Histoplasmosis : Un update

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1 Histoplasmosis : Un update Ayako SANO Histoplasma capsulatum 1, , , 11 deep-seated mycoses, systemic mycoses edical ycology Research Center, Chiba University (1-8-1, Inohana, Chuo-ku, Chiba, , Chiba)

2 Aspergillus fumigatus Candida albicans Cladophialophora carrionii Cladophialophora bantiana Cryptococcus neoformans Exophiala dermatitidis onsecaea pedrosoi Sporothrix schenkii Blastomyces dermatitidis Coccidioides immitis Histoplasma capsulatumh. capsulatum var. capsulatum, H. capsulatum var. duboisii Histoplasma farciminosumhistoplasma capsulatum var. farciminosum Paracoccidioides brasiliensis Penicillium marneffei Aspergillus spp., Chaetomium spp., usarium spp., yrothecium spp., Penicillium spp b 1 c e a D 2.3SZ 5 4SH 12SZ d 8BT 13LR 4.75 H H H C, CL, H H, B C, CL, H, B H, B H, B H, IA H H, IH H, B H, B H, B C, H, B C, B H, B H, B H, IH 12Acta ed Okayama 11 : , : 194, : , J Dermatol 21 : , : 387, Tropical edicine and Health 33 : 40, : 92-96, , Jpn Vet ed Sci , Jpn J Vet Sci , J Vet ed Sci , , , Vet icrobiol, , J Vet ed A , edical ycology , edical ycology , J Comp Pathol , a ; b ; 20,000 c ; , 1918d ; 20052e ; DSZSHBT LRCCLHBIH

3 sapro zoonosis H. capsulatum conidiophore conidium macroconidium 7 25µm microconidium 2 6µm 1 brain heart infusion agar35 37 a a b c 25 2d 20µmx200e 20µmx400 b c d e 2 4µm 20 3 variety RNA ITS variety H. capsulatum var. capsulatum histoplasmosis capsulati H. capsulatum var. duboisii histoplasmosis duboisii 20, Yamato 12 20, 22 H. capsulatum var. farciminosum H. farciminosum histoplasmosis farciminosi 20, µm 20 23

4 , 27, H. capsulatum H. capsulatum

5 AIDS advanced chronic form3. non-fatal form 7 36 H. capsulatum var. farciminosum 2, 4 7 Rhoades 34 1.benign pulmonary form2.disseminated form Nielsen acute, fatal, disseminating disease2. H. capsulatum 4

6 70 24 RNA internal transcribed spacer ITS1-5.8S-ITS Candida glabrata 32, 33 PAS 500 DNAnested- PCR BLAST ITS-55 -GGA AGT AAA AGT CGT AAC AAG G-3 ITS-45 -TCC TCC GCT TAT TGA TAT GC-3 PCR PCR HcA5 -CAC GCC GTG GGG GGC TGG GAG CCT-3 HcCR 5 -ATG GTG GGC RGG AGC CGG CC-3 ITS-25 -GCT GCG TTC TTC ATC GAT GC-3

7 x400. x400. b a c PAS x400. a-c. x1,000 ITS-35 -GCA TCG ATG AAG AAC GCA GC-3 PCR Real-time PCR 38 H. capsulatum RNA ITS 1-5.8S-ITS 2 H. capsulatum var. capsulatum H. capsulatum var. farciminosum variety H. capsulatum var. duboisii RNA ITS 1-5.8S-ITS H. capsulatum RNA ITS 1-5.8S-ITS 2 H. capsulatum var. farciminosum H. capsulatum var. capsulatum

8 H. capsulatum var. capsulatum H. capsulatum var. duboisii GenBank Ajellomyces capsulatush. capsulatum RNA ITS 1-5.8S-ITS 2 H. capsulatum var. farciminosum H. capsulatum var. capsulatum 1 H. capsulatum var. capsulatum 2 H. capsulatum var. duboisii 1 4 RNA ITS 1-5.8S-ITS 2 H. capsulatum var. farciminosum H. capsulatum var. capsulatum H. capsulatum internal transcribed spacer ITS1-5.8S -ITS 2 H. capsulatum var. farciminosum H. capsulatum var. capsulatum IH. capsulatum var. capsulatum II III H. capsulatum var. duboisii IV. I 1 2, , H. capsulatum var. farciminosum 2 5 1

9 1 Kamei K, Sano A, Kiuchi K, et al.: The trend of imported mycoses in Japan. J Infect Chemotherap : 16-20, ,.. : , Kagawa Y, Aoki S, Iwatomi T, et al.: Histoplasmosis in the skin and gingiva in a dog. J Vet ed Sci 1998 ; : J Vet ed Sci. : , ,, : 2.. : , Ueda Y, Sano A, Tamura, et al.: Diagnosis of histoplasmosis by detection of the internal transcribed spacer region of fungal rrna gene from a paraffin-embedded skin sample from a dog in Japan. Vet icrobiol, : , Nishifuji K, Ueda Y, Sano A, et al.: Interdigital involvement in a case of primary cutaneous canine histoplasmosis in Japan. J Vet ed A : , urata Y, Sano A, Ueda Y, et al.: olecular epidemiology of canine histoplasmosis in Japan. ed ycol. : , Katayama Y, Kuwano A, Yoshihara T.: Histoplasmosis in the lung of a race horse with yersiniosis. J Vet. ed Sci : , orita T, Kishimoto, Shimada A, et al.: Disseminated histoplasmosis in a sea otterenhydra lutris. J Comp Pathol : , Oshima KI, iura S.: A histopathological report on a case of histoplasmosis in a heifer with allot's tetralogy. Nippon Juigaku Zasshi : , ,,1918, pp Yamato H, Hitomi H, aekawa S, imura K.: A case of histoplasmosis. Acta ed Okayama : , ,,. : 194, ,,,. : , Ohnishi K, Nagai Y, Okada K, et al.: Primary cutaneous histoplasmosis in papuloerythrodermaofuji. J Dermatol : , Takakura S.: A case of chronic disseminated histoplasmosis emerged during steroid maintenance therapy for rheumatoid arthritis with secondary amyloidosis and nephrotic syndrome. Tropical edicine and Health : 40, ,, 1. : 387, ,,, 1. : 92-96, , 1. : 588, Kwon-Chung KJ, Bennett JE.: 18. Histoplasmosis. In : Kwon-Chung KJ, Bennett JE, eds. edical ycology. Lea and ebiger, Philadelphia, PA, USA , Chandler W, Kaplan W, Ajello L.: 13. Histoplasmosis capsulati. In : Carruthers GB ed. A Colour Atlas and Textbook of the Histopathology of ycotic Diseases. Wolfe edical Publications Ltd., Weert, The Netherlands, 63-66, Chandler W, Kaplan W, Ajello L.: 14. Histoplasmosis duboisii. In : Carruthers GB ed. A Colour Atlas and Textbook of the Histopathology of ycotic Diseases. Wolfe edical Publications Ltd., Weert, The Netherlands, 67-69, Chandler W, Kaplan W, Ajello L.: 15. Histoplasmosis farciminosi. In : Carruthers GB ed. A Colour Atlas and Textbook of the Histopathology of ycotic Diseases. Wolfe edical Publications Ltd., Weert, The Netherlands, 70-72, Kasuga T, Taylor JW, White TJ.: Phylogenetic relationships of varieties and geographical groups of the human pathogenic fungus Histoplasma capsulatum Darling. J Clin icrobiol : , Tamura, Kasuga T, Watanabe K, et al.: Phylogenetic characterization of Histoplasma capsulatum strains based on ITS region sequences, including two new strains from Thai and Chinese patients in Japan. Nippon Ishinkin Gakkai Zasshi : 11-19, Kasuga T, White TJ, Koenig G, et al.: Phylogeography of the fungal pathogen Histoplasma capsulatum. ol Ecol : , ,, 8..,, , 6 2. : , Kikuchi K, Sugita T, akimura K, et al.: Is Histoplasma capsulatum a native inhabitant of Japan? icrobiol Immunol. Sep ; 9: , : , Smith JD : Histoplasmosis : acintire DK ed.: In Ettiene Cote : CLINICAL VETERINARY ADVISOR - Dogs and Cats.osby Elesevier. Amsterdam, The Netherlands, pp, , Kauffman CA : Histoplasmosis : a Clinical and Laboratory Update, Clinical icrobiology Reviews, : , World Organization for Animal Healthhttp: intengen_index.htm: Chapter Epizootic lymphangitis pdf _EPIZ_LYPHANGITIS.pdf, in OIE

10 Terrestrial anual Rhoades JD.: Canine histoplasmosis: 1. Clinical histoplasmosis. Am J Pub Health : , Nielsen SW.: Laboratory diagnosis of systemic mycoses in dogs. Part 1. ordern Vet Prac : , ackie JT, Kaufman L, Ellis D.: Confirmed histoplasmosis in an Australian dog. Aust Vet J : , Lenhart, SW, Schafer P, Singal, Hajjeh RA : Histoplasmosis. Protecting Workers at Risk artagon-Villamil J, Shrestha N, Sholtis, et al. : Identification of Histoplasma capsulatum from culture extracts by real-time PCR. J Clin icrobiol. : , Summerbell RC, oore K, Starink-Willemse, Van Iperen A.: ITS barcodes for Trichophyton tonsurans and T. equinum. ed ycol : , ,, 2. : , Wheat LJ, reifeld AG, Kleiman B, et al.: Infectious Diseases Society of America. Clinical practice guidelines for the management of patients with histoplasmosis : 2007 update by the Infectious Diseases Society of America. Clin Infect Dis. : , 2007.