Changing Practices to Reduce Antibiotic Resistance
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1 Changing Practices to Reduce Antibiotic Resistance Jean E. McLain, Research Scientist and Assistant Dean University of Arizona College of Agriculture and Life Sciences and Department of Soil, Water and Environmental Science Addressing Antibiotic Resistance Hotspots Session, APHL Annual Meeting June 2, 2018
2 Antibiotic Resistance: the Quintessential One Health Issue Multiple disciplines Clinical, Environmental Policy Statisticians Working locally, nationally, and globally To attain health for people, animals, and the environment
3 Antibiotic Resistance: the Quintessential One Health Issue Multiple disciplines Clinical, Environmental Policy Statisticians Working locally, nationally, and globally To attain health for people, animals, and the environment Closely linked not by disease, but by resistance
4 Antibiotic Resistance: the Quintessential One Health Issue Multiple disciplines Clinical, Environmental Policy Statisticians Working locally, nationally, and globally To attain health for people, animals, and the environment Closely linked not by disease, but by resistance What is known? What is not known?
5 Antibiotic Resistance: the Quintessential One Health Issue Multiple disciplines Clinical, Environmental Policy Statisticians Working locally, nationally, and globally To attain health for people, animals, and the environment Closely linked not by disease, but by resistance
6 Antibiotic Resistant Bacteria The ability of a bacterium to prevent an antibiotic from adversely affecting that isolate, strain, or group. Horizontal Gene Transfer confers antibiotic resistance in response to selective pressure Clinical settings High antibiotic dosages Resistance anthropogenic?
7 Antibiotic Resistant Bacteria Earliest antibiotics: naturally produced (e.g., Penicillin)
8 Antibiotic Resistant Bacteria Earliest antibiotics: naturally produced (e.g., Penicillin)
9 Antibiotic Resistant Bacteria Resistant bacteria isolated from deep terrestrial subsurface (>250 m deep caves) and prehistoric (120,000+ YBP) ice cores
10 Antibiotic Resistant Bacteria Resistant bacteria isolated from deep terrestrial subsurface (>250 m deep caves) and prehistoric (120,000+ YBP) ice cores Resistant to macrolides, aminoglycosides AND synthetics e.g., quinolones
11 Antibiotic Resistant Bacteria Resistant bacteria isolated from deep terrestrial subsurface (>250 m deep caves) and prehistoric (120,000+ YBP) ice cores Resistant to macrolides, aminoglycosides AND synthetics e.g., quinolones Resistance genes evolved in absence of selective pressure from humans, but why??
12 Antibiotic Resistant Bacteria Resistance genes evolved in absence of selective pressure from humans, but why?? Current hypothesis: competitive advantage
13 Antibiotic Resistant Bacteria Resistance genes evolved in absence of selective pressure from humans, but why?? Current hypothesis: competitive advantage Resistance genes in 2008 in Netherlands = 2-15 more prevalent than 1940* *Knapp et al. (2010) Env Sci Technol, 44:
14 Antibiotic Resistant Bacteria Resistance genes evolved in absence of selective pressure from humans, but why?? Current hypothesis: competitive advantage Resistance genes in 2008 in Netherlands = 2-15 more prevalent than 1940* Environment has a role in emergence and spread *Knapp et al. (2010) Env Sci Technol, 44:
15 Case Study #1: Water Recycling
16 Case Study #1: Water Recycling
17 Environmental Antibiotic Resistance Agricultural and clinical use of antibiotics, up to 75% excreted unaltered or as metabolites
18 Environmental Antibiotic Resistance Agricultural and clinical use of antibiotics, up to 75% excreted unaltered or as metabolites Only the most modern wastewater treatment plants are designed for selective removal of these micropollutants Recycled wastewater Biosolids
19 Environmental Antibiotic Resistance Agricultural and clinical use of antibiotics, up to 75% excreted unaltered or as metabolites Only the most modern wastewater treatment plants are designed for selective removal of these micropollutants Recycled wastewater Biosolids Proposed that this is a key source of resistance to the environment
20 Does Recycled Municipal Wastewater Induce Antibiotic Resistance?
21 Gilbert Riparian Preserve Created in 1986, seven recharge basins receive tertiary-treated recycled water
22 Gilbert Riparian Preserve Created in 1986, seven recharge basins receive tertiary-treated recycled water Control site: agricultural irrigation retention pond
23 Enterococcus spp. Field Sampling over Two Years GI tracts of humans and animals; environmental persistence Great capacity for gene transfer
24 Enterococcus spp. Field Sampling over Two Years GI tracts of humans and animals; environmental persistence Great capacity for gene transfer Emergence of multiple drugresistant strains in clinical settings Ideal bacterial group for investigating the ecology of resistance development
25 High Level Antibiotic Resistance Antimicrobial % Isolates with High-Level Resistance Groundwater Wastewater Tigecycline Erythromycin Tetracycline Ciprofloxacin Chloramphenicol Penicillin Daptomycin Vancomycin Streptomycin Nitrofurantoin Tylosin Tartrate Gentamycin Quinupristin/Dalfopristin Lincomycin Linezolid Kanamycin
26 High Level Antibiotic Resistance Antimicrobial % Isolates with High-Level Resistance Groundwater Wastewater Tigecycline Erythromycin Tetracycline Ciprofloxacin Chloramphenicol Penicillin Daptomycin Vancomycin Streptomycin Nitrofurantoin Tylosin Tartrate Gentamycin Quinupristin/Dalfopristin Lincomycin Linezolid Kanamycin
27 High Level Antibiotic Resistance Antimicrobial % Isolates with High-Level Resistance Groundwater Wastewater Tigecycline Erythromycin Tetracycline Ciprofloxacin Chloramphenicol Penicillin Daptomycin Vancomycin Streptomycin Nitrofurantoin Tylosin Tartrate Gentamycin Quinupristin/Dalfopristin Lincomycin Linezolid Kanamycin
28 High Level Antibiotic Resistance Antimicrobial % Isolates with High-Level Resistance Groundwater Wastewater Tigecycline Erythromycin Tetracycline Ciprofloxacin Chloramphenicol Penicillin Daptomycin Vancomycin Streptomycin Nitrofurantoin Tylosin Tartrate Gentamycin Quinupristin/Dalfopristin Lincomycin Linezolid Kanamycin
29 Multi-Antibiotic Resistance Superbugs 70 Reclaimed Water Recharge Groundwater Recharge Resistant Isolates (%) Zero 1 to 3 4 to 6 7+ Total Number of Antibiotics
30 Multi-Antibiotic Resistance Superbugs 70 Reclaimed Water Recharge Groundwater Recharge Resistant Isolates (%) Zero 1 to 3 4 to 6 7+ Total Number of Antibiotics
31 Multi-Antibiotic Resistance Superbugs 70 Reclaimed Water Recharge Groundwater Recharge Resistant Isolates (%) ? 0 Zero 1 to 3 4 to 6 7+ Total Number of Antibiotics
32 Antibiotic resistance: metabolically expensive What Does This Mean? Recycled Water, Biosolids = Adding Soil Carbon McLain and Williams (2014) Sustainability, 6,
33 Antibiotic resistance: metabolically expensive What Does This Mean? Recycled Water, Biosolids = Adding Soil Carbon Feeding the bacteria for 30+ years did this give less resistant enterococci a competitive advantage? McLain and Williams (2014) Sustainability, 6,
34 Antibiotic resistance: metabolically expensive What Does This Mean? Recycled Water, Biosolids = Adding Soil Carbon Feeding the bacteria for 30+ years did this give less resistant enterococci a competitive advantage? Is this unique to semi-arid soils? McLain and Williams (2014) Sustainability, 6,
35 Antibiotic resistance: metabolically expensive What Does This Mean? Recycled Water, Biosolids = Adding Soil Carbon Feeding the bacteria for 30+ years did this give less resistant enterococci a competitive advantage? Is this unique to semi-arid soils? Environmental complexity not a direct cause/effect McLain and Williams (2014) Sustainability, 6,
36 Pollution via Antibiotic Resistance Genes
37 Pollution via Antibiotic Resistance Genes
38 Pollution via Antibiotic Resistance Genes
39 Antibiotic Resistance Genes and Cell-Free DNA Water Environment Research Foundation Study ( ) by Gerrity, Rock, and McLain
40 Antibiotic Resistance Genes and Cell-Free DNA Water Environment Research Foundation Study ( ) by Gerrity, Rock, and McLain As much as 50% of total DNA was free DNA Quantified intact resistance genes by PCR, qpcr
41 What is KNOWN and What is UNKNOWN about Antibiotic Resistance in Environmental Bacteria? It is ancient studies need control sites
42 What is KNOWN and What is UNKNOWN about Antibiotic Resistance in Environmental Bacteria? It is ancient studies need control sites Human activities are depositing trace levels of antibiotics and resistance genes into the environment
43 What is KNOWN and What is UNKNOWN about Antibiotic Resistance in Environmental Bacteria? It is ancient studies need control sites Human activities are depositing trace levels of antibiotics and resistance genes into the environment Culturing studies do not show cause-and-effect
44 Case Study #2: Antibiotics in Animal Feed USA Growth promotion 34.3 million pounds in 2015 (7.7 million pounds for humans) since 1940s
45 Case Study #2: Antibiotics in Animal Feed USA Growth promotion 34.3 million pounds in 2015 (7.7 million pounds for humans) since 1940s EU began weaning in 1997; judicious use rules in 2006 Appropriate drug Effective drug At right dose Correct length of time
46 Case Study #2: Antibiotics in Animal Feed USA Growth promotion 34.3 million pounds in 2015 (7.7 million pounds for humans) since 1940s EU began weaning in 1997; judicious use rules in 2006 Therapeutic use only growth promotion is illegal
47 Case Study #2: Antibiotics in Animal Feed USA Growth promotion 34.3 million pounds in 2015 (7.7 million pounds for humans) since 1940s EU began weaning in 1997; judicious use rules in 2006 Therapeutic use only growth promotion is illegal USA FDA established rules aligning with EU in 2018 Aimed at controlling antibiotic resistant bacteria moving off farms
48 Case Study #2: Antibiotics in Animal Feed Denmark* 105 metric tons of antibiotics in 1996 for growth promotion; by 2000, nearly nil *DANMAP (2001) Danish Veterinary Laboratory, Copenhagen
49 Case Study #2: Antibiotics in Animal Feed Denmark* 105 metric tons of antibiotics in 1996 for growth promotion; by 2000, nearly nil Diminished resistance to multiple antibiotics in fecal enterococci Diminished resistance genes in feces *DANMAP (2001) Danish Veterinary Laboratory, Copenhagen
50 Case Study #2: Antibiotics in Animal Feed Denmark* 105 metric tons of antibiotics in 1996 for growth promotion; by 2000, nearly nil Diminished resistance to multiple antibiotics in fecal enterococci Diminished resistance genes in feces Vancomycin-resistant E. faecium remained the same *DANMAP (2001) Danish Veterinary Laboratory, Copenhagen
51 Case Study #2: Antibiotics in Animal Feed Denmark* 105 metric tons of antibiotics in 1996 for growth promotion; by 2000, nearly nil Diminished resistance to multiple antibiotics in fecal enterococci Diminished resistance genes in feces Vancomycin-resistant E. faecium remained the same Increase in human Salmonella infection and resistance *DANMAP (2001) Danish Veterinary Laboratory, Copenhagen
52 Case Study #2: Antibiotics in Animal Feed Over the same time period in Denmark, MRSA infections are increasing (EU/USA trend) Possibly related to international travel *DANMAP (2001) Danish Veterinary Laboratory, Copenhagen
53 Case Study #2: Antibiotics in Animal Feed Over the same time period in Denmark, MRSA infections are increasing (EU/USA trend) Possibly related to international travel Increase in enteric infections in pigs; decreased weight gain; increased mortality *DANMAP (2001) Danish Veterinary Laboratory, Copenhagen
54 Case Study #2: Antibiotics in Animal Feed Over the same time period in Denmark, MRSA infections are increasing (EU/USA trend) Possibly related to international travel Increase in enteric infections in pigs; decreased weight gain; increased mortality Increased use of therapeutic antibiotics for food animals (48 tons in 1996; 94 tons in 2001) *DANMAP (2001) Danish Veterinary Laboratory, Copenhagen
55 Changing Practices is it effective? World Health Organization: one of the most critical human health challenges of the next century
56 Changing Practices is it effective? World Health Organization: one of the most critical human health challenges of the next century One Health approach is required to address development and dissemination need communication and collaboration between sectors
57 Changing Practices is it effective? World Health Organization: one of the most critical human health challenges of the next century One Health approach is required to address development and dissemination need communication and collaboration between sectors Accurate assessments of environmental quality impacts and accurate assessments of human health risk increase in importance
58 Questions? Photo Credits
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