OIE Collaborating Centres Reports Activities
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1 OIE Collaborating Centres Reports Activities Activities in 2017 This report has been submitted : :04:00 Title of collaborating centre: Diagnosis and Vaccine Evaluation in the Address of Collaborating Centre: 1920 Dayton Ave. Ames, Iowa UNITED STATES OF AMERICA Tel.: Fax: address: byron.e.rippke@aphis.usda.gov Website: Name of Director of Institute (Responsible Official): E. Name (including Title and Position) of Head of the Collaborating Centre (formally OIE Contact Point): E., Director Name of writer: Ms. T.G.Weiland OIE Collaborating Centres Reports Activities,
2 ToR: To provide services to the OIE, in particular within the region, in the designated specialty, in support of the implementation of OIE policies and, where required, seek for collaboration with OIE Reference Laboratories ToR: To identify and maintain existing expertise, in particular within its region 1. Activities as a centre of research, expertise, standardisation and dissemination of techniques within the remit of the mandate given by the OIE Training, capacity building Cohosted the OIE/IICAB 2017 Veterinary Biologics Training Program The program provided training on manufacturing and regulatory requirements to 33 international participants representing 16 countries: Argentina, Australia, Belgium, Brazil, Canada, China, Egypt, Germany, Hong Kong, India, Japan, New Zealand, Republic of Korea, Russia, Saudi, Arabia, Singapore; also Puerto Rico. Diagnosis, biotechnology and laboratory Inspection and compliance activities for international veterinary biologics manufacturers Various facilities in a total of 7 countries (Argentina, Canada, Czech Republic, Mexico, Romania, Spain, United Kingdom) were evaluated for production of veterinary biologics in support of their importation into the United States. Veterinary medicinal products Participate in VICH and CAMEVET harmonization activities Focused on harmonization of veterinary medicinal products and providing outreach to developing countries. Vaccines Continued development of an ELISA to test potency of killed rabies vaccines (RV) In conjunction with RV manufacturers + industry experts, MAbs were tested in different ELISA formats against reference viruses and adjuvanted and non-adjuvanted vaccines. CVB is awaiting the respective optimized parameters from RV manufacturers. ToR : To propose or develop methods and procedures that facilitate harmonisation of international standards and guidelines applicable to the designated specialty 2. Proposal or development of any procedure that will facilitate harmonisation of international regulations applicable to the surveillance and, food safety or animal welfare 2 OIE Collaborating Centres Reports Activities, 2017
3 Proposal title /Content Applicable area Harmonisation of Target Animal Batch Safety Exemption issues CVB participated in TABSE harmonization, addressed in VICH documents GL50 & GL55 for live and inactivated vaccines, respectively. The VSM , Target Animal Safety Testing Exemption (August 14, 2017) was published to implement VICH guidance on TABSE. Harmonisation of Lab Animal Safety Testing CVB participated in VICH discussions regarding Lab Animal Safety testing, in order to pursue further exemptions and reduction in animal testing, a Reduce- Refine-Replace (3R) initiative. Discussions are ongoing. The draft is being worked on by the Expert Working Group. Harmonisation of Extraneous Agent Testing CVB participated in the initial discussions; a draft on harmonisation is under review. Further discussions are to follow. ToR: To establish and maintain a network with other OIE Collaborating Centres designated for the same specialty, and should the need arise, with Collaborating Centres in other disciplines ToR: To carry out and/or coordinate scientific and technical studies in collaboration with other centres, laboratories or organisations 3. Did your Collaborating Centre maintain a network with other OIE Collaborating Centres (CC), Reference Laboratories (RL), or organisations designated for the same specialty, to coordinate scientific and technical studies? Name of OIE CC/RL/other organisation(s) Location Region of networking Centre Purpose Natl. Inst. for Biological standardization & Control (NIBSC) + WHO Expert Committee on Biological Standardization (ECBS) South Mimms, UK, and Geneva, Switzerland Asia and Pacific The CVB participated in an international collaborative study to assess suitability of the candidate (NIBSC 16/204) as the 7th WHO international Standard for Rabies Vaccine; the CVB conducted the National Institutes of Health (NIH) test for rabies vaccine potency. an Directorate for the Quality of Medicines & HealthCare (EDQM) Strasbourg, France Asia and Pacific CVB completed Phase III Clostridium septicum vaccine in vitro method testing of the Biological Standardization Programme, to support reducing animal usage during production of Clostridial vaccines. OIE Collaborating Centres Reports Activities,
4 4. Did your Collaborating Centre maintain a network with other OIE Collaborating Centres, Reference laboratories, or organisations in other disciplines, to coordinate scientific and technical studies? Name of OIE CC/RL/other organisation(s) Location Region of networking Centre Purpose Centers for Disease Control and Prevention, USDA Agricultural Research Service, National Animal Health Laboratory Network, Center for Epidemiology and Animal Health USA Asia and Pacific Share influenza virus and vaccine information (for all pertinent species), and coordinate surveillance, testing, and analysis ToR: To place expert consultants at the disposal of the OIE. 5. Did your Collaborating Centre place expert consultants at the disposal of the OIE? Name of expert Kind of consultancy Subject CVB edit and review of 16 sections in various chapters for 2018 edition of OIE Manual of Diagnostic Tests and Vaccines for Terrestrial Animals Represented the US on the Committee of Veterinary Medicines for the (CAMEVET) Information sharing, trade facilitation, and harmonization of the registration of veterinary biological products Represented the US at two Veterinary International Conferences on Harmonization (VICH) Information sharing, trade facilitation, and harmonization of the registration of veterinary biological products ToR: To provide, within the designated specialty, scientific and technical training to personnel from OIE Member Countries 6. Did your Collaborating Centre provide scientific and technical training, within the remit of the mandate given by the OIE, to personnel from OIE Member Countries? a) Technical visits: 0 b) Seminars: 33 c) Hands-on training courses: 0 d) Internships (>1 month): 0 4 OIE Collaborating Centres Reports Activities, 2017
5 Type of technical training provided (a, b, c or d) Content Country of origin of the expert(s) provided with training No. participants from the corresponding country b Cohosted the OIE/IICAB 2017 Veterinary Biologics Training Program Argentina, Australia, Belgium, Brazil, Canada, China, Egypt, Germany, Hong Kong, India, Japan, New Zealand, Republic of Korea, Russia, Saudi Arabia, Singapore; also Puerto Rico. 33 ToR: To organise and participate in scientific meetings and other activities on behalf of the OIE 7. Did your Collaborating Centre organise or participate in the organisation of scientific meetings on behalf of the OIE? No ToR: To collect, process, analyse, publish and disseminate data and information relevant to the designated specialty 8. Publication and dissemination of any information within the remit of the mandate given by the OIE that may be useful to Member Countries of the OIE a) Articles published in peer-reviewed journals: 0 b) International conferences: 1 Expert member of a Focus group with invited stakeholders on field efficacy trials for veterinary vaccines, in a meeting conducted by the Veterinary Biologicals and Emerging Therapies, Veterinary Medicines Division of the an Medicines Agency, London, June 22-23, A presentation was given on US efficacy requirements to support licensing veterinary vaccines. The final version of the report from the Focus group is under review and will be published. Recommendations based on the findings of the report will be sent to relevant regulatory bodies. c) National conferences: 0 d) Other (Provide website address or link to appropriate information): 2 1. Invited, submitted, and accepted manuscript, "The manufacture of veterinary vaccines; Control of final product", Chapter 13, Food and Agriculture Organization of the United Nations, text entitled Veterinary Vaccines for Livestock. 2. Invited manuscript submitted, under review: "The manufacture of veterinary vaccines; Manufacturing facilities", Chapter 11, Food and Agriculture Organization of the United Nations, text entitled Veterinary Vaccines for Livestock. OIE Collaborating Centres Reports Activities,
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