2016 UAH Antibiograms

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1 2016 UAH Atibiograms Uiversity of Alberta Hospital Cross Cacer Istitute Stollery Childre s Hospital Departmet of Laboratory Medicie ad Pathology

2 Itroductio The atibiograms preseted herei represet cumulative aual atimicrobial susceptibility rates of the most commo microbial pathoges isolated from cliical specimes submitted to the Uiversity of Alberta Hospital (UAH) Cliical Microbiology Laboratory. This report represets the 2016 local susceptibility rates at the Uiversity of Alberta Hospital, Stollery Childre s Hospital, ad the Cross Cacer Istitute, ad is to be used as a resource to direct empiric atimicrobial therapy. Atibiograms are geerated by compilig susceptibility results from all first cliical isolates of a specific pathoge recovered from a idividual patiet per caledar year. That is, oly the first isolate, regardless of specime type or body site, is selected for aalysis. Susceptibility rates for orgaisms represeted by less tha 30 isolates are ot icluded due to the limited statistical sigificace. The susceptibility testig methods used by the UAH Cliical Microbiology Laboratory iclude VITEK-2, gradiet diffusio, microbroth dilutio ad disk diffusio. Iterpretatio of susceptibility testig results is based o Cliical ad Laboratory Stadards Istitute (CLSI) guidelies. The data preseted herei is also available at the followig website: We would like to ackowledge the effort of the etire cliical microbiology techologist staff i geeratig the data cotaied i this documet. We would also like to ackowledge Dr. Darre Hudso, UAH, for his assistace with sythesizig atibiogram data. Iquiries may be directed to Dr. Tais Digle, ProvLab, at tais.digle@albertahealthservices.ca.

3 2016 ADULT CUMULATIVE GRAM-NEGATIVE ISOLATES (PERCENT SUSCEPTIBLE ISOLATES) β-lactams Cephalosporis Amioglycosides Other Mechaisms of Actio ADULT GRAM-NEGATIVE ( 17 years old) Amoxicilli/ Clavulaate Piperacilli/ tazobactam Ertapeem Meropeem Acietobacter baumaii Imipeem Cephalexi a Cefixime Ceftazidime Ceftriaxoe Amikaci Getamici Tobramyci Ciprofloxaci Doxycyclie Nitrofuratoi a Citrobacter freudii Eterobacter aerogees Eterobacter cloacae Escherichia coli (ALL) Escherichia coli (ESBL oly) Klebsiella peumoiae (ALL) Klebsiella peumoiae (ESBL oly) Morgaella morgaii Proteus mirabilis Pseudomoas aerugiosa (CF) b Pseudomoas aerugiosa (o-cf) b Serratia marcesces Steotrophomoas maltophilia c 98 a Uriary tract isolates oly. b Represets activity of piperacilli oly. c Usig miocyclie breakpoits.

4 2016 ADULT CUMULATIVE GRAM-POSITIVE ISOLATES (PERCENT SUSCEPTIBLE OF INITIAL ISOLATES) β-lactams Other Mechaisms of Actio Amioglycosides ADULT GRAM-POSITIVE ( 17 years old) Staphylococcus aureus MRSA Staphylococcus aureus MSSA Coagulase-egative Staphylococcus species Amoxicilli Peicilli Ceftriaxoe Cloxacilli a Clidamyci Erythromyci Levofloxaci Nitrofuratoi b Staphylococcus lugduesis Vacomyci Liezolid Getamici c Streptomyci c Eterococcus faecalis Eterococcus faecium Viridas group streptococci Streptococcus agiosus group Streptococcus pyogees Streptococcus peumoiae (meigitis BPs) d Streptococcus peumoiae (o-meigitis BPs) d a Cephalospori (e.g., cefazoli) activity iferred by activity of cloxacilli for Staphylococcus spp. b Uriary tract isolates oly. c Used for syergistic purposes oly. d Breakpoits (BPs) are defied differetly for CSF ad o-csf isolates. Numbers do ot reflect meigitis rates.

5 2016 PEDIATRIC CUMULATIVE GRAM-NEGATIVE ISOLATES (PERCENT SUSCEPTIBLE ISOLATES) β-lactams Cephalosporis Amioglycosides Other Mechaisms of Actio PEDIATRIC GRAM-NEGATIVE (<17 years old) Amoxicilli/ Clavulaate Piperacilli/ tazobactam Ertapeem Meropeem Imipeem Eterobacter cloacae Escherichia coli Klebsiella peumoiae Proteus mirabilis Pseudomoas aerugiosa (CF) b Pseudomoas aerugiosa (o-cf) b Steotrophomoas maltophilia c 100 Cephalexi a Cefixime Ceftazidime Ceftriaxoe Amikaci Getamici Tobramyci Ciprofloxaci Doxycyclie Nitrofuratoi a a Uriary tract isolates oly. b Represets activity of piperacilli oly. c Usig miocyclie breakpoits.

6 β-lactams Other Mechaisms of Actio Amioglycosides 2016 PEDIATRIC CUMULATIVE GRAM-POSITIVE ISOLATES (PERCENT SUSCEPTIBLE OF INITIAL ISOLATES) PEDIATRIC GRAM-POSITIVE (<17 years old) Staphylococcus aureus MRSA Staphylococcus aureus MSSA Coagulase-egative Staphylococcus species Amoxicilli Peicilli Ceftriaxoe Cloxacilli a Clidamyci Erythromyci Levofloxaci Nitrofuratoi b Vacomyci Liezolid Getamici c Streptomyci c Eterococcus faecalis Streptococcus peumoiae (meigitis BPs) d Streptococcus peumoiae (o-meigitis BPs) d a Cephalospori (e.g., cefazoli) activity iferred by activity of cloxacilli for Staphylococcus spp. b Uriary tract isolates oly. c Used for syergistic purposes oly. d Breakpoits (BPs) are defied differetly for CSF ad o-csf isolates. Numbers do ot reflect meigitis rates.

7 2016 GSICU CUMULATIVE GRAM-NEGATIVE ad GRAM POSITIVE ISOLATES (PERCENT SUSCEPTIBLE ISOLATES) β-lactams Cephalosporis Amioglycosides Other Mechaisms of Actio GSICU GRAM-NEGATIVE a Uriary tract isolates oly. b Represets activity of piperacilli oly. Amoxicilli/ Clavulaate Piperacilli/ tazobactam Ertapeem Meropeem Escherichia coli Klebsiella peumoiae Pseudomoas aerugiosa (o-cf) b Imipeem Cephalexi a Cefixime Ceftazidime Ceftriaxoe Amikaci a Getamici Tobramyci Ciprofloxaci Nitrofuratoi a β-lactams Other Mechaisms of Actio Amioglycosides GSICU GRAM-POSITIVE Cloxacilli a Clidamyci Erythromyci Levofloxaci Nitrofuratoi b Vacomyci Liezolid Getamici c Streptomyci c Staphylococcus aureus Eterococcus faecalis a Cephalospori (e.g., cefazoli) activity iferred by activity of cloxacilli for Staphylococcus spp. b Uriary tract isolates oly. c Used for syergistic purposes oly.

8 2016 CROSS CANCER INSTITUTE CUMULATIVE GRAM-NEGATIVE ad GRAM POSITIVE ISOLATES (PERCENT SUSCEPTIBLE ISOLATES) β-lactams Cephalosporis Amioglycosides Other Mechaisms of Actio CROSS CANCER INSTITUTE GRAM-NEGATIVE a Uriary tract isolates oly Amoxicilli/ Clavulaate Piperacilli/ tazobactam Ertapeem Meropeem Escherichia coli Klebsiella peumoiae Imipeem Cephalexi a Cefixime Ceftazidime Ceftriaxoe Amikaci Getamici Tobramyci Ciprofloxaci Nitrofuratoi a β-lactams Other Mechaisms of Actio Amioglycosides CROSS CANCER INSTITUTE GRAM-POSITIVE Cloxacilli a Clidamyci Erythromyci Levofloxaci Nitrofuratoi b Vacomyci Liezolid Getamici c Streptomyci c Staphylococcus aureus Eterococcus faecalis a Cephalospori (e.g., cefazoli) activity iferred by activity of cloxacilli for Staphylococcus spp. b Uriary tract isolates oly c Used for syergistic purposes oly

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