Super Bugs and Wonder Drugs: Protecting the One While Respecting the Many

Size: px
Start display at page:

Download "Super Bugs and Wonder Drugs: Protecting the One While Respecting the Many"

Transcription

1 Super Bugs and Wonder Drugs: Protecting the One While Respecting the Many Vicki Stringfellow, MSN, CPNP-AC/PC Werner Division of Pediatric Critical Care University of Kentucky Lexington, KY Disclosure Information I am a paid continuing education program associate for Pediatric Nursing Certification Board and the primary editor of continuing education modules. Please note: Antimicrobial therapy for the neonatal and immunocompromised patient populations is beyond the scope of this presentation. Objectives Identify antimicrobial agents used for prophylaxis against and treatment of selected infectious processes in the pediatric surgical patient and explain their mechanisms of action Describe antimicrobial resistance and relate the principles of antimicrobial stewardship to the pediatric surgical patient population Discuss current available guidelines related to the prevention and treatment of infection for specific surgical procedures 1

2 History Topical application of molded bread Ancient civilizations 1640 Lab work with molds 1870s Earliest penicillin treatment successes in humans 1930s Mid 1940s -1960s Age of antibiotic resistance Present Treatment with mold in published work Alexander Fleming Widespread use of penicillin; Golden Age of antibiotic development; early acquired resistance Med Hist. 1986;30:42-56; Journal of Antimicrob Chemother. 2016;71: ; New York Times, Antibiotics Primary classes Penicillins Aminoglycosides Fluoroquinolones Cephalosporins Macrolides Tetracyclines Mechanisms of action Inhibition of cell wall synthesis Inhibition of protein synthesis Interference with cell membrane function Antimetabolite activities Inhibition of nucleic acid synthesis JNP. 2015:11(1): Resistance Intrinsic or acquired Mechanisms of resistance 1 Alteration of target binding sites or porin channels Efflux pumps and enzymes Most important contributor is antibiotic use 2 CDC reports: over 2 million illnesses and 23,000 deaths annually 2 1- JNP. 2015:11(1): CDC: 2

3 # isolates Ampicillin Ceftriaxone Ceftaroline Meropenem Penicillin Clindamycin Linezolid Vancomycin 26th Annual Scientific Conference May 1-4, 2017 Hollywood, FL Susceptibility Reporting Minimum inhibitory concentration (MIC) The lowest concentration of an antibiotic that will inhibit growth of an organism in the laboratory Organism Method Amikacin susceptibility Ampicillin susceptibility Cefazolin susceptibility Cefepime susceptibility Klebsiella pneumoniae MIC (mcg/ml) < = 8 SUSCEPTIBLE > 16 RESISTANT < = 1 SUSCEPTIBLE < = 1 SUSCEPTIBLE Antibiograms Cumulative report of susceptibility and resistance Antibiotics (X Axis)/ Facility or Lab Identification Dates for Use of the Antibiogram Specific organisms (Y AXIS) Enterococcus faecalis Oxacillin-resistant Staphylococcus aureus (MRSA) Oxacillin-sensitive Staphylococcus aureus (MSSA) Staphylococcus epidermidis Antibiotics for the Pediatric Surgical Patient Surgical site infection (SSI) 2% - 5% of inpatient surgeries 1 A 2013 review cited 1.8% for pediatric surgeries 2 Prophylaxis recommended for procedures with moderate or high infection rates, and when consequences of infection are likely to be serious 1 Factors associated with post-operative SSI 1 Number and virulence of microorganisms present; foreign matter in wound Host risk factors Surgical site; duration of procedure Red Book 2- Pediatrics 2013;132:e677-e688 3

4 Wound Classification and Prophylaxis Clean No inflammation, infection, or contamination; no entry into respiratory, alimentary or genitourinary tracts or oropharyngeal cavity Benefit of systemic antibiotic prophylaxis not justified unless risk for infection or consequences of infection is high Clean-contaminated Controlled entry into respiratory, alimentary or genitourinary tract Prophylaxis GI procedures when obstruction is present, child is receiving gastric acid suppression or has permanent foreign body; biliary tract obstruction Urinary tract procedures when bacteriuria or obstruction is present 2015 Red Book Wound Classification and Antibiotics Contaminated Previously sterile tissue with likely heavy bacterial contamination Prophylaxis for acute nonpurulent inflammation isolated within a viscus Empiric treatment if contamination has produced inflammation and infection Dirty and Infected Penetrating trauma over 4 hours, retained devitalized tissue, or existing infection or perforated viscera Empiric treatment 2015 Red Book Prophylaxis Recommendations Goals Prevent SSI and its related morbidity and mortality Reduce length of treatment and cost of care Result in no adverse effects Minimize adverse effects on microbial flora Recommendations address Indications Appropriate drug selection and dosage Preoperative timing and need for subsequent doses intraoperatively Duration of prophylaxis 2015 Red Book Med Lett Drugs Ther. 2016;58(1495):

5 Prophylaxis Recommendations Antimicrobial agent selected based on most likely pathogens and their susceptibilities, and safety and efficacy of the agent Dosage weight-based up to the usual adult dose Dose administered 60 minutes prior to surgical incision, or within 120 minutes for vancomycin or fluoroquinolones Subsequent doses administered if the procedure time exceeds two half-lives of the agent, or if there is excessive blood loss Prophylaxis continues 24 hours following the procedure 2015 Red Book Am J Health-Syst Pharm. 2013; 70: Agents: Cefazolin (Ancef) First generation cephalosporin, inhibits cell wall synthesis 1,2 Active against most staphylococci, streptococci, and enteric Gramnegative enterococci 1,2 Recommended for most procedures 1 Gastric, biliary tract, thoracic, vascular, neurosurgical, orthopedic, cardiac Traumatic wounds (excluding bites) Typical dose is 30 mg/kg (adult/maximum dose 2 grams) 1,2 Half life: neonates 3-5 hours; adult hours; repeat doses at 4 hours 1, Red Book 2- Lexicomp Pediatric & Neonatal Dosage Handbook, 2016 Agents: Vancomycin (Vancocin) Glycopeptide; inhibits cell wall synthesis 1,2 Routine use NOT recommended 1 Consider for 1 High risk of methicillin-resistant Staphylococcus aureus (MRSA) Children with known colonization or previous infection with MRSA High community rates of MRSA infection Dose 15 mg/kg; multiple dosing considerations 1,2 Half-life varies by age 2 ; repeat doses not given Red Book 2- Lexicomp Pediatric & Neonatal Dosage Handbook,

6 Prophylaxis for Colorectal Procedures Coverage against enteric gram-negative bacilli, enterococci, and anaerobic organisms 2015 Red Book recommendations Cefoxitin Metronidazole plus gentamicin Cefazolin plus metronidazole Clindamycin plus gentamicin or ciprofloxacin 2016 Medical Letter and 2013 American Society of Hospital Pharmacists recommendations also include Ampicillin/sulbactam Ertapenem (Invanz) Agents for Colorectal Procedures Ampicillin/Sulbactam (Unasyn) Penicillin and beta lactamase inhibitor, interferes with cell wall synthesis 1 Active against Escherichia coli, Enterococcus faecalis, and Bacteroides fragilis 1 Typical dose 50mg/kg 1 (adult/maximum dose 3 grams) 2,3 Half-life mean hours (1-12 years) 1 ; repeat dose at 2 hours 3 Metronidazole (Flagyl) Antibiotic and antiprotozoal, inhibits protein synthesis 1 Active against most obligate anaerobes, including Bacteroides, and Fusobacterium species 1 Typical dose 15 mg/kg 1 (adult/maximum dose 500 mg) 2,3 Half life 6-10 hours (child/ adolescent) 1 ; no repeat dose 3 1- Lexicomp Handbook, Med Lett Drugs Ther. 2016;58(1495): Am J Health-Syst Pharm. 2013; 70: Agents for Colorectal Procedures Cefoxitin (Mefoxin) Second generation cephalosporin, inhibits cell wall synthesis 1 Active against Escherichia coli and Bacteroides species 1 Typical dose 40mg/kg 1 (adult/maximum dose 2 grams) 2,3 Half-life infants 1.4 hours, adults minutes 1 ; repeat dose at 2 hours 3 Clindamycin (Cleocin) Lincosamide, inhibits protein synthesis 1 Active against Clostridium perfringens, Peptostreptococcus and Fusobacterium species 1 Typical dose 10 mg/kg 1 (adult/maximum dose 900 mg) 2,3 Half life 2-3 hours 1 ; repeat dose at 6 hours 3 1- Lexicomp Handbook, Med Lett Drugs Ther. 2016;58(1495): Am J Health-Syst Pharm. 2013; 70:

7 Prevention of Infective Endocarditis Congenital heart disease; selected orthopedic procedures; selected dental procedures 1 Coverage against skin flora, oral flora, GI/GU tract flora specific to procedure Regimens (parenteral) Ampicillin 50 mg/kg (adult dose 2 grams) 1 Cefazolin 30 mg/kg 1 / 50 mg/kg 2 (adult dose 1 gram) Ceftriaxone 50 mg/kg (adult dose 1 gram) 1 Clindamycin 20 mg/kg (adult dose 600 mg) Red Book 2- Circulation. 2007;116: Prophylaxis for Urinary Tract Procedures Recommended for urinary tract surgery or instrumentation in the presence of bacteriuria or obstructive uropathy Coverage for enteric Gram-negative bacilli and enterococci 2015 Red Book recommendations Ampicillin 50 mg/kg + gentamicin 2 mg/kg (or) Cefazolin 30 mg/kg 2016 Medical Letter and 2013 American Society of Hospital Pharmacists recommendations also include Ciprofloxacin or trimethoprim/sulfamethoxazole; Cefazolin for open or laparoscopic procedures Agents for Urinary Tract Procedures Gentamicin Aminoglycoside, interferes with protein synthesis 1 Wide gram-negative activity: Enterobacter, Klebsiella, Proteus species; Escherichia coli and Pseudomonas aeruginosa 1 Typical dose 2.5 mg/kg 1 (adult dose 5 mg/kg with weight specifications) 2,3 Half life decreases with age 1 ; no repeat dose 3 Ampicillin Penicillin, inhibits cell wall synthesis 1 Active against non-penicillinase producing strains of Escherichia coli, and Proteus mirabilis Typical dose 50mg/kg 1 (adult/maximum dose 3 grams) 2,3 Half-life hours (children and adults) 1 ; repeat dose at 2 hours 3 1- Lexicomp Handbook, Med Lett Drugs Ther. 2016;58(1495): Am J Health-Syst Pharm. 2013; 70:

8 Empiric Therapy for Appendicitis Appendicitis Provide coverage for enteric gram-negative bacilli, enterococci, and anaerobes (Bacteroides species) Agents Carbapenems: imipenem, meropenem or ertapenem Combination drugs: piperacillin-tazobactam or ticarcillin-clavulanate Cephalosporins: cefotaxime, ceftriaxone, ceftazidime, cefepime Severe beta-lactam allergy: ciprofloxacin plus metronidazole or an aminoglycoside-based regimen Clin Infect Dis. 2010;50(2): Empiric Therapy for Empyema Empyema Provide coverage for Streptococcus pneumoniae Agents Third-generation cephalosporins: ceftriaxone or cefotaxime Vancomycin or clindamycin in addition if characteristics of Staphylococcus aureus are present Duration of therapy related to adequacy of drainage; 2-4 weeks common, or approximately 10 days after resolution of fever Clin Infect Dis. 2011;53(7):e25-e76 Therapy for Clostridium difficile Disclaimer: AAP guideline on C. difficile in infants and children, which is referenced in the 2015 Red Book, was retired in late Clostridium difficile Discontinue precipitating antimicrobial agents For symptomatic children, antimicrobial therapy recommended Initial treatment, mild to moderate diarrhea and first relapse Metronidazole orally Severe disease Vancomyin enterally or as an enema (not effective IV) Metronidazole orally or IV may be used as well 2015 Red Book 8

9 Empiric Therapy for HAIs* *HAI Healthcare-associated infections Initial therapy always based on clinical factors Central line-associated bloodstream infection Provide coverage for skin flora and Gram-negatives 1 Initial therapy usually includes vancomyin paired with a second agent 2 Catheter-associated urinary tract infection Provide coverage for periurethral and perirectal flora 1 Initial therapy choices include extended spectrum penicillins or thirdgeneration cephalosporins 1- Infect Control Hosp Epidemiol. 2016;37(11): Pediatr Infect Dis J.2013;32(8): Tips for New Prescribers Utilize references; a few examples include - FDA Pediatric Labeling Information Databasehttps:// Lexicomp Pediatric and Neonatal Dosage Handbook Prescribers Digital Reference Monthly Prescribing Reference Be familiar with state rules and regulations and institutional credentialing Network! State professional organization as well as national organizations Institutional/ organizational committees Seek out and work with pharmacists and discharge planners Continuing Education Resources Always verify the credit offered is acceptable to your licensing or certifying body Sources and examples Conferences: APSNA, NAPNAP; state and local professional organizations Local universities with nursing programs Journals: Journal of Pediatric Surgical Nursing, Journal of Pediatric Health Care The Journal for Nurse Practitioners, Pediatric Annals, Neonatal Network, Advances in Neonatal Care, Pediatrics in Review Online modules: Healio (Education/CME) Pediatric Nursing Certification Board (Modules/CE) National Certification Corporation (Continuing Ed) 9

10 Questions? THANK YOU! 10

Antibiotic. Antibiotic Classes, Spectrum of Activity & Antibiotic Reporting

Antibiotic. Antibiotic Classes, Spectrum of Activity & Antibiotic Reporting Antibiotic Antibiotic Classes, Spectrum of Activity & Antibiotic Reporting Any substance of natural, synthetic or semisynthetic origin which at low concentrations kills or inhibits the growth of bacteria

More information

Childrens Hospital Antibiogram for 2012 (Based on data from 2011)

Childrens Hospital Antibiogram for 2012 (Based on data from 2011) Childrens Hospital Antibiogram for 2012 (Based on data from 2011) Prepared by: Department of Clinical Microbiology, Health Sciences Centre For further information contact: Andrew Walkty, MD, FRCPC Medical

More information

2016 Antibiotic Susceptibility Report

2016 Antibiotic Susceptibility Report Fairview Northland Medical Center and Elk River, Milaca, Princeton and Zimmerman Clinics 2016 Antibiotic Susceptibility Report GRAM-NEGATIVE ORGANISMS 2016 Gram-Negative Non-Urine The number of isolates

More information

Antibiotic Updates: Part II

Antibiotic Updates: Part II Antibiotic Updates: Part II Fredrick M. Abrahamian, DO, FACEP, FIDSA Health Sciences Clinical Professor of Emergency Medicine David Geffen School of Medicine at UCLA Los Angeles, California Financial Disclosures

More information

2015 Antibiotic Susceptibility Report

2015 Antibiotic Susceptibility Report Citrobacter freundii Enterobacter aerogenes Enterobacter cloacae Escherichia coli Haemophilus influenzenza Klebsiella oxytoca Klebsiella pneumoniae Proteus mirabilis Pseudomonas aeruginosa Serratia marcescens

More information

Aberdeen Hospital. Antibiotic Susceptibility Patterns For Commonly Isolated Organisms For 2015

Aberdeen Hospital. Antibiotic Susceptibility Patterns For Commonly Isolated Organisms For 2015 Aberdeen Hospital Antibiotic Susceptibility Patterns For Commonly Isolated s For 2015 Services Laboratory Microbiology Department Aberdeen Hospital Nova Scotia Health Authority 835 East River Road New

More information

The β- Lactam Antibiotics. Munir Gharaibeh MD, PhD, MHPE School of Medicine, The University of Jordan November 2018

The β- Lactam Antibiotics. Munir Gharaibeh MD, PhD, MHPE School of Medicine, The University of Jordan November 2018 The β- Lactam Antibiotics Munir Gharaibeh MD, PhD, MHPE School of Medicine, The University of Jordan November 2018 Penicillins. Cephalosporins. Carbapenems. Monobactams. The β- Lactam Antibiotics 2 3 How

More information

Antimicrobial Prophylaxis in the Surgical Patient. M. J. Osgood

Antimicrobial Prophylaxis in the Surgical Patient. M. J. Osgood Antimicrobial Prophylaxis in the Surgical Patient M. J. Osgood Outline Definitions surgical site infection (SSI) Risk factors Wound classification Microbiology of SSIs Strategies for prevention of SSIs

More information

Antibiotic Abyss. Discussion Points. MRSA Treatment Guidelines

Antibiotic Abyss. Discussion Points. MRSA Treatment Guidelines Antibiotic Abyss Fredrick M. Abrahamian, D.O., FACEP, FIDSA Professor of Medicine UCLA School of Medicine Director of Education Department of Emergency Medicine Olive View-UCLA Medical Center Sylmar, California

More information

Appropriate antimicrobial therapy in HAP: What does this mean?

Appropriate antimicrobial therapy in HAP: What does this mean? Appropriate antimicrobial therapy in HAP: What does this mean? Jaehee Lee, M.D. Kyungpook National University Hospital, Korea KNUH since 1907 Presentation outline Empiric antimicrobial choice: right spectrum,

More information

Antimicrobial Stewardship Program

Antimicrobial Stewardship Program Antimicrobial Stewardship Program David R. Woodard, MSc, FSHEA, CIC CDC: Antibiotic Resistance Threats in the United States, 2013 http://www.cdc.gov/drugresistance/threat-report-2013/pdf/ CDC Threat Levels

More information

Mercy Medical Center Des Moines, Iowa Department of Pathology. Microbiology Department Antibiotic Susceptibility January December 2016

Mercy Medical Center Des Moines, Iowa Department of Pathology. Microbiology Department Antibiotic Susceptibility January December 2016 Mercy Medical Center Des Moines, Iowa Department of Pathology Microbiology Department Antibiotic Susceptibility January December 2016 These statistics are intended solely as a GUIDE to choosing appropriate

More information

Concise Antibiogram Toolkit Background

Concise Antibiogram Toolkit Background Background This toolkit is designed to guide nursing homes in creating their own antibiograms, an important tool for guiding empiric antimicrobial therapy. Information about antibiograms and instructions

More information

Give the Right Antibiotics in Trauma Mitchell J Daley, PharmD, BCPS

Give the Right Antibiotics in Trauma Mitchell J Daley, PharmD, BCPS Give the Right Antibiotics in Trauma Mitchell J Daley, PharmD, BCPS Clinical Pharmacy Specialist, Critical Care Dell Seton Medical Center at the University of Texas and Seton Healthcare Family Clinical

More information

2012 ANTIBIOGRAM. Central Zone Former DTHR Sites. Department of Pathology and Laboratory Medicine

2012 ANTIBIOGRAM. Central Zone Former DTHR Sites. Department of Pathology and Laboratory Medicine 2012 ANTIBIOGRAM Central Zone Former DTHR Sites Department of Pathology and Laboratory Medicine Medically Relevant Pathogens Based on Gram Morphology Gram-negative Bacilli Lactose Fermenters Non-lactose

More information

Suggestions for appropriate agents to include in routine antimicrobial susceptibility testing

Suggestions for appropriate agents to include in routine antimicrobial susceptibility testing Suggestions for appropriate agents to include in routine antimicrobial susceptibility testing These suggestions are intended to indicate minimum sets of agents to test routinely in a diagnostic laboratory

More information

Antimicrobial Susceptibility Patterns

Antimicrobial Susceptibility Patterns Antimicrobial Susceptibility Patterns KNH SURGERY Department Masika M.M. Department of Medical Microbiology, UoN Medicines & Therapeutics Committee, KNH Outline Methodology Overall KNH data Surgery department

More information

Approach to pediatric Antibiotics

Approach to pediatric Antibiotics Approach to pediatric Antibiotics Gassem Gohal FAAP FRCPC Assistant professor of Pediatrics objectives To be familiar with common pediatric antibiotics o Classification o Action o Adverse effect To discus

More information

GENERAL NOTES: 2016 site of infection type of organism location of the patient

GENERAL NOTES: 2016 site of infection type of organism location of the patient GENERAL NOTES: This is a summary of the antibiotic sensitivity profile of clinical isolates recovered at AIIMS Bhopal Hospital during the year 2016. However, for organisms in which < 30 isolates were recovered

More information

Antibiotic Prophylaxis Update

Antibiotic Prophylaxis Update Antibiotic Prophylaxis Update Choosing Surgical Antimicrobial Prophylaxis Peri-Procedural Administration Surgical Prophylaxis and AMS at Epworth HealthCare Mr Glenn Valoppi Dr Trisha Peel Dr Joseph Doyle

More information

3/20/2011. Code 215 of Hammurabi: If a physician performed a major operation on

3/20/2011. Code 215 of Hammurabi: If a physician performed a major operation on The Good Antibiotics: the Good, the Bad and the Ugly John P. Cello, MD Professor of Medicine and Surgery, University of California, San Francisco Most organisms can be readily identified by culture, special

More information

Interactive session: adapting to antibiogram. Thong Phe Heng Vengchhun Felix Leclerc Erika Vlieghe

Interactive session: adapting to antibiogram. Thong Phe Heng Vengchhun Felix Leclerc Erika Vlieghe Interactive session: adapting to antibiogram Thong Phe Heng Vengchhun Felix Leclerc Erika Vlieghe Case 1 63 y old woman Dx: urosepsis? After 2 d: intermediate result: Gram-negative bacilli Empiric antibiotic

More information

جداول میکروارگانیسم های بیماریزای اولویت دار و آنتی بیوتیک های تعیین شده برای آزمایش تعیین حساسیت ضد میکروبی در برنامه مهار مقاومت میکروبی

جداول میکروارگانیسم های بیماریزای اولویت دار و آنتی بیوتیک های تعیین شده برای آزمایش تعیین حساسیت ضد میکروبی در برنامه مهار مقاومت میکروبی جداول میکروارگانیسم های بیماریزای اولویت دار و آنتی بیوتیک های تعیین شده برای آزمایش تعیین حساسیت ضد میکروبی در برنامه مهار مقاومت میکروبی ویرایش دوم بر اساس ed., 2017 CLSI M100 27 th تابستان ۶۹۳۱ تهیه

More information

Other Beta - lactam Antibiotics

Other Beta - lactam Antibiotics Other Beta - lactam Antibiotics Assistant Professor Dr. Naza M. Ali Lec 5 8 Nov 2017 Lecture outlines Other beta lactam antibiotics Other inhibitors of cell wall synthesis Other beta-lactam Antibiotics

More information

Antimicrobial Susceptibility Testing: Advanced Course

Antimicrobial Susceptibility Testing: Advanced Course Antimicrobial Susceptibility Testing: Advanced Course Cascade Reporting Cascade Reporting I. Selecting Antimicrobial Agents for Testing and Reporting Selection of the most appropriate antimicrobials to

More information

Safe Patient Care Keeping our Residents Safe Use Standard Precautions for ALL Residents at ALL times

Safe Patient Care Keeping our Residents Safe Use Standard Precautions for ALL Residents at ALL times Safe Patient Care Keeping our Residents Safe 2016 Use Standard Precautions for ALL Residents at ALL times #safepatientcare Do bugs need drugs? Dr Deirdre O Brien Consultant Microbiologist Mercy University

More information

CONTAGIOUS COMMENTS Department of Epidemiology

CONTAGIOUS COMMENTS Department of Epidemiology VOLUME XXIX NUMBER 3 November 2014 CONTAGIOUS COMMENTS Department of Epidemiology Bugs and Drugs Elaine Dowell SM MLS (ASCP), Marti Roe SM MLS (ASCP), Sarah Parker MD, Jason Child PharmD, and Samuel R.

More information

Burton's Microbiology for the Health Sciences. Chapter 9. Controlling Microbial Growth in Vivo Using Antimicrobial Agents

Burton's Microbiology for the Health Sciences. Chapter 9. Controlling Microbial Growth in Vivo Using Antimicrobial Agents Burton's Microbiology for the Health Sciences Chapter 9. Controlling Microbial Growth in Vivo Using Antimicrobial Agents Chapter 9 Outline Introduction Characteristics of an Ideal Antimicrobial Agent How

More information

QUICK REFERENCE. Pseudomonas aeruginosa. (Pseudomonas sp. Xantomonas maltophilia, Acinetobacter sp. & Flavomonas sp.)

QUICK REFERENCE. Pseudomonas aeruginosa. (Pseudomonas sp. Xantomonas maltophilia, Acinetobacter sp. & Flavomonas sp.) Pseudomonas aeruginosa (Pseudomonas sp. Xantomonas maltophilia, Acinetobacter sp. & Flavomonas sp.) Description: Greenish gray colonies with some beta-hemolysis around each colony on blood agar (BAP),

More information

Prophylactic antibiotic timing and dosage. Dr. Sanjeev Singh AIMS, Kochi

Prophylactic antibiotic timing and dosage. Dr. Sanjeev Singh AIMS, Kochi Prophylactic antibiotic timing and dosage Dr. Sanjeev Singh AIMS, Kochi Meaning - Webster Medical Definition of prophylaxis plural pro phy lax es \-ˈlak-ˌsēz\play : measures designed to preserve health

More information

2017 Antibiogram. Central Zone. Alberta Health Services. including. Red Deer Regional Hospital. St. Mary s Hospital, Camrose

2017 Antibiogram. Central Zone. Alberta Health Services. including. Red Deer Regional Hospital. St. Mary s Hospital, Camrose 2017 Antibiogram Central Zone Alberta Health Services including Red Deer Regional Hospital St. Mary s Hospital, Camrose Introduction This antibiogram is a cumulative report of the antimicrobial susceptibility

More information

PRACTIC GUIDELINES for APPROPRIATE ANTIBIOTICS USE

PRACTIC GUIDELINES for APPROPRIATE ANTIBIOTICS USE PRACTIC GUIDELINES for APPROPRIATE ANTIBIOTICS USE Global Alliance for Infection in Surgery World Society of Emergency Surgery (WSES) and not only!! Aims - 1 Rationalize the risk of antibiotics overuse

More information

Similar to Penicillins: -Chemically. -Mechanism of action. -Toxicity.

Similar to Penicillins: -Chemically. -Mechanism of action. -Toxicity. Similar to Penicillins: -Chemically. -Mechanism of action. -Toxicity. Cephalosporins are divided into Generations: -First generation have better activity against gram positive organisms. -Later compounds

More information

2015 Antibiogram. Red Deer Regional Hospital. Central Zone. Alberta Health Services

2015 Antibiogram. Red Deer Regional Hospital. Central Zone. Alberta Health Services 2015 Antibiogram Red Deer Regional Hospital Central Zone Alberta Health Services Introduction. This antibiogram is a cumulative report of the antimicrobial susceptibility rates of common microbial pathogens

More information

VCH PHC SURGICAL PROPHYLAXIS RECOMMENDATIONS

VCH PHC SURGICAL PROPHYLAXIS RECOMMENDATIONS VCH PHC SURGICAL PROPHYLAXIS RECOMMENDATIONS CARDIAC Staphylococcus aureus, S. epidermidis, except for For patients with known MRSA colonization, recommend decolonization with Antimicrobial Photodynamic

More information

Intrinsic, implied and default resistance

Intrinsic, implied and default resistance Appendix A Intrinsic, implied and default resistance Magiorakos et al. [1] and CLSI [2] are our primary sources of information on intrinsic resistance. Sanford et al. [3] and Gilbert et al. [4] have been

More information

Cefuroxime 1.5gm IV and Metronidazole 500mg IV. Metronidazole 500mg IV/Ampicillin-sulbactam e 3g/Ceftriaxone 2gm. +Metronidazole 500mg/Ertapenem 1gm

Cefuroxime 1.5gm IV and Metronidazole 500mg IV. Metronidazole 500mg IV/Ampicillin-sulbactam e 3g/Ceftriaxone 2gm. +Metronidazole 500mg/Ertapenem 1gm SURGICAL ANTIBIOTIC PROPHYLAXIS GENERAL SURGERY* PROCEDURE RECOMMENDED AGENTS a,b Clean None None ALTERNATIVE AGENTS (If allergic to penicillin or colonized/infected with MRSA at any site) Clean with potential

More information

Developed by Kathy Wonderly RN, MSEd,CPHQ Developed: October 2009 Most recently updated: December 2014

Developed by Kathy Wonderly RN, MSEd,CPHQ Developed: October 2009 Most recently updated: December 2014 Developed by Kathy Wonderly RN, MSEd,CPHQ Developed: October 2009 Most recently updated: December 2014 The Center for Medicare and Medicaid (CMS) is moving away from collecting data on the process of care

More information

Antibiotic prophylaxis guideline for colorectal, hepatobiliary and vascular surgery for adult patients.

Antibiotic prophylaxis guideline for colorectal, hepatobiliary and vascular surgery for adult patients. Antibiotic prophylaxis guideline for colorectal, hepatobiliary and vascular surgery for adult patients. Full Title of Guideline: Author (include email and role): Division & Speciality: Scope (Target audience,

More information

Antimicrobial Stewardship Strategy: Antibiograms

Antimicrobial Stewardship Strategy: Antibiograms Antimicrobial Stewardship Strategy: Antibiograms A summary of the cumulative susceptibility of bacterial isolates to formulary antibiotics in a given institution or region. Its main functions are to guide

More information

Gynaecological Surgery in Adults Surgical Antibiotic Prophylaxis

Gynaecological Surgery in Adults Surgical Antibiotic Prophylaxis Gynaecological Surgery in Adults Surgical Antibiotic Prophylaxis Full Title of Guideline: Author (include email and role): Division & Speciality: Scope (Target audience, state if Trust wide): Review date

More information

Antimicrobial Update. Alison MacDonald Area Antimicrobial Pharmacist NHS Highland April 2018

Antimicrobial Update. Alison MacDonald Area Antimicrobial Pharmacist NHS Highland April 2018 Antimicrobial Update Alison MacDonald Area Antimicrobial Pharmacist NHS Highland alisonc.macdonald@nhs.net April 2018 Starter Questions Setting the scene... What if antibiotics were no longer effective?

More information

Table 1. Commonly encountered or important organisms and their usual antimicrobial susceptibilities.

Table 1. Commonly encountered or important organisms and their usual antimicrobial susceptibilities. Table 1. Commonly encountered or important organisms and their usual antimicrobial susceptibilities. Gram-positive cocci: Staphylococcus aureus: *Resistance to penicillin is almost universal. Resistance

More information

Preserve the Power of Antibiotics

Preserve the Power of Antibiotics PROVIDERInsight News for providers in Northeast Nebraska April 2016 Preserve the Power of Antibiotics Antimicrobial stewardship interventions have been proven to improve individual patient outcomes, reduce

More information

Medicinal Chemistry 561P. 2 st hour Examination. May 6, 2013 NAME: KEY. Good Luck!

Medicinal Chemistry 561P. 2 st hour Examination. May 6, 2013 NAME: KEY. Good Luck! Medicinal Chemistry 561P 2 st hour Examination May 6, 2013 NAME: KEY Good Luck! 2 MDCH 561P Exam 2 May 6, 2013 Name: KEY Grade: Fill in your scantron with the best choice for the questions below: 1. Which

More information

OBSTETRICS & GYNAECOLOGY. Penicillin G 5 million units IV ; followed by 2.5 million units 4hourly upto delivery

OBSTETRICS & GYNAECOLOGY. Penicillin G 5 million units IV ; followed by 2.5 million units 4hourly upto delivery OBSTETRICS & GYNAECOLOGY A.OBSTETRICS Infection/Condition/likely organism Intrapartum Group B Streptococcal (GBS) infection; positive mothers Suggested treatment Preferred Penicillin G 5 million units

More information

Chapter Anaerobic infections (individual fields): prevention and treatment of postoperative infections

Chapter Anaerobic infections (individual fields): prevention and treatment of postoperative infections J Infect Chemother (2011) 17 (Suppl 1):62 66 DOI 10.1007/s10156-010-0141-x GUIDELINES Chapter 2-5-1. Anaerobic infections (individual fields): prevention and treatment of postoperative infections Ó Japanese

More information

Antimicrobial Therapy

Antimicrobial Therapy Antimicrobial Therapy David H. Spach, MD Professor of Medicine Division of Infectious Diseases University of Washington, Seattle Disclosure: Dr. Spach has no significant financial interest in any of the

More information

CONTAGIOUS COMMENTS Department of Epidemiology

CONTAGIOUS COMMENTS Department of Epidemiology VOLUME XXXII NUMBER 6 September 2017 CONTAGIOUS COMMENTS Department of Epidemiology Bugs and Drugs Elaine Dowell SM MLS (ASCP), Stacey Hamilton MT SM (ASCP), Samuel Dominguez MD PhD, Sarah Parker MD, and

More information

Standing Orders for the Treatment of Outpatient Peritonitis

Standing Orders for the Treatment of Outpatient Peritonitis Standing Orders for the Treatment of Outpatient Peritonitis 1. Definition of Peritonitis: a. Cloudy effluent. b. WBC > 100 cells/mm3 with >50% polymorphonuclear (PMN) cells with minimum 2 hour dwell. c.

More information

Standing Orders for the Treatment of Outpatient Peritonitis

Standing Orders for the Treatment of Outpatient Peritonitis Standing Orders for the Treatment of Outpatient Peritonitis 1. Definition of Peritonitis: a. Cloudy effluent. b. WBC > 100 cells/mm3 with >50% polymorphonuclear (PMN) cells with minimum 2 hour dwell. c.

More information

Pinni Meedha Mojutho Ammanu Dengina Koduku Part 1 Kama Kathalu

Pinni Meedha Mojutho Ammanu Dengina Koduku Part 1 Kama Kathalu Search for: Search Search Does levaquin cover anaerobes Pinni Meedha Mojutho Ammanu Dengina Koduku Part 1 Kama Kathalu Levofloxacin, sold under the trade names Levaquin among others, is an antibiotic.

More information

4/3/2017 CLINICAL PEARLS: UPDATES IN THE MANAGEMENT OF NOSOCOMIAL PNEUMONIA DISCLOSURE LEARNING OBJECTIVES

4/3/2017 CLINICAL PEARLS: UPDATES IN THE MANAGEMENT OF NOSOCOMIAL PNEUMONIA DISCLOSURE LEARNING OBJECTIVES CLINICAL PEARLS: UPDATES IN THE MANAGEMENT OF NOSOCOMIAL PNEUMONIA BILLIE BARTEL, PHARMD, BCCCP APRIL 7 TH, 2017 DISCLOSURE I have had no financial relationship over the past 12 months with any commercial

More information

SURGICAL ANTIBIOTIC PROPHYLAXIS GUIDELINES WITHIN ORTHOPAEDIC SURGERY FOR ADULT PATIENTS

SURGICAL ANTIBIOTIC PROPHYLAXIS GUIDELINES WITHIN ORTHOPAEDIC SURGERY FOR ADULT PATIENTS SURGICAL ANTIBIOTIC PROPHYLAXIS GUIDELINES WITHIN ORTHOPAEDIC SURGERY FOR ADULT PATIENTS Full Title of Guideline: Author (include email and role): Division & Speciality: Scope (Target audience, state if

More information

Appropriate Antimicrobial Therapy for Treatment of

Appropriate Antimicrobial Therapy for Treatment of Appropriate Antimicrobial Therapy for Treatment of Staphylococcus aureus infections ( MRSA ) By : A. Bojdi MD Assistant Professor Inf. Dis. Dep. Imam Reza Hosp. MUMS Antibiotics Still Miracle Drugs Paul

More information

11/10/2016. Skin and Soft Tissue Infections. Disclosures. Educational Need/Practice Gap. Objectives. Case #1

11/10/2016. Skin and Soft Tissue Infections. Disclosures. Educational Need/Practice Gap. Objectives. Case #1 Disclosures Selecting Antimicrobials for Common Infections in Children FMR-Contemporary Pediatrics 11/2016 Sean McTigue, MD Assistant Professor of Pediatrics, Pediatric Infectious Diseases Medical Director

More information

Antimicrobial Susceptibility Testing: The Basics

Antimicrobial Susceptibility Testing: The Basics Antimicrobial Susceptibility Testing: The Basics Susan E. Sharp, Ph.D., DABMM, FAAM Director, Airport Way Regional Laboratory Director, Regional Microbiology and Molecular Infectious Diseases Laboratories

More information

Antimicrobial Prophylaxis in Digestive Surgery

Antimicrobial Prophylaxis in Digestive Surgery Antimicrobial Prophylaxis in Digestive Surgery Toar JM. Lalisang, MD, PhD Digestive Surgery Division Cipto Mangunkusumo Hospital Medical Faculty Universitas Indonesia Antibiotic must be present before

More information

Infectious Disease 101: Helping the Consultant Pharmacist with Stewardship Principles

Infectious Disease 101: Helping the Consultant Pharmacist with Stewardship Principles Infectious Disease 101: Helping the Consultant Pharmacist with Stewardship Principles Conflicts of Interest None at this time May be discussing off-label indications KALIN M. CLIFFORD, PHARM.D., BCPS,

More information

Understanding the Hospital Antibiogram

Understanding the Hospital Antibiogram Understanding the Hospital Antibiogram Sharon Erdman, PharmD Clinical Professor Purdue University College of Pharmacy Infectious Diseases Clinical Pharmacist Eskenazi Health 5 Understanding the Hospital

More information

Cell Wall Weakeners. Antimicrobials: Drugs that Weaken the Cell Wall. Bacterial Cell Wall. Bacterial Resistance to PCNs. PCN Classification

Cell Wall Weakeners. Antimicrobials: Drugs that Weaken the Cell Wall. Bacterial Cell Wall. Bacterial Resistance to PCNs. PCN Classification Cell Wall Weakeners Antimicrobials: Drugs that Weaken the Cell Wall Beta Lactams Penicillins Cephalosporins Carbapenems Aztreonam Vancomycin Teicoplanin Bacterial Cell Wall Bacterial cytoplasm is hypertonic

More information

2016 Antibiogram. Central Zone. Alberta Health Services. including. Red Deer Regional Hospital. St. Mary s Hospital, Camrose

2016 Antibiogram. Central Zone. Alberta Health Services. including. Red Deer Regional Hospital. St. Mary s Hospital, Camrose 2016 Antibiogram Central Zone Alberta Health Services including Red Deer Regional Hospital St. Mary s Hospital, Camrose Introduction This antibiogram is a cumulative report of the antimicrobial susceptibility

More information

Appropriate Management of Common Pediatric Infections. Blaise L. Congeni M.D. Akron Children s Hospital Division of Pediatric Infectious Diseases

Appropriate Management of Common Pediatric Infections. Blaise L. Congeni M.D. Akron Children s Hospital Division of Pediatric Infectious Diseases Appropriate Management of Common Pediatric Infections Blaise L. Congeni M.D. Akron Children s Hospital Division of Pediatric Infectious Diseases It s all about the microorganism The common pathogens Viruses

More information

Infection Prevention Highlights for the Medical Staff. Pamela Rohrbach MSN, RN, CIC Director of Infection Prevention

Infection Prevention Highlights for the Medical Staff. Pamela Rohrbach MSN, RN, CIC Director of Infection Prevention Highlights for the Medical Staff Pamela Rohrbach MSN, RN, CIC Director of Infection Prevention Standard Precautions every patient every time a. Hand Hygiene b. Use of Personal Protective Equipment (PPE)

More information

Antibiotic Stewardship Program (ASP) CHRISTUS SETX

Antibiotic Stewardship Program (ASP) CHRISTUS SETX Antibiotic Stewardship Program (ASP) CHRISTUS SETX Program Goals I. Judicious use of antibiotics Decrease use of broad spectrum antibiotics and deescalate use based on clinical symptoms Therapeutic duplication:

More information

Antimicrobial Stewardship:

Antimicrobial Stewardship: Antimicrobial Stewardship: Inpatient and Outpatient Elements Angela Perhac, PharmD afperhac@carilionclinic.org Disclosure I have no relevant finances to disclose. Objectives Review the core elements of

More information

2010 ANTIBIOGRAM. University of Alberta Hospital and the Stollery Children s Hospital

2010 ANTIBIOGRAM. University of Alberta Hospital and the Stollery Children s Hospital 2010 ANTIBIOGRAM University of Alberta Hospital and the Stollery Children s Hospital Medical Microbiology Department of Laboratory Medicine and Pathology Table of Contents Page Introduction..... 2 Antibiogram

More information

The Basics: Using CLSI Antimicrobial Susceptibility Testing Standards

The Basics: Using CLSI Antimicrobial Susceptibility Testing Standards The Basics: Using CLSI Antimicrobial Susceptibility Testing Standards Janet A. Hindler, MCLS, MT(ASCP) UCLA Health System Los Angeles, California, USA jhindler@ucla.edu 1 Learning Objectives Describe information

More information

SHC Surgical Antimicrobial Prophylaxis Guidelines

SHC Surgical Antimicrobial Prophylaxis Guidelines SHC Surgical Antimicrobial Prophylaxis Guidelines I. Purpose/Background This document is based upon the 2013 consensus guidelines from American Society of Health-System Pharmacists (ASHP), the Infectious

More information

number Done by Corrected by Doctor Dr.Malik

number Done by Corrected by Doctor Dr.Malik number 27 Done by Fatimah Farhan Corrected by Basil Al-Bakri Doctor Dr.Malik Note: anything in red is just extra info and you will not be asked about it in the exam. In this sheet we will continue talking

More information

Bad Bugs. Pharmacist Learning Objectives. Antimicrobial Resistance. Patient Case. Pharmacy Technician Learning Objectives 4/8/2016

Bad Bugs. Pharmacist Learning Objectives. Antimicrobial Resistance. Patient Case. Pharmacy Technician Learning Objectives 4/8/2016 Pharmacist Learning Objectives Antimicrobial Resistance Julie Giddens Pharm D, BCPS Infectious Disease Clinical Pharmacist OSF Saint Francis Medical Center Peoria, IL The speaker has no conflicts to disclose

More information

Dr. Shaiful Azam Sazzad. MD Student (Thesis Part) Critical Care Medicine Dhaka Medical College

Dr. Shaiful Azam Sazzad. MD Student (Thesis Part) Critical Care Medicine Dhaka Medical College Dr. Shaiful Azam Sazzad MD Student (Thesis Part) Critical Care Medicine Dhaka Medical College INTRODUCTION ICU acquired infection account for substantial morbidity, mortality and expense. Infection and

More information

Perichondritis: Source: UpToDate Ciprofloxacin 10 mg/kg/dose PO (max 500 mg/dose) BID Inpatient: Ceftazidime 50 mg/kg/dose q8 hours IV

Perichondritis: Source: UpToDate Ciprofloxacin 10 mg/kg/dose PO (max 500 mg/dose) BID Inpatient: Ceftazidime 50 mg/kg/dose q8 hours IV Empiric Antibiotics for Pediatric Infections Seen in ED NOTE: Choice of empiric antibiotic therapy must take into account local pathogen frequency and resistance patterns, individual patient characteristics,

More information

Antibacterial therapy 1. د. حامد الزعبي Dr Hamed Al-Zoubi

Antibacterial therapy 1. د. حامد الزعبي Dr Hamed Al-Zoubi Antibacterial therapy 1 د. حامد الزعبي Dr Hamed Al-Zoubi ILOs Principles and terms Different categories of antibiotics Spectrum of activity and mechanism of action Resistancs Antibacterial therapy What

More information

Antimicrobials. Antimicrobials

Antimicrobials. Antimicrobials Antimicrobials For more than 50 years, antibiotics have come to the rescue by routinely producing rapid and long-lasting miracle cures. However, from the beginning antibiotics have selected for resistance

More information

BACTERIAL SUSCEPTIBILITY REPORT: 2016 (January 2016 December 2016)

BACTERIAL SUSCEPTIBILITY REPORT: 2016 (January 2016 December 2016) BACTERIAL SUSCEPTIBILITY REPORT: 2016 (January 2016 December 2016) VA Palo Alto Health Care System April 14, 2017 Trisha Nakasone, PharmD, Pharmacy Service Russell Ryono, PharmD, Public Health Surveillance

More information

Challenges Emerging resistance Fewer new drugs MRSA and other resistant pathogens are major problems

Challenges Emerging resistance Fewer new drugs MRSA and other resistant pathogens are major problems Micro 301 Antimicrobial Drugs 11/7/12 Significance of antimicrobial drugs Challenges Emerging resistance Fewer new drugs MRSA and other resistant pathogens are major problems Definitions Antibiotic Selective

More information

Help with moving disc diffusion methods from BSAC to EUCAST. Media BSAC EUCAST

Help with moving disc diffusion methods from BSAC to EUCAST. Media BSAC EUCAST Help with moving disc diffusion methods from BSAC to EUCAST This document sets out the main differences between the BSAC and EUCAST disc diffusion methods with specific emphasis on preparation prior to

More information

Antibiotics. Antimicrobial Drugs. Alexander Fleming 10/18/2017

Antibiotics. Antimicrobial Drugs. Alexander Fleming 10/18/2017 Antibiotics Antimicrobial Drugs Chapter 20 BIO 220 Antibiotics are compounds produced by fungi or bacteria that inhibit or kill competing microbial species Antimicrobial drugs must display selective toxicity,

More information

9/30/2016. Dr. Janell Mayer, Pharm.D., CGP, BCPS Dr. Lindsey Votaw, Pharm.D., CGP, BCPS

9/30/2016. Dr. Janell Mayer, Pharm.D., CGP, BCPS Dr. Lindsey Votaw, Pharm.D., CGP, BCPS Dr. Janell Mayer, Pharm.D., CGP, BCPS Dr. Lindsey Votaw, Pharm.D., CGP, BCPS 1 2 Untoward Effects of Antibiotics Antibiotic resistance Adverse drug events (ADEs) Hypersensitivity/allergy Drug side effects

More information

Misericordia Community Hospital (MCH) Antimicrobial Stewardship Report. July December 2013 Second and Third Quarters 2014

Misericordia Community Hospital (MCH) Antimicrobial Stewardship Report. July December 2013 Second and Third Quarters 2014 H e a l i n g t h e B o d y E n r i c h i n g t h e M i n d N u r t u r i n g t h e S o u l Misericordia Community Hospital (MCH) Antimicrobial Stewardship Report July December 213 Second and Third Quarters

More information

Principles of Infectious Disease. Dr. Ezra Levy CSUHS PA Program

Principles of Infectious Disease. Dr. Ezra Levy CSUHS PA Program Principles of Infectious Disease Dr. Ezra Levy CSUHS PA Program I. Microbiology (1) morphology (e.g., cocci, bacilli) (2) growth characteristics (e.g., aerobic vs anaerobic) (3) other qualities (e.g.,

More information

1. The preferred treatment option for an initial UTI episode in a 22-year-old female patient

1. The preferred treatment option for an initial UTI episode in a 22-year-old female patient 1 Chapter 79, Self-Assessment Questions 1. The preferred treatment option for an initial UTI episode in a 22-year-old female patient with normal renal function is: A. Trimethoprim-sulfamethoxazole B. Cefuroxime

More information

National Clinical Guideline Centre Pneumonia Diagnosis and management of community- and hospital-acquired pneumonia in adults

National Clinical Guideline Centre Pneumonia Diagnosis and management of community- and hospital-acquired pneumonia in adults National Clinical Guideline Centre Antibiotic classifications Pneumonia Diagnosis and management of community- and hospital-acquired pneumonia in adults Clinical guideline 191 Appendix N 3 December 2014

More information

Antibiotic Updates: Part I

Antibiotic Updates: Part I Antibiotic Updates: Part I Fredrick M. Abrahamian, DO, FACEP, FIDSA Health Sciences Clinical Professor of Emergency Medicine David Geffen School of Medicine at UCLA Los Angeles, California Financial Disclosures

More information

January 2014 Vol. 34 No. 1

January 2014 Vol. 34 No. 1 January 2014 Vol. 34 No. 1. and Minimum Inhibitory Concentration (MIC) Interpretive Standards for Testing Conditions Medium: diffusion: Mueller-Hinton agar (MHA) Broth dilution: cation-adjusted Mueller-Hinton

More information

New Drugs for Bad Bugs- Statewide Antibiogram

New Drugs for Bad Bugs- Statewide Antibiogram New Drugs for Bad Bugs- Statewide Antibiogram Felicia Matthews, Pharm.D., BCPS Senior Consultant, Pharmacy Specialty BE MedMined Services Disclosures Employee of BD Corporation MedMined Services Agenda

More information

General Approach to Infectious Diseases

General Approach to Infectious Diseases General Approach to Infectious Diseases 2 The pharmacotherapy of infectious diseases is unique. To treat most diseases with drugs, we give drugs that have some desired pharmacologic action at some receptor

More information

Drug Class Prior Authorization Criteria Intravenous Antibiotics

Drug Class Prior Authorization Criteria Intravenous Antibiotics Drug Class Prior Authorization Criteria Intravenous Antibiotics Line of Business: Medicaid P&T Approval Date: August 15, 2018 Effective Date: October 1, 2018 This drug class prior authorization criteria

More information

What bugs are keeping YOU up at night?

What bugs are keeping YOU up at night? What bugs are keeping YOU up at night? Barbara DeBaun, RN, MSN, CIC 26 th Annual Medical Surgical Nursing Conference South San Francisco, CA April 15, 2016 Objectives Describe the top three infectious

More information

Advanced Practice Education Associates. Antibiotics

Advanced Practice Education Associates. Antibiotics Advanced Practice Education Associates Antibiotics Overview Difference between Gram Positive(+), Gram Negative(-) organisms Beta lactam ring, allergies Antimicrobial Spectra of Antibiotic Classes 78 Copyright

More information

Infection Control of Emerging Diseases

Infection Control of Emerging Diseases 2016 EPS Training Event Martin E. Evans, MD Director, VHA MDRO Program National Infectious Diseases Service Lexington, KY & Cincinnati, OH Infection Control of Emerging Diseases 2016 EPS Training Event

More information

Antimicrobial susceptibility

Antimicrobial susceptibility Antimicrobial susceptibility PATTERNS Microbiology Department Canterbury ealth Laboratories and Clinical Pharmacology Department Canterbury District ealth Board March 2011 Contents Preface... Page 1 ANTIMICROBIAL

More information

European Committee on Antimicrobial Susceptibility Testing

European Committee on Antimicrobial Susceptibility Testing European Committee on Antimicrobial Susceptibility Testing Routine and extended internal quality control as recommended by EUCAST Version 5.0, valid from 015-01-09 This document should be cited as "The

More information

** the doctor start the lecture with revising some information from the last one:

** the doctor start the lecture with revising some information from the last one: Page 1 of 7 ** the doctor start the lecture with revising some information from the last one: #penicillin G has a good susceptibility against gram(+ve), Neisseria (-ve) #mostly active against strep. (don

More information

Pharmacology Week 6 ANTIMICROBIAL AGENTS

Pharmacology Week 6 ANTIMICROBIAL AGENTS Pharmacology Week 6 ANTIMICROBIAL AGENTS Mechanisms of antimicrobial action Mechanisms of antimicrobial action Bacteriostatic - Slow or stop bacterial growth, needs an immune system to finish off the microbe

More information

Objectives. Review basic categories of intra-abdominal infection and their respective treatments. Community acquired intra-abdominal infection

Objectives. Review basic categories of intra-abdominal infection and their respective treatments. Community acquired intra-abdominal infection Objectives Review basic categories of intra-abdominal infection and their respective treatments Community acquired intra-abdominal infection Mild/Moderate Severe Acute biliary tract infections Nosocomial

More information

Routine internal quality control as recommended by EUCAST Version 3.1, valid from

Routine internal quality control as recommended by EUCAST Version 3.1, valid from Routine internal quality control as recommended by EUCAST Version.1, valid from 01-01-01 Escherichia coli Pseudomonas aeruginosa Staphylococcus aureus Enterococcus faecalis Streptococcus pneumoniae Haemophilus

More information

Sepsis is the most common cause of death in

Sepsis is the most common cause of death in ADDRESSING ANTIMICROBIAL RESISTANCE IN THE INTENSIVE CARE UNIT * John P. Quinn, MD ABSTRACT Two of the more common strategies for optimizing antimicrobial therapy in the intensive care unit (ICU) are antibiotic

More information

CONTAGIOUS COMMENTS Department of Epidemiology

CONTAGIOUS COMMENTS Department of Epidemiology VOLUME XXIII NUMBER 1 July 2008 CONTAGIOUS COMMENTS Department of Epidemiology Bugs and Drugs Elaine Dowell, SM (ASCP), Marti Roe SM (ASCP), Ann-Christine Nyquist MD, MSPH Are the bugs winning? The 2007

More information