Antibiotic Resistance and the Antibiotic Crisis
|
|
- Britton George Parsons
- 5 years ago
- Views:
Transcription
1 Antibiotic Resistance and the Antibiotic Crisis Daniel Z. Uslan, MD Director, Antimicrobial Stewardship Program Assistant Clinical Professor Division of Infectious Diseases, UCLA
2 Learning Objectives Understand the present crisis of resistant microorganisms and declining antibiotic development Identify the reasons for physician misuse and overuse of antibiotics Describe antibiotic stewardship programs and understand their role in decreasing utilization Systematically apply specific strategies to improve antibiotic utilization Cite cultural considerations in the prevalence of this topic
3 Cultural Considerations CA Assembly Bill 1995 requires each CME activity to have a component on Cultural Diversity No studies on antibiotic prescribing differences or resistance among different races/ethnicities
4 The Dark Ages In December 1942, a 4 yo girl in excellent health developed facial cellulitis after trauma Spread relentlessly, fever to 104 F, could not sleep because her face and neck so swollen she could not swallow her own saliva Began gasping for breath Herrell 43 Proc Staff Meetings Mayo Clinic 18:65-76
5 On arrival to the hospital Moribund dead within 2 days After 14 days of penicillin Totally fine for >65 years
6
7 Why Is This Important? For most of the infectious diseases on the wards of Boston City Hospital in 1937, there was nothing that could be done beyond bed rest and good nursing care. Then came the explosive news of sulfanilamide, and the start of the real revolution in medicine. Lewis Thomas, MD Albert Lasker Award winner Member of the National Academies of Science National Book Award Lewis Thomas. Notes of a Medicine Watcher. 83. Viking Press
8 Why Is This Important? Lewis Thomas. Notes of a Medicine Watcher. 83. Viking Press I remember the astonishment when the first cases of pneumococcal and streptococcal septicemia were treated in Boston in The phenomenon was almost beyond belief. Here were moribund patients, who would surely have died without treatment, improving within a matter of hours and feeling entirely well within the next day we became convinced, overnight, that nothing lay beyond reach for the future. Medicine was off and running.
9 The Power of Antibiotics Disease Pre-Antibiotic Death Rate Death Rate with Antibiotics Change in Death Rate Community 35% 10% -25% Pneumonia 1 Hospital 60% 30% -30% Pneumonia 2 Endocarditis 3 100% 25% -75% Meningitis 4 80% 20% -60% Cellulitis 5 11% <0.5% -10% By comparison, treatment of acute MI with aspirin 6-3% 1IDSA Position Paper 08 Clin Infect Dis 47(S3):S249-65; 2IDSA/ACCP/ATS/SCCM Position Paper 10 Clin Infect Dis In Press; 3Kerr AJ. Subacute Bacterial Endocarditis. Springfield IL: Charles C. Thomas, 1955 & Lancet :383-4; 4Lancet :733-4 & Waring et al. 48 Am J Med 5:402-18; 5Spellberg et al. 09 Clin Infect Dis 49: & Madsen 73 Infection 1:76-81; 6 88 Lancet 2:349-60
10 Why Is This Important? with today s [antibiotics] it is possible to place in the hands of a barefoot, nonliterate villager more real power to affect the outcome of a critically ill [patient] than could have been exerted by the most highly trained urban physician of 25 years ago. (Dr. Walsh McDermott 1960 Science 131: ) Walsh McDermott, MD Cornell University 1 st President of Medical Board of National Academy of Sciences (precursor to IOM) Albert Lasker Award winner for early work on isoniazid
11 In just 75 years RIP Antibiotics:
12 Antibiotic-Resistance Is Skyrocketing (CDC Data) % of isolates
13 US hospital discharges with diagnosis of infection with drug-resistant microorganisms Rate per 100,000 hospital discharges Courtesy John Rex : A dramatic increase 0.3% 0.6% 1% Data from US Healthcare Cost and Utilization Network IOM Countermeasures, Big Pharma Commercial Perspectives - Rex
14 Courtesy J.G. Bartlett No New Classes to Treat Gram Negative Bacilli For 4 Decades For Gram positives, we need better drugs. For Gram negatives, we need ANY drugs. John Bartlett, MD
15
16
17 Geographical distribution of extremedrug resistant KPC Klebsiella bacteria Nov, 2006
18 Geographical distribution of extremedrug resistant KPC Klebsiella bacteria Current
19 NDM-1 E. coli & Klebsiella In 2010, reports of new resistant mechanism spread from India to UK/US All strains resistant to all antibiotics except tigecycline or colistin 10% strains resistant to both of those drugs also truly pan-resistant This is our worst nightmare Kumarasamy 10 Lancet Infectious Diseases 10: ; MMWR 10 59:750
20 Pan Resistant Superbugs 11/6/10, New York Times, report on antibiotic resistant infections For these infections, we're back to dancing around a bubbling cauldron while rubbing two chicken bones together. --Brad Spellberg, MD Page A1 (front page) Quote of the Day
21 21
22 Health Care Costs of Resistance Resistant infections prolong length of hospital stay by 24% and increase costs by 29% vs. susceptible infections (Maudlin et al. AAC 10 54: ) Cost to US of antibiotic resistance is 8 million additional hospital days and $21-34 billion/yr (Roberts et al. CID 09 49: ; & PRN Newswire Antibiotic-Resistant Infections Cost the U.S. Healthcare System in Excess of $20 Billion Annually )
23 2 million people acquire healthcare-associated infections per year
24 100,000 people die as a result More than AIDS, breast cancer, traffic accidents combined
25 Microbes vs. Humans Microbes Humans Factor Number on Earth 5x x Mass (metric tons) 5x x Generation Time 30 min 30 yr 5x10 5 Time on Earth (yrs) 3.5x10 9 4x Microbiology in the 21st century, ASM, 2004; Spellberg et al 2008 Clin Infect Dis
26 Microbes vs. Humans Genetic Promiscuity Microbes Humans* Diversity/Adaptability Cross-phylum Intra-species *genus/species Homo sapiens, family Hominidae, order Primate, class Mammalia, phylum Chordata
27 Microbes vs. Humans Equivalent promiscuity would require capability to exchange DNA with: chimpanzee (family Hominidae) orangutan (order Primate) Pretty cool grizzly bear / tiger / walrus / killer whale (class Mammalia) falcon / frog / crocodile (phylum Chordata)
28 Microbes have been creating and defeating antibiotics for 20 million times longer than Homo sapiens have even known antibiotics existed.
29 The future of humanity and microbes will likely evolve as episodes of our wits versus their genes. Nobel Laureate Joshua Lederberg Science :287-93
30 How Do We Combat Resistance? Two Options
31 1. New Antibiotics
32 New Drug Research and Development A short section
33 New Antibacterial Agents Approved
34 Timeline for Development of a New Antibiotic
35 In contrast 67 new drugs for cancer 33 for inflammation and pain 34 for metabolic/endocrine disorders 32 for pulmonary disease
BAD BUGS, NEED DRUGS Why Antibiotics Deserve Congress Attention and Immediate Action Infectious Diseases Society of America
BAD BUGS, NEED DRUGS Why Antibiotics Deserve Congress Attention and Immediate Action Infectious Diseases Society of America Cynthia L. Sears, M.D. Professor of Medicine & Oncology Johns Hopkins University
More informationDevelopment of Drugs for Skin Infections
EFPIA - Skin Infection comments 1 Development of Drugs for Skin Infections John H Rex, MD EFPIA - Skin Infection comments 2 Skin Infections Significant recent debate: Acceptable forms: A focus on fever
More informationThe Pharmacist s Role in Antimicrobial Stewardship
The Pharmacist s Role in Antimicrobial Stewardship Ruth Lynfield, MD State Epidemiologist and Medical Director Minnesota Department of Health Era of Antibiotics. Great Moments in Pharmacy, Artist George
More informationThe Rise of Antibiotic Resistance: Is It Too Late?
The Rise of Antibiotic Resistance: Is It Too Late? Paul D. Holtom, MD Professor of Medicine and Orthopaedics USC Keck School of Medicine None DISCLOSURES THE PROBLEM Antibiotic resistance is one of the
More informationCommercial Challenges: Perspectives from Big Pharma
Commercial Challenges: Perspectives from Big Pharma John H. Rex, MD Vice President Clinical Infection AstraZeneca 1 Disclaimers The following are my views and not necessarily those of my employer, AstraZeneca,
More informationAntibiotics and Duration
Antibiotics and Duration James A. McKinnell, M. D. David Geffen School of Medicine UCLA Los Angeles County Department of Public Health Acute Communicable Disease Control Unit 2 Appreciation Brad Spellberg
More informationAntibiotic Stewardship: Everyone s Responsibility. Jason G. Newland
Antibiotic Stewardship: Everyone s Responsibility Jason G. Newland MD, MEd @JasonGNewland @sharpsgroup The Children's Mercy Hospital, 2015 DISCLOSURES Grant support from Pfizer for the Sharing Antimicrobial
More informationPreventing and Responding to Antibiotic Resistant Infections in New Hampshire
Preventing and Responding to Antibiotic Resistant Infections in New Hampshire Benjamin P. Chan, MD, MPH NH Dept. of Health & Human Services Division of Public Health Services May 23, 2017 To bring a greater
More informationWhy Don t These Drugs Work Anymore? Biosciences in the 21 st Century Dr. Amber Rice October 28, 2013
Why Don t These Drugs Work Anymore? Biosciences in the 21 st Century Dr. Amber Rice October 28, 2013 Outline Drug resistance: a case study Evolution: the basics How does resistance evolve? Examples of
More information8/3/2017 ABX STEWARDSHIP
ABX STEWARDSHIP 1 Drug resistance follows the drug like a faithful shadow. - Paul Erhlich 1854-1915 2 It is not difficult to make microbes resistant to penicillin in the laboratory by exposing them to
More informationAntimicrobial Stewardship/Statewide Antibiogram. Felicia Matthews Senior Consultant, Pharmacy Specialty BD MedMined Services
Antimicrobial Stewardship/Statewide Antibiogram Felicia Matthews Senior Consultant, Pharmacy Specialty BD MedMined Services Disclosures Employee of BD Corporation MedMined Services Agenda CMS and JCAHO
More informationAntimicrobial Resistance and Papua New Guinea WHY is it important? HOW has the problem arisen? WHAT can we do?
Antimicrobial Resistance and Papua New Guinea WHY is it important? HOW has the problem arisen? WHAT can we do? John Ferguson, John Hunter Hospital, University of Newcastle, NSW, Australia Infectious Diseases
More informationBurton's Microbiology for the Health Sciences. Chapter 9. Controlling Microbial Growth in Vivo Using Antimicrobial Agents
Burton's Microbiology for the Health Sciences Chapter 9. Controlling Microbial Growth in Vivo Using Antimicrobial Agents Chapter 9 Outline Introduction Characteristics of an Ideal Antimicrobial Agent How
More informationAntimicrobial Resistance Initiative
Antimicrobial Resistance Initiative Antimicrobial Resistance Initiative Resistance to antimicrobial agents has become a threat to public health all over the world. Microorganisms become resistant to antimicrobial
More informationAntibiotic stewardship in long term care
Antibiotic stewardship in long term care Shira Doron, MD Associate Professor of Medicine Division of Geographic Medicine and Infectious Diseases Tufts Medical Center Boston, MA Consultant to Massachusetts
More informationAn Approach to Appropriate Antibiotic Prescribing in Outpatient and LTC Settings?
An Approach to Appropriate Antibiotic Prescribing in Outpatient and LTC Settings? Dr. Andrew Morris Antimicrobial Stewardship ProgramMt. Sinai Hospital University Health Network amorris@mtsinai.on.ca andrew.morris@uhn.ca
More informationINFECTIOUS DISEASES STRATEGIES TO LIMIT HOSPITALIZATION,REDUCE RISK AND ADD VALUE
INFECTIOUS DISEASES STRATEGIES TO LIMIT HOSPITALIZATION,REDUCE RISK AND ADD VALUE Ronald G Nahass, MD, MHCM, FIDSA President ID CARE Clinical Professor of Medicine-Rutgers University Robert Wood Johnson
More informationPresenter: Ombeva Malande. Red Cross Children's Hospital Paed ID /University of Cape Town Friday 6 November 2015: Session:- Paediatric ID Update
Emergence of invasive Carbapenem Resistant Enterobacteriaceae CRE infection at RCWMCH Ombeva Oliver Malande, Annerie du Plessis, Colleen Bamford, Brian Eley Presenter: Ombeva Malande Red Cross Children's
More informationAntibiotic Resistance. Antibiotic Resistance: A Growing Concern. Antibiotic resistance is not new 3/21/2011
Antibiotic Resistance Antibiotic Resistance: A Growing Concern Judy Ptak RN MSN Infection Prevention Practitioner Dartmouth-Hitchcock Medical Center Lebanon, NH Occurs when a microorganism fails to respond
More informationAntimicrobial stewardship: Quick, don t just do something! Stand there!
Antimicrobial stewardship: Quick, don t just do something! Stand there! Stanley I. Martin, MD, FACP, FIDSA Director, Division of Infectious Diseases Director, Antimicrobial Stewardship Program Geisinger
More informationAntimicrobial Stewardship
Antimicrobial Stewardship Background Why Antimicrobial Stewardship 30-50% of antibiotic use in hospitals are unnecessary or inappropriate Appropriate antimicrobial use is a medication-safety and patient-safety
More informationRise of the Superbugs: the end of antibiotics? Peter Lambert Life and Health Sciences Aston University
Rise of the Superbugs: the end of antibiotics? Peter Lambert Life and Health Sciences Aston University Willard Wigan Microbiologists grow bacteria on plates Each colony is formed from a single cell Colonies
More informationTackling the need for new antibacterial drugs
Tackling the need for new antibacterial drugs Wendy Lawson Lead Pharmacist, Infectious Diseases Imperial College Healthcare NHS Trust, London & Antibiotic Action Champion Timeline of Antibiotic Discovery
More informationFlorida Health Care Association District 2 January 13, 2015 A.C. Burke, MA, CIC
Florida Health Care Association District 2 January 13, 2015 A.C. Burke, MA, CIC 11/20/2014 1 To describe carbapenem-resistant Enterobacteriaceae. To identify laboratory detection standards for carbapenem-resistant
More informationAntimicrobial Stewardship in Ambulatory Care
Antimicrobial Stewardship in Ambulatory Care Nila Suntharam, M.D. May 5, 2017 Dr. Suntharam indicated no potential conflict of interest to this presentation. She does not intend to discuss any unapproved/investigative
More informationObjective 1/20/2016. Expanding Antimicrobial Stewardship into the Outpatient Setting. Disclosure Statement of Financial Interest
Expanding Antimicrobial Stewardship into the Outpatient Setting Michael E. Klepser, Pharm.D., FCCP Professor Pharmacy Practice Ferris State University College of Pharmacy Disclosure Statement of Financial
More informationDisclosures. Principles of Antimicrobial Therapy. Obtaining an Accurate Diagnosis Obtain specimens PRIOR to initiating antimicrobials
Disclosures Principles of Antimicrobial Therapy None Lori A. Cox MSN, ACNP-BC, ACNPC, FCCM Penn State Hershey Medical Center Neuroscience Critical Care Unit Obtaining an Accurate Diagnosis Determine site
More informationMulti-drug resistant microorganisms
Multi-drug resistant microorganisms Arzu TOPELI Director of MICU Hacettepe University Faculty of Medicine, Ankara-Turkey Council Member of WFSICCM Deaths in the US declined by 220 per 100,000 with the
More informationAntimicrobial Stewardship Program. Jason G. Newland MD, MEd Miranda Nelson, PharmD
Antimicrobial Stewardship Program Jason G. Newland MD, MEd Miranda Nelson, PharmD The Children's Mercy Hospital, 2015 Antibiotic Timeline Clatworthy 2007 Antibiotic Use in Freestanding Children s Hospitals
More informationImpact of Antimicrobial Resistance on Human Health. Robert Cunney HSE HCAI/AMR Programme and Temple Street Children s University Hospital
Impact of Antimicrobial Resistance on Human Health Robert Cunney HSE HCAI/AMR Programme and Temple Street Children s University Hospital AMR in Foodchain Conference, UCD, Dec 2014 Sir Patrick Dun s Hospital
More informationIntroduction to Chemotherapeutic Agents. Munir Gharaibeh MD, PhD, MHPE School of Medicine, The university of Jordan November 2018
Introduction to Chemotherapeutic Agents Munir Gharaibeh MD, PhD, MHPE School of Medicine, The university of Jordan November 2018 Antimicrobial Agents Substances that kill bacteria without harming the host.
More informationAntimicrobial resistance and the need for stewardship. Dr Nick Brown RCP Acute Medicine conference, 16 April 2018
Antimicrobial resistance and the need for stewardship Dr Nick Brown RCP Acute Medicine conference, 16 April 2018 Fleming s laboratory, St Mary s Hospital, London (Photo N M Brown ) It is not difficult
More information11/22/2016. Antimicrobial Stewardship Update Disclosures. Outline. No conflicts of interest to disclose
Antimicrobial Stewardship Update 2016 APIC-CI Conference November 17 th, 2016 Jay R. McDonald, MD Chief, ID Section VA St. Louis Health Care System Assistant Professor of medicine Washington University
More information8/17/2016 ABOUT US REDUCTION OF CLOSTRIDIUM DIFFICILE THROUGH THE USE OF AN ANTIMICROBIAL STEWARDSHIP PROGRAM
Mary Moore, MS CIC MT (ASCP) Infection Prevention Coordinator Great River Medical Center, West Burlington REDUCTION OF CLOSTRIDIUM DIFFICILE THROUGH THE USE OF AN ANTIMICROBIAL STEWARDSHIP PROGRAM ABOUT
More informationAntimicrobial Cycling. Donald E Low University of Toronto
Antimicrobial Cycling Donald E Low University of Toronto Bad Bugs, No Drugs 1 The Antimicrobial Availability Task Force of the IDSA 1 identified as particularly problematic pathogens A. baumannii and
More informationDoes Screening for MRSA Colonization Have A Role In Healthcare-Associated Infection Prevention Programs?
Does Screening for MRSA Colonization Have A Role In Healthcare-Associated Infection Prevention Programs? John A. Jernigan, MD, MS Division of Healthcare Quality Promotion Centers for Disease Control and
More informationAntimicrobial Stewardship:
Antimicrobial Stewardship: Inpatient and Outpatient Elements Angela Perhac, PharmD afperhac@carilionclinic.org Disclosure I have no relevant finances to disclose. Objectives Review the core elements of
More informationCarbapenemase-producing Enterobacteriaceae (CRE) T H E L A T E S T I N T H E G R O W I N G L I S T O F S U P E R B U G S
Carbapenemase-producing Enterobacteriaceae (CRE) T H E L A T E S T I N T H E G R O W I N G L I S T O F S U P E R B U G S CRE Enterobacteriaceae (Gram Negative Bacilli) Citrobacter species Escherichia coli***
More informationThe Big Picture: Using Antibiotic Use and Surveillance Data to Better Inform Stewardship in Healthcare Settings
The Big Picture: Using Antibiotic Use and Surveillance Data to Better Inform Stewardship in Healthcare Settings Becky Roberts, MS Get Smart: Know When Antibiotics Work Office of Antibiotic Stewardship
More informationResistant Gram-negative Bacteria
Introduction Antibiotic-resistant bacteria aren t new. But gram-negative bacteria, like Enterobacteriaceae, are becoming more resistant to our last-line antibiotics. Some people are calling these bacteria
More informationCompliance with antibiotic treatment guidelines in managed care patients with communityacquired pneumonia in ambulatory settings
Compliance with antibiotic treatment guidelines in managed care patients with communityacquired pneumonia in ambulatory settings Jasmanda H. Wu, Ph.D., 1 David H. Howard, Ph.D., 2 John E. McGowan, Jr.,
More informationHospital ID: 831. Bourguiba Hospital. Tertiary hospital
Global Point Prevalence Survey of Antimicrobial Consumption and Resistance in hospitals worldwide Hospital ID: 831 Habib Bourguiba Hospital Tertiary hospital Tunisia Point Prevalence Survey Habib 2017
More informationrunning head: SUPERBUGS Humphreys 1
running head: SUPERBUGS Humphreys 1 Superbugs GCH 360 Term Paper Assignment Kelly Humphreys April 30, 2014 SUPERBUGS Humphreys 2 Introduction The World Health Organization (WHO) recognizes antibiotic resistance
More informationInfection Control of Emerging Diseases
2016 EPS Training Event Martin E. Evans, MD Director, VHA MDRO Program National Infectious Diseases Service Lexington, KY & Cincinnati, OH Infection Control of Emerging Diseases 2016 EPS Training Event
More informationMAGNITUDE OF ANTIMICROBIAL USE. Antimicrobial Stewardship in Acute and Long Term Healthcare Facilities: Design, Implementation and Challenges
Antimicrobial Stewardship in Acute and Long Term Healthcare Facilities: Design, Implementation and Challenges John A. Jernigan, MD, MS Division of Healthcare Quality Promotion Centers for Disease Control
More informationAntimicrobial Stewardship
Antimicrobial Stewardship Preventing the Spread of Antibiotic Resistance and Improving Patient Care (Adapted from the Centers for Disease Control and Prevention) What is Stewardship? Antimicrobial stewardship
More informationAntibiotic resistance: how did we get here and what can we do? Peter Lambert LHS
Antibiotic resistance: how did we get here and what can we do? Peter Lambert LHS How do we diagnose and treat infection? Organisms are cultured and identified Microscopy gives a clue to identity Staphylococcus
More information3/1/2016. Antibiotics --When Less is More. Most Urgent Threats. Serious Threats
Antibiotics --When Less is More Ralph Gonzales, MD, MSPH Associate Dean, Clinical Innovation School of Medicine VP, Clinical Innovation, UCSF Health Most Urgent Threats Serious Threats Multidrug-Resistant
More informationAntimicrobial Stewardship Protecting a Valuable Resource
Antimicrobial Stewardship Protecting a Valuable Resource November 8, 2011 Medical Director Communicable Disease Service NJDHSS Edward.Lifshitz@doh.state.nj.us (609) 826-5964 One can think of the middle
More information11/22/2016. Hospital-acquired Infections Update Disclosures. Outline. No conflicts of interest to disclose. Hot topics:
Hospital-acquired Infections Update 2016 APIC-CI Conference November 17 th, 2016 Jay R. McDonald, MD Chief, ID Section VA St. Louis Health Care System Assistant Professor of medicine Washington University
More informationAntibiotic Stewardship in the LTC Setting
Antibiotic Stewardship in the LTC Setting Joe Litsey, Director of Consulting Services Pharm.D., Board Certified Geriatric Pharmacist Thrifty White Pharmacy Objectives Describe the Antibiotic Stewardship
More informationAntimicrobial Stewardship Strategy: Antibiograms
Antimicrobial Stewardship Strategy: Antibiograms A summary of the cumulative susceptibility of bacterial isolates to formulary antibiotics in a given institution or region. Its main functions are to guide
More informationReport on the APUA Educational Symposium: "Facing the Next Pandemic of Pan-resistant Gram-negative Bacilli"
Preserving the Power of Antibiotics Report on the APUA Educational Symposium: "Facing the Next Pandemic of Pan-resistant Gram-negative Bacilli" Held on Thursday, September 30, 2004 in Boston, MA Preceding
More informationGUIDE TO INFECTION CONTROL IN THE HOSPITAL. Antibiotic Resistance
GUIDE TO INFECTION CONTROL IN THE HOSPITAL CHAPTER 4: Antibiotic Resistance Author M.P. Stevens, MD, MPH S. Mehtar, MD R.P. Wenzel, MD, MSc Chapter Editor Michelle Doll, MD, MPH Topic Outline Key Issues
More informationEpidemiology and Economics of Antibiotic Resistance
Epidemiology and Economics of Antibiotic Resistance Eili Y. Klein February 17, 2016 Health Watch USA Meeting I. The burden of antibiotic resistance is a growing global threat, but hard numbers are lacking
More informationAntimicrobial Resistance and Prescribing
Antimicrobial Resistance and Prescribing John Ferguson, Microbiology & Infectious Diseases, John Hunter Hospital, University of Newcastle, NSW, Australia M Med Part 1 updates UPNG 2017 Tw @mdjkf http://idmic.net
More informationANTIMICROBIAL STEWARDSHIP: THE ROLE OF THE CLINICIAN SAM GUREVITZ PHARM D, CGP BUTLER UNIVERSITY COLLEGE OF PHARMACY AND HEALTH SCIENCES
ANTIMICROBIAL STEWARDSHIP: THE ROLE OF THE CLINICIAN SAM GUREVITZ PHARM D, CGP BUTLER UNIVERSITY COLLEGE OF PHARMACY AND HEALTH SCIENCES 1 Crisis: Antibiotic Resistance Success Strategy 2 OBJECTIVES Discuss
More informationAre we facing a superbug apocalypse? Are we facing a superbug apocalypse? - the Antibiotic Paradox
Are we facing a superbug apocalypse? 21ST CENTURY MEDICINE LECTURE SERIES: TODAY S RESEARCH, TOMORROW S HEALTHCARE Tackling infections, locally and globally www.sydney.edu.au/mbi Are we facing a superbug
More informationJuly 31, The Honorable Michael Bennet U.S. Senate 458 Russell Senate Office Building Washington, DC 20510
July 31, 2013 The Honorable Michael Bennet U.S. Senate 458 Russell Senate Office Building Washington, DC 20510 The Honorable Orrin Hatch U.S. Senate 104 Hart Senate Office Building Washington, DC 20510
More informationChallenges and opportunities for rapidly advancing reporting and improving inpatient antibiotic use in the U.S.
Challenges and opportunities for rapidly advancing reporting and improving inpatient antibiotic use in the U.S. Overview of benchmarking Antibiotic Use Scott Fridkin, MD, Senior Advisor for Antimicrobial
More informationAntibiotic Stewardship in the Hospital Setting
Antibiotic Stewardship in the Hospital Setting G. Evans, MD FRCPC Medical Director, Infection Prevention & Control Kingston General Hospital & Hotel Dieu Hospital EOPIC September 26, 2012 Stewardship stew-ard-ship
More informationConsumption of antibiotics in hospitals. Antimicrobial stewardship.
Consumption of antibiotics in hospitals. Antimicrobial stewardship. Inge C. Gyssens MD PhD Radboud university medical center, Nijmegen, The Netherlands Hasselt University, Belgium 1. Antibiotic use in
More informationCommunity-Associated C. difficile Infection: Think Outside the Hospital. Maria Bye, MPH Epidemiologist May 1, 2018
Community-Associated C. difficile Infection: Think Outside the Hospital Maria Bye, MPH Epidemiologist Maria.Bye@state.mn.us 651-201-4085 May 1, 2018 Clostridium difficile Clostridium difficile Clostridium
More informationVaccination as a potential strategy to combat Antimicrobial Resistance in the elderly
Vaccination as a potential strategy to combat Antimicrobial Resistance in the elderly Wilbur Chen, MD, MS 22-23 March 2017 WHO meeting on Immunization of the Elderly The Problem Increasing consumption
More informationMDRO s, Stewardship and Beyond. Linda R. Greene RN, MPS, CIC
MDRO s, Stewardship and Beyond Linda R. Greene RN, MPS, CIC linda_greene@urmc.rochester.edu Evolving Threat of Antimicrobial Resistance Why are MDROs important? Limited treatment options Associated with:
More information3.0 Treatment of Infection
3.0 Treatment of Infection Antibiotics and Medicine National Curriculum Link Key Stage 3 Sc1:1a - 1c. 2a 2p Sc2: 2n Unit of Study Unit 8: Microbes and Disease Unit 9B: Fit and Healthy Unit 20: 20 th Century
More informationIFMSA Policy Proposal Antimicrobial Resistance
IFMSA Policy Proposal Antimicrobial Resistance Proposed by Team of Officials Presented to the IFMSA General Assembly March Meeting 2017 in Arusha, Tanzania Policy Statement Introduction Antimicrobial resistance
More informationOutpatient Antimicrobial Stewardship. Jeffrey S Gerber, MD, PhD Division of Infectious Diseases The Children s Hospital of Philadelphia
Outpatient Antimicrobial Stewardship Jeffrey S Gerber, MD, PhD Division of Infectious Diseases The Children s Hospital of Philadelphia Overview The case for outpatient antimicrobial stewardship Interventions
More informationNursing Home Online Training Sessions Session 2: Exploring Antibiotics and Their Role in Fighting Bacterial Infections
National Nursing Home Quality Care Collaborative Nursing Home Online Training Sessions Session 2: Exploring Antibiotics and Their Role in Fighting Bacterial Infections Health Services Advisory Group (HSAG)
More informationEvolution in Everyday Life
Evolution in Everyday Life In its simplest interpretation, the term evolution means changing gene frequencies through time. Whether or not you believe that humans evolved from primates, understanding the
More information1/30/ Division of Disease Control and Health Protection. Division of Disease Control and Health Protection
Surveillance, Outbreaks, and Reportable Diseases, Oh My! Assisted Living Facility, Nursing Home and Surveyor Infection Prevention Training February 2015 A.C. Burke, MA, CIC Health Care-Associated Infection
More informationRole of the general physician in the management of sepsis and antibiotic stewardship
Role of the general physician in the management of sepsis and antibiotic stewardship Prof Martin Wiselka Dept of Infection and Tropical Medicine University Hospitals of Leicester Sepsis and antibiotic
More informationAntimicrobial Stewardship Basics Why, What, Who, and How. Philip Chung, PharmD, MS, BCPS ASAP Community Network Pharmacy Coordinator October 12, 2017
Antimicrobial Stewardship Basics Why, What, Who, and How Philip Chung, PharmD, MS, BCPS ASAP Community Network Pharmacy Coordinator October 12, 2017 Objectives List reasons for developing antimicrobial
More informationDuration of antibiotic therapy:
Duration of antibiotic therapy: How low can you go? Thomas Holland, MD Hilton Head, SC July 2017 Disclosures Consulting: The Medicines Company, Basilea Pharmaceutica Adjudication committee: Achaogen Grant
More informationSafe Patient Care Keeping our Residents Safe Use Standard Precautions for ALL Residents at ALL times
Safe Patient Care Keeping our Residents Safe 2016 Use Standard Precautions for ALL Residents at ALL times #safepatientcare Do bugs need drugs? Dr Deirdre O Brien Consultant Microbiologist Mercy University
More informationEVIDENCE BASED MEDICINE: ANTIBIOTIC RESISTANCE IN THE ELDERLY CHETHANA KAMATH GERIATRIC MEDICINE WEEK
EVIDENCE BASED MEDICINE: ANTIBIOTIC RESISTANCE IN THE ELDERLY CHETHANA KAMATH GERIATRIC MEDICINE WEEK EPIDEMIOLOGY AND BACKGROUND Every year, more than 2 million people in the United States acquire antibiotic-resistant
More informationDo Bugs Need Drugs? A community program for wise use of antibiotics
Do Bugs Need Drugs? A community program for wise use of antibiotics June 2012 Antibiotics Most significant discovery of modern medicine Save millions of lives Antibiotic resistance Caused by overuse and
More informationWhy Antimicrobial Stewardship?
Antimicrobial Stewardship: Why and How CAPT Arjun Srinivasan, MD Associate Director for Healthcare Associated Infection Prevention Programs Division of Healthcare Quality Promotion Why Antimicrobial Stewardship?
More informationHealthcare-associated Infections Annual Report December 2018
December 2018 Healthcare-associated Infections Annual Report 2011-2017 TABLE OF CONTENTS INTRODUCTION... 1 METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS INFECTIONS... 2 MRSA SURVEILLANCE... 3 CLOSTRIDIUM
More informationAntimicrobial Stewardship. Where are we now and where do we need to go?
Safe Patient Care Bugs and Drugs The ongoing challenge of MDROs and AMR 2017 @SPC2016Cork Antimicrobial Stewardship. Where are we now and where do we need to go? Frank O Riordan Antimicrobial pharmacist,
More informationCHAPTER:1 THE RATIONAL USE OF ANTIBIOTICS. BY Mrs. K.SHAILAJA., M. PHARM., LECTURER DEPT OF PHARMACY PRACTICE, SRM COLLEGE OF PHARMACY
CHAPTER:1 THE RATIONAL USE OF ANTIBIOTICS BY Mrs. K.SHAILAJA., M. PHARM., LECTURER DEPT OF PHARMACY PRACTICE, SRM COLLEGE OF PHARMACY Antibiotics One of the most commonly used group of drugs In USA 23
More informationOther Enterobacteriaceae
GUIDE TO INFECTION CONTROL IN THE HOSPITAL CHAPTER NUMBER 50: Other Enterobacteriaceae Author Kalisvar Marimuthu, MD Chapter Editor Michelle Doll, MD, MPH Topic Outline Topic outline - Key Issues Known
More informationThe challenge of growing resistance
EXECUTIVE SUMMARY Around 2.4 million people could die in Europe, North America and Australia between 2015-2050 due to superbug infections unless more is done to stem antibiotic resistance. However, three
More informationTutorial 9 notes Super Bug: Antibiotics & Evolution Kristy J. Wilson Department of Pathology Emory University History of Antibiotics http://videos.howstuffworks.com/science-channel/29783-100-greatest-discoveries-penicillinvideo.htm
More informationANTIBIOTIC STEWARDSHIP. Brian Mayhue, Pharm D, CGP Director of Pharmacy Palm Beach Gardens Medical Center
ANTIBIOTIC STEWARDSHIP Brian Mayhue, Pharm D, CGP Director of Pharmacy Palm Beach Gardens Medical Center Antibiotic Resistance It is not difficult to make microbes resistant to penicillin in the laboratory
More informationAntimicrobial Stewardship 101
Antimicrobial Stewardship 101 Betty P. Lee, Pharm.D. Pediatric Infectious Disease/Antimicrobial Stewardship Pharmacist Lucile Packard Children s Hospital Stanford Disclosure I have no actual or potential
More informationClostridium Difficile Primer: Disease, Risk, & Mitigation
Clostridium Difficile Primer: Disease, Risk, & Mitigation KALVIN YU, M.D. CHIEF INTEGRATION OFFICER, SCPMG/SCAL KAISER PERMANENTE ASSOCIATE PROFESSOR INFECTIOUS DISEASE, COLLEGE OF GLOBAL PUBLIC HEALTH,
More informationAntibiotic resistance: the rise of the superbugs
Antibiotic resistance: the rise of the superbugs Allen Cheng Associate Professor of Infectious Diseases Epidemiology, Alfred Health; Monash University About me Specialist in infectious diseases Head, Infection
More informationIt s Time to Regulate Antimicrobial Stewardship Standards in Acute Care Settings. Emily Heil, PharmD, BCPS-AQ ID, AAHIVP
It s Time to Regulate Antimicrobial Stewardship Standards in Acute Care Settings Emily Heil, PharmD, BCPS-AQ ID, AAHIVP Conflict of Interest I have no conflicts of interest to disclose related to the content
More informationGP Small Group education April/May 2015 Antibiotics Resistance is futile
GP Small Group education April/May 2015 Antibiotics Resistance is futile Acknowledgements This material was prepared by the Clinical Quality and Education team with help gratefully received from: Topic
More informationOverview of C. difficile infections. Kurt B. Stevenson, MD MPH Professor Division of Infectious Diseases
Overview of C. difficile infections Kurt B. Stevenson, MD MPH Professor Division of Infectious Diseases Conflicts of Interest I have no financial conflicts of interest related to this topic and presentation.
More informationM.L. Avent* 1,2, E.Waddell 1, K.Daveson 1 and K. Hajkowicz 1 1. Queensland Statewide Antimicrobial Stewardship 2. UQCCR, The University of Queensland
@MinyonAvent #ruralhealthconf M.L. Avent* 1,2, E.Waddell 1, K.Daveson 1 and K. Hajkowicz 1 1. Queensland Statewide Antimicrobial Stewardship 2. UQCCR, The University of Queensland Queensland State- Wide
More informationAntimicrobial Resistance. The Case for Diagnostics to Better Direct Therapy
Antimicrobial Resistance The Case for Diagnostics to Better Direct Therapy Objectives Explain the medical significance of antibiotic resistance Assess the medical impact of disease, such as pneumonia and
More informationInt.J.Curr.Microbiol.App.Sci (2017) 6(3):
International Journal of Current Microbiology and Applied Sciences ISSN: 2319-7706 Volume 6 Number 3 (2017) pp. 891-895 Journal homepage: http://www.ijcmas.com Original Research Article https://doi.org/10.20546/ijcmas.2017.603.104
More informationGet Smart For Healthcare
Get Smart For Healthcare Know When Antibiotics Work Marry Bardin, Quality Improvement Advisor June 9, 2015 Why We Need to Improve In-patient Antibiotic Use Antibiotics are misused in hospitals Antibiotic
More informationWhat is antimicrobial resistance?
What is antimicrobial resistance? Gérard MOULIN gerard.moulin@anses.fr French agency for food, environmental and occupationnal safety National agency for veterinary Medicinal Products BP 90203-35302 FOUGERES
More informationBarriers to Intravenous Penicillin Use for Treatment of Nonmeningitis
JCM Accepts, published online ahead of print on 7 July 2010 J. Clin. Microbiol. doi:10.1128/jcm.01012-10 Copyright 2010, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights
More informationPhysician Rating: ( 23 Votes ) Rate This Article:
From Medscape Infectious Diseases Conquering Antibiotic Overuse An Expert Interview With the CDC Laura A. Stokowski, RN, MS Authors and Disclosures Posted: 11/30/2010 Physician Rating: ( 23 Votes ) Rate
More informationNosocomial Antibiotic Resistant Organisms
Nosocomial Antibiotic Resistant Organisms Course Medical Microbiology Unit II Laboratory Safety and Infection Control Essential Question Does improved hand hygiene really reduce the spread of bacteria
More informationAn#bio#cs and challenges in the wake of superbugs
An#bio#cs and challenges in the wake of superbugs www.biochemj.org/bj/330/0581/bj3300581.htm ciss.blog.olemiss.edu Dr. Vassie Ware Bioscience in the 21 st Century November 14, 2014 Who said this and what
More information