Animal Health and Antibiotics Looking Ahead with Science
|
|
- Kristopher Hensley
- 5 years ago
- Views:
Transcription
1 Animal Health and Antibiotics Looking Ahead with Science t
2 The Overton Window Unthinkable Radical Acceptable Sensible Popular Policy Prohibition of therapeutic uses of medically important antimicrobials Prohibition of prevention and control uses of medically important antimicrobials Prohibition of growth promotion uses of medically important antimicrobials
3 AMDUCA? The same regulations as published in the Federal Register in 1996 still apply today. The AMDUCA regs were utilized to limit the ability to use cephalosporins in an extralabel manner in food animals.
4 Guidance Documents Guidance for Industry (GFI) 209 April, 2012 Imagining a delineation between growth promotion, prevention/control, and therapy judicious vs. hazard Principle 1: The use of medically important antimicrobial drugs in food-producing animals should be limited to those uses that are considered necessary for assuring animal health.
5 U. S. CTC, TC and OTC Cattle Approval Examples (Feed and Water) Feed efficiency/rate of gain Prevention/Control Treatment CTC: 10 mg/lb BW for up to 5 days CTC: 400 g/ton to provide 10 mg/lb per day in calves up to 250 lbs TC: 22 mg/kg for 3-5 days in calves OTC: 0.5 to 2.0 g/hd per day????? CTC: 350 mg/hd per day in beef cattle under 700 lbs CTC: 0.5 mg/lb per day in beef cattle over 700 lbs CTC: 350 mg/hd per day in beef cattle CTC: mg/hd per day in calves lbs Gone as of January 1, 2017 CTC: 70 mg/hd per day in growing cattle over 400 lbs CTC: 0.1 mg/hd per day in calves up to 250 lbs These are not all of the CTC, TC, and OTC indications, but are selected to illustrate the regimen range.
6 However, the Agency believes that it is not limited to making risk determinations based solely on documented scientific information, but may use other suitable information as appropriate.
7 Who defines medically important? Appendix A, GFI #152 List is determined by an expert FDA panel managed by the Center for Drug Evaluation and Research (CDER) Within the FDA The World Health Association also has a list of medically important antibiotoics Human health Animal health
8 WHO Prioritization within the critically important designation Glycopeptides Fluoroquinolones Cephalosporins Macrolides
9 Antimicrobials Not Classified as Medically Important Ionophores: monensin, lasalocid Flavophospholipol: bambermycins (e.g., Flavomycin, Gainpro ) Bacitracin Pleuromutilins: Tiamulin Not medically important in the U.S., but classified as highly important by WHO
10 Medically Important Antimicrobials with Feed or Water Labels Aminoglycosides: gentamicin, neomycin Lincosamides: lincomycin Macrolides: tylosin, tilmicosin (Pulmotil currently requires a VFD in swine and cattle) Penicillins (natural): penicillin G included in combination products Florfenicol: CHPC included as highly important drug in GFI #152 appendix A, Florfenicol is considered medically important. Existing VFD status for feed in aquaculture.
11 Medically Important Antimicrobials with Feed or Water Labels Streptogramins:virginiamycin Sulfonamides: Includes both potentiated (e.g., trimethoprim/sulfa) and non-potentiated sulfonamides. Tetracyclines: chlortetracycline, oxytetracycline, tetracycline
12
13 Guidance for Industry 213 December, 2013 This guidance document puts forth nonbinding recommendations for companies to comply with Guidance 209. There was a 3 month period for companies to communicate with the FDA/CVM regarding their intent to comply with the voluntary recommendations in Guidance 209. A 3 year period for companies to comply ends in December of 2016.
14 GFI 213 A company may remove the label indications for growth promotion and insert label requirements for veterinary authorization without being subjected to other requirements such as updating the label in other areas (e.g., microbial safety).
15 The VFD in one slide Written only, non-verbal Feed, free choice feed, hand fed feed, milk, milk replacer are feeds Absolutely no extralabel use Starting January 1, 2017, must have a VFD to feed the feed containing a VFD drug to food animals An animal only appears on a VFD once, multiple VFDs required for pulsing Type A medicated articles are not feeds, Type B and Type C medicated feeds are feeds.g
16 Some Other Hot Topics
17 California SB27 Goes beyond GFI #209 Routine prevention All antibiotics under veterinary control
18 Penicillin/Tetracyclines in Animal Feed 1977 NOOH on the use of penicillins and tetracyclines in animal feed 2011 NRDC, CSPI, UCS, FACT filed a law suit in U.S. District Court to force the CVM to have the hearings 2012 Judge says CVM must have the hearings 2012 Appeal by HHS/FDA/CVM 2014 Ruling in favor of FDA Appeal?
19 Executive Order The Executive Order directs establishment of the Task Force for Combating Antibiotic-Resistant Bacteria, co-chaired by the Secretaries of Defense, Agriculture, and Health and Human Services (HHS).
20 Executive Order The Executive Order directs the Secretary of HHS, in consultation with the Secretary of Agriculture, to establish a Presidential Advisory Council on Combating Antibiotic-Resistant Bacteria, to be composed of leading non-governmental experts
21 Executive Order The Presidential Advisory Council will provide advice, information, and recommendations regarding programs and policies intended to: preserve antibiotic effectiveness; strengthen surveillance of antibiotic-resistant infections; advance the development of rapid, point-of-care diagnostics for use in human healthcare and agriculture; advance research on new treatments for bacterial infections; develop alternatives to the use of antibiotics for some agricultural purposes; and improve international coordination of efforts to combat antibiotic resistance.
22 Executive Order The National Strategy provides detailed actions for five interrelated national goals to be achieved by 2020 in collaboration with partners in healthcare, public health, veterinary medicine, agriculture, and food safety, as well as in academic, Federal, and industrial research and development. The goals are: 1. Slow the emergence and prevent the spread of resistant bacteria. 2. Strengthen National efforts to identify and report cases of antibiotic resistance.
23 Executive Order The National Strategy 3. Advance the development and use of rapid diagnostic tests for the identification and characterization of antibiotic-resistant bacteria. 4. Accelerate basic and applied research and development for new antibiotics as well as other therapeutics and vaccines. 5. Improve international collaboration, capacities for antibiotic-resistance prevention, surveillance, control, and antibiotic research and development.
24 The veterinary profession is not only going to be responsible for all medically-important antimicrobial uses in food animals we are going to be accountable
25 Antibiotic Use Monitoring
26 Antimicrobial Use Monitoring In my opinion, should be actual use, tied to reason for use Total kg as a metric only serves as a stick to drive cut the use as a goal Animal Daily Doses (ADD) and Animal Regimens (AR) provide a look into drug exposure as well as number of animals receiving the regimen. There may be different regimens for the same drug in a species.
27 Antimicrobial Use Monitoring The only way to drive the needed granularity in the data is to Give agriculture the steering wheel for data collection Government audit of the sampling strategy and data handling Absolute guarantee of anonymity for participants Sampling structure must balance Ability to engage the same participants year after year New participants and random sampling of repeat participants each year for appropriate sampling of the industry. Granularity of public data and data used to drive antibiotic stewardship may vary
28 Fundamentals Denominators really, really matter Numerators are relatively easy And this has driven an interactive environment for this issue in which some engage based only on numerators
29 My View Stewardship is good, but no antibiotics not an option Never-ever systems where treated animals or groups are removed from the system are disingenuous It is about the system and the overall effect of the system on antibiotic use When there is an incentive to not treat an animal with an infectious disease, what do you think happens to speed of treatment and time to alleviation of an infectious disease?
30 What is Stewardship? 1. Responsibility for appropriate diagnostics and establishment of an accurate and functional case definition 5. Is this antibiotic intervention still necessary? Yes 2. Is there a non-antibiotic alternative which will appropriately prevent, control, or treat this disease challenge? 4. Assuring use of the antibiotic as shown to be safe and effective While 3. Selection of an antibiotic which has been demonstrated to be safe and effective for this purpose
31 Who is driving change in food animal antimicrobial use?
32 Drivers of Change in Food Animal Antimicrobial Use PARA S621 Legislation DART HR2459 PAMTA HR1552 ADUFA Cephalosporins VFD Regulation GFI 209 GFI 213 Fluoroquinolone s AMDUCA Tyson McDonald s Chipotle Retailation Panera Walmart Chic Fil - A
33 A Big Difference In duration of disease risk Chicken 4 # days 10# days Swine 6 months Beef cattle months
34 What price to say antibiotic free with no asterisk? Ionophores
35 Antimicrobial stewardship is cannot going to be used as a competitive advantage between or within food animal industries.
36 from here The days of verbal treatment protocols are gone The days of unacceptable treatment records are gone The days of nontransparent use of antimicrobials in food animals are coming to an end Neither veterinarians or producers can be passive in these efforts.
37 Antibiotic Resistance Issues
38 Alexander Fleming But I would like to sound one note of warning. Penicillin is to all intents and purposes nonpoisonous so there is no need to worry about giving an overdose and poisoning the patient. There may be a danger, though, in underdosage. It is not difficult to make microbes resistant to penicillin in the laboratory by exposing them to concentrations not sufficient to kill them, and the same thing has occasionally happened in the body.
39 Rice LB. Mechanisms of resistance and clinical relevance of resistance to beta-lactams, glycopeptides, and fluoroquinolones. Mayo Clinic Proceedings, 97: , 2012.
40 Food Animal Antibiotic Use in the United States
41 Yearly sales data are available But the last publically available human data are from 2011.
42
43
44
45
46
47
48
49
50 So, where does the "80% used in food animals" come from? Well, if you add the 4,122,397 kg of ionophores sales reported for 2011, then you come up with the following values. It doesn't move the value that much to take the ionophores out because they go into both the numerator and denominator. All Antimicrobial Sales Totals 13,569,039 3,289,175 Expressed as percent of total human and food animal sales 80.5% 19.5%
51 Food Animal Sales 2011 (kg) Human Sales 2011 (kg) Medically Important Antimicrobial Totals (kg) 9,446,641 3,289,175 Expressed as percent of total human and food animal sales of medically important antimicrobials 74.2% 25.8%
52
53 Antibiotic-Resistant Microorganism Carbapenem Resistant Enterobacteriaceae (CRE) Drug-resistant Neisseria gonorrhoeae (any drug) Infections Included HAIs caused by Klebsiella and E. coli with onset in hospitalized patients Infections not Included Estimated Annual Number of Cases Estimated Annual Number of Deaths 1, 2, 3 9, All infections 246,000 <5 Multidrug-resistant Acinetobacter (three or more drug classes) HAIs with onset in hospitalized patients 1,2 7, Drug-resistant Campylobacter (azithromycin or ciprofloxacin) Drug-resistant Candida (fluconazole) Extended-spectrum β-lactamase producing Enterobacteriaceae (ESBLs) Vancomycin-resistant Enterococcus (VRE) Multidrug-resistant Pseudomonas aeruginosa (three or more drug classes) Drug-resistant non-typhoidal Salmonella (ceftriaxone, ciprofloxacin 7, or 5 or more drug classes) All infections 310, HAIs with onset in hospitalized patients HAIs caused by Klebsiella and E. coli with onset in hospitalized patients HAIs with onset in hospitalized patients HAIs with onset in hospitalized patients 1,2 3, ,2,3 26, ,2 20, ,2 6, All infections 100,000 40
54 Antibiotic-Resistant Microorganism Infections Included Infections not Included Estimated Annual Number of Cases Estimated Annual Number of Deaths Drug-resistant Salmonella Typhi (Ciprofloxacin 7 ) All infections 3,800 <5 Drug-resistant Shigella (Azithromycin or ciprofloxacin) All infections 27,000 <5 Methicillin-resistant Staphylococcus aureus (MRSA) Invasive infections 4 80, Streptococcus pneumoniae (full resistance to clinically relevant All infections 1,200, drugs) Drug-resistant tuberculosis (any clinically relevant drug) All infections 1, Vancomycin-resistant Staphylococcus aureus (VRSA) All infections <5 <5 Erythromycin-resistant Group A Streptococcus Invasive infections 5 1, Erythromycin-resistant Group B Streptococcus Invasive infections 6 7, Summary Totals for Antibiotic-Resistant Infections 2,049,442 1,473,442 23,488 22,130 Healthcare-associated Clostridium difficile Infections infections in acute care hospitals or in patients requiring hospitalization 250,000 14,000
55 1. Infections occuring outside of acute-care hospitals (e.g., nursing homes) 2. Infections acquired in acute care hospitals but not diagnosed until after discharge 3. Infections caused by Enterobacteriaceae other than Klebsiella and E. coli (e.g., Enterobacter spp.) 4. Both healthcare and community-associated non-invasive infections such as wound and skin and soft tissue infections 5. Non-invasive infections including common upper-respiratory infections like strep throat 6. Non-invasive infections and asymptomatic intrapartum colonization requiring prophylaxis 7 Resistance or partial resistance
Mike Apley Kansas State University
Mike Apley Kansas State University 2003 - Daptomycin cyclic lipopeptides 2000 - Linezolid - oxazolidinones 1985 Imipenem - carbapenems 1978 - Norfloxacin - fluoroquinolones 1970 Cephalexin - cephalosporins
More informationCountdown to the New Veterinary Feed Directive
Countdown to the New Veterinary Feed Directive Where we are going and what got us here Mike Apley Kansas State University 2003 - Daptomycin cyclic lipopeptides 2000 - Linezolid - oxazolidinones 1985 Imipenem
More informationAntibiotics in the future tense: The Application of Antibiotic Stewardship in Veterinary Medicine. Mike Apley Kansas State University
Antibiotics in the future tense: The Application of Antibiotic Stewardship in Veterinary Medicine Mike Apley Kansas State University Changes in Food Animal Antibiotic Use How the uses of antibiotics in
More informationUsing Antimicrobials Like We Want to Keep Them. Mike Apley, DVM, PhD Kansas State University
Using Antimicrobials Like We Want to Keep Them Mike Apley, DVM, PhD Kansas State University Therapy Prevention Control Regluations Animal Medicinal Drug Use Clarification Act (AMDUCA) Regulations published
More information9/30/2016. Dr. Janell Mayer, Pharm.D., CGP, BCPS Dr. Lindsey Votaw, Pharm.D., CGP, BCPS
Dr. Janell Mayer, Pharm.D., CGP, BCPS Dr. Lindsey Votaw, Pharm.D., CGP, BCPS 1 2 Untoward Effects of Antibiotics Antibiotic resistance Adverse drug events (ADEs) Hypersensitivity/allergy Drug side effects
More informationMedically Important Antibiotics in Animal Agriculture
Medically Important Antibiotics in Animal Agriculture Craig Lewis, DVM MPH Office of the Director Center for Veterinary Medicine Farm Foundation Antimicrobial Stewardship Workshop Davis, California October,
More informationWhat bugs are keeping YOU up at night?
What bugs are keeping YOU up at night? Barbara DeBaun, RN, MSN, CIC 26 th Annual Medical Surgical Nursing Conference South San Francisco, CA April 15, 2016 Objectives Describe the top three infectious
More informationVeterinary Feed Directive Information
Veterinary Feed Directive Information Focus and Scope Veterinary- Patient-Client Relationship Veterinarian issuing a VFD is required to be licensed to practice veterinary medicine and operate in compliance
More informationVeterinary Feed Directive
Veterinary Feed Directive Medically Important Antibiotics in Animal Agriculture Outline Questions to Be Addressed What changes are being made and why? What drugs are affected, which ones are not? What
More informationAntibiotic Resistance. Antibiotic Resistance: A Growing Concern. Antibiotic resistance is not new 3/21/2011
Antibiotic Resistance Antibiotic Resistance: A Growing Concern Judy Ptak RN MSN Infection Prevention Practitioner Dartmouth-Hitchcock Medical Center Lebanon, NH Occurs when a microorganism fails to respond
More informationChanges to Antibiotic Labeling & Veterinary Feed Directive. Craig A. Payne, DVM, MS Director, Veterinary Extension & CE University of Missouri
Changes to Antibiotic Labeling & Veterinary Feed Directive Craig A. Payne, DVM, MS Director, Veterinary Extension & CE University of Missouri Outline How did we get here? What changes will occur? Getting
More informationOutline Changes to Antibiotic Labeling & Veterinary Feed Directive
Outline Changes to Antibiotic Labeling & Veterinary Feed Directive Craig A. Payne, DVM, MS Director, Veterinary Extension & CE University of Missouri How did we get here? What changes will occur? Getting
More informationVeterinary Feed Directive: What You Need to Know
Iowa Farm Bureau s Margin Management Webinar Series presents: Veterinary Feed Directive: What You Need to Know Are you prepared for implementation of the Veterinary Feed Directive on January 1, 2017? Introduction:
More informationHuman health impacts of antibiotic use in animal agriculture
Human health impacts of antibiotic use in animal agriculture Beliefs, opinions, and evidence Peter Davies BVSc, PhD College of Veterinary Medicine, University of Minnesota, USA Terminology Antibiotic Compound
More informationANTIBIOTIC RESISTANCE THREATS. in the United States, 2013
ANTIBIOTIC RESISTANCE THREATS in the United States, 2013 TABLE OF CONTENTS Foreword... 5 Executive Summary.... 6 Section 1: The Threat of Antibiotic Resistance... 11 Introduction.... 11 National Summary
More informationTABLE OF CONTENTS Foreword...5 Executive Summary...6 Section 1: The Threat of Antibiotic Resistance...11 Introduction...11 National Summary Data...
TABLE OF CONTENTS Foreword....5 Executive Summary....6 Section 1: The Threat of Antibiotic Resistance....11 Introduction....11 National Summary Data....13 Cycle of Resistance Infographics....14 Minimum
More informationANTIMICROBIAL STEWARDSHIP
ANTIMICROBIAL STEWARDSHIP Australian Pig Veterinarians Annual Conference 11-12 September, 2017 Stephen Page Advanced Veterinary Therapeutics swp@advet.com.au OUTLINE Importance of AMR Antimicrobial use
More informationChanges in Antibiotic Labeling Veterinary Feed Directive. Changes in Antibiotic Regulations. Concerns with Antibiotic Use 2/29/2016
Changes in Antibiotic Labeling Veterinary Feed Directive Craig A. Payne, DVM, MS Extension Veterinarian Commercial Agriculture Program University of Missouri Changes in Antibiotic Regulations How did we
More informationThe Rise of Antibiotic Resistance: Is It Too Late?
The Rise of Antibiotic Resistance: Is It Too Late? Paul D. Holtom, MD Professor of Medicine and Orthopaedics USC Keck School of Medicine None DISCLOSURES THE PROBLEM Antibiotic resistance is one of the
More informationChanges in Antibiotic Labeling Veterinary Feed Directive
Changes in Antibiotic Labeling Veterinary Feed Directive Craig A. Payne, DVM, MS Extension Veterinarian Commercial Agriculture Program University of Missouri Changes in Antibiotic Regulations How did we
More informationProceedings of the 19th American Academy of Veterinary Pharmacology and Therapeutics Biennial Symposium
www.ivis.org Proceedings of the 19th American Academy of Veterinary Pharmacology and Therapeutics Biennial Symposium May 17-20, 2015 Fort Collins, CO, USA Reprinted in the IVIS website with the permission
More information3/1/2016. Antibiotics --When Less is More. Most Urgent Threats. Serious Threats
Antibiotics --When Less is More Ralph Gonzales, MD, MSPH Associate Dean, Clinical Innovation School of Medicine VP, Clinical Innovation, UCSF Health Most Urgent Threats Serious Threats Multidrug-Resistant
More informationTestimony of the Natural Resources Defense Council on Senate Bill 785
Testimony of the Natural Resources Defense Council on Senate Bill 785 Senate Committee on Healthcare March 16, 2017 Position: Support with -1 amendments I thank you for the opportunity to address the senate
More informationThe Future of Antibiotic Alternatives
The Future of Antibiotic Alternatives @Elanco #feedthe9 Grady Bishop Sr. Director Market Access Elanco 1 The Global Landscape our WHY 2 Today s 3 Food Security Realities 3 The Protein Gap 4 The impact
More informationImagine. Multi-Drug Resistant Superbugs- What s the Big Deal? A World. Without Antibiotics. Where Simple Infections can be Life Threatening
Multi-Drug Resistant Superbugs- What s the Big Deal? Toni Biasi, RN MSN MPH CIC Infection Prevention Indiana University Health Imagine A World Without Antibiotics A World Where Simple Infections can be
More informationCombating Antimicrobial Resistance: The Way Forward
Combating Antimicrobial Resistance: The Way Forward James M. Hughes, MD Professor of Medicine and Public Health Emory University Atlanta, GA NIAA Antibiotic Symposium November 14, 2014 Disclosure No conflicts
More informationThe UK 5-year AMR Strategy - a brief overview - Dr Berit Muller-Pebody National Infection Service Public Health England
The UK 5-year AMR Strategy - a brief overview - Dr Berit Muller-Pebody National Infection Service Public Health England Chief Medical Officer - Annual Report 2013 Antimicrobial resistance poses catastrophic
More informationThe VFDs Are Coming!
The VFDs Are Coming! January 1, 2017 Are You Ready? Federal Regulatory Bodies 1 Growing concern over antimicrobial resistance 2 Veterinary Feed Directive (VFD) President Clinton signed the Animal Drug
More informationSafe Patient Care Keeping our Residents Safe Use Standard Precautions for ALL Residents at ALL times
Safe Patient Care Keeping our Residents Safe 2016 Use Standard Precautions for ALL Residents at ALL times #safepatientcare Do bugs need drugs? Dr Deirdre O Brien Consultant Microbiologist Mercy University
More informationUSA ACTION PLAN FOR COMBATING ANTIBIOTIC-RESISTANT BACTERIA
FMM/RAS/298: Strengthening capacities, policies and national action plans on prudent and responsible use of antimicrobials in fisheries Final Workshop in cooperation with AVA Singapore and INFOFISH 12-14
More informationSurveillance for antimicrobial resistance in enteric bacteria in Australian pigs and chickens
Surveillance for antimicrobial resistance in enteric bacteria in Australian pigs and chickens Dr Pat Mitchell R & I Manager Production Stewardship APL CDC Conference, Melbourne June 2017 Dr Kylie Hewson
More informationGlobal Overview on Antibiotic Use Policies in Veterinary Medicine
Global Overview on Antibiotic Use Policies in Veterinary Medicine Dr Shabbir Simjee Global Regulatory & Technical Advisor Microbiology & Antimicrobials Elanco Animal Health Basingstoke, England simjeess@elanco.com
More informationHow is Ireland performing on antibiotic prescribing?
European Antibiotic Awareness Campaign 2016 November Webinar Series on Antibiotic Prescribing How is Ireland performing on antibiotic prescribing? Dr Rob Cunney National Clinical Lead HCAI AMR Clinical
More informationAntimicrobial Stewardship:
Antimicrobial Stewardship: Inpatient and Outpatient Elements Angela Perhac, PharmD afperhac@carilionclinic.org Disclosure I have no relevant finances to disclose. Objectives Review the core elements of
More informationVFD : On Farm Changes Chris J. Rademacher, DVM
VFD : On Farm Changes Chris J. Rademacher, DVM ISU Swine Extension Veterinarian cjrdvm@iastate.edu Twitter: @cjrdvm Summary of FDA Guidance 209/213 1. Limits medically important antibiotics to therapeutic
More informationVaccination as a potential strategy to combat Antimicrobial Resistance in the elderly
Vaccination as a potential strategy to combat Antimicrobial Resistance in the elderly Wilbur Chen, MD, MS 22-23 March 2017 WHO meeting on Immunization of the Elderly The Problem Increasing consumption
More informationAntimicrobial stewardship: Quick, don t just do something! Stand there!
Antimicrobial stewardship: Quick, don t just do something! Stand there! Stanley I. Martin, MD, FACP, FIDSA Director, Division of Infectious Diseases Director, Antimicrobial Stewardship Program Geisinger
More informationUnderstanding the Veterinary Feed Directive
Understanding the Veterinary Feed Directive JENNIFER R. KAUF, VMD D A I R Y S I D E V E T E R I N A R Y S E R V I C E M A R T I N S B U R G, P A J U N E 2 9-3 0, 2 0 1 6 One Health Integrative effort of
More informationFDA Antibiotic Resistance Strategy
FDA Antibiotic Resistance Strategy NIAA Antimicrobial Use and Resistance Symposium November 14, 2014 William T. Flynn, DVM, MS Center for Veterinary Medicine (CVM) U.S. Food and Drug Administration (FDA)
More informationWhat s next in the antibiotic pipeline?
What s next in the antibiotic pipeline? Jennifer Tieu, Pharm.D., BCPS Clinical Pearls OSHP Spring Meeting Mercy Hospital April 13, 2018 Objective 2 Describe the drug class and mechanism of action of antibiotics
More informationConcise Antibiogram Toolkit Background
Background This toolkit is designed to guide nursing homes in creating their own antibiograms, an important tool for guiding empiric antimicrobial therapy. Information about antibiograms and instructions
More informationEC Workshop on scientific advice from AMEG
EC Workshop on scientific advice from AMEG Brussels, 26 Nov 2015 Session 2: Antibiotic Categorisation AMEG Q2 Karolina Törneke / Helen Jukes Liability disclaimer: The views or positions expressed in this
More informationSummary of the latest data on antibiotic resistance in the European Union
Summary of the latest data on antibiotic resistance in the European Union EARS-Net surveillance data November 2017 For most bacteria reported to the European Antimicrobial Resistance Surveillance Network
More informationANTIBIOTICS: TECHNOLOGIES AND GLOBAL MARKETS
ANTIBIOTICS: TECHNOLOGIES AND GLOBAL MARKETS PHM025D March 2016 Neha Maliwal Project Analyst ISBN: 1-62296-252-4 BCC Research 49 Walnut Park, Building 2 Wellesley, MA 02481 USA 866-285-7215 (toll-free
More informationAMU/AMR Policy for animals in Korea Jaehong CHANG, DVM, MS
AMU/AMR Policy for animals in Korea Jaehong CHANG, DVM, MS Deputy Director of Animal Health Management Division, Ministry of Agriculture, Food and Rural Affairs, Republic of Korea Contents Background Consequence
More informationUnderstanding the Hospital Antibiogram
Understanding the Hospital Antibiogram Sharon Erdman, PharmD Clinical Professor Purdue University College of Pharmacy Infectious Diseases Clinical Pharmacist Eskenazi Health 5 Understanding the Hospital
More informationMultidrug-Resistant Organisms: How Do We Define them? How do We Stop Them?
Multidrug-Resistant Organisms: How Do We Define them? How do We Stop Them? Roberta B. Carey, PhD Centers for Disease Control and Prevention Division of Healthcare Quality Promotion Why worry? MDROs Clinical
More informationBurton's Microbiology for the Health Sciences. Chapter 9. Controlling Microbial Growth in Vivo Using Antimicrobial Agents
Burton's Microbiology for the Health Sciences Chapter 9. Controlling Microbial Growth in Vivo Using Antimicrobial Agents Chapter 9 Outline Introduction Characteristics of an Ideal Antimicrobial Agent How
More informationKorea s experience of total ban of antibiotics in animal feed
Korea s experience of total ban of antibiotics in animal feed 217. 11. 27. JANG WON YOON D.V.M., M.S., Ph.D. College of Veterinary Medicine, Kangwon National University SUK-KYUNG LIM D.V.M., Ph.D. Animal
More informationHealthcare Facilities and Healthcare Professionals. Public
Document Title: DOH Guidelines for Antimicrobial Stewardship Programs Document Ref. Number: DOH/ASP/GL/1.0 Version: 1.0 Approval Date: 13/12/2017 Effective Date: 14/12/2017 Document Owner: Applies to:
More informationPreventing Multi-Drug Resistant Organism (MDRO) Infections. For National Patient Safety Goal
Preventing Multi-Drug Resistant Organism (MDRO) Infections For National Patient Safety Goal 07.03.01 2009 Methicillin Resistant Staphlococcus aureus (MRSA) About 3-8% of the population at large is a carrier
More informationProject Summary. Impact of Feeding Neomycin on the Emergence of Antibiotic Resistance in E. coli O157:H7 and Commensal Organisms
Project Summary Impact of Feeding Neomycin on the Emergence of Antibiotic Resistance in E. coli O157:H7 and Commensal Organisms Principal Investigators: Mindy Brashears, Ph.D., Texas Tech University Guy
More informationEducating Clinical and Public Health Laboratories About Antimicrobial Resistance Challenges
Educating Clinical and Public Health Laboratories About Antimicrobial Resistance Challenges Janet Hindler, MCLS MT(ASCP) UCLA Medical Center jhindler@ucla.edu also working as a consultant with the Association
More informationAntibiotic Use in Food Animals What, So What, Now What?
Antibiotic Use in Food Animals What, So What, Now What? Thomas R. Shryock, Ph.D. Elanco Animal Health Greenfield, IN, USA 46140 thomas.r.shryock73@lilly.com 1-317-277-5087 Office For clarity, these are
More informationAntimicrobial Stewardship Strategy: Antibiograms
Antimicrobial Stewardship Strategy: Antibiograms A summary of the cumulative susceptibility of bacterial isolates to formulary antibiotics in a given institution or region. Its main functions are to guide
More informationBeef Producers. The Judicious Use of Antimicrobials for
The Judicious Use of Antimicrobials for Beef Producers Introduction The production of safe and wholesome animal products for human consumption is a primary goal of beef producers. To achieve that goal,
More informationPacker Processor Industry Council
Packer Processor Industry Council September 26, 2013 Naples, Florida Richard Raymond, M.D. Foodborne Illnesses down 29% in last decade Media hits for foodborne illness outbreaks up 150% in last decade
More informationDR. BASHIRU BOI KIKIMOTO
OVERVIEW OF ANTIMICROBIAL RESISTANCE AND ANTIMICROBIAL USE IN GHANA PRESENTED BY : DR. BASHIRU BOI KIKIMOTO DVM. PhD VETERINARY PUBLIC HEALTH HEAD - PUBLIC HEALTH UNIT & FOOD SAFETY UNIT VENUE: SWATZILAND
More informationMercy Medical Center Des Moines, Iowa Department of Pathology. Microbiology Department Antibiotic Susceptibility January December 2016
Mercy Medical Center Des Moines, Iowa Department of Pathology Microbiology Department Antibiotic Susceptibility January December 2016 These statistics are intended solely as a GUIDE to choosing appropriate
More information5/4/2018. Multidrug Resistant Organisms (MDROs) Objectives. Outline. Define a multi-drug resistant organism (MDRO)
Multidrug Resistant Organisms (MDROs) Kasturi Shrestha, M.D. 05/11/2018 Objectives Define a multi-drug resistant organism (MDRO) Identify most challenging MDROs in healthcare Identify reasons for health
More informationAntibiotic Resistance in the Post-Acute and Long-Term Care Settings: Strategies for Stewardship
Antibiotic Resistance in the Post-Acute and Long-Term Care Settings: Strategies for Stewardship J. Hudson Garrett Jr., PhD, MSN, MPH, FNP-BC, PLNC, CDONA, IP-BC, GDCN, CDP, CADDCT, CALN, VA-BC, AS-BC,
More informationVeterinary Feed Directives
VFD Where it is today Vita Plus Swine Summit Morton, MN March 30 th, 2016 Dr. J. Tyler Holck, DVM, MS, MBA Veterinary Feed Directives How did we get here? Impact Requirements Streamlining the Work Electronic
More informationVFD Where it is today
VFD Where it is today Vita Plus Swine Summit Morton, MN March 30 th, 2016 Dr. J. Tyler Holck, DVM, MS, MBA Veterinary Feed Directives How did we get here? Impact Requirements Streamlining the Work Electronic
More informationAMR epidemiological situation: ECDC update
One Health Network on Antimicrobial Resistance (AMR) AMR epidemiological situation: ECDC update Dominique L. Monnet, on behalf of ECDC Antimicrobial Resistance and Healthcare-Associated Infections (ARHAI)
More information11/22/2016. Hospital-acquired Infections Update Disclosures. Outline. No conflicts of interest to disclose. Hot topics:
Hospital-acquired Infections Update 2016 APIC-CI Conference November 17 th, 2016 Jay R. McDonald, MD Chief, ID Section VA St. Louis Health Care System Assistant Professor of medicine Washington University
More informationJune 12, For animal antibiotics, the safety assessment is more stringent than that for human antibiotics in three ways:
June 12, 2012 Honorable Louise Slaughter Member of Congress 2469 Rayburn House Office Building Washington, DC 20515 Dear Congresswoman Slaughter: We are aware of the letters you sent in February to establishments
More informationAntimicrobial Resistance Trends in the Province of British Columbia
655 West 12th Avenue Vancouver, BC V5Z 4R4 Tel 604.707.2443 Fax 604.707.2441 www.bccdc.ca Antimicrobial Resistance Trends in the Province of British Columbia 2013 Prepared by the Do Bugs Need Drugs? Program
More informationTaking Action to Prevent and Manage Multidrug-resistant Organisms and C. difficile in the Nursing Home: Part 1 Reviewing the organisms
Taking Action to Prevent and Manage Multidrug-resistant Organisms and C. difficile in the Nursing Home: Part 1 Reviewing the organisms Nimalie D. Stone, MD,MS Division of Healthcare Quality Promotion National
More informationSuggestions for appropriate agents to include in routine antimicrobial susceptibility testing
Suggestions for appropriate agents to include in routine antimicrobial susceptibility testing These suggestions are intended to indicate minimum sets of agents to test routinely in a diagnostic laboratory
More information03/09/2014. Infection Prevention and Control A Foundation Course. Talk outline
Infection Prevention and Control A Foundation Course 2014 What is healthcare-associated infection (HCAI), antimicrobial resistance (AMR) and multi-drug resistant organisms (MDROs)? Why we should be worried?
More informationPresented by: Mary McGoldrick, MS, RN, CRNI
Managing Infection Control Challenges in the Home Mary McGoldrick, MS, RN, CRNI Home Care and Hospice Consultant Saint Simons Island, GA CE Credit in Five Easy Steps! 1. Scan your badge as you enter each
More informationPRACTIC GUIDELINES for APPROPRIATE ANTIBIOTICS USE
PRACTIC GUIDELINES for APPROPRIATE ANTIBIOTICS USE Global Alliance for Infection in Surgery World Society of Emergency Surgery (WSES) and not only!! Aims - 1 Rationalize the risk of antibiotics overuse
More informationConsequences of Antimicrobial Resistant Bacteria. Antimicrobial Resistance. Molecular Genetics of Antimicrobial Resistance. Topics to be Covered
Antimicrobial Resistance Consequences of Antimicrobial Resistant Bacteria Change in the approach to the administration of empiric antimicrobial therapy Increased number of hospitalizations Increased length
More informationRxPress. May/Jun Vol 16 No 3. The White House Releases Plan to Combat Antibiotic-Resistant Bacteria
May/Jun 2015 Vol 16 No 3 RxPress TABLE OF CONTENTS The White House Releases Plan to Combat Antibiotic-Resistant Bacteria 1-2 FDA Requests New Data on Health Care Antiseptics 2-4 Penicillin Allergies and
More informationMID 23. Antimicrobial Resistance. Consequences of Antimicrobial Resistant Bacteria. Molecular Genetics of Antimicrobial Resistance
Antimicrobial Resistance Molecular Genetics of Antimicrobial Resistance Micro evolutionary change - point mutations Beta-lactamase mutation extends spectrum of the enzyme rpob gene (RNA polymerase) mutation
More informationFlorida Health Care Association District 2 January 13, 2015 A.C. Burke, MA, CIC
Florida Health Care Association District 2 January 13, 2015 A.C. Burke, MA, CIC 11/20/2014 1 To describe carbapenem-resistant Enterobacteriaceae. To identify laboratory detection standards for carbapenem-resistant
More informationAntimicrobial Resistance
Antimicrobial Resistance Consequences of Antimicrobial Resistant Bacteria Change in the approach to the administration of empiric antimicrobial therapy Increased number of hospitalizations Increased length
More informationAntimicrobial Resistance Acquisition of Foreign DNA
Antimicrobial Resistance Acquisition of Foreign DNA Levy, Scientific American Horizontal gene transfer is common, even between Gram positive and negative bacteria Plasmid - transfer of single or multiple
More informationImplementation of a National Action Plan and International standards especially with regard to Responsible and prudent use of antimicrobials
Implementation of a National Action Plan and International standards especially with regard to Responsible and prudent use of antimicrobials Dr. Sasi Jaroenpoj, D.V.M Head of Veterinary Products and AMR
More informationAntimicrobial Resistance Food Animal Antibiotic Use
Antimicrobial Resistance Food Animal Antibiotic Use H. Scott Hurd DVM, PhD College of Veterinary Medicine, Department of Production Animal Medicine Iowa State University, Ames IA 50011, 515-294-7905. shurd@iastate.edu
More informationRecommendations for Implementation of Antimicrobial Stewardship Restrictive Interventions in Acute Hospitals in Ireland
Recommendations for Implementation of Antimicrobial Stewardship Restrictive Interventions in Acute Hospitals in Ireland A report by the Hospital Antimicrobial Stewardship Working Group, a subgroup of the
More informationMedically Important Antimicrobials in Animal Agriculture. Sheep
Medically Important Antimicrobials in Animal Agriculture Sheep Mike Murphy DVM, JD, Ph.D., DABVT, DABT Veterinary Medical Officer Office of the Director Center for Veterinary Medicine FDA Outline Take
More informationHealthcare-associated Infections Annual Report December 2018
December 2018 Healthcare-associated Infections Annual Report 2011-2017 TABLE OF CONTENTS INTRODUCTION... 1 METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS INFECTIONS... 2 MRSA SURVEILLANCE... 3 CLOSTRIDIUM
More informationEARS Net Report, Quarter
EARS Net Report, Quarter 4 213 March 214 Key Points for 213* Escherichia coli: The proportion of patients with invasive infections caused by E. coli producing extended spectrum β lactamases (ESBLs) increased
More informationAntibiotics. Antimicrobial Drugs. Alexander Fleming 10/18/2017
Antibiotics Antimicrobial Drugs Chapter 20 BIO 220 Antibiotics are compounds produced by fungi or bacteria that inhibit or kill competing microbial species Antimicrobial drugs must display selective toxicity,
More informationCONTAGIOUS COMMENTS Department of Epidemiology
VOLUME XXIII NUMBER 1 July 2008 CONTAGIOUS COMMENTS Department of Epidemiology Bugs and Drugs Elaine Dowell, SM (ASCP), Marti Roe SM (ASCP), Ann-Christine Nyquist MD, MSPH Are the bugs winning? The 2007
More informationKeeping Antibiotics Working: Nursing Leadership in Action
Keeping Antibiotics Working: Nursing Leadership in Action Pat McLaine, DrPH, MPH, RN Robyn Gilden, PhD, RN Department of Family and Community Health Maryland Nurses Association October 2016 US 2 million
More information1 January 2017, It is Coming Preparation for VFD Changes Beginning 1 January 2017
1 January 2017, It is Coming Preparation for VFD Changes Beginning 1 January 2017 ASM-00007 1 CHAPTERS Background: Food and Drug Administration (FDA) guidance documents Introduction: Veterinary Feed Directive
More informationEpidemiology and Economics of Antibiotic Resistance
Epidemiology and Economics of Antibiotic Resistance Eili Y. Klein February 17, 2016 Health Watch USA Meeting I. The burden of antibiotic resistance is a growing global threat, but hard numbers are lacking
More information11/22/2016. Veterinary Feed Directive. Medicated Feed Parentage. The Veterinarian and Medicated Feed: Roles. (Introduction) Type A medicated article
Medicated Feed Parentage Veterinary Feed Directive (Introduction) Drug(s) Feed Dragan Momcilovic DVM, PhD, DACT Veterinary Medical Officer Center for Veterinary Medicine (CVM) U.S. Food and Drug Administration
More informationReady to Launch: Antimicrobial Stewardship for All!
Ready to Launch: Antimicrobial Stewardship for All! Lucas Schulz, PharmD, BCPS AQ ID Clinical Coordinator Infectious Diseases PGY2 Infectious Diseases Residency Program Director Disclosures Consultant
More information2016 Antibiotic Susceptibility Report
Fairview Northland Medical Center and Elk River, Milaca, Princeton and Zimmerman Clinics 2016 Antibiotic Susceptibility Report GRAM-NEGATIVE ORGANISMS 2016 Gram-Negative Non-Urine The number of isolates
More informationIowa Pork Congress. Des Moines, Iowa. January 23, Richard Raymond, M.D.
Iowa Pork Congress Des Moines, Iowa January 23, 2014 Richard Raymond, M.D. Consulting relationship with Elanco Consulting relationship with Merck Animal Health Member of Tyson Fresh Foods Animal Well Being
More informationAdvanced Practice Education Associates. Antibiotics
Advanced Practice Education Associates Antibiotics Overview Difference between Gram Positive(+), Gram Negative(-) organisms Beta lactam ring, allergies Antimicrobial Spectra of Antibiotic Classes 78 Copyright
More informationTalking Points Preservation of Antibiotics for Medical Treatment Act
Talking Points Preservation of Antibiotics for Medical Treatment Act Risk assessment is the proper tool for making policy decisions about the use of antibiotics in animals. Decisions made without risk
More informationAntimicrobials & Resistance
Antimicrobials & Resistance History 1908, Paul Ehrlich - Arsenic compound Arsphenamine 1929, Alexander Fleming - Discovery of Penicillin 1935, Gerhard Domag - Discovery of the red dye Prontosil (sulfonamide)
More informationAnimal Antibiotic Use and Public Health
A data table from Nov 2017 Animal Antibiotic Use and Public Health The selected studies below were excerpted from Pew s peer-reviewed 2017 article Antimicrobial Drug Use in Food-Producing Animals and Associated
More informationRCH antibiotic susceptibility data
RCH antibiotic susceptibility data The following represent RCH antibiotic susceptibility data from 2008. This data is used to inform antibiotic guidelines used at RCH. The data includes all microbiological
More informationStewardship of Antibiotics in Food Producing Animals
Stewardship of Antibiotics in Food Producing Animals Veterinary Feed Directive Dr. Al Schultz, Vita Plus Breaking News May 25, 2016 'Nightmare Bacteria' Superbug Found for First Time in U.S NBC News Woman
More informationAntibiotics: mode of action and mechanisms of resistance. Slides made by Special consultant Henrik Hasman Statens Serum Institut
Antibiotics: mode of action and mechanisms of resistance. Slides made by Special consultant Henrik Hasman Statens Serum Institut This presentation Definitions needed to discuss antimicrobial resistance
More information