Antimicrobial Resistance Monitoring Program in Food-Producing Animals in Japan

Size: px

Start display at page:

Download "Antimicrobial Resistance Monitoring Program in Food-Producing Animals in Japan"

Phebe Beatrix Atkins
5 years ago
Views:

1 93,0 * Antimicrobial Resistance Monitoring Program in Food-Producing Animals in Japan Tetsuo ASAI* National Veterinary Assay Laboratory, Ministry of Agriculture, Forestry and Fisheries, + +/ + Tokura, Kokubunji, Tokyo +2/ 2/++, Japan Summary Antimicrobial agents are essential for human and animal health and welfare, but antimicrobial use can lead to antimicrobial resistance. The resistance arising from antimicrobial use in food-producing animals represents a potential hazard to human medicine through foodborne infection caused by resistant bacteria. In Japan, the Japanese Veterinary Antimicrobial Resistance Monitoring System (JVARM) was formed in +333 in response to international concern about the impact of antimicrobial resistance on public health. In the JVARM program, initial monitoring for antimicrobial-resistant bacteria was carried out in +333 and then the first and second stages of the JVARM program were completed in,***,**- and,**.,**1, respectively. Veterinary antimicrobial use is a selective force for appearance and prevalence of antimicrobial-resistant bacteria in food-producing animals. However, antimicrobial-resistant bacteria are found in the absence of antimicrobial selective pressure. We show here the relationship between antimicrobial usage and prevalence of resistant bacteria under the JVARM from +333 to,**1..1. JVARM +333 Japanese Veterinary Antimicrobial Resistance Monitoring System : JVARM + * +2/ 2/++ + +/ + Tel : *., -, Fax : *., -, asai-t@nval.go.jp +302

2 94 +,, 3-32,**2 +310,2 -/ / +./ +33* WHO FAO OIE WHO +331 : : a -. OIE TC +333 Japanese Veterinary Antimicrobial Resistance Monitoring System : JVARM -/,,*,,-,,/,-+ TC 1+-,0-*,,, , -* b +333,**1 3 cross resistance. ++, 2,/ bo : co-resistance +333,***,**-,**.,**1 : co-selection -,**2,**3,, ,,,,,, C. coli +. +/ +- +0

3 95 ABPC-CP-SM-TC ABPC-SM-KM-TC,2+1+2,,, CP KM GyrA QRDR + DSM-OTC,+ GyrA ParC ABPC CP Infantis TC-SM KM / GyrA QRDR + TMP Enteritidis 3 Typhimurium Infantis +., +/ Pener B D G Y C. jejuni / ABPC, SM, TC, CP ERFX G ABPC +/ +0 TC 1* - TC ABPC E. coli O12 SM KM ERFX -* TMP PC ABPC TMP ST +/ TMP - c VRE +33*, ,*,-,/-+,,,,,,,,, TC SM +33/ VRE danmap.org/ CP CP C. jejuni +1, +2 C. coli C jejuni C. coli +1, +2 - E. faecalis, +333 CP E. faecieum E. hirae MIC -. +,,.-,-,1,3,* +31* +33, +33. E. faecalis E. faecieum E. hirae CP,/ TP FFC FFC Typhimurium +333,**+ TP TP DT+*. CP +*. B,**,,**/ +, -* *,,+ ++ Typhimurium CP CP

4 96 +,, 3-32,**2 ABPC, DSM, OTC TMP Infantis Senftenberg CP DSM TMP blacmy- CP CP, blactx-m-, Newport Typhimurium PFGE +, CP CP +*,**1. /,. - S. Infantis TC SM TC-SM S. Infantis C. jejuni C. coli /2 + JVARM -, +,1 +* +0,**/. C. jejuni,, Asai, T., et al., Antimicrobial resistance in Salmonella isolates from apparently healthy food-producing animal Newport Typhimurium from,*** to,**- : the first stage of Japanese Veterinary Antimicrobial Resistance Monitoring (JVARM). J. Vet. Med. Sci. 02, ,,**0. - Asai, T., et al., Association of antimicrobial resistance in Cmapylobacter isolated from food-producing animals with antimicrobial use on farms. Jpn. J. Infect. Dis. 0*,,3*,3.,,**1.. Asai, T., et al., Long-term prevalence of antimicrobialresistant Salmonella enterica subspecies enterica serovar

5 97 Infantis in broiler chicken industry in Japan. Microbiol of Escherichia coli isolates from pigs. Microb. Drug Immunol. /+, /,,**1. Resist. +.,,-3... / Asai, T., et al., Antimicrobial resistance types and genes +0 Harada, K., et al., Serotypes and antimicrobial suscepin Salmonella enterica Infantis isolates from retail raw tibilities of Campylobacter jejuni isolates from cattle, chicken meats and broiler chicken on farms. J. Food layers and broilers in Japan. Microbiol Immunol. (in Protect. 03,,+.,+0,,**0. press). 0 Asai, T., et al., Correlation between the usage volume of +1 Ishihara, K,. et al., Y. Antimicrobial susceptibilities of veterinary therapeutic antimicrobials and resistance in Campylobacter isolated from food-producing animals on Escherichia coli isolated from the feces of food- farms ( +333,**+ ) : results from the Japanese Veteriproducing animals in Japan. Jpn J Infect Dis. /2, -03 nary Antimicrobial Resistance Monitoring Program. -1,,,**/. Int. J. Antimicrob. Agents.,.,,0+,01,,**.. 1 Esaki, H., et al., Antimicrobial susceptibility of Mann- +2 Ishihara, K., et al., Comparison of Campylobacter isoheimia haemolytica isolates from cattle in Japan from lated from humans and food-producing animals in,**+ to,**,. J Vet Med Sci. 01, 1/ 11,,**/. Japan. J. Appl. Microbiol. +**, +/- +0*,,**0. 2 Esaki, H., et al., Comparison of fluoroquinolone resist- +3 Ishihara, K., et al., The dynamics of antimicrobialance genes of Salmonella enterica serovar Choleraesuis resistant Campylobacter jejuni on Japanese broiler farms. isolates in Japan and Taiwan. Jpn J Infect Dis. /1,,21 J. Vet. Med. Sci. 02, /+/ /+2,,**0.,22,,**..,* +33, Esaki, H., et al., Antimicrobial susceptibility of Salmonella isolated from cattle, swine and poultry (,**+,**,) : report from the Japanese Veterinary Antimicrofood-producing -- +,* bial Resistance Monitoring Program. J Antimicrob,+ Kawagoe, K., et al., Changes of multi-drug resistance Chemother. /-,,00,1*,,**.. pattern in Salmonella enterica subspecies enterica serovar +* Esaki, H., et al., Epidemiological characterization of Typhimurium isolates from food-producing animals in Salmonella Typhimurium DT+*. prevalent among Japan. J. Vet. Med. Sci. 03, +,++ +,+-,,**1. food-producing animals in the Japanese veterinary anti-,, Kijima-Tanaka, M., et al., A national surveillance of microbial resistance monitoring program ( +333,**+ ). Shiga toxin-producing Escherichia coli in food-producing Microbiol Immunol..2, //- //0,,**.. animals in Japan. J. Vet. Med. B. /,,,-*,-1,,**/. ++ Harada, K., et al., Antimicrobial susceptibility of patho-,- Kijima-Tanaka, et al., A national surveillance of antigenic Escherichia coli isolated from the sick cattle and microbial resistance in Escherichia coli isolated from pigs in Japan. J Vet Med Sci. 01, 333 +**-,,**/. animals in Japan. J. Antimicrob. Che- +, Harada, K., et al., T. Role of co-resistance in the mother. /+,..1./+,,**-. development of chloramphenicol resistance in Escherichia,. Kojima, A., et al., Extended-spectrum-beta-lactamaseisolated from sick cattle and pigs. Am. J. Vet. Res. coli producing Escherichia coli strains isolated from farm 01,,-*,-/,,**0. animals from +333 to,**, : report from the Japanese +- Harada, K., et al., Characterization of macrolide- Veterinary Antimicrobial Resistance Monitoring Program. resistant Campylobacter coli isolates from food-producing Antimicrob. Agents Chemother..3, -/---/-1, animals on farms across Japan during,**.. J. Vet.,**/. Med. Sci. 02, ++*3 ++++,,**0.,/ Kojima, A., et al., Classification and antimicrobial +. Harada, K., et al., T.,**1. Contribution of multi- susceptibilities of Enterococcus species isolated from apantimicrobial resistance to the population of anti- parently healthy food-producing animals in Japan. microbial resistant Escherichia coli isolated from appar- Zoonoses Public Health (in press) ently healthy pigs in Japan. Microbiol. Immunol. /+,,0 Morioka, A., et al., In vitro activity of,. antimicrobial.3-.33,,**1. agents against Staphylococcus and Streptococcus isolated +/ Harada, K., et al., Farm-level impact of therapeutic from diseased animals in Japan. J. Vet. Med. Sci. 01, antimicrobial use on antimicrobial-resistant populations,*1,+*,,**/.

6 98 +,, 3-32,**2, * +2/ +3/,**0. R -, Takahashi, T., et al., Emergence of fluoroquinolone +/,+, resistance in Campylobacter jejuni in chickens exposed, to enrofloxacin treatment at the inherent dosage li- R censed in Japan. J. Vet. Med. B. /,,.0*.0.,,**/ OIE,3 //.-*.-.,**,. R -. +1,-,3 +32*. -* Ozawa, M., et al., Antimicrobial susceptibilities, serogroups /0 02/ 03+,**-. and molecular characterization of avian patho- -/ Tamura, Y., The Japanese veterinary antimicrobial re- genic Escherichia coli isolates in Japan. Avian Dis. /,, sistance monitoring system (JVARM). OIE interna- -3, -30. tional standards on antimicrobial resistance,,**-. pp. -+,*0,+*.

Phage type and antimicrobial susceptibility of Salmonella enterica serovar Enteritidis from food-producing animals in Japan between 1976 and 2004

NEW MICROBIOLOGICA, 31, 555-559, 2008 Phage type and antimicrobial susceptibility of Salmonella enterica serovar Enteritidis from food-producing animals in Japan between 1976 and 2004 Tetsuo Asai 1, Kazuki