Are Veterinary Medicines Causing Environmental Risks?

Size: px
Start display at page:

Download "Are Veterinary Medicines Causing Environmental Risks?"

Transcription

1 Are Veterinary Medicines Causing Environmental Risks?

2

3 Nine species of vultures in the wild numbered 40 million birds in the early 1980s. Today, only about 60,000 birds are left (Vibhu Prakash, Bombay Natural History Society)

4 Boxall et al (2003) ES&T

5

6 Ivermectin Equivalents Excretion Profile Ivermectin Metabolite 1 Metabolite Days After Treatment

7 H H H H 3C H 3C H 3C H 3C H H H H H 2 B 1a Monosaccharide H 24 Hydroxymethyl H 2 B 1a Monosaccharide Ivermectin H 2 B 1a H 3C H H 3C H H 3C H 3C H H H H H 3C H H H 3C Aglycone H H H 3C H 3C H H 3C H 3C H 3 --Desmethyl H 2 B 1a H 24 Hydroxymethyl H 2 B 1a H

8 Dissipation in the Field Dung collected 3 days after treatment 500 ml dung pats

9 Ivermectin (µg/kg dw) Ivermectin Persistence in Dung Days in Field

10 Soil sampled directly beneath pats 3 depths 0-1cm 1-3cm 3-5cm For each pat and each time point Transfer of Ivermectin to soil

11 Ivermectin (ng/g ww) Transfer of Ivermectin to soil cm 1-3 cm Field Exposure (days)

12 Concentration (ug/kg) Direct excretion into water Ivermectin Dung, water, sediment Two treatment 6 cycles 5 No detection in water (LD 0.2 ng/l) Pretreatment Treatment 1 Treatment Days after treatment

13

14 Antibiotics Sulfonamides Tetracyclines Fluoroquinolones Lincosamides Antiparasitics Macrocyclic lactones Benzimidazoles

15 Concentration (ug/kg) Persistence in soils DAT 103 DAT 152 DAT diazinon enrofloxacin florfenicol levamisole oxytetracycline phenylbutazone sulfadiazine trimethoprim tylosin Boxall et al., (2006) JAFC

16

17

18 Drainflow Concentration (ug/l) Concentrations in drainflow 1000 Kay et al., ET&C SCP TC TYL Days after Treatment

19

20

21 Surface runoff 2 days after slurry application: 47 µg/l SCP (dissolved phase) 8 µg/l TC (dissolved phase) 50 days after application: Less than 0.5 µg/l of both SCP and TC Much greater runoff generated by plot containing tractor wheelings Lots of sediment transported in surface runoff - high concentrations of TC likely

22 Leaching to groundwater Sampled throughout the soil profile using suction cups Intercepts leaching water Analysed for antibiotics and bromide tracer 3 depths (40, 80, 120 cm)

23 Field leaching studies Tylosin and oxytetracycline not detected Blackwell et al., Chemosphere2007

24 Pharmaceuticals in groundwater Class antiinflammatories antibiotics antiepileptics B-blockers X-ray contrast media hormones lipid regulators Examples diclofenac erythromycin, sulfadiazine, oxytetracyline carbamazepine sotalol iopromide estradiol, ethinylestradiol bezafibrate Monteiro and Boxall, 2010

25 Inputs to aquatic systems Cattle treated with ivermectin pour on Runoff from farmyard monitored continuously Concentrations of ivermectin in runoff detemined by HPLC-FD

26 Concentration (ng/l) Runoff results 90 Runoff volume (l) Days after first treatment

27 Peak concentrations in farmyard runoff Study site/active Concentration of active Maximum measured in product concentration in runoff ( g L -1 ) Site 1 dicyclanil 50 g/l ivermectin 8 g/l deltamethrin 1 g/l <0.100 cyromazine 6 g/l Site 2 ivermectin 5 g/l 0.085

28 Uptake into crops

29 Concentration (ug/kg) Uptake into crops amoxicillin diazinon enrofloxacin florfenicol levamisole oxytetracycline phenylbutazone sulfadiazine trimethoprim tylosin Boxall et al., JAFC (2006)

30 Effects on organisms? Limited toxicity to fish, invertebrates and green algae High toxicity to cyanobacteria Some antibiotics appear to be very toxic to terrestrial and aquatic plants Few impacts seen in standard C&N mineralisation studies with soils Effects on microbes can lead to impacts on key ecosystem processes (e.g. degradation of other substances) Human exposure very low

31 Halling Sorensen, 2000

32 Is their a risk

33 Peak concentrations in farmyard runoff Study site/active Concentration of active Maximum measured in product concentration in runoff ( g L -1 ) Site 1 dicyclanil 50 g/l LEC of g/l (Garric 2007) ivermectin 8 g/l deltamethrin 1 g/l <0.100 cyromazine 6 g/l Site 2 ivermectin 5 g/l 0.085

34 Toxicity to dung organisms Taken from Forster et al., 2010 RCR = 9000 (field study >8)

35 Ivermectin (µg/kg dw) Modelling reality Days Post Dose Excretion profile Medicine use patterns Impact on population Husbandry practices Compound dose response Insect life cycle and behaviour

36 Number of adults Are effects caused at the farm scale? - modelling insect numbers Mar Apr May Jun Jul Aug Sep ct Nov Month

37 Antibiotic resistance

38 Conclusions Veterinary medicines and their metabolites released to and occur in the environment We now have a very detailed understanding of the fate and standard effects of many veterinary drugs in the environment Standard risk assessment approaches suggest limited risk but. We may be missing the important pathways and important endpoints More intelligent approaches could help

Environmental Side Effects of Medication. Alistair B A Boxall Environment Department

Environmental Side Effects of Medication. Alistair B A Boxall Environment Department Environmental Side Effects of Medication Alistair B A Boxall Environment Department Location North East of England 1 Hour 40 minutes to London (high speed train) Close to International Airports Leeds/Bradford

More information

Mixtures of veterinary medicinal compounds in manured soils

Mixtures of veterinary medicinal compounds in manured soils Workshop Pharmaceuticals in Soil, Sludge and Slurry Mixtures of veterinary medicinal compounds in manured soils Nadine Tauchnitz Daniela Gildemeister, Silvia Berkner Dessau-Roßlau, 18th June to 19th June

More information

Key Lecture: Entry, occurrence, behavior and effects of pharmaceuticals in the environment

Key Lecture: Entry, occurrence, behavior and effects of pharmaceuticals in the environment Workshop Pharmaceuticals in Soil, Sludge and Slurry (Dessau, 18 th June to 19 th June 2013) Key Lecture: Entry, occurrence, behavior and effects of pharmaceuticals in the environment Gerd Hamscher Faculty

More information

ManureTracker: On the Trail of Hormones, Antimicrobials and Antimicrobial Resistance Genes

ManureTracker: On the Trail of Hormones, Antimicrobials and Antimicrobial Resistance Genes ManureTracker: On the Trail of Hormones, Antimicrobials and Antimicrobial Resistance Genes Francis J. Larney 1, Srinivas Sura 2, Shanwei Xu 1, Edward Topp 2, and Tim A. McAllister 1 1 Agriculture & Agri-Food

More information

Table 2 Structures and properties of the study compounds with full citations < (ectoparasiticide)

Table 2 Structures and properties of the study compounds with full citations < (ectoparasiticide) 1 Table 2 tructures and properties of the study compounds with full citations Compound CA Molecular Log Kow pka Log Koc 1 oil DT50 1 tructure weight (l/kg) (days) Amoxicillin 26787-78-0 365.4 0.87 2 2.8,

More information

Agriculture & Agri-Food Canada, Research Centre, Lethbridge, AB. Environment Canada, Saskatoon, Saskatchewan

Agriculture & Agri-Food Canada, Research Centre, Lethbridge, AB. Environment Canada, Saskatoon, Saskatchewan The Fate of Antimicrobial Residues during Composting and Stockpiling of Manure Srinivas Sura 1,2, Tim A. McAllister 1, Francis J. Larney 1, Allan J. Cessna 2, Inoka D. Amarakoon 3, Lisa D. Tymensen 4,

More information

Strength Animal species Recommended dose. Member State Applicant Invented name Pharmaceutical form

Strength Animal species Recommended dose. Member State Applicant Invented name Pharmaceutical form ANNEX I LIST OF THE NAMES, PHARMACEUTICAL FORM, STRENGTH OF THE VETERINARY MEDICINAL PRODUCT, ANIMAL SPECIES, ROUTE OF ADMINISTRATION, APPLICANT IN THE MEMBER STATES 1/10 Member State Applicant Invented

More information

Pollutants of Emerging Concern in Orange County Stormwater. Synthetic Pyrethroid Pesticides Fipronil Pesticide

Pollutants of Emerging Concern in Orange County Stormwater. Synthetic Pyrethroid Pesticides Fipronil Pesticide Pollutants of Emerging Concern in Orange County Stormwater Synthetic Pyrethroid Pesticides Fipronil Pesticide Regulatory Drivers Basin Plan narrative objective The concentration of toxic pollutants in

More information

Fate and Transport of Hormones & Antimicrobials

Fate and Transport of Hormones & Antimicrobials Fate and Transport of Hormones & Antimicrobials Linda S. Lee Purdue University Dept. of Agronomy April 25, 2008 1 Basic Properties & Source Concentrations Fate Processes Transport Processes 2 Hormones:

More information

Occurrence of Pharmaceuticals, Hormones, and Organic Wastewater Compounds in Pennsylvania Waters

Occurrence of Pharmaceuticals, Hormones, and Organic Wastewater Compounds in Pennsylvania Waters Occurrence of Pharmaceuticals, Hormones, and Organic Wastewater Compounds in Pennsylvania Waters U.S. Geological Survey Scientific Investigations Report 2012-5106 Background Pharmaceuticals, Hormones,

More information

Potential Impacts of Antibiotics in the Environment

Potential Impacts of Antibiotics in the Environment Potential Impacts of Antibiotics in the Environment Amy Pruden Assistant Professor, Civil Engineering, Colorado State University 11 12 R1 R2 10 13 D 9 14 8 15 C R3 R4 7 16 B 6 17 5 A 4 1 3 2 H CNH 2 H

More information

Drug Use on the Farm & Antibiotic Resistance in Raw, Stored, & Treated Manures

Drug Use on the Farm & Antibiotic Resistance in Raw, Stored, & Treated Manures Drug Use on the Farm & Antibiotic Resistance in Raw, Stored, & Treated Manures Jason Oliver, PhD Cornell PRO-DAIRY Dairy Environmental Systems Dairy Practices Council Annual Conference Buffalo, NY Nov.

More information

Pesticide and antibiotic pollution in the Mekong Delta

Pesticide and antibiotic pollution in the Mekong Delta Pesticide and antibiotic pollution in the Mekong Delta Chau, N.D.G., Renaud, F. G., Sebesvari, Z., Rosendal, I., Amelung, W 6 th WISDOM seminar, 10 14 June, 2013 Bonn Slide 1 Vortrag > Autor > Dokumentname

More information

Environmental impacts of Veterinary Medicines - State of knowledge, options for improvement

Environmental impacts of Veterinary Medicines - State of knowledge, options for improvement Environmental impacts of Veterinary Medicines - State of knowledge, options for improvement Thomas Backhaus University of Gothenburg thomas.backhaus@gu.se Scope of the problem 6051 tons active ingredients

More information

Impact of pharmaceuticals discharges on the receiving environment: a two years monitoring results

Impact of pharmaceuticals discharges on the receiving environment: a two years monitoring results Impact of pharmaceuticals discharges on the receiving environment: a two years monitoring results www.isa-lyon.fr TRACES Group Technology and Research in Analytical Chemistry for Environment, health and

More information

Environmentally persistent pharmaceutical pollutants; effects on living organisms

Environmentally persistent pharmaceutical pollutants; effects on living organisms SAICM First meeting of the Openended Working Group, Belgrade, 15 18 November 2011 Technical briefing on Environmentally persistent pharmaceutical pollutants; effects on living organisms Åke Wennmalm, MD

More information

Occurrence and transformation of veterinary pharmaceuticals and biocides in manure: a literature review

Occurrence and transformation of veterinary pharmaceuticals and biocides in manure: a literature review DOI 10.1186/s12302-016-0091-8 REVIEW Open Access Occurrence and transformation of veterinary pharmaceuticals and biocides in : a literature review Manuel Wohde 1*, Silvia Berkner 2, Thomas Junker 3, Sabine

More information

A Unique Approach to Managing the Problem of Antibiotic Resistance

A Unique Approach to Managing the Problem of Antibiotic Resistance A Unique Approach to Managing the Problem of Antibiotic Resistance By: Heather Storteboom and Sung-Chul Kim Department of Civil and Environmental Engineering Colorado State University A Quick Review The

More information

Occurrence of Antibiotics in Drinking Water

Occurrence of Antibiotics in Drinking Water Occurrence of Antibiotics in Drinking Water Zhengqi Ye, Howard S. Weinberg Michael T. Meyer U. S. Geological Survey, Kansas Abstract The occurrence of antibiotics in the aquatic environment has raised

More information

AMR dissemination in the environment Professor Liz Wellington

AMR dissemination in the environment Professor Liz Wellington AMR dissemination in the environment Professor Liz Wellington The connectivity of potential sources of antibioticresistant bacteria Antibiotic resistance in the environment: soil, sediments, water bodies

More information

Are VETERINARY MEDICINES Causing Environmental Risks? ALISTAIR B. A. BOXALL CRANFIELD CENTRE FOR ECOCHEMISTRY (UNITED KINGDOM)

Are VETERINARY MEDICINES Causing Environmental Risks? ALISTAIR B. A. BOXALL CRANFIELD CENTRE FOR ECOCHEMISTRY (UNITED KINGDOM) Are VETERINARY MEDICINES Causing Environmental Risks? ALISTAIR B. A. BOXALL CRANFIELD CENTRE FOR ECOCHEMISTRY (UNITED KINGDOM) U.S. DANA W. KOLPIN GEOLOGICAL SURVEY BENT HALLING-SØRENSEN THE DANISH UNIVERSITY

More information

Amoxicillin trihydrate and potassium clavulanate. Amoxicillin trihydrate and potassium clavulanate. Amoxicillin trihydrate and potassium clavulanate

Amoxicillin trihydrate and potassium clavulanate. Amoxicillin trihydrate and potassium clavulanate. Amoxicillin trihydrate and potassium clavulanate Annex I List of the name, pharmaceutical form, strength of the veterinary medicinal product, animal species, route of administration, applicant in the Member States 1 Member State EU/EEA Applicant Name

More information

Occurrence, fate, and ecotoxicity of antibiotics in agro-ecosystems. A review

Occurrence, fate, and ecotoxicity of antibiotics in agro-ecosystems. A review Occurrence, fate, and ecotoxicity of antibiotics in agro-ecosystems. A review Du, Liu To cite this version: Du, Liu. Occurrence, fate, and ecotoxicity of antibiotics in agro-ecosystems. A review. Agronomy

More information

Methods development to detect antibiotic activity in water samples

Methods development to detect antibiotic activity in water samples Methods development to detect antibiotic activity in water samples Stefan Kools (Grontmij AquaSense) Marta Wilgosz (Grontmij AquaSense, WUR) Evertjan van de Brandhof (RIVM) Gerard Stroomberg (Waterdienst)

More information

BEHAVIOR OF NURSERY-BOX-APPLIED FIPRONIL AND FIPRONIL SULFONE IN RICE PADDY FIELD THUYET D. Q., WATANABE H., MOTOBAYASHI T., OK J.

BEHAVIOR OF NURSERY-BOX-APPLIED FIPRONIL AND FIPRONIL SULFONE IN RICE PADDY FIELD THUYET D. Q., WATANABE H., MOTOBAYASHI T., OK J. XIV Symposium in Pesticide Chemistry, 2011 BEHAVIOR OF NURSERY-BOX-APPLIED FIPRONIL AND FIPRONIL SULFONE IN RICE PADDY FIELD THUYET D. Q., WATANABE H., MOTOBAYASHI T., OK J. Department of Agricultural

More information

Dewormer/Insecticide Best Management Practices For Conservation Grazing on MN Wildlife Management Areas (WMAs) November 19, 2014

Dewormer/Insecticide Best Management Practices For Conservation Grazing on MN Wildlife Management Areas (WMAs) November 19, 2014 Dewormer/Insecticide Best Management Practices For Conservation Grazing on MN Wildlife Management Areas (WMAs) November 19, 2014 What is the Problem? Successful pest management is an essential part of

More information

Fipronil & Current Use Pesticides. RMP Emerging Contaminants Workgroup April 5 th, 2013

Fipronil & Current Use Pesticides. RMP Emerging Contaminants Workgroup April 5 th, 2013 Fipronil & Current Use Pesticides RMP Emerging Contaminants Workgroup April 5 th, 2013 Needs Current Use Pesticides Fipronil should we add water matrix? What other pesticides should we consider? In what

More information

EurEau s Contribution to the European Commission s Strategic Approach on Veterinary Pharmaceuticals in the Environment

EurEau s Contribution to the European Commission s Strategic Approach on Veterinary Pharmaceuticals in the Environment EurEau s Contribution to the European Commission s Strategic Approach on Veterinary Pharmaceuticals in the Environment Summary Globally, pharmaceutical products are regularly administered to both livestock

More information

Parasite Prevention Strategies for Bison.

Parasite Prevention Strategies for Bison. Parasite Prevention Strategies for Bison Donald H. Bliss, Ph.D. Veterinary Parasitologist MidAmerica Ag Research Verona, WI drbliss@chorus.net www.midamericaagresearch.net Parasite Control is Paramount

More information

ANNEX I. Marketing Authorisation Holder (Name and address): Reference Member State:

ANNEX I. Marketing Authorisation Holder (Name and address): Reference Member State: ANNEX I LIST OF THE PHARMACEUTICAL FORMS, STRENGTHS, ROUTES OF ADMINISTRATION, PACKAGING AND PACKAGE SIZES OF THE VETERINARY MEDICINAL PRODUCT IN THE MEMBER STATES ANNEX I Marketing Authorisation Holder

More information

Environmental Risk Assessment Summary Trimethoprim

Environmental Risk Assessment Summary Trimethoprim r Environmental Risk Assessment Summary Trimethoprim Introduction The publication of environmental risk assessment summaries is part of Roche s engagement on developing a better understanding of issues

More information

Quantification of EPA 1694 Pharmaceuticals and Personal Care Products in Water at the ng/l Level Utilizing Online Sample Preparation with LC-MS/MS

Quantification of EPA 1694 Pharmaceuticals and Personal Care Products in Water at the ng/l Level Utilizing Online Sample Preparation with LC-MS/MS Application Note: 58 Key Words EQuan System TSQ Vantage PPCPs Water Analysis Quantification of EPA 1694 Pharmaceuticals and Personal Care Products in Water at the ng/l Level Utilizing Online Sample Preparation

More information

Deborah A. Cera - Division of Compliance Center for Veterinary Medicine, FDA

Deborah A. Cera - Division of Compliance Center for Veterinary Medicine, FDA Deborah A. Cera - Division of Compliance Center for Veterinary Medicine, FDA 1 1 Databases RVIS Interagency Database TRIMS An Interactive Database Containing Information Obtained During FDA/State Inspections

More information

One Analysis, One Column, Less than 9 Minutes for Over 60 Multiclass Antibiotics

One Analysis, One Column, Less than 9 Minutes for Over 60 Multiclass Antibiotics Featured Application: Multiclass Veterinary Antibiotics on Raptor C8 by LC- One Analysis, One Column, Less than 9 Minutes for Over 0 Multiclass Antibiotics Highly efficient peak separation and fast analysis

More information

Result of the OIE data collection

Result of the OIE data collection Delfy Góchez Chargée de mission Result of the OIE data collection Lessons learned and expectations Beirut, November 8th 2017 Reporting Options The sections of the OIE Template named Reporting Options 1,

More information

Extraction and Cleanup Protocols for LC-MS/MS Multiresidue Determination of Veterinary Drugs in Tissue and Milk Samples

Extraction and Cleanup Protocols for LC-MS/MS Multiresidue Determination of Veterinary Drugs in Tissue and Milk Samples Extraction and Cleanup Protocols for LC-MS/MS Multiresidue Determination of Veterinary Drugs in Tissue and Milk Samples Malin Wangler, Waters Sweden Michael S. Young and Kim vantran Waters Milford 2011

More information

Analysis of Hormones & Anabolics

Analysis of Hormones & Anabolics Analysis of Hormones & Anabolics Hormones and anabolics can be used as growth promoters in livestock breeding to enhance average daily weight gain and meat/fat ratio. As a consequence, hormone and anabolic

More information

Freedom of Information

Freedom of Information ND ref. FOI/16/244 Freedom of Information Thank you for your 01/08/16 request for the following information: Under the Freedom of Information Act, please could you provide me with an extract from the hospital

More information

Pharmaceutical Compounds, Antibiotics, Hormones, and Wastewater Compounds in Pennsylvania Waters

Pharmaceutical Compounds, Antibiotics, Hormones, and Wastewater Compounds in Pennsylvania Waters Pharmaceutical Compounds, Antibiotics, Hormones, and Wastewater Compounds in Pennsylvania Waters Kent Crawford U.S. Geological Survey Pennsylvania Water Science Center PaDEP Emerging Contaminant Forum

More information

Draft agreed by the Environmental Risk Assessment Working Party (ERAWP) 30 April 2018

Draft agreed by the Environmental Risk Assessment Working Party (ERAWP) 30 April 2018 1 2 3 8 November 2018 EMA/CVMP/ERA/632109/2014 Committee for Medicinal Products for Veterinary Use (CVMP) 4 5 6 7 Reflection paper on antimicrobial resistance in the environment: considerations for current

More information

Chapter 2 Residual Veterinary Pharmaceuticals in Animal Manures and Their Environmental Behaviors in Soils

Chapter 2 Residual Veterinary Pharmaceuticals in Animal Manures and Their Environmental Behaviors in Soils Chapter 2 Residual Veterinary Pharmaceuticals in Animal Manures and Their Environmental Behaviors in Soils Weiping Song and Mingxin Guo Abstract The worldwide heavy use of veterinary pharmaceuticals in

More information

Environmental Risk Assessment for Veterinary Antibiotics and Hormone in Malaysian Agricultural Soil

Environmental Risk Assessment for Veterinary Antibiotics and Hormone in Malaysian Agricultural Soil Original Article Environmental Risk Assessment for Veterinary Antibiotics and Hormone in Malaysian Agricultural Soil *Yu Bin HO 1, Mohamad Pauzi ZAKARIA 2, Puziah Abdul LATIF 2, Nazamid SAARI 3 1. Dept.

More information

Journal of Environment and Earth Science ISSN (Paper) ISSN (Online) Vol.7, No.2, 2017

Journal of Environment and Earth Science ISSN (Paper) ISSN (Online) Vol.7, No.2, 2017 ISSN 2224-3216 (Paper) ISSN 2225-948 (Online) Vol.7, No.2, 217 Occurrence and Fate of Antibiotics as Trace Contaminants in Wastewater Collection and Disposal Systems Case Study: University of Dar es Salaam

More information

Toxic Bioassays: LC50 Sediment Testing of the Insecticide Fipronil with the Non-Target Organism, Hyalella azteca. Susan Ma

Toxic Bioassays: LC50 Sediment Testing of the Insecticide Fipronil with the Non-Target Organism, Hyalella azteca. Susan Ma Toxic Bioassays: LC50 Sediment Testing of the Insecticide Fipronil with the Non-Target Organism, Hyalella azteca Susan Ma Abstract The use of the insecticide fipronil has dramatically increased in recent

More information

COMMITTEE FOR VETERINARY MEDICINAL PRODUCTS

COMMITTEE FOR VETERINARY MEDICINAL PRODUCTS The European Agency for the Evaluation of Medicinal Products Veterinary Medicines Evaluation Unit EMEA/MRL/389/98-FINAL July 1998 COMMITTEE FOR VETERINARY MEDICINAL PRODUCTS ENROFLOXACIN (extension to

More information

Poultry Science Journal ISSN: (Print), (Online)

Poultry Science Journal ISSN: (Print), (Online) Madadi et al., 2014 25 Poultry Science Journal ISSN: 2345-6604 (Print), 2345-6566 (Online) http://psj.gau.ac.ir Evaluation of Drug Interactions and Prescription Errors of Poultry Veterinarians in North

More information

January 23, 2014 Anna O Brien, DVM Veterinary Medical Officer Office of New Animal Drug Evaluation Center for Veterinary Medicine-FDA

January 23, 2014 Anna O Brien, DVM Veterinary Medical Officer Office of New Animal Drug Evaluation Center for Veterinary Medicine-FDA CVM s Antiparasitic Resistance Management Strategy January 23, 2014 Anna O Brien, DVM Veterinary Medical Officer Office of New Animal Drug Evaluation Center for Veterinary Medicine-FDA Goals for this presentation

More information

ENVIRONMENTAL FATE OF FIPRONIL

ENVIRONMENTAL FATE OF FIPRONIL EVIRMETAL FATE F FIPRIL Pete Connelly Environmental Monitoring Branch Department of Pesticide Regulation California Environmental Protection Agency P.. Box 4015 Sacramento, CA 95812-4015 December 2001

More information

Multi-residue Method I for Veterinary Drugs by HPLC (Animal and Fishery Products)

Multi-residue Method I for Veterinary Drugs by HPLC (Animal and Fishery Products) Multi-residue Method I for Veterinary Drugs by HPLC (Animal and Fishery Products) 1. Analytes See Table 7. 2. Instruments High performance liquid chromatograph-photodiode array detector (HPLC-DAD) High

More information

Aquaculture Drugs: Industry Concerns

Aquaculture Drugs: Industry Concerns Washington DC New York Denver Seattle Aquaculture Drugs: Industry Concerns Lisa Weddig Vice President, Regulatory and Technical Affairs National Fisheries Institute Who is NFI? Leading advocacy organization

More information

Antibiotic Residues in Animal Waste: Occurrence and Degradation in Conventional Agricultural Waste Management Practices

Antibiotic Residues in Animal Waste: Occurrence and Degradation in Conventional Agricultural Waste Management Practices Curr Pollution Rep (2016) 2:135 155 DOI 10.1007/s40726-016-0037-1 WATER POLLUTION (S SENGUPTA, SECTION EDITOR) Antibiotic Residues in Animal Waste: Occurrence and Degradation in Conventional Agricultural

More information

Residues. Mike Apley, DVM, PhD

Residues. Mike Apley, DVM, PhD Residues Mike Apley, DVM, PhD Residues: It s Black and White Residues occur when detected concentrations of the marker residue are above the approved tolerance for that drug in that tissue. Residues are

More information

MidAmerica Ag Research

MidAmerica Ag Research MidAmerica Ag Research Donald H. Bliss, Ph.D. Veterinary Parasitologist Verona, WI www.midamericaagresearch.net Iowa State Review of 170 Publications Economic Analysis of Pharmaceutical Technologies in

More information

Middlesex University Research Repository

Middlesex University Research Repository Middlesex University Research Repository An open access repository of Middlesex University research http://eprints.mdx.ac.uk Tuckwell, Rebecca (2015) The impact on receiving waters of pharmaceutical residues

More information

Protect your trees in the ground: What s new on the antimicrobial front?

Protect your trees in the ground: What s new on the antimicrobial front? June 12-14, 2013 Ninth Annual Florida Citrus Industry Annual Conference Protect your trees in the ground: What s new on the antimicrobial front? Hyatt Regency Coconut Point, Bonita Springs June 12-14,

More information

For the treatment and prevention of infections caused by:

For the treatment and prevention of infections caused by: SUMMARY OF PRODUCT CHARACTERISTICS 1. NAME OF THE VETERINARY MEDICINAL PRODUCT CYDECTIN 0.1 % W/V ORAL SOLUTION for sheep 2. QUALITATIVE AND QUANTITATIVE COMPOSITION Each ml contains Active substance Moxidectin

More information

Analysis of Multiclass Veterinary Drugs in Baby Food by Ultra Fast Chromatography with High Performance Triple Quadrupole Mass Spectrometry

Analysis of Multiclass Veterinary Drugs in Baby Food by Ultra Fast Chromatography with High Performance Triple Quadrupole Mass Spectrometry Analysis of Multiclass Veterinary Drugs in Baby Food by Ultra Fast Chromatography with High Performance Triple Quadrupole Mass Spectrometry Charles Yang, 1 Dipankar Ghosh, 1 Mary Blackburn, 1 Jamie Humphries

More information

Deworming: Relationships, Resistance, Refugia

Deworming: Relationships, Resistance, Refugia Deworming: Relationships, Resistance, Refugia Drs. Sandy Stuttgen & Sarah Mills-Lloyd Agriculture Educators University of Wisconsin Extension Parasite Control Requires an Integrated Approach Clean Pastures

More information

Antibiotic usage in the British sheep industry. Dr Peers Davies

Antibiotic usage in the British sheep industry. Dr Peers Davies Antibiotic usage in the British sheep industry Dr Peers Davies 40% of all livestock biomass in the UK (ESVAC report 2016) Current Estimates and Data Sources No published, quantitative estimates of antimicrobial

More information

Impact of veterinary antibiotics in the environment

Impact of veterinary antibiotics in the environment Retrospective Theses and Dissertations 2008 Impact of veterinary antibiotics in the environment Keri Lynn Deppe Henderson Iowa State University Follow this and additional works at: http://lib.dr.iastate.edu/rtd

More information

Summary of Product Characteristics

Summary of Product Characteristics Summary of Product Characteristics 1 NAME OF THE VETERINARY MEDICINAL PRODUCT Zearl 10 mg/ml Solution for Injection for Cattle and Sheep. 2 QUALITATIVE AND QUANTITATIVE COMPOSITION Each ml contains: Active

More information

Anthelmintic resistance in beef cattle what are the levels and what can be done to lessen its impact?

Anthelmintic resistance in beef cattle what are the levels and what can be done to lessen its impact? Anthelmintic resistance in beef cattle what are the levels and what can be done to lessen its impact? Dr Orla Keane Teagasc, Grange Teagasc Beef Conference 30 th Oct 2018 Overview Background Anthelmintic

More information

Beef Calving Statistics (01/07/ /06/2016)

Beef Calving Statistics (01/07/ /06/2016) LoCall (1/7/1 --- /6/16) IE167 1() 1. Summary Data Report is based on beef cows with a calving record in the cattle breeding database and where the calving date is between (Embryo births excluded) Total

More information

Risk-Based Approach to Developing the National Residue Sampling Plan

Risk-Based Approach to Developing the National Residue Sampling Plan Report of the Scientific Committee of the Food Safety Authority of Ireland 2014 Risk-Based Approach to Developing the National Residue Sampling Plan (For Veterinary Medicinal Products and Medicated Feed

More information

ProHeart 6 Safety Assessment by Fort Dodge Animal Health

ProHeart 6 Safety Assessment by Fort Dodge Animal Health ProHeart 6 Safety Assessment by Fort Dodge Animal Health January 31, 2005 Rami Cobb, BVSc (Hons.) MACVSc Vice President Pharmaceutical Research & Development Fort Dodge Animal Health ProHeart 6 Introduction

More information

SUMMARY OF PRODUCT CHARACTERISTICS

SUMMARY OF PRODUCT CHARACTERISTICS SUMMARY OF PRODUCT CHARACTERISTICS Revised: December 2011 1. NAME OF THE VETERINARY MEDICINAL PRODUCT Dectomax 10 mg/ml Solution for Injection for Pigs (UK) Zearl 10 mg/ml Solution for Injection for Pigs

More information

range of RA s accessible during the night.

range of RA s accessible during the night. ***** 2008 Night-time Astronomical Calendar for Kitt Peak ***** By John Thorstensen, Dartmouth College This calendar is designed to provide information useful for the planning of nighttime observations.

More information

range of RA s accessible during the night.

range of RA s accessible during the night. ***** 2010 Night-time Astronomical Calendar for Kitt Peak ***** By John Thorstensen, Dartmouth College This calendar is designed to provide information useful for the planning of nighttime observations.

More information

Summary of Product Characteristics

Summary of Product Characteristics Summary of Product Characteristics 1 NAME OF THE VETERINARY MEDICINAL PRODUCT DECTOMAX 10 mg/ml Solution for Injection for Cattle, Sheep and Pigs 2 QUALITATIVE AND QUANTITATIVE COMPOSITION Each ml contains:

More information

Guidance for completing the OIE template for the collection of data on antimicrobial agents intended for use in animals

Guidance for completing the OIE template for the collection of data on antimicrobial agents intended for use in animals Guidance for completing the OIE template for the collection of data on antimicrobial agents intended for use in animals Contents Introduction... 1 Required information and choices for reporting... 2 Baseline

More information

COMMITTEE FOR VETERINARY MEDICINAL PRODUCTS

COMMITTEE FOR VETERINARY MEDICINAL PRODUCTS The European Agency for the Evaluation of Medicinal Products Veterinary Medicines and Information Technology EMEA/MRL/728/00-FINAL April 2000 COMMITTEE FOR VETERINARY MEDICINAL PRODUCTS STREPTOMYCIN AND

More information

General Directorate of Animal Health and EpizooticDiseases Control. Dr.Sabah Hassan Abdelgadir Sudan Focal Point for Veterinary products

General Directorate of Animal Health and EpizooticDiseases Control. Dr.Sabah Hassan Abdelgadir Sudan Focal Point for Veterinary products REPUBLIC OF SUDAN Ministry of Animal Resources General Directorate of Animal Health and EpizooticDiseases Control Dr.Sabah Hassan Abdelgadir Sudan Focal Point for Veterinary products Sudan experiences

More information

Resistance to ectoparasiticides as a result of malpractices by farmers. Dr Tom Strydom Malelane Research Unit

Resistance to ectoparasiticides as a result of malpractices by farmers. Dr Tom Strydom Malelane Research Unit Resistance to ectoparasiticides as a result of malpractices by farmers Dr Tom Strydom Malelane Research Unit One host tick resistance to acaricides increased to alarming rates over past 20 years Reasons:

More information

SAFETY DATA SHEET Page 1 of 5 Product Name: First Drench Hi-Mineral Reviewed on: 2 February 2018

SAFETY DATA SHEET Page 1 of 5 Product Name: First Drench Hi-Mineral Reviewed on: 2 February 2018 Page 1 of 5 SECTION 1: IDENTIFICATION OF THE SUBSTANCE AND SUPPLIER Product name: Product code: Recommended use: Company details: Address: First Drench Hi-Mineral A006859 A combination drench for the control

More information

Situation update of dengue in the SEA Region, 2010

Situation update of dengue in the SEA Region, 2010 Situation update of dengue in the SEA Region, 21 The global situation of Dengue It is estimated that nearly 5 million dengue infections occur annually in the world. Although dengue has a global distribution,

More information

Changing Practices to Reduce Antibiotic Resistance

Changing Practices to Reduce Antibiotic Resistance Changing Practices to Reduce Antibiotic Resistance Jean E. McLain, Research Scientist and Assistant Dean University of Arizona College of Agriculture and Life Sciences and Department of Soil, Water and

More information

Mira Čelić1, Meritxell Gros1, Marinella Farre2, Damia Barceló1,2, Mira Petrović1,3

Mira Čelić1, Meritxell Gros1, Marinella Farre2, Damia Barceló1,2, Mira Petrović1,3 Occurrence, distribution and fate of pharmaceuticals as chemical markers of contamination from urban sources in the vulnerable area of the Ebro Delta (Spain) Mira Čelić 1, Meritxell Gros 1, Marinella Farre

More information

COS List. Page 1. trading & distribution excellence since Product CEP no. CoS status Country. Acamprosate OBTAINED Korea

COS List. Page 1. trading & distribution excellence since Product CEP no. CoS status Country. Acamprosate OBTAINED Korea Page 1 trading & distribution excellence since 1986 Acamprosate 2001-160 OBTAINED Korea Acarbose* pending pending China Acetyl Salicylic Acid (Aspirin) * 2001-399 OBTAINED China Acyclovir 2001-283 OBTAINED

More information

IJCBS, 10(2016): International Journal of Chemical and Biochemical Sciences (ISSN )

IJCBS, 10(2016): International Journal of Chemical and Biochemical Sciences (ISSN ) IJCBS, 10(2016):10-15 International Journal of Chemical and Biochemical Sciences (ISSN 2226-9614) Journal Home page: www.iscientific.org/journal.html International Scientific Organization Quantification

More information

ANTIBIOTICS: TECHNOLOGIES AND GLOBAL MARKETS

ANTIBIOTICS: TECHNOLOGIES AND GLOBAL MARKETS ANTIBIOTICS: TECHNOLOGIES AND GLOBAL MARKETS PHM025D March 2016 Neha Maliwal Project Analyst ISBN: 1-62296-252-4 BCC Research 49 Walnut Park, Building 2 Wellesley, MA 02481 USA 866-285-7215 (toll-free

More information

Antibiotics in the Environment: A Review

Antibiotics in the Environment: A Review ISSN: 2319-7706 Volume 4 Number 11 (2015) pp. 278-285 http://www.ijcmas.com Review Article Antibiotics in the Environment: A Review Smita Pareek*, Nupur Mathur, Anuradha Singh and Amrita Nepalia Environmental

More information

crippling production of the bacterial cell wall that protects the cell from the external environment PS

crippling production of the bacterial cell wall that protects the cell from the external environment PS Antibiotic Selection and Use in Cattle Dee Griffin DVM MS, Texas A&M Veterinary Medical Center, Canyon, TX 79016 Antibiotic use in food animals is increasingly scrutinized Much of the world s antibiotic

More information

For the treatment of mixed parasitic infections in cats caused by roundworms and tapeworms of the following species:

For the treatment of mixed parasitic infections in cats caused by roundworms and tapeworms of the following species: Printed from (http://www.noahcompendium.co.uk). (c) Copyright 2018. All Rights Reserved. Date: Wednesday, October 24, 2018 11:47 Bayer plc Telephone:0118 206 3000 Website:www.bayer.co.uk Email:animal.health@bayer.com

More information

OUR BAY AND RIVERS ON DRUGS pharmaceuticals and illicit drugs as agents of ecological change

OUR BAY AND RIVERS ON DRUGS pharmaceuticals and illicit drugs as agents of ecological change OUR BAY AND RIVERS ON DRUGS pharmaceuticals and illicit drugs as agents of ecological change Emma J. Rosi, Senior Scientist and Director Baltimore Ecosystem Study LTER Baltimore Ecosystem Study Pharmaceuticals

More information

COMMITTEE FOR MEDICINAL PRODUCTS FOR VETERINARY USE

COMMITTEE FOR MEDICINAL PRODUCTS FOR VETERINARY USE European Medicines Agency Veterinary Medicines and Inspections EMEA/CVMP/211249/2005-FINAL July 2005 COMMITTEE FOR MEDICINAL PRODUCTS FOR VETERINARY USE DIHYDROSTREPTOMYCIN (Extrapolation to all ruminants)

More information

Your sheep health is your wealth

Your sheep health is your wealth Your sheep health is your wealth Matt Playford, Dawbuts Pty Ltd, Camden NSW PLEASE INSERT LOGO HERE 1 Cost of endemic diseases Lane (2015) MLA WORMS $436m Key point is that we are still not spending enough

More information

Enrofloxacin and Ciprofloxacin Uptake by Plants from Soil

Enrofloxacin and Ciprofloxacin Uptake by Plants from Soil Agronomy Research 8 (1), 807 814, 20 Enrofloxacin and Ciprofloxacin Uptake by Plants from Soil M. Lillenberg 1, S. V. Litvin 2, L. Nei 2, M.Roasto 1 and K. Sepp 3 1 Department of Food Science and Hygiene,

More information

SIMAGCHEM CORPORATION

SIMAGCHEM CORPORATION SIMAGCHEM CORPORATION Corporation SIMAGCHEM was established in 1996. We are a dynamic and innovative chemical supplier company based in China. In term of our teamwork and EPR -BDL database, we are professional

More information

ARCI Controlled Therapeutic Medication Schedule for Horses - Version 3.2 Revised December 9, 2016.

ARCI Controlled Therapeutic Medication Schedule for Horses - Version 3.2 Revised December 9, 2016. ARCI Schedule for Horses - Version 3.2 Revised December 9, 2016. Acepromazine 10 nanograms per milliliter as 2-(1- hydroxyethyl) promazine sulfoxide (HEPS) in urine Single intravenous dose of acepromazine

More information

Current EU Antibiotic Maximum Residue Limits

Current EU Antibiotic Maximum Residue Limits R-Biopharm Rhône Current EU Antibiotic Maximum Residue Limits March 2011 R-Biopharm Rhône Current EU Antibiotic Limits 2 Contents Antibiotics in Food Aminoglycosides...4 Ansamycins...4 Beta-lactams...5

More information

Promoting Appropriate Antimicrobial Prescribing in Secondary Care

Promoting Appropriate Antimicrobial Prescribing in Secondary Care Promoting Appropriate Antimicrobial Prescribing in Secondary Care Stuart Brown Healthcare Acquired Infection and Antimicrobial Resistance Project Lead NHS England March 2015 Introduction Background ESPAUR

More information

ARCI Controlled Therapeutic Medication Schedule for Horses - Version 4.1 Revised January, 2019

ARCI Controlled Therapeutic Medication Schedule for Horses - Version 4.1 Revised January, 2019 ARCI Schedule for Horses - Version 4.1 Revised January, 2019 Acepromazine 10 nanograms per milliliter as 2-(1- hydroxyethyl) promazine sulfoxide (HEPS) in urine Single intravenous dose of acepromazine

More information

20mL, 50mL, 100mL. 20mL, 50mL, 100mL. 20mL, 50mL, 100mL. 20mL, 50mL, 100mL. 20mL, 50mL, 100mL. 50mL, 100mL. 50mL, 100mL.

20mL, 50mL, 100mL. 20mL, 50mL, 100mL. 20mL, 50mL, 100mL. 20mL, 50mL, 100mL. 20mL, 50mL, 100mL. 50mL, 100mL. 50mL, 100mL. VETERINARY PHARMACEUTICALS PRODUCTS / ACTIVE INGREDIENTS PRESENTATION TARGET SPECIES ANTIBIOTICS ENROZOL SOLUTION FOR INJECTION ENROFLOXACIN 100 mg/ml ZOLIGEN SOLUTION FOR INJECTION GENTAMICIN SULPHATE

More information

COMMISSION OF THE EUROPEAN COMMUNITIES COMMISSION STAFF WORKING DOCUMENT

COMMISSION OF THE EUROPEAN COMMUNITIES COMMISSION STAFF WORKING DOCUMENT EN EN EN COMMISSION OF THE EUROPEAN COMMUNITIES Brussels, 6.8.2008 SEC(2008) 2375 COMMISSION STAFF WORKING DOCUMENT ON THE IMPLEMENTATION OF NATIONAL RESIDUE MONITORING PLANS IN THE MEMBER STATES IN 2006

More information

United Kingdom Veterinary Medicines Directorate Woodham Lane New Haw Addlestone Surrey KT15 3LS DECENTRALISED PROCEDURE

United Kingdom Veterinary Medicines Directorate Woodham Lane New Haw Addlestone Surrey KT15 3LS DECENTRALISED PROCEDURE United Kingdom Veterinary Medicines Directorate Woodham Lane New Haw Addlestone Surrey KT15 3LS DECENTRALISED PROCEDURE PUBLICLY AVAILABLE ASSESSMENT REPORT FOR A VETERINARY MEDICINAL PRODUCT Date Created:

More information

Summary of Product Characteristics

Summary of Product Characteristics Summary of Product Characteristics 1 NAME OF THE VETERINARY MEDICINAL PRODUCT Chanimec 10 mg/ml solution for injection. 2 QUALITATIVE AND QUANTITATIVE COMPOSITION Each ml contains: Active substance: Ivermectin

More information

Analysis of Veterinary Drugs in Meat with the Agilent 6495 Triple Quadrupole LC/MS

Analysis of Veterinary Drugs in Meat with the Agilent 6495 Triple Quadrupole LC/MS Analysis of Veterinary Drugs in Meat with the Agilent 6495 Triple Quadrupole LC/MS Application Note Food Authors Tarun Anumol, Joan M. Stevens, and Jerry Zweigenbaum Agilent Technologies Inc. Abstract

More information

USE OF ANTIBIOTICS FOR ANIMALS IN VIETNAM. Nguyen Quoc An Dept. of Animal Health MARD

USE OF ANTIBIOTICS FOR ANIMALS IN VIETNAM. Nguyen Quoc An Dept. of Animal Health MARD USE OF ANTIBIOTICS FOR ANIMALS IN VIETNAM Nguyen Quoc An Dept. of Animal Health MARD Summary of antibiotics utilisation for animals Total of product s Products of Vietnam Total Enterprise s Imported drugs

More information

[Version 7.3.2, 10/2011] ANNEX I SUMMARY OF PRODUCT CHARACTERISTICS

[Version 7.3.2, 10/2011] ANNEX I SUMMARY OF PRODUCT CHARACTERISTICS [Version 7.3.2, 10/2011] ANNEX I SUMMARY OF PRODUCT CHARACTERISTICS 1 1. NAME OF THE VETERINARY MEDICINAL PRODUCT NEOPRINIL POUR-ON 5 mg/ml pour-on solution for cattle 2. QUALITATIVE AND QUANTITATIVE COMPOSITION

More information

[Version 7.3.2, 10/2011] ANNEX I SUMMARY OF PRODUCT CHARACTERISTICS

[Version 7.3.2, 10/2011] ANNEX I SUMMARY OF PRODUCT CHARACTERISTICS [Version 7.3.2, 10/2011] ANNEX I SUMMARY OF PRODUCT CHARACTERISTICS 1 1. NAME OF THE VETERINARY MEDICINAL PRODUCT NEOPRINIL POUR-ON 5 mg/ml pour-on solution for cattle 2. QUALITATIVE AND QUANTITATIVE COMPOSITION

More information