BULLETIN # 43. Manitoba Drug Benefits and Interchangeability Formulary Amendments. The following amendments will take effect on June 15, 2004.

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1 BULLETIN # 43 Manitoba Drug Benefits and Interchangeability Formulary Amendments The following amendments will take effect on June 15, The amended Manitoba Specified Drug Regulation and Drug Interchangeability Formulary Regulation will be available on the Manitoba Health website on the effective date of June 15, Bulletin 43 is currently available for download: Inside This Issue Part 1 Additions Pages 1-2 Part 2 Additions & Amendments Pages 2-6 Part 3 Additions Pages 6 New Interchangeable Categories Pages 7-9 New Interchangeable Products Pages Product Deletions Page 12 Category Deletions Page 13 Interchangeable Product Price Changes Pages Discontinued Products Page 14 Manufacturers Update Pages 15-17

2 Part 1 Additions Bulletin #43 DIN TRADE NAME GENERIC STRENGTH FORM MFR* Accuretic quinapril HCl/ hydrochlorothiazide 20 mg/25 mg PFI Apo-Citalopram citalopram 20 mg 40 mg Apo-Levocarb CR levodopa/carbidopa 200 mg/50 mg Co Citalopram citalopram 20 mg 40 mg mg Co Pravastatin pravastatin sodium 20 mg mg Co Ranitidine ranitidine 150 mg 300 mg Controlled Release Coversyl perindopril erbumine 8 mg SEV Gen-Citalopram citalopram 20 mg 40 mg GPM Gen-Gabapentin gabapentin 100 mg 300 mg 400 mg Capsules GPM Methylprednisolone Acetate methylprednisolone acetate 40 mg/ml 40 mg/ml wp 80 mg/ml 80 mg/ml wp Novo-Fosinopril fosinopril 10 mg Novo-Lamotrigine lamotrigine 20 mg 25 mg 100 mg 150 mg Novo-Paroxetine paroxetine HCl 10 mg 20 mg 30 mg pms-citalopram citalopram 20 mg Injection 40 mg PMS pms-mirtazapine mirtazapine 30 mg PMS pms-mometasone mometasone furoate 0.1% Topical Ointment PMS Preterax perindopril erbumine/ indapamide 2 mg/0.625 mg SEV ratio-lamotrigine lamotrigine 150 mg RPH ratio-metformin metformin HCl 850 mg RPH ratio-mometasone mometasone furoate 0.1% Topical Ointment RPH ratio-simvastatin simvastatin 5 mg 10 mg 20 mg 40 mg 80 mg APX APX COB COB COB SIL NOP NOP NOP RPH 1 of 17

3 Part 1 Additions cont'd Rhoxal-citalopram citalopram 20 mg 40 mg mg mg Rhoxal-simvastatin simvastatin 20 mg mg mg Risperdal M-Tab Sab-Opticort risperidone framycetin sulfate/ gramicidin/ dexamethasone 0.5 mg 1 mg 2 mg 5 mg/0.05 mg/ 0.5 mg/ml Supeudol oxycodone 10 mg 20 mg Testosterone Bulletin #43 Orally Disintegrating Otic/Ophthalmic Solution Suppositories Cypionate testosterone cypionate 100 mg/ml Injection SIL TC lamivudine 300 mg GSK Zyprexa Zydis olanzapine 15 mg Orally Disintegrating LIL *Abbreviation of Manufacturers' Names RXP RXP JAN SIL SIL Part 1 Deletions HP-PAC (Moved to Part 2) lansoprazole/clarithromycin/ amoxicillin 30 mg/500 mg/ 500 mg Capsule/Tablet/ Capsule ABB Losec A Losec M (Moved to Part 2) (Moved to Part 2) omeprazole/clarithromycin/ amoxicillin omeprazole/clarithromycin/ metronidazole 20 mg/500 mg/ 1000 mg 20 mg/250 mg/ 500 mg Tablet/Tablet/ Capsule Tablet/Tablet/ Tablet AZC AZC Part 2 Additions and Amendments mg Apo-Ciproflox ciprofloxacin 500 mg APX 750 mg (a) Step-down care following hospital separation in patients treated with parenteral antibiotics; (b) Treatment of Pseudomonal infections or resistant gram-negative infections; (c) Treatment of resistant Gonococcal infections; (d) Treatment of infections in persons allergic to alternative agents (eg. penicillins, cephalosporins and sulfonamides); (e) Treatment of infections in immunocompromised patients; (f) Treatment of diabetic foot infections and complications of orthopedic surgery; (g) Treatment of chronic bacterial prostatitis. 2 of 17

4 Part 2 Additions cont'd Apo-Meloxicam meloxicam 7.5 mg 15 mg For the long-term treatment of osteoarthritis or rheumatoid arthritis in patients who have one or more of the following risk factors: (a) Previous peptic ulcer, gastrointestinal bleeding, gastric outlet obstruction (endoscopy or radiographic evidence); (b) Elderly (more than 65 years of age); (c) Concurrent warfarin therapy; (d) Bleeding disorders; (e) Concurrent prednisone therapy at doses greater than 5 mg/day for more than 2 weeks. APX NOTE: For treatment of osteoarthritis, patients must have completed an adequate trial of acetaminophen. If a patient is receiving a proton pump inhibitor (PPI) for reflux disease, COX-2 inhibitors are not warranted for additional protection. Ophthalmic Apo-Ofloxacin ofloxacin 0.3% Solution For the treatment of ophthalmic infections caused by gram-negative organisms or those not responding to alternative agents. APX Apo-Omeprazole omeprazole 20 mg Capsules APX For the treatment of: (a) Duodenal or gastric ulcers in patients not responding to or experiencing unusual or severe adverse reactions to a reasonable trial with H2 blockers, sucralfate or misoprostol; (b) Severe erosive reflux esophagitis or Zollinger-Ellison disease; (c) H. pylori in conjunction with appropriate antibiotic therapy mg Co Ciprofloxacin ciprofloxacin 500 mg COB 750 mg (a) Step-down care following hospital separation in patients treated with parenteral antibiotics; (b) Treatment of Pseudomonal infections or resistant gram-negative infections; (c) Treatment of resistant Gonococcal infections; (d) Treatment of infections in persons allergic to alternative agents (eg. penicillins, cephalosporins and sulfonamides); (e) Treatment of infections in immunocompromised patients; (f) Treatment of diabetic foot infections and complications of orthopedic surgery; (g) Treatment of chronic bacterial prostatitis Eligard leuprolide acetate 7.5 mg 22.5 mg - For treatment of advanced prostate cancer. Injection SAW 3 of 17

5 Part 2 Additions cont'd Bulletin # mg Gen-Ciprofloxacin ciprofloxacin 500 mg GPM 750 mg (a) Step-down care following hospital separation in patients treated with parenteral antibiotics; (b) Treatment of Pseudomonal infections or resistant gram-negative infections; (c) Treatment of resistant Gonococcal infections; (d) Treatment of infections in persons allergic to alternative agents (eg. penicillins, cephalosporins and sulfonamides); (e) Treatment of infections in immunocompromised patients; (f) Treatment of diabetic foot infections and complications of orthopedic surgery; (g) Treatment of chronic bacterial prostatitis HP-PAC (Moved from Part 1) lansoprazole/clarithromycin/ amoxicillin 30 mg/500 mg/ 500 mg Capsule/Tablet/ Capsule ABB - For H. pylori eradication. -- Losec A omeprazole/clarithromycin/ (Moved from Part 1) amoxicillin - For H. pylori eradication. 20 mg/500 mg/ 1000 mg Tablet/Tablet/ Capsule AZC -- Losec M omeprazole/clarithromycin/ (Moved from Part 1) metronidazole - For H. pylori eradication. 20 mg/250 mg/ 500 mg Tablet/Tablet/ Tablet AZC mg Novo-Ciprofloxacin ciprofloxacin 500 mg NOP 750 mg (a) Step-down care following hospital separation in patients treated with parenteral antibiotics; (b) Treatment of Pseudomonal infections or resistant gram-negative infections; (c) Treatment of resistant Gonococcal infections; (d) Treatment of infections in persons allergic to alternative agents (eg. penicillins, cephalosporins and sulfonamides); (e) Treatment of infections in immunocompromised patients; (f) Treatment of diabetic foot infections and complications of orthopedic surgery; (g) Treatment of chronic bacterial prostatitis Novo-Clavamoxin amoxicillin/clavulanic acid 875 mg/125 mg NOP (a) Treatment of patients not responding to alternative antibiotics (e.g. amoxicillin); (b) Treatment of patients with infections caused by organisms known to be resistant to alternative antibiotics (e.g. amoxicillin). 4 of 17

6 Part 2 Additions cont'd pms-meloxicam meloxicam 7.5 mg 15 mg For the long-term treatment of osteoarthritis or rheumatoid arthritis in patients who have one or more of the following risk factors: (a) Previous peptic ulcer, gastrointestinal bleeding, gastric outlet obstruction (endoscopy or radiographic evidence); (b) Elderly (more than 65 years of age); (c) Concurrent warfarin therapy; (d) Bleeding disorders; (e) Concurrent prednisone therapy at doses greater than 5 mg/day for more than 2 weeks. PMS NOTE: For treatment of osteoarthritis, patients must have completed an adequate trial of acetaminophen. If a patient is receiving a proton pump inhibitor (PPI) for reflux disease, COX-2 inhibitors are not warranted for additional protection. Part 2 Additions cont'd mg ratio-ciprofloxacin ciprofloxacin 500 mg RPH 750 mg (a) Step-down care following hospital separation in patients treated with parenteral antibiotics; (b) Treatment of Pseudomonal infections or resistant gram-negative infections; (c) Treatment of resistant Gonococcal infections; (d) Treatment of infections in persons allergic to alternative agents (eg. penicillins, cephalosporins and sulfonamides); (e) Treatment of infections in immunocompromised patients; (f) Treatment of diabetic foot infections and complications of orthopedic surgery; (g) Treatment of chronic bacterial prostatitis ratio-meloxicam meloxicam 7.5 mg 15 mg For the long-term treatment of osteoarthritis or rheumatoid arthritis in patients who have one or more of the following risk factors: (a) Previous peptic ulcer, gastrointestinal bleeding, gastric outlet obstruction (endoscopy or radiographic evidence); (b) Elderly (more than 65 years of age); (c) Concurrent warfarin therapy; (d) Bleeding disorders; (e) Concurrent prednisone therapy at doses greater than 5 mg/day for more than 2 weeks. RPH NOTE: For treatment of osteoarthritis, patients must have completed an adequate trial of acetaminophen. If a patient is receiving a proton pump inhibitor (PPI) for reflux disease, COX-2 inhibitors are not warranted for additional protection. 5 of 17

7 Part 2 Additions cont'd Bulletin # mg Rhoxal-ciprofloxacin ciprofloxacin 500 mg RXP 750 mg (a) Step-down care following hospital separation in patients treated with parenteral antibiotics; (b) Treatment of Pseudomonal infections or resistant gram-negative infections; (c) Treatment of resistant Gonococcal infections; (d) Treatment of infections in persons allergic to alternative agents (eg. penicillins, cephalosporins and sulfonamides); (e) Treatment of infections in immunocompromised patients; (f) Treatment of diabetic foot infections and complications of orthopedic surgery; (g) Treatment of chronic bacterial prostatitis. Part 3 The following products will be considered for Pharmacare reimbursement upon an individual prescriber/patient request basis Apo-Tryptophan L-tryptophan 500 mg Capsules APX (a) Adjunct therapy for refractory depression. Patients must have tried at least 2 other antidepressants. (b) Fibromyalgia failing trial of cyclic antidepressants, benzodiazepines OR SSRI's (selective seratonin reuptake inhibitors) Apo-Tryptophan L-tryptophan 500 mg APX 1 g (a) Adjunct therapy for refractory depression. Patients must have tried at least 2 other antidepressants. (b) Fibromyalgia failing trial of cyclic antidepressants, benzodiazepines OR SSRI's (selective seratonin reuptake inhibitors) Keppra levetiracetam 250 mg 500 mg 750 mg LUD - As an add-on anticonvulsant or for control of pain where initiated by a pain clinic and where other similar agents have failed Pegasys peginterferon alfa-2a 180 mcg/0.5 ml Pre-Filled Syringe 180 mcg/ml & Vial - For the treatment of adult patients with documented diagnosis of chronic hepatitis C. Details on criteria can be obtained from the EDS office at Manitoba Health. HLR 6 of 17

8 New Interchangeable Categories The following new interchangeable categories and products were added: Generic Name - Strength - Form DIN Trade Name Manufacturer Price in Dollars Ciprofloxacin mg - $ Cipro BAY Apo-Ciproflox APX Co Ciprofloxacin COB Gen-Ciprofloxacin GPM Novo-Ciprofloxacin NOP Rhoxal-ciprofloxacin RXP ratio-ciprofloxacin RPH Ciprofloxacin mg - $ Cipro BAY Apo-Ciproflox APX Co Ciprofloxacin COB Gen-Ciprofloxacin GPM Novo-Ciprofloxacin NOP Rhoxal-ciprofloxacin RXP ratio-ciprofloxacin RPH Ciprofloxacin mg - $ Cipro BAY Apo-Ciproflox APX Gen-Ciprofloxacin GPM Novo-Ciprofloxacin NOP Co Ciprofloxacin COB Rhoxal-ciprofloxacin RXP ratio-ciprofloxacin RPH Citalopram - 20 mg - $ Celexa LUD Apo-Citalopram APX Co Citalopram COB Gen-Citalopram GPM pms-citalopram PMS Rhoxal-citalopram RXP of 17

9 New IC Categories cont'd.. Bulletin #43 Citalopram - 40 mg - $ Celexa LUD Apo-Citalopram APX Co Citalopram COB Gen-Citalopram GPM pms-citalopram PMS Rhoxal-citalopram RXP Fluconazole - 2 mg/ml - Injection Per ml $ Diflucan PFI Fluconazole NOP Fosinopril Sodium - 10 mg - $ Monopril SQU Novo-Fosinopril NOP Fosinopril Sodium - 20 mg - $ Monopril SQU Novo-Fosinopril NOP Framycetin Sulfate/Gramicidin/Dexamethasone - 5 mg/0.05 mg/0.5 mg/ml - Otic/Ophthalmic Solution Per ml $ Sofracort AVT Sab-Opticort SIL Levodopa/Carbidopa mg/50 mg - Controlled Release $ Sinemet CR DUP Apo-Levocarb CR APX Meloxicam mg - $ Mobicox BOE Apo-Meloxicam APX pms-meloxicam PMS ratio-meloxicam RPH Meloxicam - 15 mg - $ Mobicox BOE Apo-Meloxicam APX pms-meloxicam PMS ratio-meloxicam RPH Methylprednisolone Acetate - 40 mg/ml - Injection Per ml $ Depo-Medrol PMJ Methylprednisolone Acetate SIL of 17

10 New IC Categories cont'd Bulletin #43 Methylprednisolone Acetate - 40 mg/ml - Injection (with preservative) Per ml $ Depo-Medrol PMJ Methylprednisolone Acetate SIL Methylprednisolone Acetate - 80 mg/ml - Injection Per ml $ Depo-Medrol PMJ Methylprednisolone Acetate SIL Methylprednisolone Acetate - 80 mg/ml - Injection (with preservative) Per ml $ Depo-Medrol PMJ Methylprednisolone Acetate SIL Mirtazapine - 30 mg - $ Remeron ORG pms-mirtazapine PMS Mometasone Furoate - 0.1% - Topical Ointment Per Gram $ Elocom SCH pms-mometasone PMS ratio-mometasone RPH Ofloxacin - 0.3% - Ophthalmic Solution Per ml $ Ocuflox ALL Apo-Ofloxacin APX Omeprazole - 20 mg - Capsules $ Losec () AZC Apo-Omeprazole APX Testosterone Cypionate mg/ml - Injection Per ml $ Depo-Testosterone PMJ Testosterone Cypionate SIL of 17

11 New Interchangeable Products The following products have been added to existing interchangeable drug categories: Amoxicillin/Clavulanic Acid mg/125 mg - $ Novo-Clavamoxin NOP Gabapentin mg - Capsules $ Gen-Gabapentin GPM ** Gabapentin mg - Capsules $ Gen-Gabapentin GPM ** Gabapentin mg - Capsules $ Gen-Gabapentin GPM ** Lamotrigine - 25 mg - $ Novo-Lamotrigine NOP Lamotrigine mg - $ Novo-Lamotrigine NOP Lamotrigine mg - $ Novo-Lamotrigine NOP ratio-lamotrigine RPH Metformin HCl mg - $ ratio-metformin RPH Metronidazole mg - Oral Capsules $ Apo-Metronidazole APX ** Paroxetine HCl - 10 mg - $ Novo-Paroxetine NOP Paroxetine HCl - 20 mg - $ Novo-Paroxetine NOP Paroxetine HCl - 30 mg - $ Novo-Paroxetine NOP Pravastatin Sodium - 10 mg - $ Co Pravastatin COB of 17

12 New IC Products cont'd.. Bulletin #43 Pravastatin Sodium - 20 mg - $ Co Pravastatin COB Pravastatin Sodium - 40 mg - $ Co Pravastatin COB Ranitidine HCl mg - $ Co Ranitidine COB Ranitidine HCl mg - $ Co Ranitidine COB Simvastatin - 5 mg - $ ratio-simvastatin RPH Rhoxal-simvastatin RXP Simvastatin - 10 mg - $ ratio-simvastatin RPH Rhoxal-simvastatin RXP Simvastatin - 20 mg - $ ratio-simvastatin RPH Rhoxal-simvastatin RXP Simvastatin - 40 mg - $ ratio-simvastatin RPH Rhoxal-simvastatin RXP Simvastatin - 80 mg - $ ratio-simvastatin RPH Rhoxal-simvastatin RXP L-Tryptophan mg - Capsules $ Apo-Tryptophan APX L-Tryptophan mg - $ Apo-Tryptophan APX L-Tryptophan - 1 g - $ Apo-Tryptophan APX ** The price change has resulted in a change to the lowest price in the category of 17

13 Product Deletions The following products have been deleted (notification was provided in Bulletin 42) Adrucil fluorouracil 50 mg/ml Solution Apo-Ibuprofen ibuprofen 300 mg 400 mg Aristocort triamcinolone 4 mg Atropine atropine 1% Ophthalmic Solution Celestoderm V/2 betamethasone valerate 0.05% Cream Celestoderm V/2 betamethasone valerate 0.05% Ointment Celestoderm V betamethasone valerate 0.1% Ointment Cipro 100 ciprofloxacin 100 mg Clonapam clonazepam 0.5 mg 1 mg 2 mg Cortate hydrocortisone 1% Topical Ointment Edecrin etacrynic acid 50 mg Ludiomil maprotiline 10 mg Motrin ibuprofen 600 mg MS Contin morphine sulfate 30 mg 60 mg 100 mg 200 mg Suppositories Novolin ge Lente insulin 100 U/mL Injection Novolin ge Ultralente insulin 100 U/mL Injection Novo-Profen ibuprofen 300 mg Orudis SR ketoprofen 200 mg Pentasa mesalamine 250 mg pms-fluconazole fluconazole 150 mg Capsules Procyclid procyclidine HCl 5 mg Propanthel propantheline bromide 15 mg Rovamycine spiramycin 250 mg Capsules Surmontil trimipramine 100 mg Vanceril beclomethasone Metered Dose 50 mcg dipropionate Inhaler Vivelle estradiol-17b 37.5 mcg 50 mcg 75 mcg 100 mcg Transdermal Patch Voltaren diclofenac sodium 25 mg Wellferon interferon alfa-n1 3,000,000 U/mL Injection Wellferon interferon alfa-n1 10,000,000 U/mL Injection 12 of 17

14 - Atropine Sulfate - 1% - Ophthalmic Solution - Estradiol - 50 mcg - Transdermal Patch - Estradiol - 75 mcg - Transdermal Patch - Estradiol mcg - Transdermal Patch - Hydrocortisone - 1% - Topical Ointment - Maprotiline - 10 mg - - Propantheline Bromide - 15 mg - Category Deletions Interchangeable Product Price Changes The following changes in prices have occurred: ($) Acular ketorolac tromethamine 0.5% Ophthalmic Solution Apo-Amoxi Clav amoxicillin/clavulanic acid 875 mg/125 mg ** Apo-Hydroxyurea hydroxyurea 500 mg Capsules ** Apo-Lamotrigine lamotrigine 150 mg ** Apo-Oflox ofloxacin 200 mg ** Apo-Oflox ofloxacin 300 mg ** Apo-Oflox ofloxacin 400 mg ** Apo-Pimozide pimozide 2 mg ** Apo-Pimozide pimozide 4 mg ** Apo-Verap SR verapamil HCl 180 mg Sustained Release ** Betaderm betamethasone-17- valerate 0.05% Ointment ** Betaderm betamethasone-17- valerate 0.1% Ointment ** Betagan levobunolol HCl 0.5% Ophthalmic Solution FML fluorometholone 0.1% Ophthalmic Suspension Gen-Etidronate etidronate disodium 200 mg ** Gen-Hydroxyurea hydroxyurea 500 mg Capsules Gen-Verapamil SR verapamil HCl 180 mg Sustained Release Imovane zopiclone 7.5 mg MS Contin morphine sulfate 15 mg Sustained Release of 17

15 Price changes cont'd.. ($) MS Contin morphine sulfate 30 mg Sustained Release MS Contin morphine sulfate 60 mg Sustained Release MS IR morphine sulfate 5 mg MS IR morphine sulfate 10 mg Orap pimozide 2 mg Orap pimozide 4 mg Os-Cal calcium carbonate 500 mg pms-lamotrigine lamotrigine 150 mg Polytrim trimethoprim sulfate/polymyxin B sulfate 1 mg/10,000 U/mL Ophthalmic Solution Pred Forte prednisolone acetate 1% Ophthalmic Suspension Propine dipivefrin HCl 0.1% Ophthalmic Solution ratio-bisacodyl bisacodyl 10 mg Suppositories ratio-paroxetine paroxetine 10 mg ratio-paroxetine paroxetine 20 mg ** (1.2210) ratio-paroxetine paroxetine 30 mg ** (1.2980) Senokot sennosides A & B 8.6 mg ** The price change has resulted in a change to the lowest price in the category. ( ) Denotes the price of the lowest generic product in the product category. Discontinued Products The following products will be deleted with the next Formulary amendments mg/5 ml Apo-Ampi ampicillin mg/5 ml Oral Liquid Gentamicin Sulfate gentamicin sulfate 10 mg/ml Injection Gentamicin Sulfate gentamicin sulfate 40 mg/ml Injection -- Glucostix blood glucose reagent -- Strips mg Idarac floctafenine mg Surmontil trimipramine 25 mg 14 of 17

16 Manufacturer Updates The following products have been transferred to Paladin Labs Inc. (PAL): Sandomigran pizotifen 0.5 mg Sandomigran DS pizotifen 1 mg Sintrom acenocoumarol 1 mg 4 mg Zaditen ketotifen 1 mg Zaditen ketotifen 1 mg/5 ml Syrup Notice of product name change for ratiopharm (RPH): ratio-haloperidol (Previously: Peridol) haloperidol 2 mg The manufacturer for the following product has been changed to TaroPharma (TPT): Ketoderm ketoconazole 2% Cream The following products have been transferred to Pfizer (PFI): Adriamycin doxorubicin HCl 2 mg/ml Injection Adriamycin doxorubicin HCl 10 mg/5 ml Injection Adriamycin doxorubicin HCl 50 mg/25 ml Injection Adrucil fluorouracil 50 mg/ml Injection Aldactazide 25 spironolactone/ hydrochlorothiazide 25 mg/25 mg Aldactazide 50 spironolactone/ hydrochlorothiazide 50 mg/50 mg Aldactone spironolactone 100 mg Aldactone spironolactone 25 mg Ansaid flurbiprofen 100 mg Ansaid flurbiprofen 50 mg Aromasin exemestane 25 mg Arthrotec 50 diclofenac/misoprostol 50 mg/0.2 mg Arthrotec 75 diclofenac/misoprostol 75 mg/0.2 mg Brevicon (21) norethindrone/ 0.5 mg/0.035 mg Brevicon (28) norethindrone/ 0.5 mg/0.035 mg Brevicon (21) norethindrone/ 1 mg/0.035 mg Brevicon (28) norethindrone/ 1 mg/0.035 mg Celebrex celecoxib 100 mg Capsules Celebrex celecoxib 200 mg Capsules Chronovera verapamil HCl 180 mg Chronovera verapamil HCl 240 mg 15 of 17

17 Pfizer products cont'd Colestid colestipol HCl 1 g Colestid colestipol HCl 5 g Packets Colestid colestipol HCl 7.5 g Packets Cortef hydrocortisone 10 mg Cortef hydrocortisone 20 mg Cyklokapron tranexamic acid 100 mg/ml Injection Cyklokapron tranexamic acid 500 mg Cytosar cytarabine 100 mg Injection Cytosar cytarabine 1 g Injection Cytotec misoprostol 100 mcg Cytotec misoprostol 200 mcg Dalacin C clindamycin 150 mg Capsules Dalacin C clindamycin 300 mg Capsules Dalacin C clindamycin 15 mg/ml Solution Dalacin T clindamycin 10 mg/ml Topical Solution Daypro oxaprozin 600 mg Caplets Demulen 30 (21) ethynodiol diacetate/ 2 mg/0.03 mg Demulen 30 (28) ethynodiol diacetate/ 2 mg/0.03 mg Depo-Provera medroxyprogesterone acetate 150 mg/ml Injection Depo-Provera medroxyprogesterone acetate 10 mg/ml Injection Depo-Testosterone testosterone 100 mg/ml Injection Dipentum olsalazine sodium 250 mg Capsules Emcyt estramustine sodium phosphate 140 mg Capsules Halcion triazolam 0.25 mg Idamycin idarubicin HCl 10 mg Injection Idamycin idarubicin HCl 5 mg Injection Loniten minoxidil 10 mg Loniten minoxidil 2.5 mg Medrol methylprednisolone 16 mg Medrol methylprednisolone 4 mg Medrol Acne methylprednisolone acetate/aluminum -- Lotion chlorhydroxide/sulfur Mycobutin rifabutin 150 mg Capsules Neo-Medrol Acne methylprednisolone acetate/neomycin/ aluminum chlorhydroxide/ -- Lotion colloidal sulfur Ogen estropipate mg Ogen estropipate 1.25 mg Ogen estropipate 2.5 mg Pharmorubicin epirubicin 2 mg/ml Injection Provera medroxyprogesterone acetate 100 mg Provera medroxyprogesterone acetate 10 mg 16 of 17

18 Pfizer products cont'd Provera medroxyprogesterone acetate 2.5 mg Provera medroxyprogesterone acetate 5 mg Provera Pak medroxyprogesterone acetate 10 mg Provera Pak medroxyprogesterone acetate 5 mg Salazopyrin sulfasalazine 500 mg En Salazopyrin sulfasalazine 500 mg Select (21) norethindrone/ 1 mg/0.035 mg Select (28) norethindrone/ 1 mg/0.035 mg Solu-Cortef hydrocortisone sodium succinate 100 mg Injection Solu-Cortef hydrocortisone sodium succinate 1 g Injection Solu-Cortef hydrocortisone sodium succinate 250 mg Injection Solu-Cortef hydrocortisone sodium succinate 500 mg Injection Synphasic (21) norethindrone/ 1 mg/0.035 mg Synphasic (28) norethindrone/ 1 mg/0.035 mg Unidet tolterodine l-tartrate 2 mg Capsules Unidet tolterodine l-tartrate 4 mg Capsules Xalacom latanoprost/timolol 0.05 mg/5 mg/ml Ophthalmic Solution Xalatan latanoprost 0.005% Ophthalmic Solution Xanax alprazolam 0.25 mg Xanax alprazolam 0.5 mg Xanax alprazolam 1 mg Xanax TS alprazolam 2 mg Zanosar streptozocin 1 g Injection 17 of 17

Reminder to Pharmacists. Issuance of Bulletin #58

Reminder to Pharmacists. Issuance of Bulletin #58 Corporate and Provincial Program Support 300 Carlton, Winnipeg MB R3B 3M9 www.manitoba.ca/health Reminder to Pharmacists Issuance of Bulletin #58 Bulletin #58, effective April 29, 2008, completes the initial