Ruminant Product Profiles

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1 Ruminant Product Profiles Abacare LV Aerotet Forte Intracillin 1000 Milking Cow HeadStart & HeadStart Gold Oxyfoam Forte PenClox 1200 HPMC Amphoprim Bolus Intracillin 300 Injection Phenax Classic Amphoprim Injection Intracillin LA Diarrest & Revive Bovipen Lepto 2-Way & Lepto 3-Way SMARTShot B 12 + Se Campylovexin Masticillin RTU Injection SMARTShot B 12 Prime Lamb Cefaguard RTU Injection Metri-Clean Tetraguard LA Combat Nitromec Injection Multimin + Cu TopLine Copperguard Neoprinil Pour On Tyloguard RTU Injection Duocare LV + Se Nitroclox LA Vibrostrep FlukeCare + Se Ovastim Flumenil Pour On Ovipen

2 Abacare LV For the treatment and control of Abamectin sensitive strains of internal parasites (including benzimidazole, levamisole and morantel resistant strains) of sheep and lambs. Low Volume Broad Spectrum Mixing with Duocare LV + Se provides a triple combination drench INDICATIONS: DuoCare LV + Se contains Levamisole, a member of the imidazothiazole ( clear ) family of chemicals and Fenbendazole, a member of the benzimidazole ( white ) family of chemicals. It is effective against sensitive and single-resistant mature and immature strains of the roundworms listed below: Haemonchus contortus - Barber s pole worm, Teladorsagia [Ostertagia] spp - Small brown stomach worm, Trichostrongylus spp - Black scour worm (including moderately macrocyclic lactone resistant strains), Cooperia spp - Small intestinal worm, Nematodirus spp - Thin necked intestinal worm, Strongyloides papillosus - Intestinal threadworm, Bunostomum spp - Hookworm, Oesphagostomum spp - Nodule worm, Chabertia ovina - Large mouthed bowel worm, Dictyocaulus filarial - Large lungworm, It will aid in the control of Moniezia spp - Tapeworm. COMBINED USE: Combined use of drench actives may improve efficacy and slow the development of resistance. AbaCare LV can be combined in equal volumes with DuoCare LV + Se (A10301) to produce a stable mixture for oral dosing of sheep and lambs. The mixture contains 1.0g/L Abamectin and 40g/L Levamisole HCI, 25g/L Fenbendazole & 0.5g/L Selenium. This combined solution must be well mixed before use and dosed at a rate of 1mL/5kg bodyweight. The mixture remains stable for up to 3 months if stored as per label conditions. DOSAGE: 1mL per 10kg bodyweight. Liveweight (kg) Dose Volume (ml) Sheep Treated per 10L Animals in excess of 80kg to be dosed at 1mL per 10kg. PACK SIZE: 10L. CONTRAINDICATIONS: Do not use in lambs under six (6) weeks of age or less than 15 kg bodyweight. MEAT: Within 21 days of the last treatment. MILK: Not less than 35 days following the last treatment. 1

3 Aerotet Forte Aerotet Forte An aerosol for the treatment of topical superficial infections of the skin and open wounds due to tetracycline sensitive organisms, and to aid in the treatment of foot and hoof infections in cows and horses. Containing gentian violet. Broad spectrum antibacterial spray Marks treated areas Nil withholding Propylene Glycol for emollient effect ACTION: Oxytetracycline is a broad-spectrum antibacterial, specifically inhibiting protein synthesis in susceptible organisms. A very broad anti-infective action is obtained due to the additive effect of all ingredients - oxytetracycline, gentian violet, propylene glycol and isopropyl alcohol. The high proportion of propylene glycol in the base gives an emollient effect. Gentian violet is an astringent antiseptic healing aid, and also offers obvious marking of treated areas. PRECAUTIONS: Keep out of reach of children. Not to be taken or administered orally. Do not inhale vapour; use in a well-ventilated area. Do not apply to eyes or other mucous membranes. Contents under pressure. Do not puncture or incinerate. Keep away from naked flames. DESCRIPTION: An aerosol can of 200g, delivering 4.4% OXYTETRACYCLINE HCl and 0.4% GENTIAN VIOLET in an emollient solution for external application, with hydrocarbon as the propellant. WITHOLDING PERIODS: NIL DOSAGE: Clean the area of any discharges or debris prior to application. For foot infection, trim the hoof to expose infection. Shake can well. Holding the can 10-15cm from the affected area, spray a 1-2 second burst, or more as required. Keep the area dry following application. Repeat the administration every 12 hours or as required. Registered pursuant to the ACVM Act 1997, No A6115. See for registration conditions. Only available under Veterinary Authorisation. 2

4 Amphoprim Bolus Amphoprim Bolus Sulphamethoxypyridazine & Trimethoprim for the treatment of a wide range of primary and secondary bacterial infections. Broad spectrum Sulphonamide antibiotic tablet Once a day administration Effective blood levels for up to 24 hours Oral or intrauterine administration INDICATIONS: Amphoprim Bolus is indicated in the treatment of a wide range of primary and secondary bacterial infections due to Gram positive and Gram negative organisms. These include: (a) respiratory bacterial infections especially pneumonia and bronchitis; (b) urogenital infections - pyometra, metritis, vaginitis, nephritis; (c) gastro-intestinal infections including those caused by Salmonella spp, and E. coli pathogenic strains; (d) local and generalised infections e.g. wound infections, joint infections, septicaemias etc The sulphamethoxpyridazine - trimethoprim combination synergises to inhibit bacterial cell metabolism, by blocking 2 sequential steps of the enzymatic pathway leading to the synthesis of bacterial folic acid. The effect is bactericidal in susceptible organisms, including Gram positive and Gram negative bacteria. Sulphamethoxypyridazine and trimethoprim are readily absorbed from the gastrointestinal tract and give effective blood levels for up to 24 hours DESCRIPTION: An antibacterial tablet, containing the active ingredients 1g SULPHAMETHOXYPYRIDAZINE and 200mg TRIMETHOPRIM. White scored tablets, for oral or intrauterine administration, available in packs of 20. CONTRAINDICATIONS: Amphoprim bolus is contraindicated in cases of renal or hepatic insufficiency, and should not be used in animals with known sulphonamide sensitivity. DO NOT USE IN BOBBY CALVES. WITHOLDING PERIODS: MEAT: 21 days. MILK: 5 days. DOSAGE & ADMINISTRATION: Oral Administration: Given orally whole, or dissolved in water. Cattle, calves, horses, foals, sheep and goats. Standard oral dose is one bolus per 50kg bodyweight, once daily for 3-5 days. Calves: in cases of severe bacterial diarrhoea or pneumonia, the dose rate should be increased to 2 Boluses per 50kg bodyweight daily for 3-5 days. Intrauterine Application: For metritis in cows and mares, place one bolus into the uterus. Repeat in hours if required. Ensure adequate drinking water is available during treatment. Registered pursuant to the ACVM Act 1997, No. A See for registration conditions. Only available under Veterinary Authorisation. 3

5 Amphoprim Injection Amphoprim Injection Contains 4g Trimethoprim & 20g Sulphadimethyl Pyrimidine. For use in horses, cattle, pigs, sheep, dogs and cats for the treatment of diseases of the: Respiratory tract, Digestive tract, Urogenital tract, Local and generalised infections. Broad spectrum Sulphonamide antibiotic injection By Subcutaneous, intramuscular or intravenous injection Water based Milk withholding 48 hours INDICATIONS: For use in horses, cattle, pigs, sheep, goats, dogs and cats for the treatment of diseases of the: Respiratory tract; pneumonia, bronchitis, Digestive tract; gastritis, enteritis, gastroenteritis, traumatic reticulitis, Urogenital tract; pyometra, metritis, vaginitis, nephritis, Local and generalised infections; mastitis, foot infections, wound infections, septicaemias. Up to 80% of Staphylococcus intermedius isolates have been shown to be susceptible to sulphadimethyl pyrimidine/ trimethoprim. High percentages of sensitivity are also found in infections with Proteus mirabilis, Bacillus anthracis, Hemophilus influenza, Pasteurella spp, Salmonella spp., Escherichia coli., Staphylococcus spp. and Streptococcus spp. Leptospira, Pseudomonas, Erysipelothrix and M. tuberculosis organisms are NOT sensitive to sulpha-trimethoprim. Amphoprim offers a cost-effective option for those conditions where susceptible infection is present. The Sulphadimethyl pyrimidine - trimethoprim combination acts synergistically to inhibit bacterial cell metabolism by blocking two sequential steps of the enzymatic pathway leading to the synthesis of bacterial folic acid. The effect is bactericidal in susceptible organisms, including Grampositive and Gram-negative bacteria. There are advantages having a water based injectable: ease of injection, less risk of intravascular heamolysis or extravascular necrosis, neutral ph and faster bioavailability. DESCRIPTION: A sterile, water based, pale yellow, solution for injection containing the active ingredients SULPHADIMETHYL PYRIMIDINE 200 mg/ml and TRIMETHOPRIM 40 mg/ml. Available in 100 ml glass multi-dose bottles. CONTRAINDICATIONS: Do not administer to animals with known sulphonamide sensitivity. MEAT: 5 days. MILK: 2 days. HORSES: 63 days. DOSAGE & ADMINISTRATION: General: 1 ml/15 kg bodyweight daily by subcutaneous, intramuscular or intravenous injection for 3-5 days. For i.m or s.c injections over 5 ml administer in 2 or more sites. Note: the recommended dose should not be exceeded in the horse. Give in the anterior half of the neck in food producing animals. Registered pursuant to the ACVM Act 1997, No A4730. See for registration conditions. Only available under Veterinary Authorisation. 4

6 Bovipen A sterile, aqueous suspension of 300,000i.u./mL procaine penicillin G. Manufactured in New Zealand and available in durable 200 ml plastic pillow packs. Cattle species-specific injectable penicillin Convenient Plastic Pillow pack Needles & syringe supplied Procaine penicillin is a moderately soluble drug that provides a therapeutic effect from a single injection for the 24 hours before the next injection is to be given. Penicillin inhibits cell wall synthesis in susceptible bacteria. INDICATION: First-line treatment for unspecified infections and treatment of known and common infections caused by penicillinsensitive Gram+ve organisms, (eg. clostridial infections) in cattle. DOSAGE & ADMINISTRATION: Administer 16mL of Bovipen /400kg b.w. in the anterior half of the neck (close to the head), by i/m or s/c injection. When used prophylactically (in the absence of clinical symptoms), administer the dose once only by i/m or s/c injection. Where a clinical infection is being treated, administer the dose daily for 3 days. MILK: Milk intended for human consumption must be discarded during treatment and for the following times after the last treatment: one dose 48 hours (4 milkings); two doses 60 hours (5 milkings); three or more doses 72 hours (6 milkings). MEAT: 10 days. CONTRAINDICATIONS: Not for use in bobby calves. Not to be used in animals with a known history of sensitivity to products containing penicillin or its analogues. Not to be used for the treatment of infections caused by organisms known to be resistant to penicillin. SPECIAL PRECAUTIONS: Penicillins may cause hypersensitivity (allergy) following injection, ingestion or skin contact. Do not handle this product if you know you are sensitised to, or if you have been advised not to work with, such preparations. Handle this product with great care to avoid exposure, taking all recommended precautions. OTHER INFORMATION: Protect from direct sunlight. Store below 18 C. Product may be refrigerated. Do not freeze. Shake well before use. Keep out of reach of children. Restricted Veterinary Medicine. Available only under veterinary authorisation. Registered pursuant to the ACVM Act 1997, No. A7186. Registered to: Stockguard Laboratories (NZ) Ltd, Maui St, Pukete Park, Hamilton, New Zealand. Distributed by: Virbac New Zealand, Maui St, Pukete Park, Hamilton, New Zealand. 5

7 Campylovexin Provides protection against all the strains of Campylobacter in New Zealand. Stimulates immunity to C. fetus fetus thus protecting sheep against Campylobacter abortion. The only Campylobacter vaccine with proven efficacy against all known New Zealand strains of C. fetus fetus. Proven in the field for 30 years Proven to reduce abortion rates Shown to improve tailing % by 9.3% CAMPYLOVEXIN PROTECTS AGAINST ALL 26 NEW ZEALAND STRAINS OF CAMPYLOBACTER FETUS FETUS: Campylovexin is the only vaccine proven to protect against all 26 strains of Campylobacter fetus fetus so far identified in New Zealand. Its effectiveness has been conclusively proven in a three year PhD research investigation and in thirty years of successful use on New Zealand farms. Tens of millions of sheep and thousands of farmers bear testament to how well Campylovexin protects against one of the major causes of reduced lambing performance. DOSAGE & ADMINISTRATION: Administer by subcutaneous injection only. Inject 2mL in the anterior half of the neck. EWES: In the first year give a sensitiser and booster dose 4-8 weeks apart. Both vaccinations should be given prior to mating. In following years an annual booster should be administered prior to mating. NEW STOCK being introduced to the breeding flock: Give 2 vaccinations 4-8 weeks apart, prior to mating. Number of ewes Campylovexin investment Extra Lambs At $50 At $60 At $80 At $ $ $4650 $5580 $7440 $ $ $9300 $11160 $14880 $ $ $13950 $16740 $22320 $ $ $18600 $22320 $29760 $ $ $23250 $27900 $37200 $46500 Return on investment 627% 772% 1063% 1353% DESCRIPTION: Inactivated vaccine of ovine Campylobacter fetus fetus. Packs of 250mL and 500mL. Stimulates production of antibodies against C. fetus fetus. INDICATIONS: For use where there is risk of abortion due to C. fetus fetus. Protects against C. fetus fetus abortions in sheep and consequently can contribute toward improving lambing performance. SIDE EFFECTS: A slight reaction may occur at the site of injection but will normally disappear in a few weeks. Occasionally, for up to a week after vaccination, some ewes may develop symptoms ranging from mild loss of appetite through to ataxia, recumbency and death. Affected ewes may respond to treatment with metabolic solutions containing calcium and magnesium but hypomagnesaemia is not necessarily the primary cause. CONTRAINDICATIONS: Do not use within 1 week of start of mating (see side effects). WITHHOLDING PERIOD: Meat and Milk: NIL Registered pursuant to the ACVM Act 1997 No. A4130. See for registration conditions. Only available under Veterinary Authorisation. Continued over page... 6

8 Vaccination against Campylobacter disease improves productivity. Ten years worth of scanning information involving more than 600 sets of flock data has thrown new light on the path to better productivity. It highlighted a range of management practices (e.g. shearing dates, grazing policy) that impact on both conception rates and tailing percentages. One key factor in lambing performance identified in the analysis is vaccination against Campylobacter disease with Campylovexin. Analysis of the scanning data showed that vaccinated flocks enjoyed significantly better protection against losses caused by Campylobacter disease than unvaccinated flocks on the same property. Campylobacter disease is a major cause of lambing losses. These can manifest themselves as abortion storms or more isolated and hard-to-detect abortions. Analysis of the scanning data has shown a positive response to vaccination, even on properties where Campylobacter has never been diagnosed. Cost Benefit Analysis of using Campylovexin. Animals are vaccinated to: a. Prevent abortions to protect ewes against contracting campylobacter disease, and aborting their foetuses. Abortions mainly occur after the third month of pregnancy. b. To prevent infected ewes spreading the disease to other ewes. An aborting ewe rarely shows a systemic effect, however, C. fetus fetus may persist in the uterine discharge for up to 6 weeks. c. To prevent reduced fertility recent evidence based on response to vaccination suggests C. f fetus is also a cause of reduced fertility. Profitability Abortions on farm are a production loss as is reduced fertility, even low levels can have a significant impact on the farm business profitability. Campylobacter leads to significant losses in productivity. It is one of the leading causes of ewe abortions, and it produces weakened lambs that are much more likely to not survive. These losses are preventable. Vaccination with Campylovexin as part of your clients lambing performance programmes will protect against abortions, increase lamb viability and significantly improve productivity for your clients. Analysis of nine years of largescale scanning data demonstrates the benefits of vaccinating with Campylovexin. Camplyovexin provides maximum protection for the flock achieving maximum productivity. New Zealand produced Campylobacter vaccine protects against lamb losses. Vaccinating against Campylobacter disease protects unborn lambs from the infectious bacteria that invade the placenta and foetus. By protecting these lambs and helping prevent abortion losses, your tailing percentages can be significantly improved. Even if campylobacter has not been diagnosed on your farm, the disease may well be present. Preventative vaccination could help eliminate a hardto-detect but important cause of lamb losses. Campylobacter jejuni is commonly isolated from the faeces of normal healthy domestic animals, poultry, pigs, cattle, sheep and wild birds. As examples, Meanger and Marshall 2 found up to a third of cows sampled in a NZ study were intestinal carriers. Adhikari et al 3 found C. jejuni in the faeces of 54% of dairy cows, 40% of urban sparrows, 11% of rodents and 9% of flies. Furthermore, it is often reported as a contaminant of sheep and cattle carcasses at meat plants and in unpasteurised milk. The role of C. jejuni as a primary pathogen is uncertain. It has been isolated from scouring cattle and sheep. It is considered as a minor cause of abortion in sheep in New Zealand. It is not considered a cause of infertility. Most animals have antibodies against this organism from natural exposure to this ubiquitous organism. Data from Gribbles Veterinary Pathology shows that the majority of campylobacter cases are due to C. fetus fetus not C. jejuni. farms were C. fetus fetus and 4 (5%) isolates from 3 (11%) of farms were C. jejuni6. 3. A detailed study 1,7 of 320 NZ wide sheep abortion campylobacter isolates from 221 farms in 2000 showed that 92% of isolates from 90% of farms were C. fetus fetus and 10% from 8% of farms were C.jejuni. C. coli was isolated once. Regionally there was considerable variation, however given the small number of isolates in some regions this data must be interpreted with caution. In summary, the great majority of campylobacter abortions in sheep are caused by C. fetus fetus. C.jejuni is isolated in a minor number of sheep abortions that appear to be regional in nature. 20 Data from Gribbles Veterinary Pathology shows that the majority of campylobacter cases as a % of total submissions in both 2004 (11.2 vs. 1.1%) and 2005 (14.5 vs. 1.8%) were due to C. fetus fetus not C. jejuni. 1. A report on sheep abortion diagnoses in South Otago for 1999 shows 17.2% of all cases due to C. fetus fetus and 3.1% due to C. jejuni A study of 85 campylobacter sheep abortion isolates in 1999 from 28 Hawkes Bay farms showed 81 (95%) isolates from 25 (89%) % of cases Total 2004 Total 2005 C. fetus fetus C. jejuni 1. Grogono-Thomas et al (2003) Role of S-layer protein antigenic diversity in the immune responses of sheep experimentally challenged with C.fetus susp. fetus. Infection and immunity 71, Meanger JD and Marshall RB (1989) Seasonal prevalence of thermophillic campylobacter infections in dairy cattle and a study of infection in sheep. NZVJ 37 p Adhikari B.et al (2203) Prevalence and clonal diversity of C. jejuni from dairy farms and urban sources. NZVJ 52 (6) p AgVax Developments Ltd. Media material Proc 30th An. Sem., Soc. of S & B C Vets, NZVA p Smart JA (2000) Latest experiences of Salmonella Brandenburg. Proc 30th An. Sem.,Soc. of S & B C Vets NZVA p Mannering SA, et al (2003) Pulsed-field gel electrophoresis typing of Campylobacter fetus fetus sheep abortions in the Hawkes Bay region of New Zealand. NZVJ 51(1) p Mannering SA, et al (2004) Pulsed-field gel electrophoresis typing of Campylobacter fetus fetus isolated from sheep abortions in NZ. NZVJ 52 (6), p

9 Cefaguard TM RTU Injection A sterile suspension containing 50mg/mL Ceftiofur, as the hydrochloride. Available in packs containing 4 ready to use 30mL vials, 4 syringes and 4 needles. Nil milk withholding 34 x 30mL plastic bottles vials - one - one bottle, bottle, one one cow cow Subcutaneous or Intramuscular injection Ceftiofur is a broad-spectrum, third generation cephalosporin antibiotic, active against both Gram+ve and Gram-ve bacteria. It interferes with cell wall synthesis and is resistant to betalactamases. PIGS: Treatment of swine bacterial respiratory disease associated with Haemophilus pleuropneumoniae, Pasteurella multocida, Salmonella choleraesuis and Streptococcus suis type 2. INDICATION: CATTLE: Treatment of bovine footrot, acute metritis and respiratory disease (BRD) associated with Pasteurella haemolytica, P. multocida and Haemophilus somnus; footrot associated with Fusobacterium necrophorum and Bacteroides melaninogenicus; and acute metritis (0 14 days post partum) associated with bacteria susceptible to ceftiofur. DOSAGE & ADMINISTRATION: Shake the vial vigorously until the deposit has been evenly re-suspended. Administer by i/m or s/c injection into the anterior half of the neck. Inject no more than 10mL/injection site. CATTLE: For BRD and footrot, 1mg/kg (2mL/100kg b.w) daily for 3 days. Repeat on days 4 and 5, if required. For acute post partum metritis, 2.2mg/kg (4.4mL/100kg b.w) daily for 5 days. PIGS: 3mg/kg (3mL/50kg b.w) daily for 3 days. MILK: Nil. MEAT: 2 days. SIDE EFFECTS: Muscle discolouration may be observed around the injection site for up to 11 days. CONTRAINDICATIONS: Not for use in bobby calves. Do not use in animals with a known hypersensitivity to cephalosporins or other beta-lactam antibiotics such as penicillin. SPECIAL PRECAUTIONS: Beta-lactam antibiotics may cause hypersensitivity (allergy) following injection, ingestion or skin contact. Do not handle this product if you know you are sensitised to, or if you have been advised not to work with, such preparations. Handle this product with great care to avoid exposure, taking all recommended precautions. OTHER INFORMATION: Store below 25 C. Do not freeze. Protect from sunlight. Contents should be used within 42 days after the first dose is removed. Restricted Veterinary Medicine. Available only under veterinary authorisation. Registered pursuant to the ACVM Act 1997, No. A9978. Registered to: Stockguard Laboratories (NZ) Ltd, Maui St, Pukete Park, Hamilton, New Zealand. Distributed by: Virbac New Zealand, Maui St, Pukete Park, Hamilton, New Zealand. 8

10 Copperguard A sterile suspension of calcium copper edetate containing 50mg/mL of copper. Available in 200mL pillow packs. Calcium Copper edetate Nil milk withholding Easy syringeability, plastic pillow pack After injection, the copper in this product is absorbed from the injection site and transported to the liver where it is stored until required during times of inadequate copper intake. It is then slowly released into the blood to maintain adequate serum copper levels. INDICATION: Prevention and treatment of copper deficiency in cattle, sheep and deer. DOSAGE & ADMINISTRATION: Shake thoroughly before use to ensure a uniform suspension. By s/c injection only. Administer in the anterior half of the neck. In cattle, sheep and deer, the dose may be repeated every 4 months. CATTLE over 4 months of age: 2mL. Dose may be increased up to a maximum of 4mL if severe copper deficiency has been confirmed by clinical symptoms or liver biopsy. ADULT SHEEP: 1mL. DEER: 1mL/50kg b.w. MILK: Nil MEAT: Nil CONTRAINDICATIONS: Excessive copper is toxic. Only use this product if copper deficiency has been diagnosed. Do not use in conjunction with other forms of copper supplementation. Do not administer at the same time as any other treatment, eg. drenches or vaccines. Do not use in animals with impaired liver function. Do not use in cattle under 4 months of age, as young animals are more susceptible to copper toxicity. SIDE EFFECTS: Localised tissue reaction may occur at the injection site, especially in young deer. HUMAN FIRST AID, SYMPTOMS OF POISONING: Accidental self-inoculation of copper may cause serious tissue damage. Seek urgent medical advice. OTHER INFORMATION: Store below 30 C, out of direct sunlight. Restricted Veterinary Medicine. Available only under veterinary authorisation. Registered pursuant to the ACVM Act 1997, No. A Registered to: Stockguard Laboratories (NZ) Ltd, Maui St, Pukete Park, Hamilton, New Zealand. Distributed by: Virbac New Zealand, Maui St, Pukete Park, Hamilton, New Zealand. SPECIAL PRECAUTIONS: Only treat animals in good health. Minimise stress to the animals during administration. 9

11 Duocare LV + Se Dual Levamisole and Fenbendazole combination with selenium for adult sheep and lambs. Low Volume Broad Spectrum Mixing with AbaCare LV provides triple combination INDICATIONS: DuoCare LV + Se contains Levamisole, a member of the imidazothiazole (clear) family of chemicals and Fenbendazole, a member of the benzimidazole (white) family of chemicals. It is effect against sensitive and single-resistant mature & immature strains of the Roundworms listed below: Haemonchus contortus - Barber s pole worm, Teladorsagia [Ostertagia spp] circumcincata - Small brown stomach worm, Trichostrongylus spp - Black scour worm, including moderately macrocyclic lactone resistant strains, Cooperia spp. - small intestinal worm, Nematodirus spp. - thin necked intestinal worm, Strongyloides papillosus - Intestinal threadworm, Bunostomum spp. - Hookworm, Oesophagostomum spp. - Nodule worm, Chabertia ovina - Large mouthed bowel worm, Dictyocaulus filaria - Large lungworm, it will aid in the control of (Moniezia spp.) Tapeworm. COMBINED USE: Combined use of drench actives may improve efficacy and slow the development of resistance. DuoCare LV + Se can be combined in equal volumes with AbaCare LV (A10306) to produce a stable mixture for oral dosing of sheep and lambs. The mixture contains 40g/L Levamisole HCI, 25g/L Fenbendazole, 0.5g/L Selenium and 1.0g/L Abamectin. This combined solution must be well mixed before use and dosed at a rate of 1mL/5kg bodyweight. The mixture remains stable for up to 3 months if stored as per label conditions. DOSAGE: 1mL per 10kg bodyweight. Sheep over 75kg to be dosed at 1mL per 10kg bodyweight. Liveweight (kg) Dose Volume (ml) Sheep Treated per 10L MEAT: Within 10 days of the last treatment. MILK: Not less than 8 milkings or approximately 96 hours following the last treatment. PACK SIZE: 10L. CONTRAINDICATIONS: Do not use in lambs under six (6) weeks of age or less than 15 kg bodyweight. 10

12 FlukeCare + Se FlukeCare +Se For the treatment and control of benzimidazole sensitive mature and immature roundworms, lungworms and early immature (including 2 week old fluke), mature and immature liver fluke (Fasciola hepatica) in cattle and sheep. Use the most effective double combination broad spectrum drench for treating liver fluke. All three stages of liver fluke with superior control of early immature liver fluke Broad Spectrum anthelmintic Synergistic anthelmintic combination - Patent WOY 1994/ WHAT IS FLUKECARE + SE? Effective control of liver fluke from 2 week old to adult stages. Patented formulation of triclabendazole and oxfendazole. Liquid oral drench with free flowing formulation. Contains selenium. Oral drench to give control of benzimidazole sensitive roundworms and lungworms. WHY USE FLUKECARE + SE? Liver fluke has a huge impact on profits if left untreated. Roundworms - Controls all benzimidazole sensitive major mature and immature roundworms (including inhibited Ostertagia) and lungworms. Suitable for dairy cows - Ideal dry-off treatment for dairy cattle (35 day milk withold). New improved formulation - flows through drenching equipment easily even at low temperatures. Kg force DRENCHABILITY - MAXIMUM FORCE REQUIRED TO EXPEL DRENCH THROUGH EQUIPMENT Water FlukeCare + Se Fasimec Pour on for cattle Fasinex 240 DESCRIPTION: Contains 12mg/kg of triclabendazole, 45.3mg/kg of Oxfendazole and 0.1mg/kg of selenium. Available in a 10L drum. MEAT: 28 days MILK: 35 days. DOSE RATE GUIDE: CATTLE Liveweight kg Dose Volume ml Cattle Treated per 10L Up to 100 1mL per 10kg COMBINED USE: MEAT: 21 days MILK: 35 days Registered pursuant to the ACVM Act 1997, No. A See for registration conditions. DOSAGE: 1mL per 10kg bodyweight orally. DOSE RATE GUIDE: SHEEP Liveweight kg Dose Volume ml Sheep Treated per 10L Continued over page... 11

13 FlukeCare +Se Liver Fluke bites profits! Impact on milk production Suggested values for milk loss due to liver fluke infection are up to 1 kg/day over a lactation 1. A heavy infection can cost around 300L in lost milk production per cow per year. The effect of liver fluke (fasciola hepatica) on milk production is well documented 2. In high risk fluke areas fluke is a significant threat to milk production. In cattle, fluke can cause a loss in body condition, a drop in milk yield and fertility, and sometimes diarrhoea. It can also increase susceptibility of the animals to other infections and metabolic disorders. A high incidence of liver fluke infestation can reduce milk butterfat concentration 3. Impact on Reproduction Liver fluke infections have been shown to reduce conception rates in heifers by 50% 4. Impact on growth rate Liver fluke infection in growing cattle has been shown to depress live weight gain by between 0.07 kg/week and 1.2 kg/week, depending on the size of the fluke burden 1. A heavy infection can cost up to 28.5% 5,6 in reduced weight gain. Liver fluke (fasciola hepatica) can affect weight gains in young growing cattle having a direct effect on your income. The graph below charts the reduction in body weight expressed as weight loss in grams per week on calves in differing severity of liver fluke infection. Impact on weaning weights Crossland et al (1977), cited by Clarkson showed that ewes with 33 flukes had a 14% reduction in output, attributed to fewer births, lower birth weights and decreased weight gains of Iambs. 7 Reid & Armour (1978), cited by Clarkson showed that lambs from ewes with 40 flukes were 5 kg lighter at weaning than lambs from ewes with only 2 flukes 7. Impact on wool yield Roseby (1970), cited by Clarkson obtained a reduction in production of 20-39% of wool in ewes with 186 flukes compared with uninfected controls 7. Edwards, al-saigh, Williams and Chamberlain (1976), cited by Clarkson showed that infection with 100,500 and 1,000 met a cercariae (mc) reduced wool production over a year by 24%, 30% and 44%, respectively 7. Hawkins & Morris (1978), cited by Clarkson showed that sheep harbouring 45 flukes had a 14% reduction in wool, 67 flukes a 22% reduction and 230 flukes a 33% reduction 7. A study in 1984 showed that when sheep were infected with liver fluke for between 8 to 12 weeks, the reduction in appetite alone caused a reduction in wool growth of between 19.5% to 21.3% 8. When fluke were stopped in their tracks and killed early in their life cycle at 4 weeks of age, the suppression of appetite still had an impact on wool growth but at a significantly lower level than older infections. Each fluke can cause the loss of 0.5ml of blood per day from the liver. A moderate infestation in cattle of fluke can lead to blood loss of up to half a litre each week, so often infected animals can be anaemic. Reduction of milk production in cows affected with liver fluke 3 Loss of milk production in litres per cow per lactation Reduction of body weight in calves infected with liver fluke 2 Reduction in growth rate grams/week Range in production loss due to liver fluke The impact of reduced feed intake due to liver fluke on wool growth (shown as % reduction in wool growth) 8 Reduction in wool growth (%) Duration of infection (weeks) DPI Study: Efficacy on 2 week old stages* % Reduction in total fluke count - 2 weeks weeks Flukes present in liver -200g 8 weeks 200 Flukes present in liver 12 weeks -1200g 26 weeks Why is it important to control immature liver fluke as early as two weeks? Removal of liver fluke at the earliest possible stage reduces the damage sustained to the liver. Studies have shown that the earlier fluke can be removed the greater the productivity response (growth rates). *Studies undertaken by NSW DPI showed that FlukeCare + Se Removed virtually all fluke aged 2 and 4 weeks (99% + efficacy) There was no visual damage to the livers of cattle treated with FlukeCare + Se FlukeCare + Se Triclabendazole at 10mg per kg pour on (tric + aba) 1. The University of Reading, Department of Agricultural and Food Economics, The Economics of Fascioliasis (Liver fluke). 2. Ross, JG. (1970). British Veterinary Journal, 126: xiii - xv. 3. Department of Agriculture and Rural Development, Technical Note, Dairy, 13, April Oakley, G.A., et al (1979).Veterinary Record, 104: Dargie, JD. (1986) In Ed. MJ Howell, Parasitology-Quo Vadit. 1986,pp Hutton Oddy, Meat and Livestock Australia, 2003 Armidale Feeder Steer School. 7. M. J. CLARKSON (1998) University of Liverpool. 8. C.D. Hawkins. Veterinary Parasitology, 15 (1984) * Virbac data on file. 12

14 Flumenil Pour On Scientifically formulated to kill ticks at every stage of the lifecycle larvae, nymph and adult in deer, dairy and beef cattle. Treats and controls all 3 stages of lifecycle Nil meat and milk withholding Rainfast DESCRIPTION: ACTIVE CONSTITUENT: 10g/L Flumethrin. Available in 1L and 5L. Flumenil Pour On is active against all 3 stages of the New Zealand cattle tick (Haemaphysalis longicornis) lifecycle. It also causes infertility of ticks which survive treatment, by inhibiting egg laying or rendering eggs sterile. This action helps reduce contamination of pasture. Cattle and Deer MEAT: Nil. MILK: Nil. DOSAGE AND ADMINISTRATION: Apply Flumenil Pour On evenly along the midline of the back from the front of the shoulders to the tail head. Use a plastic measuring cup or automatic drenching gun to apply. Retreatment should be undertaken when ticks start to reappear. For optimum control of ticks on deer, breeding hinds should be treated every three weeks from August to fawning. This program will reduce the number of nymphs reaching the adult stage, which infest fawn during November/December. Treatment of hinds can be continued after fawning if this is practical. Other stock should be treated every three weeks from August, or as required. RAIN RESISTANCE: Control of ticks is not affected by rain falling within a few hours of treatment. Registered pursuant to the ACVM Act 1997, No A See for registration conditions. CATTLE (liveweight) DOSE VOLUME Up to 200kg 20mL 200 to 300kg 30mL 301 to 400kg 40mL Over 400kg 50mL DEER Up to 6 months Yearlings and adults DOSE VOLUME 10mL 20mL Flumenil Pour On spreads through the oils of skin and hair coat of all of parts of the animal s body. Behaviours such as grooming, tail swishing and scratching, aid the movement of active ingredient to the extremities of the body, which are often affected by ticks. 13

15 HeadStart HeadStart Calcium and energy starter drench to stimulate appetite and metabolism Only starter drench proven to stimulate production, boosting energy, appetite and metabolism. Proven increased energy Proven increased Calcium and Magnesium HeadStart Gold HeadStart Gold The Gold Standard transitional oral drench for calving and lambing....as good as gold. Low volume 750mL cattle dose Researched and scientifically developed Proven to deliver Proven higher milk solid production Calcium HeadStart contains two forms of calcium: Calcium Propionate is the only form of readily absorbed calcium that provides both energy and a sustained release of calcium. Calcium Chloride provides a readily absorbed form of calcium for immediate utilisation when speed is the key. Energy sources Proven and effective sources of energy including propionate. The key to energy is the combination of quick and sustained release. HeadStart provides both. Vitamin B Complex Yeast extract fortified with Vitamin B Complex stimulates both metabolism and appetite. Readily available Added Cobalt! Sustained availability. Magnesium Readily absorbed source of magnesium to help prevent hypomagnesaemic tetany (grass staggers). DESCRIPTION: A dark brown thixotropic gel; a stabilised emulsion for oral administration to cows. Contains refined food-grade ingredients. 1L, 5L, 20L, 60L and 200L containers. Calcium is provided for Immediate and sustained availability. The total dose is effective protection from hypocalcaemia. Provides immediately available energy sources, which can be metabolised by the cow to provide glucose. Monopropylene glycol is a recognised source of glucose for the cow; however propionate has been shown to have superior value for this purpose. INDICATIONS: CATTLE: Using 1L of HeadStart or 750mL of HeadStart Gold, within 12 hours of calving assists recovery from hypocalcaemia, will boost appetite and metabolism and has shown to provide an increase in production. SHEEP: Use 100ml of HeadStart or 75mL of HeadStart Gold to stimulate appetite and help control sleepy sickness and milk fever in pregnant ewes. CONTAINS: PROVIDES PER 1L: Calcium (Elemental) 45g, Magnesium (Elemental) 9.2g, Available energy 15MJ. PROVIDES PER 100ML: Calcium (Elemental) 4.5g, Magnesium (Elemental) 0.92g, Available energy 1.5MJ. MEAT AND MILK: Nil Continued over page... 14

16 Trials Study 1: Increased Calcium Cows treated with HeadStart within 12 hours of calving demonstrated a statistically significant increase in blood calcium. mm ol/l Mean blood calcium Calcium Hours 6 Study 2: Increased Magnesium Cows treated with HeadStart within 12 hours of calving demonstrated a statistically significant increase in blood magnesium. mm ol/l Mean blood magnesium Magnesium Hours 6 Study 3: Improved Energy Cows treated with HeadStart demonstrate a positive energy balance as indicated by NEFA levels. Negative energy balance after calving can cause poor reproductive performance and limits production through reduced milk protein and lactose. mm ol/l Energy balance NEFAs Hours 6 Study 4: Higher (MS) Production Cows treated with 1L HeadStart within 24 hours of calving demonstrated a statistically significant higher milk solids production for a whole season (+8kg) than cows not treated with HeadStart. * Virbac Data on file. mm ol/l Kg Milk Solids for Total Lactation Controls HeadStart 15

17 Intracillin 1000 Milking Cow Intracillin 1000 Milking Cow An oily suspension containing 1,000,000 i.u. procaine penicillin G per single-dose syringe. Available in boxes of 21 single-dose syringes. 1000mg Procaine Benzyl Penicillin Registered extended therapy claim of 6 tubes given 12 hours apart Registered milk withholding for combination therapy with Masticillin RTU Injection The high dose of penicillin in this product makes it a very effective treatment for the majority of cases of mastitis in dairy cattle caused by Gram+ve bacteria. Particularly effective against Streptococcus uberis, which is responsible for up to 75% of spring mastitis in New Zealand. INDICATION: Treatment of mastitis infections in lactating cows. canal of each infected quarter immediately following each of 3 consecutive milkings, ie. three 12-hourly doses. Massage the infused contents of each syringe up the teat canal. If required, an extended treatment of 6 syringes (1 after each of 6 successive milkings) may be given. For difficult mastitis cases, treatment may be combined with a course of the parenteral, Masticillin. For details, see the leaflet provided with the product. DOSAGE & ADMINISTRATION: Clean and disinfect the udder, paying particular attention to the teat orifice. Administer 1 syringe per infected quarter. The contents of 1 syringe should be infused into the teat MILK: For either 3 or 6 treatments, 96 hours (8 milkings) following the last treatment. 3 x Intracillin x Masticillin hours (9 milkings) following the last treatment MEAT: 28 days. CONTRAINDICATIONS: Not for the treatment of infections caused by organisms that are not susceptible, or have developed resistance, to penicillin. Not to be used in animals with a known history of sensitivity to penicillin-containing products. OTHER INFORMATION: Store below 25 C. DO NOT REFRIGERATE. Restricted Veterinary Medicine. Available only under veterinary authorisation. Registered pursuant to the ACVM Act 1997, No. A7787. Registered to: Stockguard Laboratories (NZ) Ltd, Maui St, Pukete Park, Hamilton, New Zealand. Distributed by: Virbac New Zealand, Maui St, Pukete Park, Hamilton, New Zealand. SPECIAL PRECAUTIONS: Penicillins may cause hypersensitivity (allergy) following injection, ingestion or skin contact. Do not handle this product if you know you are sensitised to, or if you have been advised not to work with, such preparations. Handle this product with great care to avoid exposure, taking all recommended precautions. 16

18 Intracillin 300 Injection A sterile, aqueous suspension of 300,000i.u./mL procaine penicillin G. Available in 200mL pillow packs. Convenient Plastic Pillow pack Variable dose range of 10,000iu - 25,000iu penicillin/kg Needles and syringe supplied Procaine penicillin is a moderately soluble drug that provides a therapeutic effect from a single injection for the 24 hours before the next injection is to be given. Penicillin inhibits cell wall synthesis in susceptible bacteria. INDICATION: First-line treatment for unspecified infections and treatment of known and common infections caused by penicillinsensitive Gram +ve organisms, eg. clostridial infections. DOSAGE & ADMINISTRATION: Usual dose ranges from 10,000i.u. to 25,000i.u. penicillin/kg b.w. depending on the severity of the infection being treated. Lower doses may lead to a build-up of resistant bacteria. Higher doses may be used at the discretion of a veterinarian. CATS and DOGS: 0.5 4mL. SHEEP, CALVES, FOALS and PIGS: 3 8mL. DAIRY COWS (400kg): 16mL. HORSES and CATTLE (up to 500kg): 10 20mL. HORSES and CATTLE (over 500kg): 20 50mL. When used prophylactically (in the absence of clinical symptoms), administer the dose once only by i/m or s/c injection. Where a clinical infection is being treated, administer the dose daily for 3 days. In food-producing animals, to minimise tissue rejection at slaughter product must be injected in the neck behind the ear. BOVINE MILK: Milk intended for human consumption must be discarded during treatment and for the following times after the last treatment: One dose 48 hours (4 milkings); two doses 60 hours (5 milkings); 3 or more doses 72 hours (6 milkings). OVINE MILK: 35 days after the last treatment. MEAT: Cattle, Sheep and Pigs 10 days, Horses 63 days. CONTRAINDICATIONS: Not for use in bobby calves. Not to be used in animals with a known history of sensitivity to products containing penicillin or its analogues. Not to be used for the treatment of infections caused by organisms known to be resistant to penicillin. No products containing procaine and/or procaine penicillin are to be used in race horses within 504 hours (21 days) of racing. SPECIAL PRECAUTIONS: Penicillins may cause hypersensitivity (allergy) following injection, ingestion or skin contact. Do not handle this product if you know you are sensitised to, or if you have been advised not to work with, such preparations. Handle this product with great care to avoid exposure, taking all recommended precautions. OTHER INFORMATION: Protect from direct sunlight. Store below 18 C. Product may be refrigerated. Do not freeze. Shake well before use. Keep out of reach of children. Restricted Veterinary Medicine. Available only under veterinary authorisation. Registered pursuant to the ACVM Act 1997, No. A5301. Registered to: Stockguard Laboratories (NZ) Ltd, Maui St, Pukete Park, Hamilton, New Zealand. Distributed by: Virbac New Zealand, Maui St, Pukete Park, Hamilton, New Zealand. 17

19 Intracillin LA Intracillin L.A. A sterile, aqueous suspension of 150,000i.u./mL procaine penicillin G and 150,000i.u./mL benzathine penicillin G. Manufactured in New Zealand and available in 100mL pillow packs. 108 hour milk withholding time Variable dose range of 10,000iu - 25,000iu penicillin/kg Convenient Plastic Pillowpack Procaine penicillin is a moderately soluble drug that provides a therapeutic effect from a single injection for up to 24 hours. Benzathine penicillin gives this product a long-acting effect for sustained treatment of difficult, penicillin-sensitive infections or continued therapy where daily injection is not practical. Offers prolonged protection when used as a preventative treatment in the absence of clinical symptoms. Penicillin inhibits cell wall synthesis in susceptible bacteria. CONTRAINDICATIONS: Not for use in bobby calves. Not to be used in animals with a known history of sensitivity to products containing penicillin or its analogues. Not to be used in the treatment of infections caused by organisms known to be resistant to penicillin. No products containing procaine and/or procaine penicillin are to be used in race horses within 504 hours (21 days) of racing. INDICATION: First-line treatment for unspecified infections and treatment of known and common infections caused by penicillinsensitive Gram+ve organisms, eg. clostridial infections. DOSAGE & ADMINISTRATION: Usual dose ranges from 10,000i.u. to 25,000i.u. penicillin/kg b.w, depending on the severity of the infection being treated. Lower doses may lead to a build-up of resistant bacteria. Higher doses may be used at the discretion of a veterinarian. General guidelines: CATS AND DOGS: 0.5 4mL. SHEEP, CALVES, FOALS and PIGS: 3 8mL. DAIRY COWS 400kg (Single dose only): 16mL. HORSES and CATTLE (up to 500kg): 10 20mL. HORSES and CATTLE (over 500kg): 20 50mL. Administer 1 injection of the selected dose immediately. In all species, except dairy cows, another dose is recommended 48 hours later, and a third injection may be administered in another 48 hours, if necessary. For larger doses, consider dividing the dose and inject one half in each side of the neck. BOVINE MILK: 108 hours (9 milkings). OVINE MILK: 35 days after last treatment. MEAT: Cattle, Sheep and Pigs 30 days. Horses 63 days. SPECIAL PRECAUTIONS: Penicillins may cause hypersensitivity (allergy) following injection, ingestion or skin contact. Do not handle this product if you know you are sensitised to, or if you have been advised not to work with, such preparations. Handle this product with great care to avoid exposure, taking all recommended precautions. OTHER INFORMATION: Protect from direct sunlight. Store below 18 C. Product may be refrigerated. Do not freeze. Shake well before use. Keep out of reach of children. Restricted Veterinary Medicine. Available only under veterinary authorisation. Registered pursuant to the ACVM Act 1997, No. A6308. Registered to: Stockguard Laboratories (NZ) Ltd, Maui St, Pukete Park, Hamilton, New Zealand. Distributed by: Virbac New Zealand, Maui St, Pukete Park, Hamilton, New Zealand. 18

20 Lepto 2-Way Lepto 2-Way For the control of leptospirae infection in cattle by immunisation against Leptospirae interrogans serovar hardjo and L. interrogans serovar pomona. To prevent urinary shedding of leptospirae of the named serovars, and thus reduce the risk of human Leptospirosis infection. Low risk of site reactions after vaccination Duration of protection for at least 12 months after primary vaccination Ease of use, minimal agitation required Lepto 3-Way Lepto 3-Way For the control of leptospirae infection in cattle by immunisation against Leptospirae interrogans serovar hardjo, L. interrogans serovar copenhageni (icterohaemorrhagia) and L. interrogans serovar pomona. To prevent urinary shedding of leptospirae of the named serovars, and thus reduce the risk of human Leptospirosis infection. Low risk of site reactions after vaccination Duration of protection for at least 12 months after primary vaccination Ease of use, minimal agitation required INDICATIONS: For the control of leptospirae infection in cattle by immunisation against Leptospirae interrogans serovar hardjo and L. interrogans serovar pomona (Lepto 2 Way) and L. interrogans copenhageni (Lepto 3 Way). To prevent urinary shedding of leptospirae of the named serovars, and thus reduce the risk of human Leptospirosis infection. DOSAGE: Cattle: 2 ml by subcutaneous injection, given into the anterior half of the neck; with a further dose of 2 ml given four to six weeks later. Note: the dose of 2 ml is recommended for all life-stages. All animals then require a single 2 ml booster injection each 12 months. HERD VACCINATION: To begin a herd vaccination program all animals must be vaccinated in the autumn, with a second dose given 4-6 weeks later. An annual booster dose must be given each autumn. Calves, cows and pigs intended for introduction to a herd must receive 2 doses, 4-6 weeks apart. This programme is applicable to dairy or beef herds. VACCINATION OF CALVES: Early vaccination of calves is advisable to protect against acute Leptospirosis ( red-water ), and to minimise the risk of animals becoming carriers prior to vaccination. A course may begin from 12 weeks of age, but in this case it is essential to administer a booster dose at 6 to 9 months of age, to align with future herd vaccination. In all cases, two doses should be given, 4-6 weeks apart, and finishing no later than 9 months of age, and a booster vaccination should be given within 12 months. This may require a further single dose of vaccine to align calves vaccinated out of season (i.e. when young, or in a town supply herd), with the annual herd booster in autumn. INTRODUCED STOCK: In the absence of known prior vaccination, dose twice at a 4-6 week interval. To eliminate possible shedding from animals already leptospirosis infected, a course of dihydrostreptomycin (3 25 mg/kg) is recommended. DESCRIPTION: Lepto 2 Way: This vaccine is prepared from cultured strains of Leptospira interrogans serovars hardjo and pomona. Lepto 3 Way: This vaccine is prepared from cultured strains of Leptospira interrogans serovars hardjo, copenhageni (icterohaemorrhagiae) and pomona. Stimulates the immune system to produce antibodies against the organisms L. interrogans serovars hardjo, and pomona (Lepto 2 Way), and L. interrogans copenhageni (Lepto 3 Way), the main causes of leptospirae infection in cattle. In cattle challenged with live cultures of the serovar L. hardjo shedding of leptospirae in the urine was prevented by vaccination with Lepto 2-Way and Lepto 3 Way. ADMINISTRATION: 2 ml by subcutaneous injection, given into the anterior half of the neck. Registered pursuant to the ACVM Act 1997 No. A9166, A8314. See for registration conditions. Only available under Veterinary Authorisation. Continued over page... 19

21 Extensive controlled challenge trials and a New Zealand study confirm Lepto 2-Way and Lepto 3-Way s ability to: Prevent cattle shedding and Renal Colonisation Prevention from shedding viable leptospires in vaccinated cattle after challenge with live cultures of all three serovars compared to unvaccinated controls and therefore providing protection against L. hardjo, L. pomona, L. icterohaemorrhagiae bacteraemia. Vaccinates challenged with either L. pomona or L. icterohaemorrhagiae failed to demonstrate viable leptospires in serial urine samples for all animals on all occasions of sampling. Excellent results were also seen for L. hardjo most clearly demonstrated when only a single sensitiser vaccination prevented viable leptospires being recovered from serial urine samples after challenge. The entire unvaccinated control group had leptospires recovered on at least one occasion demonstrating that challenge was highly effective. Provide Protective Antibody Response Micro agglutination titres (MAT) to all three serovars (hardjo, pomona and icterohaemorrhagiae) show a significant rise in vaccinated animals, whether they received one or two vaccinations. As would be expected, the titre rise was higher in the group that received the two vaccinations at a four week interval. The MA antibody titres followed the pattern that would be expected. Importantly they remained negative in the unvaccinated control group (indicating no natural infection or challenge occurred). Provide 12 months Duration of Immunity In the majority of animals, MA titres decline by 6 months post vaccination so some other means of determination of duration of immunity is required. The indirect passive protection test involves removing serum from vaccinated cattle at defined times after vaccination and administering it to laboratory animals that are then challenged with leptospires. Fatalities and subsequent recovery of leptospires from kidneys in negative controls are compared to serum treated animals. Protection for a minimum of 12 months was demonstrated against L. pomona and 18 months for L. icterohaemorrhagia in these studies Provide full protection against all serovars contained in each vaccine Challenge studies using micro-agglutination titre levels, passive protection models and leptospiral survival in bovine blood. These forms of testing are robust methods of testing. The Passive Protection test is an animal model used to prove that antibodies developed in cattle after vaccination with Lepto 2-Way and Lepto 3-Way are protective against challenge. This form of testing is also commonly used in batch potency testing. New Zealand trial work conducted in 2007 with Lepto 3-Way supports that annual vaccination timing is important to provide adequate levels of colostrum transfer. In this study it was found that calves from cows or heifers vaccinated less than 60 days before they calved were more likely to record low or negative MA titres to leptospira hardjo (Chart 1). Whilst even low titres may still be protective, higher levels are more likely to protect for longer. The data demonstrates that as the period between vaccination and calving increases towards 90 days, the prevalence of low titres to L. hardjo decreases. Immunoglobulin levels measured in this study also support the suggestion that higher overall levels of IgG derived from colostrum in neonatal calves is associated with higher serum MA titres to leptospira serovar hardjo. To ensure calves are given the best opportunity from birth to be adequately protected against leptospirosis it is important to consider the following points Cows / Heifers are in good health and adequately fed. Vaccination is performed with a vaccine that stimulates antibody production and in New Zealand, one that also demonstrates proven lack of renal shedding after challenge by L. hardjo-bovis. Timing vaccination to allow for maximum antibody concentration coincident with synthesis of colostrum in the mammary gland. Therefore optimum timing depends upon: Calving date. Time before calving that colostrum is synthesised. Time between vaccination and maximum antibody titres expected in the dam. Adequate ingestion of colostrum by the calf after birth to achieve transfer of antibodies. Lepto 3-Way outlined in this information is relevant to the three serovars contained in the vaccine which is L. hardjo, L. pomona and L. icterohaemorrhagiae. For additional information regarding trial work conducted with Virbac Lepto 2-Way or Lepto 3-Way, please refer to the Technical Update. Frequency 100% 80% 60% 40% 20% Lepto 2-Way information outlined in this information is relevant to the two serovars contained in the vaccine which is L. hardjo and L. pomona. 0% Booster days before calving Titres <1:100 Titres =>1:100 20

22 Masticillin TM RTU Injection A sterile, aqueous suspension containing 15 million i.u. micronised procaine penicillin G in an aqueous suspension formulated for extended activity. Available in packs containing 4 ready to use 30mL vials, 4 syringes and 4 needles. Single treatment of high-dose micronised procaine penicillin Registered shorter Bobby Calf Meat withholding Needles & syringes supplied Registered milk withholding for combination therapy with Intracillin 1000 MC New Zealand trial work The high dose of penicillin, together with the unique TM formulation of Masticillin, ensure that effective levels are maintained in the udder for a duration that is sufficient to provide bactericidal activity against sensitive organisms. Therapeutic levels of penicillin persist in the milk following a single treatment for much longer than the levels following multiple injections with penethamate hydriodide at an equivalent dose. The pharmacokinetic properties ensure penetration of the mammary tissue, particularly of inflamed quarters, with high penicillin concentrations being achieved at the site of infection. INDICATION: Treatment of clinical and subclinical mastitis sensitive to penicillin, including that caused by Streptococcus uberis. DOSAGE & ADMINISTRATION: Only 1 treatment is required. Shake well before use. Inject two 15mL doses, by i/m or s/c injection, one each side of the anterior half of the neck. For difficult mastitis cases, treatment may be combined with a course of the intramammary, Intracillin 1000 Milking Cow. For details, see the leaflet provided with the product. MILK: 132 hours (11 milkings) or 6 milkings (144 hours) if milking once a day. 1 x Masticillin + 3 x Intracillin hours (9 milkings) following the last treatment MEAT: 10 days. Bobby calves from treated cows 4 days. Calf must be removed from dam within 24 hours of calving. CONTRAINDICATIONS: Do not give the full 30mL dose at one injection site; 20mL syringes are supplied with the product to help prevent this occurring. Not for the treatment of infections caused by organisms that are not susceptible to penicillin. Not to be used in animals with a known history of sensitivity to penicillin-containing products. SPECIAL PRECAUTIONS: Penicillins may cause hypersensitivity (allergy) following injection, ingestion or skin contact. Do not handle this product if you know you are sensitised to, or if you have been advised not to work with, such preparations. Handle this product with great care to avoid exposure, taking all recommended precautions. OTHER INFORMATION: Store below 18 C. Product may be refrigerated. Do not freeze. Restricted Veterinary Medicine. Available only under veterinary authorisation. Registered pursuant to the ACVM Act 1997, No. A8037. Registered to: Stockguard Laboratories (NZ) Ltd, Maui St, Pukete Park, Hamilton, New Zealand. Distributed by: Virbac New Zealand, Maui St, Pukete Park, Hamilton, New Zealand. 21

23 Metri-Clean TM Each 19-gram dose contains 500mg cephapirin as the benzathine salt. Available in pails of 20 or 50 single dose syringes and 500mL (25-dose) pillow packs. Snap-lock catheters (pipettes), plastic gloves and Metri-Clean multidose applicators are provided. Syringes packaged in plastic buckets in two convenient sizes 20 s 5 or 50 s Packets of pipettes supplied at no charge Full length gloves supplied at no charge on request Easy cap removal Cephapirin is a first-generation cephalosporin. It has a broad spectrum of activity against a range of Gram+ve and Gramve bacteria through interference with cell wall synthesis. It is a penicillinase-resistant, beta-lactam antibiotic and is active in the infected uterus. After a single treatment, the concentration of cephapirin in the tissue remains above the MIC s of sensitive bacteria for at least 24 hours. INDICATION: Treatment of subacute and chronic endometritis (inflammation of the uterus lining) in cows, caused by cephapirin-sensitive bacteria. Also for the treatment of repeat breeder cases (more than three unsuccessful inseminations) when bacterial infection is the suspected cause. DOSAGE & ADMINISTRATION: Thoroughly clean the vulva area. Take a single syringe and using aseptic procedures as much as possible to avoid contaminating the pipette, insert the tip of the syringe firmly into the end of the pipette. Glove 1 hand and insert it into the animal s rectum to locate the cervix. Gently grasp the cervix and by gently oscillating it, introduce the pipette into the lumen of the uterus. Depress the syringe plunger to infuse the contents of the syringe into the uterus (some product will remain in the pipette). Usually 1 treatment is sufficient for a complete cure. Can be used 1 day after insemination. MILK: NIL. MEAT: 4 days. CONTRAINDICATIONS: Do not administer to animals known to be allergic to cephalosporins. Do not administer with other antibiotic preparations. SPECIAL PRECAUTIONS: Beta-lactam antibiotics may cause hypersensitivity (allergy) following injection, ingestion or skin contact. Do not handle this product if you know you are sensitised to, or if you have been advised not to work with, such preparations. Handle this product with great care to avoid exposure, taking all recommended precautions. OTHER INFORMATION: Store at C. Restricted Veterinary Medicine. Available only under veterinary authorisation. Registered pursuant to the ACVM Act 1997, No. A Registered to: Stockguard Laboratories (NZ) Ltd, Maui St, Pukete Park, Hamilton, New Zealand. Distributed by: Virbac New Zealand, Maui St, Pukete Park, Hamilton, New Zealand. 22

24 Multimin + Cu Multimin + Cu is a unique concept of trace element supplementation for New Zealand farmers. Multimin + Cu is designed to be administered strategically to optimise the essential trace elements selenium, copper, zinc and manganese. Zinc (40mg/mL) as disodium zinc EDTA Copper (15mg/mL) as copper disodium EDTA Manganese (10mg/mL) as disodium manganese EDTA Selenium (5mg/mL) as sodium selenite It is formulated to optimise trace elements when there is a short-term deficiency caused by a stress, or a single critical event. New Zealand clinical trials prove that the strategic use of Multimin + Cu delivers a significant improvement in reproduction, immunity, growth and production. When to give Multimin + Cu: The ideal time to give administer Multimin + Cu is around four weeks before stressful times such as mating, calving, transport and weaning. This ensures trace elements are fully accessible and available to the stock when they need it. Multimin + Cu comes as an easy to use injection for maximum effectiveness: Bypasses gut so does not react with minerals in the environment which may decrease absorption and availability of the minerals Formulation minimises site reaction Nil meat or milk withholding period No colour staining on tissue DESCRIPTION: Zinc, copper, manganese and selenium delivered as an easy to use low volume aqueous injectable solution. Multimin MultiMin is ph neutral and tissue friendly. Copper, manganese and zinc are highly bio-available due to chelation. INDICATIONS: To optimise the trace element status of cattle & deer at critical times. CONTAINS: Four trace elements: Zn (40mg/mL) as disodium zinc EDTA Cu (15mg/mL) as copper disodium EDTA Mn (10mg/mL) as disodium manganese EDTA Se (5mg/mL) as sodium selenite Cattle - intramuscular and subcutaneous Deer - intramuscular only DOSAGE: Cattle < 1 year: Cattle >1 <2 years: Cattle >2 years: Deer: 1mL per 50kg 1mL per 75kgs 1mL per 100kgs 1mL/100kgs Registered pursuant to the ACVM Act 1997, No A9374. See for registration conditions. Multimin MultiMin should not be used with concurrent copper and selenium. Multimin + Cu will soon be available in a convenient 200mL pack. This will provide greater flexibility for small, medium and large farming operations to use Multimin + Cu in a wider range of species (Cattle and Deer) and stock class (calves, heifers, cows, bulls, hinds, stags and fawns). Along with a 200mL pack joining the 500mL in the range, Multimin + Cu also has a new look keep an eye out for the shiny, gold packaging. 23

25 Neoprinil Pour On For the treatment and control of internal and external parasites of beef and dairy cattle (including lactating cows) and internal parasites of deer, including lungworm and sucking & biting lice. Persistent activity against a broad spectrum of parasites Nil milk, meat and bobby calf withholding periods Rainfast INDICATIONS: Eprinomectin is a member of the avermectin/milbemycin class of endectocides. For the treatment and control in all ages of beef and dairy cattle (including lactating cows) of: Adult and Immature Gastrointestinal worms: Ostertagia ostertagi (including inhibited immature), Ostertagia lyrata (Adult Only), Haemonchus contortus, Trichostrongylus axei, Trichostrongylus colubriformis, Oesophagostomum radiatum, Nematodirus helvetianus, Bunostomum phlebotomum, Trichuris discolour (Adult Only), Trichuris globulosa (Adult Only), Cooperia oncophora, Cooperia punctate and Cooperia surnabada. Lungworms: Adult and immature Dictyocaulus viviparous. Sucking Lice and Biting Lice: Bovicola bovis, Linognathus vituli, Haematopinus eurysternus and Solenopotes capillatus. Sarcoptic and chorioptic mites: Sarcoptes scabiei var bovis and Chorioptes bovis. And for the treatment and control in all ages of deer of: Adult and Immature Gastrointestinal worms: Ostertagia circumcincta, Ostertagia leptospicularis, Trichostrongylus axei and Oesophagostomum venulosum. Lungworms: Dictyocaulus ekerti (viviparous) For best results Neoprinil Pour On for Cattle and Deer should be part of a total parasite control program. Check the effectiveness of anthelmintics at least annually. INCREASE MILK PRODUCTION: Increases milk production in grazing dairy cows. Data has shown that milk production increases by a median of approximately +0.6kg liquid milk per day when cows or heifers infected with gastrointestinal nematode parasites are treated with an effective anthelmintic; this increase occurs without any reduction in milk quality. DESCRIPTION: ACTIVE CONSTITUENT: 5g/L Eprinomectin. Neoprinil Pour On for Cattle and Deer contains Eprinomectin which provides activity against a broad spectrum of internal and external parasites. MEAT: Nil. MILK: Nil. DOSAGE: 1mL/10kg. Liveweight (kg) Dose Volume (ml) PACK SIZE: 2.5L, 5L & 20L packs Registered pursuant to the ACVM Act 1997, No A See for registration conditions. 24

26 Nitroclox TM LA Nitroclox LA Nitroclox LA is an intramammary formulation containing 200mg cloxacillin in a long-acting base. Available in boxes of 21 single-dose syringes. Flexible treatment options - 24 or 48 hourly treatment intervals, TAD, OAD Registered extended therapy claim of 3 to 6 tubes given 24 hours apart New Zealand trial work Cloxacillin, is a semi-synthetic isoxazolyl penicillin. There are a considerable number of reports in the literature showing that Streptococcus uberis is the main cause of mastitis in the early part of the lactation season and that penicillin is the drug of choice for such infections. Later in the season, Staphylococcus aureus and other pathogens become more important. Penicillin alone is not effective against many strains of S. aureus because it is inactivated by the beta lactamase enzymes these strains produce. Cloxacillin is resistant to the action of beta lactamases and so is effective against all strains of S. aureus, as well as streptococci and Trueperella pyogenes. INDICATION: Treatment of mastitis infections in lactating cows. DOSAGE & ADMINISTRATION: Clean and disinfect the udder, paying particular attention to the teat orifice. Administer the entire contents of 1 syringe per infected quarter immediately following milking. Massage the infused contents of each syringe up the teat canal. Repeat the treatment twice more at 24 hour intervals, i.e. 3 x 24 hourly treatments. Three syringes provide a full course of treatment. If required, an extended treatment of 6 syringes at 24-hour intervals may be given. MILK: When milking twice a day: for 3 to 6 x 24-hour doses or 3 x 48-hour doses, 84 hours (7 milkings) following the last treatment. When milking once a day: 3 x 24-hour doses, 72 hours (3 x once-a-day milkings) following the last treatment. MEAT: 7 days. CONTRAINDICATIONS: Not for the treatment of infections caused by organisms that are not susceptible, or have developed resistance, to cloxacillin. Not to be used in animals with a known history of sensitivity to products containing penicillin. SPECIAL PRECAUTIONS: Penicillins may cause hypersensitivity (allergy) following injection, ingestion or skin contact. Do not handle this product if you know you are sensitised to, or if you have been advised not to work with, such preparations. Handle this product with great care to avoid exposure, taking all recommended precautions. OTHER INFORMATION: Store below 25 C. DO NOT REFRIGERATE. Restricted Veterinary Medicine. Available only under veterinary authorisation. Registered pursuant to the ACVM Act 1997, No. A Registered to: Stockguard Laboratories (NZ) Ltd, Maui St, Pukete Park, Hamilton, New Zealand. Distributed by: Virbac New Zealand, Maui St, Pukete Park, Hamilton, New Zealand. 25

27 Nitromec Injection Combat Nitromec Injection Triple active broad spectrum anthelmintic flukicidal injection for cattle. It s easy to see the benefits of using Combat Nitromec Injection, the world s first triple active broad spectrum anthelmintic flukicidal injection for cattle that treats all three stages of liver fluke infection. The only injectable that treats all three stages of liver fluke with superior control of early immature liver fluke. Proven superiority over pour-on flukicides. Potent 3-in-1 combination of Nitroxynil, Clorsulon & Ivermectin. Nitroxynil is a halogenated phenol with activity against adult stages of liver fluke and some parasitic nematodes by uncoupling of oxidative phosphorylation and changes in the permeability of fluke muscle membranes. Clorsulon is a benzenesulphonamide that is believed to inhibit glycolysis in fluke leading to starvation and death. Ivermectin has its lethal effect on invertebrates through its action upon muscle glutamate gated chloride channels causing irreversible chloride-dependent depolarisation. Somatic and pharyngeal muscles become paralysed leading to death of the parasites. INDICATIONS: For the treatment and control of the following Ivermectin sensitive internal and external parasites of Cattle: Gastro-intestinal roundworms: For the control of adult and immature: Ostertagia ostertagi Small brown stomach worms (including third and fourth stage larvae and inhibited immatures) Haemonchus spp. Barber s pole worm Trichostrongylus axei Stomach hair work (including third and fourth stage larvae) Trichostrongylus colubriformis Intestinal hair worm Cooperia spp Small intestinal worm (including third and fourth stage larvae) Oesophagostomum radiatum Nodule worm (including third and fourth stage larvae) Bunostomum phlebotomum (including third and fourth stage larvae) And adult stages of: Trichuris spp. Whipworm Strongyloides papillosus Intestinal worm Lungworms: adult and immature including inhibited stages of Dictyocaulus viviparus Sucking Lice: Linognathus vituli Long nosed sucking louse Haematopinus eurysternus Short nosed sucking louse Solenopotes capillatus Little blue sucking louse And also aids in control of: Biting Lice: Bovicola (Damalinia) bovis For the treatment and control of: Early Immature (including 2-week old), Immature and Adult Liver Fluke: Fasciola hepatica WARNING: Do not use on lactating cows or pregnant cattle that may in the future produce milk for human consumption. WITHHOLDING PERIOD: MEAT: Animals producing meat and offal for human consumption must not be sold for slaughter either during treatment or within 56 days of the last treatment. Calves born to cows treated with Combat Nitromec during pregnancy must not be slaughtered from human consumption within 56 days of calving. Where intramuscular injection may have occurred, animals producing meat and offal for human consumption must not be slaughtered within 91 days of the last treatment. MILK: Do not use on lactating cows or pregnant cattle that may in the future produce milk for human consumption. STORAGE: Store below 30 C. Store bottle in carton to protect from light. Store locked up. Keep out of reach of children. Registered pursuant to the ACVM Act 1997, No. A See for registration conditions. 26

28 Ovastim Ovastim An easy to use PAR that increases the eggs available in a ewe for fertilisation by the ram, increasing fecundity and encouraging twinning. Contains polyandroalbumin as the active ingredient. Ovastim is a vaccine used to increase the fecundity in breeding ewes. Proven by New Zealand and Australian trials Can be used at the same time as Campylovexin Up to 24 months between booster vaccinations INDICATIONS: Ovastim is a conjugated sterate, which will increase the ovulation rate in prime lamb producing ewes and consequently will increase the number of lambs born. Ovastim is not recommended for Merino ewes. Encouraging multiple births in Merino flocks is not good farming practice. Ewes in poor condition, due to inadequate nutrition or disease such as parasitic disease, may not respond. It is essential that the flock be managed as a twin bearing flock. Adequate nutrition, shelter and supervision must be provided to ensure maximum survival. Above average Increase in body weight of ewes is an indicator of potential twins. These ewes should be drafted from the main mob and managed as for twin births and survival. Ovastim is suited to high yielding lamb production systems and rapid breeding of replacement stock. WHEN DO I USE OVASTIM? Flexibility the key for Farmer use! Ovastim recommended treatment protocol. PRIMARY COURSE 2 injections required 1st dose : 2ml dose given 6-9 weeks before mating (sensitiser) 2nd dose: 2ml dose given 3-4 weeks before mating (booster) Note: 1. There must be at least 3 weeks between the sensitiser and booster 2. There must be at least 3 weeks between the booster and ram joining 3. There is some flexibility regarding the period between sensitiser and booster (3-6 weeks is acceptable). 1ST DOSE PRIMARY COURSE 2ND DOSE 9 WEEKS 6 WEEKS 3 WEEKS INTRODUCE RAMS ANNUAL BOOSTER Previously treated ewes should be given one 2ml dose 3-4 weeks before mating. A single booster vaccination administered up to 24 months (2 years) after previous vaccination has been demonstrated by trial work, to result in an increase in fecundity. DESCRIPTION: Ovastim is a sterile, clear & colourless solution containing Polyandroalbumin 600mg/L. For subcutaneous injection, available in 100 ml (50 dose) glass multidose vials and a 1L Flexipack (500 doses). Ovastim causes a specific androstenedione antibody response, which increases ovulation. Ovulation rate is the most important determinant in the number of lambs born. The increase in lambs is primarily through an increase in the number of twin births. Ovastim produces a natural response and does not adversely affect the survival rate or growth rate of lambs. MEAT AND MILK: Nil DOSAGE: Not for use in rams. Not recommended for merino ewes. Administer by subcutaneous injection only. Registered pursuant to the ACVM Act 1997, Nos A8081, A4130. See for registration conditions. Only available under Veterinary Authorisation. Continued over page... 27

29 Ovastim Ovastim trial support Consistent results support Ovastim use Over 50 farms (including both research and commercial farms) Trials conducted in New Zealand and Australia involving thousands of sheep Representative breeds of sheep and farm management systems used. Ovastim - New Zealand trial summary Number of farms Average increase in ovulation rate Average increase in lambing rate* Average increase in weaning rate** 28 63% 29% 27% * Lambing rate defined as number of lambs born per ewe joined. ** Weaning rate defined as number of lambs weaned per ewe joined. All trials were conducted using a 6 week mating period. New Zealand Trials: Ovastim has been proven under New Zealand conditions to successfully booster the immune response to androstenedione previously sensitised by other commercially available androstenedione vaccines. Study Objective: To conduct a field trial to assess the potency of Ovastim and another commercially available androstenedione-protein complex and to compare results from treated ewes with results from untreated control ewes. Conclusions: Ovastim effectively boosters the immune response previously sensitised by other commercially available androstenedione vaccines. Treatment with both Ovastim and the commercially available androstenedione vaccine results in an increase in the titres of androstenedione antibody and the number of lambs produced per ewe when compared to control (untreated) ewes. Number of lambs per ewe scanned Scanning results Control Androvax Ovastim Return on Investment: Estimation based on 29% lamb percentage increase - New Zealand trials average increase in lambing percentage. $1.50 per lamb dose Extra lamb income at: Number of ewes Ovastim investment Extra lambs At $50 At $60 At $80 At $ $ $14500 $ $ $ $ $ 2900 $ $ $ $ $ $ $ $ $ $ $ $ $ $ $ $ $ $ Return on Investment 867% 1060% 1447% 1833% Androvax is a registered trademark of Schering-Plough Intervet. 28

30 Ovipen A sterile, aqueous suspension of 150,000i.u./mL procaine penicillin G and 150,000i.u./mL benzathine penicillin G. Manufactured in New Zealand and available in 100mL pillow packs. Ovine species-specific injectable LA penicillin High dose of 1mL/10kg Convenient Plastic Pillow pack Procaine penicillin is a moderately soluble drug that provides a therapeutic effect from a single injection for up to 24 hours. Benzathine penicillin gives this product a long-acting effect for sustained treatment of difficult, penicillin-sensitive infections or continued therapy where daily injection is not practical. Offers prolonged protection when used as a preventative treatment in the absence of clinical symptoms. Penicillin inhibits cell wall synthesis in susceptible bacteria. INDICATION: Long-acting treatment of infections in sheep caused by organisms that are susceptible to treatment with penicillin. DOSAGE & ADMINISTRATION: Administer 1mL/10kg b.w, in the anterior half of the neck (close to the head), by i/m or s/c injection. MILK: 35 days after last treatment. MEAT: 30 days. CONTRAINDICATIONS: Not to be used in animals with a known history of sensitivity to products containing penicillin or its analogues. Not to be used for the treatment of infections caused by organisms known to be resistant to penicillin. OTHER INFORMATION: Protect from direct sunlight. Store below 18 C. Product may be refrigerated. Do not freeze. Shake well before use. Keep out of reach of children. Restricted Veterinary Medicine. Available only under veterinary authorisation. Registered pursuant to the ACVM Act 1997, No. A7187. Registered to: Stockguard Laboratories (NZ) Ltd, Maui St, Pukete Park, Hamilton, New Zealand. Distributed by: Virbac New Zealand, Maui St, Pukete Park, Hamilton, New Zealand. SPECIAL PRECAUTIONS: Penicillins may cause hypersensitivity (allergy) following injection, ingestion or skin contact. Do not handle this product if you know you are sensitised to, or if you have been advised not to work with, such preparations. Handle this product with great care to avoid exposure, taking all recommended precautions. 29

31 Oxyfoam Forte Oxyfoam Forte Foaming pessary for therapy and/or prophylaxis of puerperal genital infections in cows. For use in the treatment of abortion, retained placenta, endometritis, and pyometritis, when oxytetracycline sensitive organisms are present. Infection prevention. Superior Foaming Action Broad Spectrum Practical Waterproof Packaging ACTION: The broad-spectrum antibiotic oxytetracycline is effective in the treatment and prevention of puerperal infections, because it has a pronounced effect on a wide range of Grampositive and Gram-negative bacteria. On contact of the tablet with the uterine fluids, at least 2 litres of carbon dioxide foam is produced, which spreads the antibiotic throughout the uterine cavity, and ensures intimate contact with the entire endometrium. INDICATIONS: For therapy and/or prophylaxis of puerperal genital infections in cows. For use in the treatment of abortion, retained placenta, endometritis, and pyometritis, when oxytetracycline sensitive organisms are present. An adjunct in treatment of prolapse of the uterus and/or vagina and complicated parturition: when these conditions may include or predispose to infection. Oxyfoam pessaries have superior foaming characteristics from a competitor 1g oxytetracycline pessary with which it was compared. It could be extrapolated that this could mean that intrauterine dispersion of oxytetracycline would be superior for Oxyfoam compared with its competitor product. It would also take a smaller volume of water to disperse the Oxyfoam pessary in a dry uterus. PRECAUTIONS: Resistance may develop to any chemical. Ask your local veterinarian or animal health advisor for recommended parasite management practices for your area to reduce the development of resistance. WITHOLDING PERIODS: MILK: 96 hours MEAT: 7 days Cow: Prophylaxis : 1 pessary Therapy : 1-2 pessaries Dosage may be repeated at the discretion of the veterinarian at intervals of hours. Registered pursuant to the ACVM Act 1997, No A6307. See for registration conditions. Only available under Veterinary Authorisation. DOSAGE Do not insert the desiccant tablet with the pessary (only the pessary is required). 30

32 PenClox TM 1200 High Potency Milking Cow PenClox TM 1200 High Potency Milking Cow is indicated for the treatment of mastitis in lactating dairy cows, especially in cases caused by Streptococci or penicillin-resistant Staphylococci. Dual combination of 1gm Pencillin & 200mg Cloxacillin Above MIC 90 of Streptococcus spp., Staph. aureus & CNS for duration of treatment Patented formulation New Zealand trial work DOSAGE & ADMINISTRATION: The entire contents of one syringe should be infused into the teat canal of each infected quarter immediately following milking. Repeat the treatment twice more at 24-hour intervals. Three syringes provide a full course of treatment. Milk out the infected quarter. Clean teat thoroughly and wipe with cotton wool soaked in methylated spirits. Allow to dry. Insert the tip partly into the udder. Dip or spray teat with a recognised teat antiseptic. It is an offence for users of this product to cause residues exceeding the relevant MRL in the New Zealand (Maximum Residues Limits of Agricultural Compounds) Food Standards. MILK: When milking twice a day: For 3, 4, 5, or 6 treatments given 24 hours apart: Milk intended for sale for human consumption must be discarded during treatment and for not less than 9 milkings or approximately 108 hours following the last treatment. When milking once a day: For 3 treatments given 24 hours apart: Milk intended for sale for human consumption must be discarded during treatment and for not less than 5 once-a-day milkings or approximately 120 hours following the last treatment. MEAT: Animals producing meat or offal for human consumption must not be sold for slaughter either during or within 10 days of cessation of the last treatment. CONTRAINDICATIONS: Bobby calves: milk from treated cows should not be fed to bobby calves during the treatment or with-holding period. FIRST AID: The main health hazard from this material is the risk of sensitisation through continuous or repeated exposure. Sensitisation can lead to allergic reactions, ranging from a skin rash to anaphylactic shock (which may be fatal). Any person showing signs of sensitisation to Penicillin should be excluded from any situation where contact with this product may occur. Registered pursuant to the ACVM Act 1997, No. A Registered to: Stockguard Laboratories (NZ) Ltd, Maui St, Pukete Park, Hamilton, New Zealand. Distributed by: Virbac New Zealand, Maui St, Pukete Park, Hamilton, New Zealand. 31

33 Phenax Classic Phenax Classic For the vaccination of sheep and goats against contagious pustular dermatitis (scabby mouth or orf). Presented in a 150-dose applicator with easy-flow application needles and twist top. Trusted, Reliable, Market Proven. New Zealand Strain New Zealand Manufactured Simple Effective Vaccine Applicator Included INDICATIONS: For the vaccination of sheep and goats against contagious pustular dermatitis (scabby mouth or orf). Virus antigen stimulates immunity to contagious pustular dermatitis (scabby mouth) in sheep and goats. SPECIAL PRECAUTIONS: Care should be taken because Phenax is a live virus vaccine that can be transmitted to and infect humans. Care should be taken to avoid contact with the vaccine, especially to cuts, scratches or abrasions. In the event of contact, wash the affected area with clean soapy water and treat with a disinfectant. In the event of infection, seek the advice of your local medical practitioner. DESCRIPTION: A live virus vaccine of contagious pustular dermatitis (scabby mouth or orf) virus. Presented in a 150-dose applicator with easy-flow application needles and twist top. CONTRAINDICATIONS: Contains infectious orf virus so vaccination should not by carried out on properties that have no history of the disease. MEAT AND MILK: Nil DOSAGE: Deposit a droplet of vaccine on the inside of the thigh. Make two scratches about 25mm in length forming an X through the droplet. The skin must be broken, but do not scratch so heavily that blood washes the vaccine away. The bluecoloured vaccine should be visible along the scratches. A successful response to the vaccine will be indicated by a skin reaction (whitish thickened or raised area over the scratch mark with reddening of the surrounding peripheral tissue) that will be seen one week after administration. For full details refer to package insert. Registered pursuant to the ACVM Act 1997 No. A6422. See www. foodsafety.govt.nz for registration conditions. Only available under Veterinary Authorisation. Continued over page... 32

34 Directions for use Unscrew the cap and remove the tamper-proof seal using the tool at the end of the cap. Invert and tap the applicator to allow a droplet of vaccine to fall onto the vaccination site. Generally this is the inner thigh region of the animal. Make two (2) scratches (Approx. 25mm) forming an X through the droplet. The skin must be broken, but do not scratch so heavily that blood washes the vaccine away. The blue coloured vaccine should be visible along the scratches. Unscrew cap and remove tamper-proof seal with the tool in the cap Invert and tap the applicator to allow a droplet of vaccine to fall onto the vaccination site Mark thighs with two scratches in an X formation through the droplet Note: Vaccine must make contact with the scratches for the induction of a take Cleaning Occasionally the applicator may become blocked with sheep wool. To clear pull wire gently (preferably with pliers) until it stops and re-insert. Note: Care is to be taken not to have contact with the vaccine. Evaluation Vaccination will induce the formation of a macropapullar lesion at the vaccination site. The lesion typically appears as a whitish thickened or raised area about the skin over the scratch mark, often up to 2-5mm across with accompanying reddening to the surrounding periphery approximately 5-8 days after vaccination. Examine a minimum of 20 animals to evaluate the vaccination process. Any animals that have not had takes of their vaccination should be revaccinated and examined after a further 8 days. Phenax Classic Scabby Mouth Vaccine is potent and is thoroughly tested before distribution. Failure to produce takes in vaccinated animals may be due to poor vaccination technique, pre-existing immunity in the vaccinated animals, or vaccine used outside the expiry date for the batch. Successful take Raised area of skin whitish in colour Unsuccessful take Thin brown line of healing scratch Post-vaccination care Vaccinated animals can be returned to conventional pasture conditions. It is advisable to avoid grazing animals on pastures where heavy growth of thistle, gorse or other rough fodder is available for up to 25 days following vaccination. Vaccinated animals seldom contract overt scabby mouth and re-vaccination is not necessary 33

35 Diarrest TM & Revive Diarrhoeic animals will die if they lose up to 15% of their body fluid. Help your calves recover from scours in a matter of hours with Revive and Diarrest. DIARREST: The only electrolytes proven treatments to provide earlier and sustained correction of the energy and fluid replacement needs for rapid recovery from diarrhoea thanks to a balanced formulation of superior energy and electrolyte sources. Provides broad action for complex diarrhoeas Recovery period is shortened Can mix with milk or water without interfering with the clotting of milk (casein) proteins. REVIVE POWDER: Supportive treatment for mild diarrhoea (scours) in calves, lambs & foals. To replace electrolytes, reverse dehydration, supplement energy needs and correct acidosis. The only electrolyte proven treatments to provide earlier and sustained correction of the energy and fluid replacement needs for rapid recovery from diarrhoea thanks to a balanced formulation of superior energy and electrolyte sources. Patented Ratio of superior energy sources dextrose and lactose combined with electrolytes Bicarbonate and bicarbonate precursors Can mix with milk or water without interfering with the clotting of milk (casein) proteins. REVIVE SYRUP: Supportive treatment for mild diarrhoea (scours) in calves, lambs & foals. To replace electrolytes, reverse dehydration, supplement energy needs and correct acidosis. The only electrolyte proven treatments to provide earlier and sustained correction of the energy and fluid replacement needs for rapid recovery from diarrhoea thanks to a balanced formulation of superior energy and electrolyte sources. Patented Ratio of superior energy sources dextrose and lactose combined with electrolytes Bicarbonate and bicarbonate precursors Can mix with milk or water without interfering with the clotting of milk (casein) proteins. DESCRIPTION: Revive Syrup: A straw-coloured viscous liquid containing the active ingredients per 250mL. Revive Powder: An off-white powder containing the active ingredients per 2 litre dose. Diarrest Powder: An off-white powder containing the active ingredients per 2 litre dose. Revive: Formulated to replace electrolytes, reverse dehydration, supplement energy needs and correct acidosis. Diarrest: Formulated to provide full maintenance energy requirements, replace electrolytes reverse dehydration and correct acidosis. MEAT AND MILK: Nil. No Antibiotic. INDICATIONS: Revive: The result is a supportive treatment for diarrhoea (scours) in calves, lambs and foals. Diarrest: The result is a supportive treatment for diarrhoea (scours) in calves. Registered pursuant to the ACVM Act 1997, Nos. A7259, A7296 & A7413. See for registration conditions. Continued over page... 34

36 Trials Study 1: Assessing carbohydrate digestibility Based on the production of Hydrogen from residual carbohydrates by gut microflora. Hydrogen is mainly eliminated via dissolution in the blood, then expired across alveoli. By feeding a standard dose of carbohydrate and measuring breath hydrogen over several hours it is possible to estimate the efficiency of utilisation. This is a sensitive test, widely used in human studies. Lactulose is undigestable and used as a benchmark for comparison. Breath Hydrogen (ppm) Breath hydrogen in calves following oral carbohydrates Time after ingestion (h) 150g Rice Flour 150g Maize Flour 135g Glucose 135g Lactulose Study 2: Assessing sugars for digestibility in calves Studies at AHSC, Massey comparing monosaccharide, disaccharide, & combinations. The results demonstrate that the ratio of the disaccharide lactose and monosaccharide glucose are optimal in Revive and Diarrest for complete utilisation of the sugar content and is superior to a monosaccharide only ORT. Even a relatively small increase in the amount of lactose markedly increases breath hydrogen indicating incomplete digestion of carbohydrates. Variation from T=0 (ppm) Breath hydrogen in calves following oral carbohydrates Hours following treatment 60g Glucose (eg Lectade Plus) 1.25g Lactose/kg bwt 40g Glucose & 70g Lactose 40g Glucose & 50g Lactose Study 3: Induced diarrhoea in calves This was a project run for Virbac NZ at AHSC, Massey. Calves had diarrhoea due to infection with E. coli K99, plus rotavirus and a range of biochemical parameters were measured, including plasma volume, ECF, Na+, blood glucose, HCO3. Compared to a control electrolyte product Diarrest and Revive provided: 1. Earlier, more sustained correction of hypoglycaemia 2. Best serum sodium recovery 3. Superior restoration of ECF 4. Rapid correction of acidosis 5. Best weight maintenance/gain Conc. (mmol/l) Preinfection Serum sodium changes Day 0 Day 1 Day 2 Days of treatment Diarrest Revive Control Day 3 Oral Replacement Therapies (ORT) comparison Provided by 2 x 2L Energy ( kcal) Osmolarity (<700mlOsm/L is acceptable) Vytrate Lectade Plus Revive Revive Syrup Diarrest

37 SMARTShot B 12 + Se SMARTShot B 12 + Se An oily suspension, containing 12mg/mL selenium as barium selenate and 3mg/mL hydroxocobalamin hydrochloride encapsulated in a lactide/glycolide co-polymer for extended release. Available in 500mL pillow packs. Flexible treatment options - tailor dose to suit length of efficacy required in lambs Veterinary world-first patented microencapsulation technology Long-acting Vitamin B 12 & Selenium injection Convenient Plastic Pillow pack The gradual dissolution of the encapsulating polymer produces a steady, prolonged release of vitamin B 12, which is necessary for optimal energy and protein metabolism in ruminants. The extended release of selenium assists in maintaining the integrity of cell membranes, the functioning of the immune system and healthy thyroid activity. INDICATION: Long term prevention and treatment of cobalt (vitamin B 12 ) and selenium deficiencies in sheep and cattle, especially when grazing cobalt and selenium deficient pastures. Cobalt deficiency in soil or pasture leads to low vitamin B 12 in body tissues. Vitamin B 12 is an essential cofactor for energy and protein metabolism in ruminants and a deficiency may cause anorexia leading to ill thrift, starvation and poor growth, particularly in young animals. Selenium is an essential trace element that influences the responsiveness of the immune system and maintains the integrity of cell membranes through the action of the antioxidant selenoenzyme, glutathione peroxidase. A deficiency can cause white muscle disease (myopathy), limits the growth of young animals and reduces fertility in ewes and cows. DOSAGE & ADMINISTRATION: Shake well before and during use to ensure the product is fully re-suspended. Administer only with the SmartShot injector, by s/c or i/m injection into the anterior half of the neck. Sterilise all injection apparatus before use. Needles should be changed frequently and as necessary. Avoid simultaneous use of other selenium-containing products LAMBS AT DOCKING: 0.5mL for lambs that are to be fattened for slaughter. 1mL for lambs that are to be kept as ewe replacements. LAMBS AT WEANING: 2mL. EWES: 5mL. CALVES: 1mL/25kg l.w.. PERSISTENT ACTIVITY: LAMBS FOR SLAUGHTER: Following injection of lambs with 0.5mL from 3 weeks of age (at docking time), vitamin B 12 and selenium levels will be maintained at adequate concentrations for 3-4 months until time of slaughter. LAMBS AS EWE REPLACEMENTS: Following injection of lambs with 1mL from 3 weeks of age (at docking time), vitamin B 12 and selenium levels will be maintained at adequate concentrations for 180 days, and in some cases the effect may last for days for vitamin B 12 and 300 days for selenium. However, users are advised to consult their veterinarian before assuming adequacy beyond 180 days. EWES: Following the pre-mating injection of ewes, vitamin B 12 and selenium levels will be maintained at adequate concentrations for 180 days, and in some cases the effect may be for days (especially for selenium). However, users are advised to consult their veterinarian before assuming adequacy beyond 180 days. Adequate levels will be maintained in the offspring until 1 month of age for vitamin B 12 and from birth to weaning for selenium. CALVES: Following injection of calves from 3 weeks of age, serum vitamin B 12 levels will be maintained at concentrations ensuring adequacy for up to 3½ months and selenium levels for at least 10 months. Continued over page... 36

38 WITHHOLDING TIMES: MILK: NIL. MEAT: NIL. CONTRAINDICATIONS: Not to be administered to lambs or calves younger than 3 weeks of age. SPECIAL PRECAUTIONS: Avoid simultaneous use of other selenium-containing products. Before use, veterinary advice should be sought to establish pasture cobalt and selenium levels, and blood and liver levels of vitamin B12 in the animals, to ensure that other causes of ill thrift are not overlooked. Veterinary advice should also be obtained on the selenium status of the animals and on the risks associated with other routine treatments such as dosing with anthelmintics that may contain selenium. Do not handle until all safety precautions have been read and understood. Avoid direct contact. If contact does occur, seek medical attention/ advice. When handling, wear chemical-resistant gloves. TOXICITY/OVERDOSE/ANTIDOTE: Barium selenate is suspected of causing genetic defects in humans. It is ecotoxic in the aquatic and soil environments. This material is dangerous if swallowed, inhaled or absorbed through the skin. HUMAN FIRST AID, SYMPTOMS OF POISONING: Refer to the Material Safety Data Sheet included in each carton. OTHER INFORMATION Store upright in a cool place, preferably refrigerated. Do not freeze. Protect from light. Registered pursuant to the ACVM Act 1997, No. A9402. Registered to: AgResearch Ltd. Distributed by: Virbac New Zealand, Maui St, Pukete Park, Hamilton, New Zealand. 37

39 SMARTShot B 12 Prime Lamb SMARTShot B 12 Prime Lamb An oily suspension specifically formulated for treating lambs, but also suitable for ewes and calves, containing 3mg/mL hydroxocobalamin hydrochloride encapsulated in a lactide/glycolide co-polymer for extended release. Available in 500mL pillow packs. Flexible treatment options - tailor dose to suit length of efficacy required in lambs Veterinary world-first patented microencapsulation technology Long-acting Vitamin B 12 injection Convenient Plastic Pillow pack The gradual dissolution of the encapsulating polymer produces a steady, prolonged release of vitamin B 12, which is necessary for optimal energy and protein metabolism in ruminants. INDICATION: For long term prevention and treatment of cobalt (vitamin B 12 ) deficiency in lambs, ewes and calves, especially when grazing cobalt-deficient pastures. Cobalt deficiency in soil or pasture leads to low vitamin B 12 in body tissues. Vitamin B 12 is an essential cofactor for energy and protein metabolism in ruminants and a deficiency may cause anorexia leading to ill thrift, starvation and poor growth, particularly in young animals. MILK: NIL. MEAT: NIL. CONTRAINDICATIONS: Not to be administered to lambs younger than 3 weeks of age. SPECIAL PRECAUTIONS: Before use, veterinary advice should be sought to establish pasture cobalt levels and blood and liver levels of vitamin B 12 in the animals, to ensure that other causes of ill thrift are not overlooked. DOSAGE & ADMINISTRATION: Shake well before and during use to ensure the product is fully re-suspended. Administer only with the SMARTShot injector, by s/c or i/m injection into the anterior half of the neck. Sterilise all injection apparatus before use. Needles should be changed frequently and as necessary. LAMBS that are to be fattened for slaughter: 0.5mL administered at docking. LAMBS that are to be kept as ewe replacements: 1mL administered at docking or weaning. EWES: 5mL. CALVES: 1mL /25kg l.w. PERSISTENT ACTIVITY: LAMBS for slaughter: Following injection with 0.5mL from 3 weeks of age (docking time), vitamin B12 levels will be maintained at adequate concentrations for 3 4 months until time of slaughter. LAMBS as ewe replacements: Following injection with 1mL from 3 weeks of age (at docking or weaning), vitamin B 12 levels will be maintained at adequate concentrations for 180 days and in some cases the effect may last for days. However, users are advised to consult their veterinarian before assuming adequacy beyond 180 days. EWES: Following injection with 5mL pre-mating, vitamin B 12 levels will be maintained at adequate concentrations for 180 days and in some cases the effect may last for days. However, users are advised to consult their veterinarian before assuming adequacy beyond 180 days. Adequate vitamin B 12 levels will be maintained in the offspring until 1 month of age. CALVES: Following injection with 1mL/25kg l.w. from 3 weeks of age, serum vitamin B 12 levels will be maintained at concentrations ensuring adequacy for up to 3½ months. Restricted Veterinary Medicine. Available only under veterinary authorisation. Registered pursuant to the ACVM Act 1997, No. A9984. Registered to: AgResearch Ltd. Distributed by: Virbac New Zealand, Maui St, Pukete Park, Hamilton, New Zealand. 38

40 Tetraguard LA Tetraguard LA An aqueous ready to use injectable solution containing 200mg/mL of oxytetracycline, as the long-acting magnesium complex. Presented in amber glass 100mL and 250mL multi-dose vials. Convenient 100mL & 250mL pack sizes One of only 2 registered tetracycline injections with s/c administration claim Made in New Zealand Oxytetracyclines are bacteriostatic compounds (bactericidal at high concentrations), which inhibit protein synthesis in the target organisms. INDICATION: Parenteral treatment of bacterial infections in cattle, sheep and pigs. Especially useful in the treatment of respiratory, arthritic, reproductive, enteric and inflammatory diseases. DOSAGE & ADMINISTRATION: By s/c or i/m injection at the rate of 20mg/kg b.w, ie. 1mL/10kg l.w. For doses over 10mL, it is desirable to split the total dose between several injection sites. MILK: 168 hours (14 milkings). MEAT: 28 days. CONTRAINDICATIONS: Do not use in horses, dogs or cats. Do not use in animals with a known history of allergic reactions to tetracyclines or with impaired liver function. SIDE EFFECTS: Transient reactions may occur at the injection site. Anaphylactic reactions have been reported rarely in calves following tetracycline injections. Prompt treatment with antihistamines is indicated. OTHER INFORMATION: Protect from direct sunlight. Store in a cool place. Registered pursuant to the ACVM Act 1997, No. A6389. Registered to: Stockguard Laboratories (NZ) Ltd, Maui St, Pukete Park, Hamilton, New Zealand. Distributed by: Virbac New Zealand, Maui St, Pukete Park, Hamilton, New Zealand. 39

41 TopLine For the treatment and control of Abamectin sensitive internal and external parasites of beef and dairy cattle. State-of-the-art science, the last word in Abamectin pour-on formulations for cattle. Persistent activity against biting and sucking lice for 56 days Nil Milk withhold Rain fast INDICATIONS: For the treatment and control of adult and immature stages of Gastro-intestinal roundworms: Ostertagia ostertagi - Small brown stomach worms (including inhibited stages) Trichostrongylus axei - Stomach hair worm Trichostrongylus colubriformis Hair worm Haemonchus spp Barber s pole worm Oesophagostomum radiatum - Nodule worm Cooperia oncophora* Small intestine worm Cooperia punctata* - Small intestine worm Nematodirus spathiger - Thin necked intestinal worm Oesophagostomum venulosum - Large bowel worm Trichuris spp - Whipworm Strongyloides papillosus - Intestinal worm * Active against immature stages of some New Zealand ML resistant strains of Cooperia spp. LUNGWORM: Dictyocaulus viviparus. SUCKING LICE AND BITING LICE: Linognathus vituli Long nosed sucking louse Haematopinus eurysternus Short nosed sucking louse Damalinia bovis - Biting louse Solenopotes capillatus Little blue sucking louse. PERSISTENT ACTIVITY: At the recommended dose rate, TopLine effectively prevents reinfestation from the biting louse Damilinia bovis and the sucking louse Linognathus vituli for at least 56 days. RAIN RESISTANCE: For best results it is recommended that TopLine be applied to dry animals. However, rainfall before and after use will not affect efficacy. PRODUCTION ENHANCEMENT: Increases milk production in grazing dairy cows. Data has shown that milk production increases by a median of approximately +0.6kg liquid milk per day when cows or heifers infected with gastrointestinal nematode parasites are treated with an effective anthelmintic; this increase occurs without any reduction in milk quality. SIMULTANEOUS USE WITH SELENIUM POUR-ON PRODUCTS: Studies show that the use of this product at the recommended dose at the same time as selenium pour-on products should not adversely affect efficacy against abomasal and small intestinal nematodes. DESCRIPTION: ACTIVE CONSTITUENT: 10mg/mL (1% w/v) Abamectin. Liveweight kg Dose Volume =ml Cattle Treated per 5L Available in 2.5L and 5L Topline contains Abamectin, a member of the Avermectin family of drenches. It is effective against sensitive strains of internal and external parasites: MEAT: 35 days MILK: Nil DOSAGE: For topical application to cattle. 1mL/20kg body weight (500µg abamectin / kg liveweight). Cattle in excess of 650 kg should be dosed at 1 ml per 20 kg bodyweight The following graph shows a dose rate guide for cattle. Registered pursuant to the ACVM Act 1997, No. A See for registration conditions. 40

42 Tyloguard RTU Injection Tyloguard A sterile ready to use injectable solution containing 200mg/mL tylosin base. Manufactured in New Zealand. Available in 75mL and 200mL pillow packs. Dose-specific 75mL pack and larger 200mL available Tylosin base as active Registered by i/v route and milk withholding for combination therapy with Mastiguard MC Convenient Plastic Pillow packs Needles & syringes supplied Tylosin is a member of the macrolide group of antibiotics. It is active against the most common mastitis pathogens isolated from cases of bovine mastitis in New Zealand. Due to the ph trap phenomenon Tylosin will selectively accumulate in areas of low ph, as for example occurs in inflamed udder tissue. INDICATION: Treatment of bacterial and mycoplasmal infections caused by tylosin-sensitive organisms in cattle, sheep, pigs and goats, eg. mastitis, respiratory infections, footrot, metritis, dysentery, erysipelas, etc. DOSAGE & ADMINISTRATION: Administer by i/m injection in the anterior half of the neck. In cattle, the SLOW i/v route may be used. CATTLE and CALVES: 5 10mg/kg b.w. (2.5 5mL/100kg) daily for no more than 5 days. If the i/v route is used initially, maintain therapeutic levels by administering an i/m dose 12 hours later. For difficult cases of mastitis, treatment may be combined with a course of the intramammary, Mastiguard Milking Cow. For details, see leaflet provided with the product. PIGS: 5 10mg/kg b.w. (2.5 5mL/100kg) daily for no more than 3 days. SHEEP and GOATS: 10mg/kg b.w. (2.5mL/50kg) daily for no more than 5 days. MILK: Bovine milk 72 hours (6 milkings). Sheep and goat milk 35 days. 3 MEAT: x Tyloguard 21 days + after 3 x Mastiguard last treatment hours (6 milkings) following the last treatment 3 x Tyloguard + 6 x Mastiguard hours (11 milkings) following the last treatment 5 x Tyloguard + 6 x Mastiguard - 96 hours (8 milkings) following the last treatment MEAT: 21 days after last treatment. SIDE EFFECTS: As with any injectable, a reaction may occur in some animals, eg. pain and swelling at the injection site. On rare occasions, there may be oedema and protrusion of the rectal mucosa and erythema in pigs and cattle. However, these reactions resolve when treatment is discontinued. OTHER INFORMATION: Protect from direct sunlight. Store below 30 C. Registered pursuant to the ACVM Act 1997, No. A9713. Registered to: Stockguard Laboratories (NZ) Ltd, Maui St, Pukete Park, Hamilton, New Zealand. Distributed by: Virbac New Zealand, Maui St, Pukete Park, Hamilton, New Zealand. 41

43 Vibrostrep A sterile, aqueous high potency solution containing 500,000i.u. streptomycin/ml (250mg dihydrostreptomycin, as sulphate) and 250mg streptomycin, as sulphate. Manufactured in New Zealand and available in 100mL pillow packs. First-choice antibiotic for Woody Tongue & Vibriosis Made in New Zealand Convenient Plastic Pillow packs Dihydrostreptomycin and streptomycin interfere with protein synthesis in susceptible strains of bacteria. The slight differences in structure between the two drugs allow some bacteria to be resistant to one drug but not the other. INDICATION: Treatment of vibriosis (campylobacteriosis), leptospirosis, actinobacillosis and infections caused by organisms susceptible to dihydrostreptomycin and streptomycin in pigs, sheep and cattle. DOSAGE & ADMINISTRATION: By i/m or s/c injection. In animals producing food, injection must be in the anterior half of the neck. COWS for BOVINE VIBRIOSIS (campylobacteriosis): Infuse 2 10mL into the uterus and inject 3 4mL/100kg b.w. by i/m or s/c injection, daily for 3 days. BULLS for BOVINE VIBRIOSIS (campylobacteriosis): Infuse 2 10mL into the preputial cavity, massaging in, and give 3 4mL/100kg b.w. by i/m or s/c injection, daily for 3 days. PIGS, SHEEP and CATTLE: For the treatment of vibriosis (campylobacteriosis), leptospirosis, actinobacillosis (woody tongue) and other infections caused by organisms susceptible to streptomycin and dihydrostreptomycin, inject 3 4mL/100kg b.w. once daily, for 3 days by i/m or s/c injection. Daily administration of 5,000,000 units of penicillin may improve the effectiveness of treatment. Lower doses may lead to a build-up of resistant bacteria. Higher doses may be used at the discretion of a veterinarian. CONTRAINDICATIONS: Not for use in bobby calves. Not to be used for the treatment of infections caused by organisms that are known to be resistant to dihydrostreptomycin or streptomycin. Not recommended for use in animals with renal dysfunction or in those already being treated with aminoglycoside (-mycins) antibiotics. OTHER INFORMATION: Store in original container, tightly closed, away from foodstuffs. Keep out of reach of children. Registered pursuant to the ACVM Act 1997, No. A3144. Registered to: Stockguard Laboratories (NZ) Ltd, Maui St, Pukete Park, Hamilton, New Zealand. Distributed by: Virbac New Zealand, Maui St, Pukete Park, Hamilton, New Zealand. MILK: 72 hours (6 milkings). MEAT: 30 days. 42

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