5, 1998. 4 42229-35, 2001. 4 42229-35, 2001. 5Vet icrobiol, 94219-24, 2003 6J Vet ed A 52472-480, 2005. 7edical ycology 43233-245, 2007. 7edical ycology 43233-245, 2007. 9J Comp Pathol 125219-23, 2001. a ; 19841213 94b ; 20,000 c ; 5214-216, 1918d ; 20052e ; DSZSHBT LRCCLHBIH
sapro zoonosis H. capsulatum conidiophore conidium macroconidium 7 25µm microconidium 2 6µm 1 brain heart infusion agar35 37 a a 25 2 1 357 b c 25 2d 20µmx200e 20µmx400 b c d e 2 4µm 20 3 variety 20 23 RNA ITS variety 24 26 H. capsulatum var. capsulatum histoplasmosis capsulati H. capsulatum var. duboisii histoplasmosis duboisii 20, 22 1957 Yamato 12 20, 22 H. capsulatum var. farciminosum H. farciminosum histoplasmosis farciminosi 20, 23 8 15µm 20 23
30 20 23, 27, 28 1 2 H. capsulatum H. capsulatum 8 1 29 3 4 31 32
AIDS 1 15 33 advanced chronic form3. non-fatal form 7 36 H. capsulatum var. farciminosum 2, 4 7 Rhoades 34 1.benign pulmonary form2.disseminated form Nielsen 35 1. acute, fatal, disseminating disease2. H. capsulatum 4
70 24 RNA internal transcribed spacer ITS1-5.8S-ITS 2 110 24 35 37 1 32 32 2000 37 16 4 7 31 Candida glabrata 32, 33 PAS 500 DNAnested- PCR BLAST http:blast.ncbi.nlm.nih.govblast.cgi ITS-55 -GGA AGT AAA AGT CGT AAC AAG G-3 ITS-45 -TCC TCC GCT TAT TGA TAT GC-3 PCR PCR 10 100 HcA5 -CAC GCC GTG GGG GGC TGG GAG CCT-3 HcCR 5 -ATG GTG GGC RGG AGC CGG CC-3 ITS-25 -GCT GCG TTC TTC ATC GAT GC-3
x400. x400. b a c PAS x400. a-c. x1,000 ITS-35 -GCA TCG ATG AAG AAC GCA GC-3 PCR 95 4 94 1 50 1 72 2 40 72 10 7 Real-time PCR 38 H. capsulatum RNA ITS 1-5.8S-ITS 2 H. capsulatum var. capsulatum H. capsulatum var. farciminosum variety H. capsulatum var. duboisii 24 26 RNA ITS 1-5.8S-ITS 2 500 600 39 H. capsulatum RNA ITS 1-5.8S-ITS 2 H. capsulatum var. farciminosum H. capsulatum var. capsulatum
H. capsulatum var. capsulatum H. capsulatum var. duboisii 7 2008 GenBank Ajellomyces capsulatush. capsulatum RNA ITS 1-5.8S-ITS 2 H. capsulatum var. farciminosum H. capsulatum var. capsulatum 1 H. capsulatum var. capsulatum 2 H. capsulatum var. duboisii 1 4 RNA ITS 1-5.8S-ITS 2 H. capsulatum var. farciminosum H. capsulatum var. capsulatum H. capsulatum internal transcribed spacer ITS1-5.8S -ITS 2 H. capsulatum var. farciminosum H. capsulatum var. capsulatum IH. capsulatum var. capsulatum II III H. capsulatum var. duboisii IV. I 1 2, 4 7 32 18, 40 4 41 H. capsulatum var. farciminosum 2 5 1
1 Kamei K, Sano A, Kiuchi K, et al.: The trend of imported mycoses in Japan. J Infect Chemotherap : 16-20, 2003. 2,.. : 239-244, 2003. 3 Kagawa Y, Aoki S, Iwatomi T, et al.: Histoplasmosis in the skin and gingiva in a dog. J Vet ed Sci 1998 ; : 863-865. J Vet ed Sci. : 863-865, 1998. 4,, : 2.. : 217-223, 2001. 5 Ueda Y, Sano A, Tamura, et al.: Diagnosis of histoplasmosis by detection of the internal transcribed spacer region of fungal rrna gene from a paraffin-embedded skin sample from a dog in Japan. Vet icrobiol, : 219-224, 2003. 6 Nishifuji K, Ueda Y, Sano A, et al.: Interdigital involvement in a case of primary cutaneous canine histoplasmosis in Japan. J Vet ed A : 472-480, 2005. 7 urata Y, Sano A, Ueda Y, et al.: olecular epidemiology of canine histoplasmosis in Japan. ed ycol. : 233-247, 2007. 8 Katayama Y, Kuwano A, Yoshihara T.: Histoplasmosis in the lung of a race horse with yersiniosis. J Vet. ed Sci : 1229-1231, 2001. 9 orita T, Kishimoto, Shimada A, et al.: Disseminated histoplasmosis in a sea otterenhydra lutris. J Comp Pathol : 219-223, 2001. 10Oshima KI, iura S.: A histopathological report on a case of histoplasmosis in a heifer with allot's tetralogy. Nippon Juigaku Zasshi : 333-339, 1972. 11 20..,,1918, pp152-222. 12Yamato H, Hitomi H, aekawa S, imura K.: A case of histoplasmosis. Acta ed Okayama : 347-364, 1957. 13,,. : 194, 1961. 14,,,. : 256-257, 1984. 15Ohnishi K, Nagai Y, Okada K, et al.: Primary cutaneous histoplasmosis in papuloerythrodermaofuji. J Dermatol : 586-589, 1994. 16Takakura S.: A case of chronic disseminated histoplasmosis emerged during steroid maintenance therapy for rheumatoid arthritis with secondary amyloidosis and nephrotic syndrome. Tropical edicine and Health : 40, 2005. 17,, 1. : 387, 2004. 18,,, 1. : 92-96, 2008. 19, 1. : 588, 2008. 20Kwon-Chung KJ, Bennett JE.: 18. Histoplasmosis. In : Kwon-Chung KJ, Bennett JE, eds. edical ycology. Lea and ebiger, Philadelphia, PA, USA 464-513, 1992. 21Chandler W, Kaplan W, Ajello L.: 13. Histoplasmosis capsulati. In : Carruthers GB ed. A Colour Atlas and Textbook of the Histopathology of ycotic Diseases. Wolfe edical Publications Ltd., Weert, The Netherlands, 63-66, 1980. 22Chandler W, Kaplan W, Ajello L.: 14. Histoplasmosis duboisii. In : Carruthers GB ed. A Colour Atlas and Textbook of the Histopathology of ycotic Diseases. Wolfe edical Publications Ltd., Weert, The Netherlands, 67-69, 1980. 23Chandler W, Kaplan W, Ajello L.: 15. Histoplasmosis farciminosi. In : Carruthers GB ed. A Colour Atlas and Textbook of the Histopathology of ycotic Diseases. Wolfe edical Publications Ltd., Weert, The Netherlands, 70-72, 1980. 24Kasuga T, Taylor JW, White TJ.: Phylogenetic relationships of varieties and geographical groups of the human pathogenic fungus Histoplasma capsulatum Darling. J Clin icrobiol : 653-63, 1999. 25Tamura, Kasuga T, Watanabe K, et al.: Phylogenetic characterization of Histoplasma capsulatum strains based on ITS region sequences, including two new strains from Thai and Chinese patients in Japan. Nippon Ishinkin Gakkai Zasshi : 11-19, 2002. 26Kasuga T, White TJ, Koenig G, et al.: Phylogeography of the fungal pathogen Histoplasma capsulatum. ol Ecol : 3383-3401, 2003. 27,, 8..,, 2002. 28, 6 2. : 896-900, 2002. 29Kikuchi K, Sugita T, akimura K, et al.: Is Histoplasma capsulatum a native inhabitant of Japan? icrobiol Immunol. Sep ; 9: 455-459, 2008. 30. : 915-935, 1943. 31Smith JD : Histoplasmosis : acintire DK ed.: In Ettiene Cote : CLINICAL VETERINARY ADVISOR - Dogs and Cats.osby Elesevier. Amsterdam, The Netherlands, pp, 525-527, 2006. 32Kauffman CA : Histoplasmosis : a Clinical and Laboratory Update, Clinical icrobiology Reviews, :115-132, 2007. 33World Organization for Animal Healthhttp:www.oie. intengen_index.htm: Chapter 2.5.4. Epizootic lymphangitis.http:www.oie.intengnormesmmanual 2008pdf2.05.04_EPIZ_LYPHANGITIS.pdf, in OIE
Terrestrial anual 2008. 34Rhoades JD.: Canine histoplasmosis: 1. Clinical histoplasmosis. Am J Pub Health : 1512-1514, 1972. 35Nielsen SW.: Laboratory diagnosis of systemic mycoses in dogs. Part 1. ordern Vet Prac : 210-216, 1979. 36ackie JT, Kaufman L, Ellis D.: Confirmed histoplasmosis in an Australian dog. Aust Vet J : 362-363, 1997. 37Lenhart, SW, Schafer P, Singal, Hajjeh RA : Histoplasmosis. Protecting Workers at Risk.www.cdc.govniosh, http:www.cdc.govnioshdocs2005-109, 2004. 38artagon-Villamil J, Shrestha N, Sholtis, et al. : Identification of Histoplasma capsulatum from culture extracts by real-time PCR. J Clin icrobiol. : 1295-1298, 2003. 39Summerbell RC, oore K, Starink-Willemse, Van Iperen A.: ITS barcodes for Trichophyton tonsurans and T. equinum. ed ycol : 193-200, 2007. 40,, 2. : 250-254, 1991. 41Wheat LJ, reifeld AG, Kleiman B, et al.: Infectious Diseases Society of America. Clinical practice guidelines for the management of patients with histoplasmosis : 2007 update by the Infectious Diseases Society of America. Clin Infect Dis. : 807-825, 2007.