A Simply Smart Choice for Point-of-Care Testing
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1 A Simply Smart Choice for Point-of-Care Testing The entire WITNESS line of canine and feline diagnostics tests are accurate, affordable, and easy to use WITNESS HEARTWORM WITNESS LH WITNESS RELAXIN
2 Canine Parvovirus Antigen Test Kit WITNESS HEARTWORM WITNESS LH WITNESS RELAXIN
3 Canine Parvovirus Antigen Test Kit PROVIDES IMMEDIATE RESULTS SO YOUR CLIENTS CAN REST EASY ACCURATE. AFFORDABLE. SIMPLE. Experience the demonstrated accuracy and affordability of WITNESS CPV test kits along with Zoetis service and support. No time lost waiting to snap Room temperature storage Accurate test results in approximately 10 minutes WITNESS CPV WITNESS FeLV WITNESS HEARTWORM WITNESS LH WITNESS RELAXIN
4 Canine Parvovirus Antigen Test Kit WITNESS CPV is a convenient, easy-to-use, in-clinic test that detects all canine parvovirus strains shed in feces. NO REFRIGERATION WITNESS CPV has a 12-month shelf life at room temperature. NO SNAPPING Unlike other point-of-care tests, WITNESS CPV doesn t need to be snapped. No snapping, so no splashing. RAPID RESULTS With accurate results in approximately 10 minutes, you can give your clients immediate confirmation and allow for prompt quarantine and treatment of your patients. EASY TO INTERPRET You get simple-to-understand results, with no complex interpretation needed: One line on the right = negative Two lines = positive* WHAT COULD BE SIMPLER? a. b. Swirl vigorously Add 3 drops of sample Wait 10 minutes Negative for CPV antigen Positive for CPV antigen For more information, visit Animalhealthdx.com. To order, call Zoetis customer service at ZOETIS-1 ( ) or visit shop.zoetisus.com. *Samples from healthy vaccinated animals may produce a false-positive result when tested 4 to 10 days after canine parvovirus vaccination. WITNESS CPV WITNESS FeLV WITNESS HEARTWORM WITNESS LH WITNESS RELAXIN
5 Feline Leukemia Virus Antigen Test Kit WITNESS CPV WITNESS FeLV WITNESS HEARTWORM WITNESS LH WITNESS RELAXIN
6 Feline Leukemia Virus Antigen Test Kit ACCURATE, RAPID RESULTS SO YOUR CLIENTS CAN REST EASY ACCURATE. AFFORDABLE. SIMPLE. Experience the demonstrated accuracy and affordability of WITNESS FeLV test kits along with Zoetis service and support. No time lost waiting to snap Room temperature storage Accurate results in approximately 10 minutes or less WITNESS CPV WITNESS FeLV WITNESS HEARTWORM WITNESS LH WITNESS RELAXIN
7 Feline Leukemia Virus Antigen Test Kit WITNESS FeLV is a convenient, easy-to-use, in-clinic test that detects the presence of the feline leukemia virus antigen that is found in high levels in infected cats. Antigen test results are not affected by FeLV vaccination or maternal antibodies. Kittens can be tested at any age. NO REFRIGERATION WITNESS FeLV has a 12-month shelf life at room temperature. NO SNAPPING Rapid Immuno Migration (RIM ) technology is a simple process, as opposed to the ELISA method. So unlike other in-clinic tests, you don t waste time waiting to snap. Plus, you only need one drop of sample (anticoagulated whole blood, plasma, or serum). RAPID RESULTS With accurate results in approximately 10 minutes, you can deliver the immediate test results clients want, giving them peace of mind sooner or getting your patients on a management plan earlier. EASY TO INTERPRET Simple-to-understand results, with no complex interpretation needed: One line on the right = negative Two lines = positive WHAT COULD BE SIMPLER? Negative for FeLV antigen Apply 1 drop of anticoagulated whole blood, plasma or serum Add 2 Drops of Buffer Wait 10 minutes Positive for FeLV antigen For more information, visit Animalhealthdx.com. To order, call Zoetis customer service at ZOETIS-1 ( ) or visit shop.zoetisus.com. WITNESS CPV WITNESS FeLV WITNESS HEARTWORM WITNESS LH WITNESS RELAXIN
8 Feline Leukemia Virus Antigen-Feline Immunodeficiency Virus Antibody Test Kit WITNESS HEARTWORM WITNESS LH WITNESS RELAXIN
9 Feline Leukemia Virus Antigen-Feline Immunodeficiency Virus Antibody Test Kit ACCURATE. AFFORDABLE. SIMPLE. ACCURATE FeLV: 92.9% (95% CI: 67.8% %) sensitivity* and 96.5% (95% CI: 82.1% %) specificity 1 FIV: 93.8% (95% CI: 85.0% %) sensitivity* and 93.4% (95% CI: 83.1% %) specificity 2 AFFORDABLE Cost-effective alternative to other FeLV-FIV diagnostic tests SIMPLE Only one buffer and one pipette needed for both tests Requires no snapping; results in approximately ten minutes One drop of sample needed for each result No refrigeration necessary; 12-month shelf life *Sensitivity represents the ability to correctly identify positive samples. Specificity represents the ability to correctly identify negative samples. 1. Data on file, Study Report No. D880Z-US (v1.0) p. 12. Zoetis Inc. 2. Data on file, Study Report No. D880Z-US (v1.0) p. 13. Zoetis Inc. WITNESS HEARTWORM WITNESS LH WITNESS RELAXIN
10 Feline Leukemia Virus Antigen-Feline Immunodeficiency Virus Antibody Test Kit SIMPLE THREE-STEP PROCESS Test Kit is an accurate, affordable, and simple in-clinic test that detects the presence of feline leukemia virus antigen and feline immunodeficiency virus antibodies EASY-TO-INTERPRET RESULTS A Negative FIV: line at 3 Negative FeLV: line at 3 Apply 1 drop of plasma, serum, or anticoagulated whole blood B Apply 2 drops of buffer to each sample well Positive FIV: lines at 2 & 3 Negative FeLV: line at 3 C Wait 10 minutes Negative FIV: line at 3 Positive FeLV: lines at 2 & 3 D Positive FIV: lines at 2 & 3 Positive FeLV: lines at 2 & 3 HOW TO GET THE MOST OUT OF YOUR WITNESS FELV-FIV TEST KIT Check the expiration date on the side of the test carton. The test expires 12 months from the date of manufacture. Perform the test within 10 minutes after removal from the foil pouch. Obtain the appropriate sample plasma, serum, or anticoagulated whole blood. Avoid touching or damaging the membrane of windows 1, 2, and 3. Place the device on a flat, horizontal surface while performing the test. Use a separate pipette for each patient sample. Hold pipette and buffer bottle vertically when dispensing. TRUSTED CUSTOMER SUPPORT For more information, visit Animalhealthdx.com. To order, call Zoetis customer service at ZOETIS-1 ( ) or visit shop.zoetisus.com. WITNESS HEARTWORM WITNESS LH WITNESS RELAXIN
11 Heartworm Antigen Test Kit WITNESS HEARTWORM WITNESS LH WITNESS RELAXIN
12 Heartworm Antigen Test Kit PROOF THAT EACH GENERATION GETS BETTER THE 3RD GENERATION TEST THAT DELIVERS ACCURATE RESULTS ACROSS MULTIPLE POPULATIONS IN AN EASY-TO-USE FORMAT An excellent choice for point-of-care testing that is: ACCURATE Excellent sensitivity, 97.7% (95% CI: 94.1% %)* and specificity, 99.3% (95% CI: 97.0% %) compared to a reference laboratory diagnostic test1 *Sensitivity represents the ability to correctly identify positive samples. Specificity represents the ability to correctly identify negative samples. SIMPLE Easy to store, easy to perform, easy to interpret Results in approximately 10 minutes with no additional sample preparation or time-sensitive test manipulation required (snapping) AFFORDABLE An affordable alternative to other point-of-care heartworm diagnostic tests Consistent specificity across different populations 2 Using DiroCHEK as a reference method Shelter Dogs Clinic Dogs* Purpose-bred Dogs Specificity 100% (95% CI: 98.4% - 100%) 99.7% (95% CI: 95.5% - 100%) 100% (95% CI: 98.3% - 100%) Sample Size n=151 n=342 n= Data on file, Study Report No. DH67W-US , Zoetis Inc. 2. Data on file, Study Report No. D860Z-US , Zoetis Inc. WITNESS HEARTWORM WITNESS LH WITNESS RELAXIN
13 Heartworm Antigen Test Kit Provides results comparable to IDEXX SNAP 4DX1 Using DiroCHEK as a reference method WITNESS Heartworm IDEXX SNAP 4DX Sensitivity* 97.7% (95% CI: 94.1% %) 94.7% (95% CI: 89.9% %) Specificity 99.3% (95% CI: 97.0% %) 100.0% (95% CI: 98.4% %) DiroCHEK is an Enzyme-Linked Immunosorbent Assay (ELISA) for the detection of antigen to adult Dirofilaria immitis in canine and feline plasma or serum. *Sensitivity represents the ability to correctly identify positive samples. Specificity represents the ability to correctly identify negative samples. 1. Data on file, Study Report No. DH67W-US , Zoetis Inc. Faster and easier to use Features WITNESS Heartworm IDEXX SNAP Sample can be plasma, serum, or whole blood YES YES Requires only one drop of sample YES NO Space on test cartridge to write pet name YES NO Refrigeration recommended NO YES to maximize shelf life* Requires sample preparation and mixing NO YES Time-sensitive test manipulation required (snapping) NO YES Requires complex interpretation of test results NO YES Approximate total test time *Applies to SNAP 4DX Plus 10 min ~10 min PLUS kit warming (if necessary) PLUS multi-step sample preparation time PLUS time-sensitive test manipulation (snapping) IDEXX SNAP 4DX Test is a trademark of IDEXX Laboratories, Inc. TRUSTED CUSTOMER SUPPORT For more information, visit To order, call Zoetis customer service at ZOETIS-1 ( ) or WITNESS HEARTWORM WITNESS LH WITNESS RELAXIN
14 Luteinizing Hormone Test Kit WITNESS HEARTWORM WITNESS LH WITNESS RELAXIN
15 Luteinizing Hormone Test Kit ACCURATE. AFFORDABLE. SIMPLE. PREDICTING WHELPING DATES Determining LH surge is more precise in predicting when litter will arrive, knowing whelping normally occurs 65 +/ 2 days after LH surge. 1 DETERMINING OVARIAN (SPAY) STATUS WITNESS LH helps determine canine and feline spay status. NO REFRIGERATION At room temperature, WITNESS LH has an 18-month shelf life (from the date of manufacture). EASY TO USE Demonstrated Rapid Immuno Migration (RIM ) technology allows for an easy, streamlined process. Needs only three drops of sample (serum only). RAPID RESULTS Accurate results in approximately 20 minutes. WITNESS CPV WITNESS FeLV WITNESS HEARTWORM WITNESS LH WITNESS RELAXIN
16 Luteinizing Hormone Test Kit DETERMINE OVULATION TIMING WITNESS LH provides a precise way to determine ovulation timing. 2 The optimal time to breed is realized through determination of the LH surge. The canine LH surge usually occurs between days three and twelve after observable signs of heat (proestral bleeding) and lasts approximately 24 hours. Ovulation occurs two days after LH surge. The ova then require another two to three days to mature to the point they can support fertilization (see Figure 1). The canine fertile period falls between days four and seven after the canine LH surge, with the most fertile days being five and six (the day of the LH surge is counted as Day 0). Canine Fertile Period EVENTS LH SURGE OVULATION OVA MATURE PEAK FERTILITY WHAT COULD BE SIMPLER? Figure 1 proestral bleeding behavioral estrus diestrus Negative Test Line 2 is not evident or lighter than Control Line 3 Apply 3 drops of sample (serum only) using the pipette Wait 20 minutes Positive Test Line 2 is darker than or similar to Control Line 3 For more information, visit Animalhealthdx.com. To order, call Zoetis customer service at ZOETIS-1 ( ) or visit shop.zoetisus.com. References 1. Cohen JA, Holle DM, Meyers-Wallen VN. Accuracy of canine parturition date prediction from LH peak. Clin Theriogenology. 2009;1: Santos NR. Evaluation of a commercially available luteinizing hormone test to determine the breeding time in the bitch. Poster presented at: International Symposium on Canine and Feline Reproduction - ISCFR 2012; July 26-29, 2012; Whistler, British Columbia, Canada. Poster 36. WITNESS HEARTWORM WITNESS LH WITNESS RELAXIN
17 Canine and Feline Pregnancy Test Kit WITNESS CPV WITNESS FeLV WITNESS HEARTWORM WITNESS LH WITNESS RELAXIN
18 Canine and Feline Pregnancy Test Kit THE EASY WAY TO DETECT CANINE/FELINE PREGNANCY EASY TO INTERPRET Simple-to-understand results EASY TO USE Demonstrated: Rapid Immuno Migration (RIM ) technology allows for an easy, efficient process. Needs only 2 drops of plasma or serum (no whole blood) and 2 drops of buffer. RAPID RESULTS Accurate results in approximately 10 minutes NO REFRIGERATION Room temperature storage; 18-month shelf life (from the date of manufacture) SIMPLY A SMART CHOICE FOR POINT-OF-CARE DIAGNOSTIC SOLUTIONS SO YOUR CLIENTS CAN REST EASY Experience the demonstrated accuracy, affordability, and simplicity of WITNESS RELAXIN test kits. WITNESS HEARTWORM WITNESS LH WITNESS RELAXIN
19 Canine and Feline Pregnancy Test Kit WITNESS RELAXIN may detect pregnancy as early as 20 days post-lh surge in canines and 20 days after mating in felines. Factors such as breed, size of the canine/feline, and litter size may influence the level of serum relaxin. Although approximately 80% of pregnant canines/felines are detected between 20 and 28 days, some may not be detected as positive until day 31. Negative results should be retested at least seven days later. 1 Relaxin is secreted primarily by the placenta and is a reliable indicator of pregnancy. Levels of relaxin remain elevated throughout gestation and decline quickly following whelping/queening or abortion. FELINE PREGNANCIES DETECTED 100% CANINE PREGNANCIES DETECTED 100% LH SURGE/INITIAL PROGESTERONE RISE FERTILE PERIOD (DAYS 4-7) DAY DAY BREEDING QUEENING BREEDING (DAYS -2 TO 7) WHELPING WHAT COULD BE SIMPLER? Negative One line window 3 Should retest one week later Apply 2 drops of plasma or serum (no whole blood) using the pipette Add 2 drops of buffer Wait 10 minutes Positive Two lines windows 2 and 3 Retest to confirm positive result For more information, visit Animalhealthdx.com. To order, call Zoetis customer service at ZOETIS-1 ( ) or visit shop.zoetisus.com. References 1. DiGangi BA, Griffin B, Levy JK, Smith BF, Baker HJ. Use of a commercially available relaxin test for detection of pregnancy in cats. J Am Vet Med Assoc. 2010;237: All trademarks are the property of Zoetis Services LLC or a related company or a licensor unless otherwise noted Zoetis Services LLC. All rights reserved. WIT WITNESS HEARTWORM WITNESS LH WITNESS RELAXIN
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