In Vitro Antimicrobial Activity of CP-99,219, a Novel Azabicyclo-Naphthyridone

Size: px
Start display at page:

Download "In Vitro Antimicrobial Activity of CP-99,219, a Novel Azabicyclo-Naphthyridone"

Transcription

1 ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, Feb. 993, p /93/ $0.00/0 Copyright 993, American Society for Microbiology Vol. 37, No. In Vitro Antimicrobial Activity of, a Novel Azabicyclo-Naphthyridone BETH BRIGGS GOODING AND RONALD N. JONES* Anti-Infectives Research Center, Department of Pathology, University of Iowa College of Medicine, Iowa City, Iowa 5 Received 7 July 99/Accepted December 99 is a trifluoronaphthyridone with significant antibacterial activity that includes the family Enterobacteraceae (MICs for 90% of the strains tested [MIC90s], <0.05 to,ug/ml), MoraxeUla catarrhalis, Haemophilus influenzae, and gonococci (MICs, <0.05 p.g/ml). LegioneUla spp. were also susceptible, with MICs of 0.00 to,ug/ml. demonstrated activity greater than that of ciprofloxacin, ofloxacin, or enoxacin against Pseudomonas aeruginosa (MICg., p,g/ml), Xanthomonas maltophilia (MIC90,,ug/ml), Staphylococcus haemolyticus (MIC90,,ug/ml), Enterococcus faecalis (MIC90,,ug/ml), and pneumococci (MIC90,,ug/ml). Numerous ciprofloxacin-resistant isolates were susceptible to, a new compound showing potential value for further in vivo trials. is a novel investigational fluoroquinolone with a structure differing from those of norfloxacin, ciprofloxacin, and enoxacin (,,, ). It contains the C-7 ring moiety 7-(3-azabicyclo[3..0]hexyl) on a basic naphthyridone configuration. The bicyclo C-7 substitution has been previously evaluated and described in CP-7,667 (5). The -N substitution of is a difluorinated structure identical to that of tosufloxacin (3, 0) that produces enhanced activity against some ciprofloxacin-resistant organisms. In this study, we compared activity with those of four clinically available quinolones (ciprofloxacin, enoxacin, norfloxacin, and ofloxacin) by using standardized methods. Isolates from patients at University of Iowa hospitals and clinics in 99 and 99 were tested. Most of the strains were recent bloodstream isolates or from sterile (nonurinary) body fluids. The 00 Legionella pneumophila isolates were from both clinical and environmental sources (State of Iowa medical centers, 9 to 99). was provided by Pfizer Central Research (Groton, Conn.). The standard powders of ciprofloxacin, enoxacin, norfloxacin, ofloxacin, oxacillin, ampicillin, and erythromycin were obtained from their domestic manufacturers. Broth microdilution trays containing the fluoroquinolones diluted in cation-adjusted Mueller-Hinton broth were produced and quality controlled by Prepared Media Laboratories (Tualatin, Oreg.). The trays were stored at -60 C or below until used. National Committee for Clinical Laboratory Standards-recommended methods were used for dilution tests. For gonococci, fastidious species, and anaerobic bacteria, National Committee for Clinical Laboratory Standards modifications were utilized (6, 7). The antimicrobial agents for Legionella tests were diluted in buffered-starchyeast extract agar, and the isolates were inoculated at a concentration of 06 CFU per spot (9). The MIC results for nearly 00 clinical isolates are summarized in Table. had MICs for 90% of the strains tested (MIC90s) that were generally two- to eightfold greater than those of ciprofloxacin for the family Enterobac- * Corresponding author. 39 teriaceae (range, <0.05 to,ug/ml) but equal to or twofold less than those of ofloxacin. The activity of CP- 99,9 was comparable to or greater (MIC0s, c,ug/ml) than that of ciprofloxacin, ofloxacin, or enoxacin against Pseudomonas aeruginosa, Xanthomonas maltophilia, and methicillin-susceptible Staphylococcus aureus. The staphylococci least susceptible to were those having methicillin or oxacillin resistance. showed its greatest activity among the fluoroquinolones when tested against S. haemolyticus and other staphylococci (MIC90, or,ug/ml). enterococcal activity (MICg, or,ug/ml) was most comparable to that of ciprofloxacin but greater than that of ofloxacin or enoxacin. activity against the key respiratory tract pathogens Moraxella catarrhalis, Haemophilus influenzae, and pneumococci was very potent (all MICs, <,ug/ml; MIC0s, '0.05 to,ug/ml). This degree of potency was equal to or eightfold higher than that of ciprofloxacin. Neisseria species were extremely susceptible to (MIC90s, 0.00 to 0.00,g/ml), as were Bacillus cereus strains that produced a broad-spectrum beta-lactamase. Anaerobic bacteria such as Bacteroides fragilis (MIC50,,ug/ml) were the only species consistently resistant to. Legionella pneumophila was equally susceptible to, ciprofloxacin, and ofloxacin. This measured activity was eightfold greater than that of erythromycin (Table )., a new azabicyclo naphthyridone resembling CP-7,667 (5) and tosufloxacin, was evaluated in vitro against 70 recent bacterial isolates from a large university medical center. Generally, had a greater potency and spectrum of activity (susceptibility was defined as c,g/ml) (7) than ciprofloxacin or ofloxacin. Organisms for which the MICs were. p,g/ml were rare among current clinical strains (P. aeruginosa, B. fragilis, oxacillinresistant S. aureus, and S. haemolyticus). These preliminary in vitro results indicate that has a wide spectrum of activity and potential for use against some strains resistant to currently available fluoroquinolones. Further studies of pharmacokinetics, toxi-

2 350 NOTES ANTIMICROB. AGENTS CHEMOTHER. TABLE. In vitro activity of compared with those of other fluorinated antibiotics against gram-positive and gram-negative pathogens Organism Antimicrobial MIC (,g/ml) Citrobacter diversus (0) Citrobacterfreundii (0) Enterobacter aerogenes (0) C0.00 C C0.05- C C < Enterobacter agglomerans (0) ' Enterobacter cloacae (0) Escherichia coli (0) ' < Kiebsiella oxytoca () Kebsiella pneumoniae (0) Morganella morganii (0) Proteus mirabilis (0) Proteus vulgaris (0) Continued on following page

3 VOL. 37, 993 NOTES 35 TABLE -Continued Organism Antimicrobial MIC (,ug/ml) Providencia rettgeri (0) Providencia stuartii (0) Salmonella enteritidis (0) Serratia marcescens (0) Shigella spp. (0) Yersinia enterocolitica (0) Acinetobacter spp. (0) Pseudomonas aeruginosa (30) Xanthomonas maltophilia (0) Moraxella catarrhalis (0) Haemophilus influenzae (5) Neisseria gonorrhoeae (30) Neisseria spp. (0) Ampicillin 0.05 ' ' ' '0.05 ' >6 '0.05 ' > C ' ' <- - ' < <0.00- <- < > > - ->6 - '0.05 < < > Continued on following page

4 35 NOTES ANTIMICROB. AGENTS CHEMOTHER. TABLE -Continued Organism Antimicrobial MIC (LLg/ml) Bacteroides fragilis (6) Legionella pneumophila (00) Erythromycin Staphylococcus aureus, oxacillin susceptible (0) C Staphylococcus aureus, oxacillin resistant (0) C0.05 > > > - -> 6 - Staphylococcus epidermidis (0) > >6 < > - -> 6 - Staphylococcus haemolyticus (0) Oxacillin.0.05 >6 C > - -> Other coagulase-negative staphylococci (0)' C Enterococcus faecalis () Enterococcus faecium (0) 6 > >6 - -> ->6 - Streptococci Group A (0) Group B (0) Groups C, F, G () Streptococcus pneumoniae (30) < Bacillus cereus (0) ' a Includes seven species.

5 VOL. 37, 993 NOTES 353 cology, and other in vitro characteristics appear to be indicated. We are grateful for the technical support of M. Barrett, M. Erwin, D. Johnson, S. Anderson, and L. Miller. This study was funded in part by a technical/research grant from Pfizer Inc. REFERENCES. Chin, N.-X., and H. C. Neu. 9., a quinolone carboxylic acid compound against aerobic and anaerobic bacteria. Antimicrob. Agents Chemother. 5: Fuchs, P. C., A. L. Barry, R. N. Jones, and C. Thornsberry. 95. Evaluation of in vitro antibacterial activity of enoxacin: comparison with other orally absorbed antimicrobial agents, proposed disk diffusion test interpretive criteria, and quality control limits. Diagn. Microbiol. Infect. Dis. 3: Hooper, D. C., and J. S. Wolfson. 99. Fluoroquinolone antimicrobial agents. N. Engl. J. Med. 3: Ito, A., K. Hirai, M. Inoue, H. Koga, S. Suzue, T. Irikura, and S. Mitsuhashi. 90. In vitro antibacterial activity of AM-75, a new nalidixic acid analog. Antimicrob. Agents Chemother. 7: Jones, R. N., and M. E. Erwin. 99. In vitro activity of CP-7667 compared to four other fluoroquinolones. Diagn. Microbiol. Infect. Dis. 5: National Committee for Clinical Laboratory Standards. 99. Tentative standard M-T. Methods for antimicrobial susceptibility testing of anaerobic bacteria. National Committee for Clinical Laboratory Standards, Villanova, Pa. 7. National Committee for Clinical Laboratory Standards Approved standard, M7-A. Standard methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically. National Committee for Clinical Laboratory Standards, Villanova, Pa.. Sato, K., Y. Matsuura, M. Inoue, T. Une, Y. Osada, H. Ogawa, and S. Mitsuhashi. 9. In vitro and in vivo activity of DL-0, a new oxazine derivative. Antimicrob. Agents Chemother. : Sawatari, K., N. Ito, M. Nagasawa, H. Nakasato, H. Koga, K. Watanabe, H. Tanaka, K. Fujita, Y. Shiegeno, K. Yanaguchi, K. Izumikawa, A. Saito, and K. Hara. 95. New susceptibility testing medium (BSYE agar) for Legionella and Legionella -like organisms. Chemotherapy 3: Wolfson, J. S., and D. C. Hooper. 99. Fluoroquinolone antimicrobial agents. Clin. Microbiol. Rev. :37-.

In Vitro Activity of DR-3355, an Optically Active Ofloxacin

In Vitro Activity of DR-3355, an Optically Active Ofloxacin ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, Sept. 1988, p. 1336-1340 0066-4804/88/091336-05$02.00/0 Copyright C 1988, American Society for Microbiology Vol. 32, No. 9 In Vitro Activity of, an Optically Active

More information

4 th and 5 th generation cephalosporins. Naderi HR Associate professor of Infectious Diseases

4 th and 5 th generation cephalosporins. Naderi HR Associate professor of Infectious Diseases 4 th and 5 th generation cephalosporins Naderi HR Associate professor of Infectious Diseases Classification Forth generation: Cefclidine, cefepime (Maxipime),cefluprenam, cefoselis,cefozopran, cefpirome

More information

against Clinical Isolates of Gram-Positive Bacteria

against Clinical Isolates of Gram-Positive Bacteria ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, Feb. 993, p. 366-370 Vol. 37, No. 0066-0/93/00366-05$0.00/0 Copyright 993, American Society for Microbiology In Vitro Activity of CP-99,9, a New Fluoroquinolone,

More information

PDF hosted at the Radboud Repository of the Radboud University Nijmegen

PDF hosted at the Radboud Repository of the Radboud University Nijmegen PDF hosted at the Radboud Repository of the Radboud University Nijmegen The following full text is a publisher's version. For additional information about this publication click this link. http://hdl.handle.net/2066/26062

More information

In Vitro and In Vivo Antibacterial Activities of T-3761, a New Quinolone Derivative

In Vitro and In Vivo Antibacterial Activities of T-3761, a New Quinolone Derivative ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, Mar. 1993, p. 384-392 0066-4804/93/030384-09$02.00/0 Copyright 1993, American Society for Microbiology Vol. 37, No. 3 In Vitro and In Vivo Antibacterial Activities

More information

Antibacterial Spectrum

Antibacterial Spectrum ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, Sept. 1992, p. 1894-1901 0066-4804/92/091894-08$02.00/0 Copyright 1992, American Society for Microbiology Vol. 36, No. 9 In Vitro and In Vivo Antibacterial Activities

More information

2012 ANTIBIOGRAM. Central Zone Former DTHR Sites. Department of Pathology and Laboratory Medicine

2012 ANTIBIOGRAM. Central Zone Former DTHR Sites. Department of Pathology and Laboratory Medicine 2012 ANTIBIOGRAM Central Zone Former DTHR Sites Department of Pathology and Laboratory Medicine Medically Relevant Pathogens Based on Gram Morphology Gram-negative Bacilli Lactose Fermenters Non-lactose

More information

Aberdeen Hospital. Antibiotic Susceptibility Patterns For Commonly Isolated Organisms For 2015

Aberdeen Hospital. Antibiotic Susceptibility Patterns For Commonly Isolated Organisms For 2015 Aberdeen Hospital Antibiotic Susceptibility Patterns For Commonly Isolated s For 2015 Services Laboratory Microbiology Department Aberdeen Hospital Nova Scotia Health Authority 835 East River Road New

More information

Reassessment of the "Class" Concept of Disk Susceptibility Testing

Reassessment of the Class Concept of Disk Susceptibility Testing Reassessment of the "Class" Concept of Disk Susceptibility Testing Disks versus Minimal Inhibitory Concentrations with Eleven Cephalosporins ARTHUR L. BARRY, PH.D., CLYDE THORNSBERRY, PH.D., RONALD N.

More information

Cipro for gram positive cocci in urine

Cipro for gram positive cocci in urine Buscar... Cipro for gram positive cocci in urine 20-6-2017 Pneumonia can be generally defined as an infection of the lung parenchyma, in which consolidation of the affected part and a filling of the alveolar

More information

with Stability to Dehydropeptidase I

with Stability to Dehydropeptidase I ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, Feb. 99, p. 5- Vol. 33, No. 0066-0/9/005-0$0.00/0 Copyright C 99, American Society for Microbiology In Vitro Antibacterial Activity of, a Carbapenem Antibiotic with

More information

Evaluation of the BIOGRAM Antimicrobial Susceptibility Test System

Evaluation of the BIOGRAM Antimicrobial Susceptibility Test System JOURNAL OF CLINICAL MICROBIOLOGY, Nov. 1985, p. 793-798 0095-1137/85/110793-06$02.00/0 Copyright 1985, American Society for Microbiology Vol. 22, No. 5 Evaluation of the BIOGRAM Antimicrobial Susceptibility

More information

Help with moving disc diffusion methods from BSAC to EUCAST. Media BSAC EUCAST

Help with moving disc diffusion methods from BSAC to EUCAST. Media BSAC EUCAST Help with moving disc diffusion methods from BSAC to EUCAST This document sets out the main differences between the BSAC and EUCAST disc diffusion methods with specific emphasis on preparation prior to

More information

C&W Three-Year Cumulative Antibiogram January 2013 December 2015

C&W Three-Year Cumulative Antibiogram January 2013 December 2015 C&W Three-Year Cumulative Antibiogram January 213 December 215 Division of Microbiology, Virology & Infection Control Department of Pathology & Laboratory Medicine Contents Comments and Limitations...

More information

In Vitro Evaluation of a Novel Ketolide Antimicrobial Agent, RU-64004

In Vitro Evaluation of a Novel Ketolide Antimicrobial Agent, RU-64004 ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, Feb. 1997, p. 454 459 Vol. 41, No. 2 0066-4804/97/$04.00 0 Copyright 1997, American Society for Microbiology In Vitro Evaluation of a Novel Ketolide Antimicrobial

More information

2015 Antibiogram. Red Deer Regional Hospital. Central Zone. Alberta Health Services

2015 Antibiogram. Red Deer Regional Hospital. Central Zone. Alberta Health Services 2015 Antibiogram Red Deer Regional Hospital Central Zone Alberta Health Services Introduction. This antibiogram is a cumulative report of the antimicrobial susceptibility rates of common microbial pathogens

More information

Table 1. Commonly encountered or important organisms and their usual antimicrobial susceptibilities.

Table 1. Commonly encountered or important organisms and their usual antimicrobial susceptibilities. Table 1. Commonly encountered or important organisms and their usual antimicrobial susceptibilities. Gram-positive cocci: Staphylococcus aureus: *Resistance to penicillin is almost universal. Resistance

More information

2017 Antibiogram. Central Zone. Alberta Health Services. including. Red Deer Regional Hospital. St. Mary s Hospital, Camrose

2017 Antibiogram. Central Zone. Alberta Health Services. including. Red Deer Regional Hospital. St. Mary s Hospital, Camrose 2017 Antibiogram Central Zone Alberta Health Services including Red Deer Regional Hospital St. Mary s Hospital, Camrose Introduction This antibiogram is a cumulative report of the antimicrobial susceptibility

More information

Lab Exercise: Antibiotics- Evaluation using Kirby Bauer method.

Lab Exercise: Antibiotics- Evaluation using Kirby Bauer method. Lab Exercise: Antibiotics- Evaluation using Kirby Bauer method. OBJECTIVES 1. Compare the antimicrobial capabilities of different antibiotics. 2. Compare effectiveness of with different types of bacteria.

More information

spectrum of two fluoroquinolone-cephalosporin, dual-action compounds with carboxamido bonds

spectrum of two fluoroquinolone-cephalosporin, dual-action compounds with carboxamido bonds ORIGINAL ARTICLE and : antimicrobial activity and spectrum of two fluoroquinolone-cephalosporin, dual-action compounds with carboxamido bonds David M.Johnson and Ronald N. Jones Medical Microbiology Division,

More information

Evaluation of the AutoMicrobic System for Susceptibility Testing of Aminoglycosides and Gram-Negative Bacilli

Evaluation of the AutoMicrobic System for Susceptibility Testing of Aminoglycosides and Gram-Negative Bacilli JOURNAL OF CLINICAL MICROBIOLOGY, Mar. 1987, p. 546-550 0095-1137/87/030546-05$02.00/0 Copyright C 1987, American Society for Microbiology Vol. 25, No. 3 Evaluation of the AutoMicrobic System for Susceptibility

More information

2016 Antibiogram. Central Zone. Alberta Health Services. including. Red Deer Regional Hospital. St. Mary s Hospital, Camrose

2016 Antibiogram. Central Zone. Alberta Health Services. including. Red Deer Regional Hospital. St. Mary s Hospital, Camrose 2016 Antibiogram Central Zone Alberta Health Services including Red Deer Regional Hospital St. Mary s Hospital, Camrose Introduction This antibiogram is a cumulative report of the antimicrobial susceptibility

More information

2 0 hr. 2 hr. 4 hr. 8 hr. 10 hr. 12 hr.14 hr. 16 hr. 18 hr. 20 hr. 22 hr. 24 hr. (time)

2 0 hr. 2 hr. 4 hr. 8 hr. 10 hr. 12 hr.14 hr. 16 hr. 18 hr. 20 hr. 22 hr. 24 hr. (time) Key words I μ μ μ μ μ μ μ μ μ μ μ μ μ μ II Fig. 1. Microdilution plate. The dilution step of the antimicrobial agent is prepared in the -well microplate. Serial twofold dilution were prepared according

More information

BACTERIAL SUSCEPTIBILITY REPORT: 2016 (January 2016 December 2016)

BACTERIAL SUSCEPTIBILITY REPORT: 2016 (January 2016 December 2016) BACTERIAL SUSCEPTIBILITY REPORT: 2016 (January 2016 December 2016) VA Palo Alto Health Care System April 14, 2017 Trisha Nakasone, PharmD, Pharmacy Service Russell Ryono, PharmD, Public Health Surveillance

More information

INFECTIOUS DISEASES DIAGNOSTIC LABORATORY NEWSLETTER

INFECTIOUS DISEASES DIAGNOSTIC LABORATORY NEWSLETTER INFECTIOUS DISEASES DIAGNOSTIC LABORATORY NEWSLETTER University of Minnesota Health University of Minnesota Medical Center University of Minnesota Masonic Children s Hospital May 2017 Printed herein are

More information

with Other Orally Administered Drugs

with Other Orally Administered Drugs ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, Aug. 1983, p. 209-215 0066-4804/83/080209-07$00/0 Copyright C 1983, American Society for Microbiology Vol. 24, No. 2 In Vitro Evaluation of Three New Macrolide Antimicrobial

More information

ln-vitro activity of newer quinolones against aerobic bacteria

ln-vitro activity of newer quinolones against aerobic bacteria Journal of Antimicrobial Chemotherapy (96) 7, Suppl. B, 9-39 ln-vitro activity of newer quinolones against aerobic bacteria R. Anckenthaler, M. Michea-Hamzehponr and J. C. Pectere Laboratoire Central de

More information

Mercy Medical Center Des Moines, Iowa Department of Pathology. Microbiology Department Antibiotic Susceptibility January December 2016

Mercy Medical Center Des Moines, Iowa Department of Pathology. Microbiology Department Antibiotic Susceptibility January December 2016 Mercy Medical Center Des Moines, Iowa Department of Pathology Microbiology Department Antibiotic Susceptibility January December 2016 These statistics are intended solely as a GUIDE to choosing appropriate

More information

Received 5 February 2004/Returned for modification 16 March 2004/Accepted 7 April 2004

Received 5 February 2004/Returned for modification 16 March 2004/Accepted 7 April 2004 ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, Aug. 2004, p. 3112 3118 Vol. 48, No. 8 0066-4804/04/$08.00 0 DOI: 10.1128/AAC.48.8.3112 3118.2004 Copyright 2004, American Society for Microbiology. All Rights Reserved.

More information

QUICK REFERENCE. Pseudomonas aeruginosa. (Pseudomonas sp. Xantomonas maltophilia, Acinetobacter sp. & Flavomonas sp.)

QUICK REFERENCE. Pseudomonas aeruginosa. (Pseudomonas sp. Xantomonas maltophilia, Acinetobacter sp. & Flavomonas sp.) Pseudomonas aeruginosa (Pseudomonas sp. Xantomonas maltophilia, Acinetobacter sp. & Flavomonas sp.) Description: Greenish gray colonies with some beta-hemolysis around each colony on blood agar (BAP),

More information

Antimicrobial susceptibility

Antimicrobial susceptibility Antimicrobial susceptibility PATTERNS Microbiology Department Canterbury ealth Laboratories and Clinical Pharmacology Department Canterbury District ealth Board March 2011 Contents Preface... Page 1 ANTIMICROBIAL

More information

2010 ANTIBIOGRAM. University of Alberta Hospital and the Stollery Children s Hospital

2010 ANTIBIOGRAM. University of Alberta Hospital and the Stollery Children s Hospital 2010 ANTIBIOGRAM University of Alberta Hospital and the Stollery Children s Hospital Medical Microbiology Department of Laboratory Medicine and Pathology Table of Contents Page Introduction..... 2 Antibiogram

More information

Evaluation of a computerized antimicrobial susceptibility system with bacteria isolated from animals

Evaluation of a computerized antimicrobial susceptibility system with bacteria isolated from animals J Vet Diagn Invest :164 168 (1998) Evaluation of a computerized antimicrobial susceptibility system with bacteria isolated from animals Susannah K. Hubert, Phouc Dinh Nguyen, Robert D. Walker Abstract.

More information

2015 Antibiotic Susceptibility Report

2015 Antibiotic Susceptibility Report Citrobacter freundii Enterobacter aerogenes Enterobacter cloacae Escherichia coli Haemophilus influenzenza Klebsiella oxytoca Klebsiella pneumoniae Proteus mirabilis Pseudomonas aeruginosa Serratia marcescens

More information

BactiReg3 Event Notes Module Page(s) 4-9 (TUL) Page 1 of 21

BactiReg3 Event Notes Module Page(s) 4-9 (TUL) Page 1 of 21 www.wslhpt.org 2601 Agriculture Drive Madison, WI 53718 (800) 462-5261 (608) 265-1111 2015-BactiR Reg3 Shipment Date: September 14, 2015 Questions or comments should be directed to Amanda Weiss at 800-462-5261

More information

Antibiotic. Antibiotic Classes, Spectrum of Activity & Antibiotic Reporting

Antibiotic. Antibiotic Classes, Spectrum of Activity & Antibiotic Reporting Antibiotic Antibiotic Classes, Spectrum of Activity & Antibiotic Reporting Any substance of natural, synthetic or semisynthetic origin which at low concentrations kills or inhibits the growth of bacteria

More information

In vitro Activity of Gemifloxacin Against Recent Clinical Isolates of Bacteria in Korea

In vitro Activity of Gemifloxacin Against Recent Clinical Isolates of Bacteria in Korea J Korean Med Sci 2002; 17: 737-42 ISSN 1011-8934 Copyright The Korean Academy of Medical Sciences In vitro Activity of Gemifloxacin Against Recent Clinical Isolates of Bacteria in Korea Gemifloxacin is

More information

Leveraging the Lab and Microbiology Department to Optimize Stewardship

Leveraging the Lab and Microbiology Department to Optimize Stewardship Leveraging the Lab and Microbiology Department to Optimize Stewardship Presented by: Andrew Martinez MLS(ASCP), MT(AMT), MBA Alaska Native Medical Center Microbiology Supervisor Maniilaq Health Center

More information

MICRONAUT MICRONAUT-S Detection of Resistance Mechanisms. Innovation with Integrity BMD MIC

MICRONAUT MICRONAUT-S Detection of Resistance Mechanisms. Innovation with Integrity BMD MIC MICRONAUT Detection of Resistance Mechanisms Innovation with Integrity BMD MIC Automated and Customized Susceptibility Testing For detection of resistance mechanisms and specific resistances of clinical

More information

Tel: Fax:

Tel: Fax: CONCISE COMMUNICATION Bactericidal activity and synergy studies of BAL,a novel pyrrolidinone--ylidenemethyl cephem,tested against streptococci, enterococci and methicillin-resistant staphylococci L. M.

More information

Ciprofloxacin, Enoxacin, and Ofloxacin against Aerobic and

Ciprofloxacin, Enoxacin, and Ofloxacin against Aerobic and ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, Aug. 1988, p. 1143-1148 Vol., No. 8 0066-4804/88/081143-06$00/0 Copyright 1988, American Society for Microbiology Comparative Activities of, Amoxicillin-Clavulanic

More information

RCH antibiotic susceptibility data

RCH antibiotic susceptibility data RCH antibiotic susceptibility data The following represent RCH antibiotic susceptibility data from 2008. This data is used to inform antibiotic guidelines used at RCH. The data includes all microbiological

More information

Concise Antibiogram Toolkit Background

Concise Antibiogram Toolkit Background Background This toolkit is designed to guide nursing homes in creating their own antibiograms, an important tool for guiding empiric antimicrobial therapy. Information about antibiograms and instructions

More information

2016 Antibiotic Susceptibility Report

2016 Antibiotic Susceptibility Report Fairview Northland Medical Center and Elk River, Milaca, Princeton and Zimmerman Clinics 2016 Antibiotic Susceptibility Report GRAM-NEGATIVE ORGANISMS 2016 Gram-Negative Non-Urine The number of isolates

More information

Bacteriological Characterization

Bacteriological Characterization ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, Sept. 1978, p. 414-419 0066-4804/78/0014-0414$02.00/O Copyright X) 1978 American Society for Microbiology Vol. 14, No. 3 Printed in U.S.A. CP-45,899, a Beta-Lactamase

More information

2009 ANTIBIOGRAM. University of Alberta Hospital and the Stollery Childrens Hospital

2009 ANTIBIOGRAM. University of Alberta Hospital and the Stollery Childrens Hospital 2009 ANTIBIOGRAM University of Alberta Hospital and the Stollery Childrens Hospital Division of Medical Microbiology Department of Laboratory Medicine and Pathology 2 Table of Contents Page Introduction.....

More information

Guidelines for Laboratory Verification of Performance of the FilmArray BCID System

Guidelines for Laboratory Verification of Performance of the FilmArray BCID System Guidelines for Laboratory Verification of Performance of the FilmArray BCID System Purpose The Clinical Laboratory Improvement Amendments (CLIA), passed in 1988, establishes quality standards for all laboratory

More information

microbiology testing services

microbiology testing services microbiology testing services You already know Spectra Laboratories for a wide array of dialysis-related testing services. Now get to know us for your microbiology needs. As the leading provider of renal-specific

More information

European Committee on Antimicrobial Susceptibility Testing

European Committee on Antimicrobial Susceptibility Testing European Committee on Antimicrobial Susceptibility Testing Routine and extended internal quality control for MIC determination and disk diffusion as recommended by EUCAST Version 8.0, valid from 018-01-01

More information

IN VITRO COMBINATION EFFECTS OF NORFLOXACIN, GENTAMICIN, AND Ĉ- LACTAMS ON Ĉ- LACTAM RESISTANT PSEUDOMONAS AERUGINOSA

IN VITRO COMBINATION EFFECTS OF NORFLOXACIN, GENTAMICIN, AND Ĉ- LACTAMS ON Ĉ- LACTAM RESISTANT PSEUDOMONAS AERUGINOSA IN VITRO COMBINATION EFFECTS OF NORFLOXACIN, GENTAMICIN, AND Ĉ- LACTAMS ON Ĉ- LACTAM RESISTANT PSEUDOMONAS AERUGINOSA YONGYUTH JITTAROPAS NAOTO 1), RIKITOMI 2), and Kaizo MATSUMOTO 2) 1) Department of

More information

Suggestions for appropriate agents to include in routine antimicrobial susceptibility testing

Suggestions for appropriate agents to include in routine antimicrobial susceptibility testing Suggestions for appropriate agents to include in routine antimicrobial susceptibility testing These suggestions are intended to indicate minimum sets of agents to test routinely in a diagnostic laboratory

More information

Development of Resistant Bacteria Isolated from Dogs with Otitis Externa or Urinary Tract Infections after Exposure to Enrofloxacin In Vitro

Development of Resistant Bacteria Isolated from Dogs with Otitis Externa or Urinary Tract Infections after Exposure to Enrofloxacin In Vitro A. M. Brothers, P. S. Gibbs, and R. E. Wooley Development of Resistant Bacteria Isolated from Dogs with Otitis Externa or Urinary Tract Infections after Exposure to Enrofloxacin In Vitro Amy M. Brothers,

More information

TABLE OF CONTENTS. Urine - Gram Positive Susceptibility Reporting 1 Staphylococcus species, MRSA...11

TABLE OF CONTENTS. Urine - Gram Positive Susceptibility Reporting 1 Staphylococcus species, MRSA...11 Policy #MI\ANTI\v23 Page 1 of 3 Section: Antimicrobial Susceptibility Testing Subject Title: Table of Contents Manual Issued by: LABORATORY MANAGER Original Date: January 10, 2000 Approved by: Laboratory

More information

Antimicrobial Susceptibility Testing: Advanced Course

Antimicrobial Susceptibility Testing: Advanced Course Antimicrobial Susceptibility Testing: Advanced Course Cascade Reporting Cascade Reporting I. Selecting Antimicrobial Agents for Testing and Reporting Selection of the most appropriate antimicrobials to

More information

In Vitro Susceptibility to Pexiganan of Bacteria Isolated from Infected Diabetic Foot Ulcers

In Vitro Susceptibility to Pexiganan of Bacteria Isolated from Infected Diabetic Foot Ulcers In Vitro Susceptibility to Pexiganan of Bacteria Isolated from Infected Diabetic Foot Ulcers Yigong Ge, Dorothy MacDonald, Marietta M. Henry, Howard I. Hait, Kimberly A. Nelson, Benjamin A. Lipsky, Michael

More information

Over the past several decades, the frequency of. Resistance Patterns Among Nosocomial Pathogens* Trends Over the Past Few Years. Ronald N.

Over the past several decades, the frequency of. Resistance Patterns Among Nosocomial Pathogens* Trends Over the Past Few Years. Ronald N. Resistance Patterns Among Nosocomial Pathogens* Trends Over the Past Few Years Ronald N. Jones, MD Multiple surveillance studies have demonstrated that resistance among prevalent pathogens is increasing

More information

What s new in EUCAST methods?

What s new in EUCAST methods? What s new in EUCAST methods? Derek Brown EUCAST Scientific Secretary Interactive question 1 MIC determination MH-F broth for broth microdilution testing of fastidious microorganisms Gradient MIC tests

More information

In Vitro Activity of Netilmicin, Gentamicin, and Amikacin

In Vitro Activity of Netilmicin, Gentamicin, and Amikacin ANTIMICROBIAL AGzNTS AND CHEMOTHERAPY, Jan. 1977, p. 126-131 Copyright X 1977 American Society for Microbiology Vol. 11, No. 1 Printed in U.S.A. In Vitro Activity of Netilmicin, Gentamicin, and Amikacin

More information

Epidemiology and Microbiology of Surgical Wound Infections

Epidemiology and Microbiology of Surgical Wound Infections JOURNAL OF CLINICAL MICROBIOLOGY, Feb. 2000, p. 918 922 Vol. 38, No. 2 0095-1137/00/$04.00 0 Copyright 2000, American Society for Microbiology. All Rights Reserved. Epidemiology and Microbiology of Surgical

More information

National Clinical Guideline Centre Pneumonia Diagnosis and management of community- and hospital-acquired pneumonia in adults

National Clinical Guideline Centre Pneumonia Diagnosis and management of community- and hospital-acquired pneumonia in adults National Clinical Guideline Centre Antibiotic classifications Pneumonia Diagnosis and management of community- and hospital-acquired pneumonia in adults Clinical guideline 191 Appendix N 3 December 2014

More information

January 2014 Vol. 34 No. 1

January 2014 Vol. 34 No. 1 January 2014 Vol. 34 No. 1. and Minimal Inhibitory Concentration (MIC) Interpretive Standards for Testing Conditions Medium: diffusion: Mueller-Hinton agar (MHA) roth dilution: cation-adjusted Mueller-Hinton

More information

The Basics: Using CLSI Antimicrobial Susceptibility Testing Standards

The Basics: Using CLSI Antimicrobial Susceptibility Testing Standards The Basics: Using CLSI Antimicrobial Susceptibility Testing Standards Janet A. Hindler, MCLS, MT(ASCP) UCLA Health System Los Angeles, California, USA jhindler@ucla.edu 1 Learning Objectives Describe information

More information

Treatment of Bone, Joint, and Soft-Tissue Infections with Oral Ciprofloxacin

Treatment of Bone, Joint, and Soft-Tissue Infections with Oral Ciprofloxacin ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, Feb. 1987, p. 151-155 0066-4804/87/020151-05$02.00/0 Copyright C) 1987, American Society for Microbiology Vol. 31, No. 2 Treatment of Bone, Joint, and Soft-Tissue

More information

HOSPITAL-ACQUIRED INFECTIONS AND QASM PATIENTS

HOSPITAL-ACQUIRED INFECTIONS AND QASM PATIENTS Royal Australasian College of Surgeons Queensland Audit of Surgical Mortality (QASM) HOSPITAL-ACQUIRED INFECTIONS AND QASM PATIENTS (JULY 2011 TO JUNE 2016) Contact Queensland Audit of Surgical Mortality

More information

SYMMETRY FOAMING HAND SANITIZER with Aloe & Vitamin E Technical Data

SYMMETRY FOAMING HAND SANITIZER with Aloe & Vitamin E Technical Data 508 SYMMETRY FOAMING HAND SANITIZER with Aloe & Vitamin E Technical Data Physical Properties Active Ingredient: Ethyl Alcohol 62% (70% v/v) Appearance: Clear, Colorless Solution Fragrance: Floral Form:

More information

Drug Class Prior Authorization Criteria Intravenous Antibiotics

Drug Class Prior Authorization Criteria Intravenous Antibiotics Drug Class Prior Authorization Criteria Intravenous Antibiotics Line of Business: Medicaid P&T Approval Date: August 15, 2018 Effective Date: October 1, 2018 This drug class prior authorization criteria

More information

Intracellular Activity of Tosufloxacin (T-3262) against Salmonella

Intracellular Activity of Tosufloxacin (T-3262) against Salmonella ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, June 1990, p. 949-953 0066-4804/90/060949-05$02.00/0 Copyright 1990, American Society for Microbiology Vol. 34, No. 6 Intracellular Activity of Tosufloxacin (T-3262)

More information

Bacterial Pathogens in Urinary Tract Infection and Antibiotic Susceptibility Pattern from a Teaching Hospital, Bengaluru, India

Bacterial Pathogens in Urinary Tract Infection and Antibiotic Susceptibility Pattern from a Teaching Hospital, Bengaluru, India ISSN: 2319-7706 Volume 4 Number 11 (2015) pp. 731-736 http://www.ijcmas.com Original Research Article Bacterial Pathogens in Urinary Tract Infection and Antibiotic Susceptibility Pattern from a Teaching

More information

CONTAGIOUS COMMENTS Department of Epidemiology

CONTAGIOUS COMMENTS Department of Epidemiology VOLUME XXIII NUMBER 1 July 2008 CONTAGIOUS COMMENTS Department of Epidemiology Bugs and Drugs Elaine Dowell, SM (ASCP), Marti Roe SM (ASCP), Ann-Christine Nyquist MD, MSPH Are the bugs winning? The 2007

More information

Activity of Linezolid Tested Against Uncommonly Isolated Gram-positive ACCEPTED

Activity of Linezolid Tested Against Uncommonly Isolated Gram-positive ACCEPTED AAC Accepts, published online ahead of print on 8 January 2007 Antimicrob. Agents Chemother. doi:10.1128/aac.01496-06 Copyright 2007, American Society for Microbiology and/or the Listed Authors/Institutions.

More information

What s next in the antibiotic pipeline?

What s next in the antibiotic pipeline? What s next in the antibiotic pipeline? Jennifer Tieu, Pharm.D., BCPS Clinical Pearls OSHP Spring Meeting Mercy Hospital April 13, 2018 Objective 2 Describe the drug class and mechanism of action of antibiotics

More information

Title: N-Acetylcysteine (NAC) Mediated Modulation of Bacterial Antibiotic

Title: N-Acetylcysteine (NAC) Mediated Modulation of Bacterial Antibiotic AAC Accepts, published online ahead of print on June 00 Antimicrob. Agents Chemother. doi:0./aac.0070-0 Copyright 00, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights

More information

IV Antibiotics for Lyme Disease (Ceftriaxone, Cefotaxime sodium, Doxycycline, Penicillin G potassium)

IV Antibiotics for Lyme Disease (Ceftriaxone, Cefotaxime sodium, Doxycycline, Penicillin G potassium) Federal Employee Program 1310 G Street, N.W. Washington, D.C. 20005 202.942.1000 Fax 202.942.1125 5.01.15 Subject: IV Antibiotics Lyme Disease Page: 1 of 9 Last Review Date: November 30, 2018 IV Antibiotics

More information

CUMULATIVE ANTIBIOGRAM

CUMULATIVE ANTIBIOGRAM BC Children s Hospital and BC Women s Hospital & Health Centre CUMULATIVE ANTIBIOGRAM 2017 Division of Medical Microbiology Department of Pathology and Laboratory Medicine Page 1 of 5 GRAM-POSITIVE BACTERIA

More information

UK Journal of Pharmaceutical and Biosciences Available at ISSN:

UK Journal of Pharmaceutical and Biosciences Available at   ISSN: UK Journal of Pharmaceutical and Biosciences Vol. 5(2), 45-49, 2017 RESEARCH ARTICLE UK Journal of Pharmaceutical and Biosciences Available at www.ukjpb.com ISSN: 2347-9442 Anti-Microbial Susceptibility

More information

Supplementary Appendix

Supplementary Appendix Supplementary Appendix This appendix has been provided by the authors to give readers additional information about their work. Supplement to: Bennett-Guerrero E, Pappas TN, Koltun WA, et al. Gentamicin

More information

Cleaning and Disinfection Protocol Vegetative Bacteria

Cleaning and Disinfection Protocol Vegetative Bacteria Cleaning and Disinfection Protocol Vegetative Bacteria This document has been developed in accordance with current applicable infection control and biosecurity guidelines. It is intended for use as a guideline

More information

Evaluation of MicroScan MIC Panels for Detection of

Evaluation of MicroScan MIC Panels for Detection of JOURNAL OF CLINICAL MICROBIOLOGY, May 1988, p. 816-820 Vol. 26, No. 5 0095-1137/88/050816-05$02.00/0 Copyright 1988, American Society for Microbiology Evaluation of MicroScan MIC Panels for Detection of

More information

Intrinsic, implied and default resistance

Intrinsic, implied and default resistance Appendix A Intrinsic, implied and default resistance Magiorakos et al. [1] and CLSI [2] are our primary sources of information on intrinsic resistance. Sanford et al. [3] and Gilbert et al. [4] have been

More information

Disk Susceptibility Studies with Cefazolin and Cephalothin

Disk Susceptibility Studies with Cefazolin and Cephalothin ANTIMICROBiAL AGENTS AND CHEMOTHEMRAPY, Jan. 1974, p. 63-67 Copyright i 1974 American Society for Microbiology Vol. 5, No. 1 Printed in U.SA. Disk Susceptibility Studies with Cefazolin and Cephalothin

More information

Susceptibility Testing and Resistance Phenotypes Detection in Bacterial Pathogens Using the VITEK 2 System

Susceptibility Testing and Resistance Phenotypes Detection in Bacterial Pathogens Using the VITEK 2 System Polish Journal of Microbiology 2005, Vol. 54, No 4, 311 316 Susceptibility Testing and Resistance Phenotypes Detection in Bacterial Pathogens Using the VITEK 2 System EL BIETA STEFANIUK*, AGNIESZKA MRÓWKA

More information

The Disinfecting Effect of Electrolyzed Water Produced by GEN-X-3. Laboratory of Diagnostic Medicine, College of Medicine, Soonchunhyang University

The Disinfecting Effect of Electrolyzed Water Produced by GEN-X-3. Laboratory of Diagnostic Medicine, College of Medicine, Soonchunhyang University The Disinfecting Effect of Electrolyzed Water Produced by GEN-X-3 Laboratory of Diagnostic Medicine, College of Medicine, Soonchunhyang University Tae-yoon Choi ABSTRACT BACKGROUND: The use of disinfectants

More information

BSAC standardized disc susceptibility testing method (version 8)

BSAC standardized disc susceptibility testing method (version 8) Journal of Antimicrobial Chemotherapy (2009) 64, 454 489 doi:10.1093/jac/dkp244 Advance Access publication 8 July 2009 BSAC standardized disc susceptibility testing method (version 8) J. M. Andrews* for

More information

Original Article. Ratri Hortiwakul, M.Sc.*, Pantip Chayakul, M.D.*, Natnicha Ingviya, B.Sc.**

Original Article. Ratri Hortiwakul, M.Sc.*, Pantip Chayakul, M.D.*, Natnicha Ingviya, B.Sc.** Original Article In Vitro Activity of Cefminox and Other β-lactam Antibiotics Against Clinical Isolates of Extended- Spectrum-β-lactamase-Producing Klebsiella pneumoniae and Escherichia coli Ratri Hortiwakul,

More information

Cleaning and Disinfection Protocol for Gram-Negative and Gram-Positive Bacteria, including Antibiotic Resistant Bacteria

Cleaning and Disinfection Protocol for Gram-Negative and Gram-Positive Bacteria, including Antibiotic Resistant Bacteria Cleaning and Disinfection Protocol for Gram-Negative and Gram-Positive Bacteria, including Antibiotic Resistant Bacteria This document has been developed in accordance with current applicable infection

More information

University, New York, New York Received for publication 7 May was measured by the broth dilution method as previously

University, New York, New York Received for publication 7 May was measured by the broth dilution method as previously ANTmIcaoBIAL AGuNTS AND CHUMTrHURAPY, Sept. 1976, p. 526-534 Copyright C 1976 American Society for Microbiology Vol. 10, No. 3 Printed in U.S.A. In Vitro Study of Netilmicin Compared with Other Aminoglycosides

More information

ANTIMICROBIAL RELATED LIS CANNED MESSAGES

ANTIMICROBIAL RELATED LIS CANNED MESSAGES Policy # MI\ANTI\04\v01 Page 1 of 5 Section: Antimicrobial Susceptibility Testing Manual Subject Title: Antimicrobial Related LIS Canned Issued by: LABORATORY MANAGER Original Date: November 21, 2005 Approved

More information

CONTAGIOUS COMMENTS Department of Epidemiology

CONTAGIOUS COMMENTS Department of Epidemiology VOLUME XXIX NUMBER 3 November 2014 CONTAGIOUS COMMENTS Department of Epidemiology Bugs and Drugs Elaine Dowell SM MLS (ASCP), Marti Roe SM MLS (ASCP), Sarah Parker MD, Jason Child PharmD, and Samuel R.

More information

Recommendations Regarding Use of Rapid Blood Pathogen Identification Panel Data

Recommendations Regarding Use of Rapid Blood Pathogen Identification Panel Data Recommendations Regarding Use of Rapid Blood Pathogen Identification Panel Data Trevor Van Schooneveld MD, Scott Bergman, PharmD, BCPS, Paul Fey, PhD, Mark Rupp, MD The Clinical Microbiology laboratory

More information

Summary of Investigation Results

Summary of Investigation Results Summary of Investigation Results Fluoroquinolones (oral and injectable dosage forms) January 10, 2019 Non-proprietary name a. Moxifloxacin hydrochloride b. Tosufloxacin tosilate hydrate c. Levofloxacin

More information

Advanced Practice Education Associates. Antibiotics

Advanced Practice Education Associates. Antibiotics Advanced Practice Education Associates Antibiotics Overview Difference between Gram Positive(+), Gram Negative(-) organisms Beta lactam ring, allergies Antimicrobial Spectra of Antibiotic Classes 78 Copyright

More information

A retrospective analysis of urine culture results issued by the microbiology department, Teaching Hospital, Karapitiya

A retrospective analysis of urine culture results issued by the microbiology department, Teaching Hospital, Karapitiya A retrospective analysis of urine culture results issued by the microbiology department, Teaching Hospital, Karapitiya LU Edirisinghe 1, D Vidanagama 2 1 Senior Registrar in Medicine, 2 Consultant Microbiologist,

More information

Detection of ESBL Producing Gram Negative Uropathogens and their Antibiotic Resistance Pattern from a Tertiary Care Centre, Bengaluru, India

Detection of ESBL Producing Gram Negative Uropathogens and their Antibiotic Resistance Pattern from a Tertiary Care Centre, Bengaluru, India ISSN: 2319-7706 Volume 4 Number 12 (2015) pp. 578-583 http://www.ijcmas.com Original Research Article Detection of ESBL Producing Gram Negative Uropathogens and their Antibiotic Resistance Pattern from

More information

Performance Information. Vet use only

Performance Information. Vet use only Performance Information Vet use only Performance of plates read manually was measured in three sites. Each centre tested Enterobacteriaceae, streptococci, staphylococci and pseudomonas-like organisms.

More information

Childrens Hospital Antibiogram for 2012 (Based on data from 2011)

Childrens Hospital Antibiogram for 2012 (Based on data from 2011) Childrens Hospital Antibiogram for 2012 (Based on data from 2011) Prepared by: Department of Clinical Microbiology, Health Sciences Centre For further information contact: Andrew Walkty, MD, FRCPC Medical

More information

Michael T. Sweeney* and Gary E. Zurenko. Infectious Diseases Biology, Pharmacia Corporation, Kalamazoo, Michigan 49007

Michael T. Sweeney* and Gary E. Zurenko. Infectious Diseases Biology, Pharmacia Corporation, Kalamazoo, Michigan 49007 ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, June 2003, p. 1902 1906 Vol. 47, No. 6 0066-4804/03/$08.00 0 DOI: 10.1128/AAC.47.6.1902 1906.2003 Copyright 2003, American Society for Microbiology. All Rights Reserved.

More information

Vitek QC Sets. Vitek 2 Identification QC Sets

Vitek QC Sets. Vitek 2 Identification QC Sets Vitek 2 Identification QC Sets MicroBioLogics is selling two types of Vitek 2 microorganism identification sets. They are listed below in two columns. The first column lists the 2008 quality control microorganisms

More information

Patterns of Susceptibility to Fluoroquinolones Among Anaerobic Bacterial Isolates in the United States

Patterns of Susceptibility to Fluoroquinolones Among Anaerobic Bacterial Isolates in the United States S377 Patterns of Susceptibility to Fluoroquinolones Among Anaerobic Bacterial Isolates in the United States Ellie J. C. Goldstein From R. M. Alden Research Laboratory, Santa Monica Hospital Medical Center,

More information

Antimicrobial Susceptibility in Gram-Negative Bacteremia: Are

Antimicrobial Susceptibility in Gram-Negative Bacteremia: Are ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, Nov. 1989, p. 1855-1859 0066-4804/89/111855-05$02.00/0 Copyright 1989, American Society for Microbiology Vol. 33, No. 11 Antimicrobial Susceptibility in Gram-Negative

More information

British Society for Antimicrobial Chemotherapy

British Society for Antimicrobial Chemotherapy British Society for Antimicrobial Chemotherapy Standing Committee on Susceptibility Testing Version 13.0, 10-06-2014 Content Page Additional information Changes in version 13 2 Suggestions for appropriate

More information