IACUC Updates from the Office of Research
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1 IACUC Updates from the Office of Research Christopher Keane, Vice President for Research Phyllis Erdman, IACUC Chair Nina Woodford, Attending Veterinarian, OCV Mike Kluzik, Director, ORA
2 Meeting Agenda 1. Presentation Introduction (C. Keane) Role of the IACUC (P. Erdman) Training & communication (P. Erdman) Policy updates (N. Woodford) Conclusion (C. Keane) 2. Question & answer period
3 Ethics and compliance are essential elements of a safe and successful research enterprise
4 Office of Research Organization Chart Vice President for Research Dr. Christopher J. Keane Institutional Animal Care and Use Committee Institutional Review Board Institutional Biosafety Committee Radiation Safety Committee Assistant to VP Sandy Watson Director Administrative Services Mary Frei Communications E. Sorensen Grand Challenge Points of Contact Research Misconduct, Fiscal/Admin Lisa Brown-Haas, Alicia Foth Alternative Energy Research Advancement and Partnerships Research Support and Operations Research Assurances Campus Veterinarian Centers, Institutes, and Labs - Research/ Instrumentation Cores Economic Development R. Cavalieri G. Dutta D. Nordquist M. Kluzik N. Woodford A Lazarus A. Fatland
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7 WSU IACUC - Membership Chair Associate or full professor at WSU Membership (minimum no less than 5) One practicing scientist with experience in research involving animals One DVM training/experience in lab animal medicine with appropriate university-wide authority (Office of Campus Veterinarian or designee) One member not affiliated with WSU One member with expertise in non-scientific area One faculty/staff/ap from WSU with experience in care & use of animals in instruction or research. Note: no more than 3 members from same dept. at any given time
8 IACUC Chairperson Community member (non- Affiliated) Practicing Scientist Ethics Expert, Non-Scientist Voting Members & Alternates Campus Veterinarian
9 IACUC Responsibilities Responsible for the assessment and oversight of the animal care and use program Protocol reviews On-site facility inspections Program review includes Training Occupation safety Policies and procedures Resources Animal concerns & compliance
10 ORA, OCV & IACUC provide support to the research community 1. Communication 2. Enhancements in service
11 Communication Websites in revision IACUC OCV Training Mandated surgical training Refresher Training Review of regulations and roles Common compliance issues Updates on new regulations and IACUC policies Post Approval Review
12 Enhancements in Service Increase staffing at OCV & ORA Animal subjects approval form External review Reporting concerns about animals Policy revisions WSU IACUC Policy #24 WSU IACUC Policy #27
13 Reporting Concerns about Animals IACUC office: or IACUC chair: or OCV: or or
14 WSU IACUC Policy #24 in Revision Amendment Policy 3 methods for handling amendments 1. Classic handling: Full committee review (FCR) or designated member review (DMR) by IACUC 2. Minor administrative changes by the IACUC coordinator 3. Veterinary verification and consultation (VVC) by IACUC-designated veterinarian.
15 WSU IACUC Policy #24 in Revision Veterinary verification and consultation IACUC- designated veterinarian Change in anesthesia, analgesia, sedation or experimental substances Change in euthanasia method if approved in the AVMA Guidelines for the Euthanasia of Animals Changes in the duration, frequency, type, or number of procedures performed (if procedure is already approved on the existing protocol)
16 WSU IACUC Policy #24 in Revision Amendment Policy Advantages to Policy #24 Permits researchers to immediately apply some significant changes Reduces the risk of compromising an ongoing research activity. Reduces regulatory burden
17 WSU IACUC Policy #27: PROCEDURE FOR ADDRESSING NON-COMPLIANCE WITH IACUC POLICIES OR PROCEDURES NOT NEW - Recently revised Defines review process Provides examples of non-compliance Examples originate from OLAW and AWA regulations
18 Examples of Animal-Related Compliance Deviations Procedures conducted without IACUC approval Drugs administered without IACUC approval Procedures conducted by unapproved personnel without direct supervision Failure to maintain surgical or medical records Failure to monitor animals as necessary to insure well-being Failure to carry out veterinary orders Failure to correct deficiencies identified during a semiannual inspection in a timely manner Failure to report adverse events/unexpected outcomes to OCV and the IACUC OD html
19 WSU IACUC Policy #27: Process Reported suspect non-compliance Preliminary inquiry Subcommittee review No non-compliance No non-compliance Non-compliance identified Welfare plan Report to IACUC Letter to PI, Dept, VPR Corrective actions Report to funding agency
20 Conclusion Compliance is a team effort PI Research personnel & students Animal care community ORA IACUC OCV Other: OR, IBC, IRB,
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