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1 Research Responsibility: Budget Institutional Animal Care Program Preparation and Research Compliance Services Development Basic Budget Construction

2 IACP Institution Animal Care Program Supporting Animal Research through the IACUC Institutional Animal Care and Use Committee

3 I A C P Dr. Steve Goddard Associate Vice Chancellor for Research Institutional Official Dr. Kelly Heath Attending Veterinarian and Director Dr. Craig Kreikemeier Clinical Veterinarian Katherine A. Pinkerton Assistant Director Compliance and Training Megan Ebbers IACUC Project Manager

4 Katherine A. Pinkerton Assistant Director Compliance Officer Training Coordinator

5 Institutional Animal Care and Use Committee

6 I A C U C Diversified membership: Chairperson Scientist Veterinarian Non-Scientist Member not affiliated with the Institution Reporting to the IO: Institutional Official

7 IACUC Reviews animal use protocols. Evaluates program of animal care. Investigates allegations of non-compliance. Makes recommendations to the institutional official.

8 IACUC Inspection of Animal Facilities, Laboratories, And Holding Areas.

9 Gudmundsen Sandhills Laboratory Whitman, NE

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11 IACUC Approval Criteria The animal model selected should be for the project based upon anatomical, physiological or other characteristics in consideration of the scientific objectives and the need to obtain valid results. The procedures involving animals should only be those which are necessary in order to achieve the scientific aims of the research and should be conducted in appropriate facilities. The living conditions of the animals must be appropriate for their species and contribute to their health and well being.

12 Animal Use Protocol Key Points to Consider: Appropriate animal species

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14 Animal Use Protocol Key Points to Consider: Appropriate animal species Brief layman s description

15 Pawnee Lake School of Natural Resources

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17 Animal Use Protocol Key Points to Consider: Appropriate animal species Brief layman s description Consider need for approval of Biohazards, Chemical and Radiology hazards

18 Or Snow, Sleet or Ice

19 Animal Use Protocol Key Points to Consider: Appropriate animal species Brief layman s description Consider need for approval of Biohazards, Chemical and Radiology hazards Justify the use of animals

20 Animal Use Protocol Key Points to Consider: Appropriate animal species Brief layman s description Consider need for approval of Biohazards, Chemical and Radiology hazards Justify the use of animals Provide a statistically sound rationale for the number of animals utilized

21

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23 Power Analysis

24 Harm Benefit..

25

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27 Animal Use Protocol Key Points to Consider: Appropriate animal species Brief layman s description Consider need for approval of Biohazards, Chemical and Radiology hazards Justify the use of animals Provide a statistically sound rationale for the number of animals utilized Search various sources, such as MEDLINE, Animal Welfare Information Center, for duplication of research

28 Animal Use Protocol Key Points to Consider: Appropriate animal species Brief layman s description Consider need for approval of Biohazards, Chemical and Radiology hazards Justify the use of animals Provide a statistically sound rationale for the number of animals utilized Search various sources, such as MEDLINE, Animal Welfare Information Center, for duplication of research Provide scientific design

29 Goals.. Theory. Hypothesis..

30 Animal Use Protocol Key Points to Consider: Appropriate animal species Brief layman s description Consider need for approval of Biohazards, Chemical and Radiology hazards Justify the use of animals Provide a statistically sound rationale for the number of animals utilized Search various sources, such as MEDLINE, Animal Welfare Information Center, for duplication of research Provide scientific design Describe samples to be taken, or drugs to be administered to the animal

31 Animal Use Protocol Key Points to Consider: Appropriate animal species Brief layman s description Consider need for approval of Biohazards, Chemical and Radiology hazards Justify the use of animals Provide a statistically sound rationale for the number of animals utilized Search various sources, such as MEDLINE, Animal Welfare Information Center, for duplication of research Provide scientific design Describe samples to be taken, or drugs to be administered to the animal Diet and holding area for the animal

32 Animal Use Protocol Key Points to Consider: Appropriate animal species Brief layman s description Consider need for approval of Biohazards, Chemical and Radiology hazards Justify the use of animals Provide a statistically sound rationale for the number of animals utilized Search various sources, such as MEDLINE, Animal Welfare Information Center, for duplication of research Provide scientific design Describe samples to be taken, or drugs to be administered to the animal Diet and holding area for the animal Full Feed?? Restricted Diet??

33 Animal Use Protocol Key Points to Consider: Appropriate animal species Brief layman s description Consider need for approval of Biohazards, Chemical and Radiology hazards Justify the use of animals Provide a statistically sound rationale for the number of animals utilized Search various sources, such as MEDLINE, Animal Welfare Information Center, for duplication of research Provide scientific design Describe samples to be taken, or drugs to be administered to the animal Diet and holding area for the animal Animal restraint Stress and Pain relief

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35 Animal Use Protocol Key Points to Consider: Appropriate animal species Brief layman s description Consider need for approval of Biohazards, Chemical and Radiology hazards Justify the use of animals Provide a statistically sound rationale for the number of animals utilized Search various sources, such as MEDLINE, Animal Welfare Information Center, for duplication of research Provide scientific design Describe samples to be taken, or drugs to be administered to the animal Diet and holding area for the animal Animal restraint Stress and Pain relief Details of surgical procedures

36 All facilities must have a detail disaster plan in place by July, 2013!

37 Regulatory Oversight: USDA (United States Dept. of Agriculture) PHS (Public Health Service) UNL (University of Nebraska)

38 Animal Welfare Act Public Health Service University of Nebraska Policy and Procedures Manual for the Use of Animals Regulatory Branch: USDA Animal and Plant Health Inspection Service Regulatory Branch: OLAW Office of Laboratory Animal Welfare

39 Animal Welfare Act Public Health Service University of Nebraska Policy and Procedures Manual for the Use of Animals Regulatory Branch: USDA Animal and Plant Health Inspection Service Regulatory Branch: OLAW Office of Laboratory Animal Welfare

40 Animal Welfare Act Regulations Covered Species

41 Animal Welfare Act Regulations

42 IACP: Animal Use Protocol Assistance with experimental design Veterinary consultation and review prior to IACUC submission Provide training. Notification of yearly review and 3 year renewal Updated training certificates and transcripts for current technicians and new staff.

43 IACP: General Regulation Training General overview of regulations working with animals on campus. Offered as a class at least twice a semester, and/or as needed by appointment. Or online at: For all PI s, Grad Students, Undergrad students, or associates. Required for all persons handling animals in research or listed on a protocol.

44 IACP: Species Specific Training Online training available for all animals used in research. Available 24/7. One on one species handling and manipulation training by appointment. Training for ALAT, LAT or LATG available online.

45 One-on-one training by species

46 Development of SOP s and Guidelines

47 qw&sns=fb

48 Questions? Comments? Kathy Pinkerton Assistant Director, IACUC Compliance and Training Coordinator Mussehl Hall East Campus

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