CATALOGUE OF VETERINARY DRUGS AND FEED ADDITIVES

Transcription

1 QUALITY TRADITIONS CATALOGUE OF VETERINARY DRUGS AND FEED ADDITIVES Development, production, sale WWW BIOFARM KHARKIV COM

2 LLC «AT Biopharm» was established in 1995 and currently holds leading position in the Ukrainian market of veterinary drugs and feed additives. All departments of our company are certified according to international standards ISO 9001:2015 and ISO 22000:2005. The factory was built in compliance with the requirements of GMP and has modern equipment. The modern microbiological and chemicalanalytical laboratories of the plant are certified according to ISO It has highquality equipment that allows to control the quality of raw materials and finished products, thus eliminating the smallest probability of entry the poor quality raw materials in production. Our products are under great demand because of: Research and revealing of the original highly effective combinations; Product development by highly qualified specialists of the scientific department; Using of raw materials from EU countries; GMP-certified manufacturing facilities; Strict quality control; Original patented high quality veterinary drugs and feed additives. We are offering high effective products at reasonable prices providing rapid and reliable service. Our pleasure is to make your business more profitable

3 CONTENT ANTIMICROBIAL DRUGS OF SYSTEMIC ACTION AMOXILEK (amoxicillin, gentamicin)...2 AMPICOL (amoxicillin, colistin)...3 CEBACTAL (cefquinome)...4 DOXYTIL (doxycycline, tylosin, ascorbic acid)...5 ENROL 10% (enrofloxacin)...7 FLOSAN (florfenicol)...8 FLOSAN 4% (florfenicol)...9 FLOSAN 30% (florfenicol)...10 FORACOL (ciprofloxacin, trimethoprim, colistin)...11 SPELIMIX (spectinomycin, lincomycin)...12 SPELIMIX 44 (spectinomycin, lincomycin)...13 SPELIMIX 100 (spectinomycin, lincomycin)...14 SPELIMIX FORTE (florfenicol, lincomycin, spectinomycin)...15 SUPRIM 240 (trimethoprim, sulfametoxazol)...17 TIAKUR (doxycycline, tiamulin)...18 TIAKUR 250 (doxycycline, tiamulin)...19 TIAMIX (tiamulin, lincomycin, spectinomycin)...20 TILMICOL (tilmicosin)...22 TILOTRIN (tylosin)...23 TRIFLON (enrofloxacin, trimethoprim)...24 TRIFLON 100 (enrofloxacin, trimethoprim)...25 TRIMECOL (colistin, trimethoprim)...26 TRIMICOSIN (enrofloxacin, tilmicosin, trimethoprim)...27 TRIMICOSIN М (enrofloxacin, tilmicosin, trimethoprim)...28 DRUGS AGAINST NECROTIC ENTERITIS BIOENRADIN (enramycin)...29 BIONON (nosiheptide)...30 GENTOVIT 10% (gentamicin)...31 ANTI-MASTITIS DRUGS FARMAST (amoxicillin, gentamicin, prednisolone)...32 MASTILEK (cefquinome, prednisolone)...33 MASTILEK FORTE (cefquinome, prednisolone, enrofloxacin)...34 TRIMAST FORTE (enrofloxacin, trimethoprim, prednisolone)...35 COCCIDIOSTATS DIAСOX 0.2% (diclazuril)...36 EIMERIX (monensin)...37 MADURO (maduramycin)...38 MADURO FORTE (maduramycin, diclazuril)...39 NICAMAX (maduramycin, nicarbazin)...40 QUINOSAN (decoquinate)...41 RONICOX (robenidine)...42 SALIMIX (salinomycin)...43 SALIMIX PLUS (salinomycin, diclazuril)...44 SOLICOX (diclazuril)...45 PARASITICIDES FENOTAL 22 (fenbendazole)...46 INTRAMEK (ivermectin)...48 NEOVERM (ivermectin)...50 PRAFEN PLUS (prasiquantel, fenbendazole)...52 PRAFEN PLUS UNIOR (prasiquantel, fenbendazole)...53 VITAMINS AND GROWTH PROMOTERS HEPATONIC (hepatoprotective complex)...54 HEPATONIC FORTE (hepatoprotective complex)...55 MIXOVIT А (polyvitaminic complex)...56 MIXOVIT АDЕ Se (vitamin А, D3, Е, selenium)...57 MIXOVIT B (complex of B group vitamins)...58 ANTIANEMIC DRUGS BIOFERON (iron dextran)...59 DRUGS FOR EXTERNAL APPLICATION UNISAN (chlorhexidine bigluconate, zinc oxide)...60 ACIDIFIERS ACIMIX (zinc acetate, copper sulfate, formic acid, propionic acid, lactic acid)...61 NONSTEROIDAL ANTI-INFLAMMATORY DRUGS APIRON (acetylsalicylic acid)...62

4 ANTIMICROBIAL DRUGS OF SYSTEMIC ACTION AMOXILEK Suspension for injection Yellowish-white suspension. 1 ml of the drug contains: active ingredients: amoxicillin (amoxicillin trihydrate) 150 mg; gentamicin (gentamicin sulfate) 40 mg; excipient vegetable oil. АТС vet: QJ01RA01. Antibacterials for systemic use. Combinations of antibacterials. Penicillins, combinations with other antibacterials. Amoxicillin is a broad-spectrum bactericidal antibiotic of the penicillin group. It is effective against gram-positive strains of Staphylococcus spp., which do not produce penicillinase, Clostridium spp., Arcanobacterium spp., Bacillus anthracis, Listeria monocytogenes, Erysipelothrix rhusiopathiae) and gram-negative microorganisms (Pasteurella spp., Mannheimia haemolytica, Haemophillus spp., Actinobacillus spp., Escherichia coli, Salmonella spp., Moraxella spp. and Fusobacterium spp.). Amoxicillin inhibits synthesis of mucopeptide one of the components of bacterial cell wall, which strengthens mechanical stability of microorganism and makes destructive impact upon bacterium in its growth stage. Gentamicin belongs to aminoglycoside antibiotics. It makes bactericidal effect upon gram-negative microorganisms, that is: Enterobacter aerogenes, Klebsiella pneumoniae, Pseudomonas aeruginosa, Escherichia coli, Salmonella spp. and Shigella spp. Gentamicin is also effective against such gram-positive bacteria as Treponema hyodysenteriae, Staphylococcus aureus and β-hemolytic Streptococcus. It produces direct effect upon ribosomes, where it inhibits biosynthesis of proteins and decreases accuracy of translation of genetic code. Penetration of gentamicin into bacterial cell strengthens in case cell wall permeability increases due to the effect of amoxicillin. Such synergism makes it possible to use less aminoglycosides. The combination of amoxicillin and gentamicin creates broad antibacterial spectrum of action of the drug upon grampositive (mostly streptococci, staphylococci and corynebacteria) and gram-negative microorganisms (particularly, Escherichia coli, Pasteurella spp., Salmonella spp. and Pseudomonas spp.). Such a combination improves therapeutic properties of either antibiotic applied individually. Treatment of animals against diseases caused by amoxicillin and gentamicin-sensitive microorganisms: swine: pneumonia, diarrhea, enteritis, colibacteriosis, metritis, mastitis; sheep and goats: pneumonia, diarrhea, enteritis, pasteurellosis, colibacteriosis; cattle: pneumonia, diarrhea, enteritis, mastitis, metritis, superficial abscess; horses: pneumonia, diarrhea, enteritis, superficial abscess, genitourinary and limb diseases. Administer the drug intramuscularly in a dose of 1 ml per 10 kg body weight of an animal once daily for 3-5 days. Shake the vial thoroughly before use. Do not prescribe to animals with individual hypersensitivity to amoxicillin and gentamicin. Do not use in non-target animals. Do not administer to rabbits, hamsters, guinea pigs and other small herbivorous animals. Do not administer to animals with kidney function, hearing organs and vestibular system disorders. Animal slaughter for meat is possible in 30 days following the last administration. Consumption of milk by people is possible in 3 days following the last administration. Meat and milk obtained before the mentioned term shall be utilized or fed to non-productive animals depending on the statement of veterinary physician. It is recommended to administer the drug in two body areas of an animal to increase absorption of high drug doses in body tissues. Glass vials of 100 ml with rubber stoppers and aluminum caps. Store in a dry dark place out of the reach of children at С. 28 days following the first sampling from the vial in case of storage in a dark place at 2-8 С. 2

5 ANTIMICROBIAL DRUGS OF SYSTEMIC ACTION AMPICOL Water-soluble powder for oral administration White water-soluble powder. 1 ml of the drug contains: active ingredients: colistin sulfate IU; amoxicillin trihydrate 200 mg; excipient glucose. АТС vet QJ01. Antibacterials for systemic use. The composition of the drug includes combination of amoxicillin and colistin, which has a synergistic antimicrobial effect. Colistin is an antibiotic of the polymyxin group, which demonstrates an effective bactericidal activity against gram-negative microorganisms (E. сolі, Salmonella spp., Pasteurella spp., Haemophіlus spp., Bordetella spp.). The mechanism of action of colistin consists in violation of integrity of bacterium cytoplasmic membrane. Antibiotic interacts with phospholipids and penetrates inside, destroying the cell membrane structure, permeability of which changes soon after interaction with the drug. Except for antibacterial effect, colistin binds phospholipid A and neutralizes biological effect of bacterial endotoxin. Amoxicillin is a broad-spectrum semi-synthetic antibiotic of the penicillin group, which has bactericidal effect against gram-positive and gram-negative microorganisms (E. сolі, Campylobacter spp., Corynebacterіum spp., Erysіpelothrіx spp., Clostrіdіum spp., Streptococcus spp., Staphylococcus spp., Actіnobacіllus spp., Haemophіlus spp., Pasteurella spp., Proteus mіrabіlіs, Salmonella spp.). Amoxicillin prevents synthesis of bacteria cell walls, inhibiting the activity of enzymes of transpeptidase and carboxypeptidase, which causes osmotic balance disorders, resulting in death of microorganisms at their growth stage. Colistin is poorly absorbed in intestinal tract; therefore, it acts effectively in treatment of diseases of digestive tract. In contrast to low concentrations of colistin in blood serum and tissues, its concentration in various segments of digestive tract is constantly high. Particularly, concentration of the antibiotic is higher in colon and caecum as compared to concentration in oral cavity. Colistin is poorly absorbed systemically following its oral administration: 40% of the antibiotic accumulates in an unchanged form in feces, 60% is bound to phospholipids and liposaccharides of gramnegative bacteria. It is eliminated with feces. Amoxicillin remains stable in stomachs of animals. It is absorbed in larger quantities from digestive tract as compared to ampicillin when administered orally. Amoxicillin is quickly distributed in body fluids, particularly in synovial fluid. Its plasma protein binding level reaches 37-38%. The half-life period makes h. It is primarily eliminated from the body with urine. Treatment of calves, goatlings and lambs of up to 3 months of age, in swine and broiler chickens of gastrointestinal diseases caused by amoxicillin and colistin-sensitive microorganisms. Orally with drinking water or feed in the following doses: calves, goatlings and lambs of up to 3 months of age: 5 g per 100 kg body weight twice daily for 3-5 days with feed or drinking water; broiler chickens, swine: 1 kg per 1 t of drinking water for 3-5 days. In case of administration with drinking water the drug solution shall be the only source of drinking water throughout the whole treatment period! Do not prescribe to animals with hypersensitivity to colistin and amoxicillin as well as with kidney injuries. Do not use concurrently with chloramphenicol, tetracyclines and sulfanilamides. Do not administer to ruminants with functionally developed proventriculi and hens laying eggs for human consumption. Ampicol is not prescribed in sub-therapeutic doses. Animal slaughter for meat is possible in 8 days following the last administration. Meat obtained before the mentioned term shall be utilized or fed to non-productive animals depending on the statement of veterinary physician. Turbidity or residues may be observed following preparation of stock solution with the use of hard water, which do not influence therapeutic effectivity of the drug. Packages of film or foil materials of g. Store in a dry dark place out of the reach of children at 5-30 С. 8 hours following dissolution in water. 3

6 ANTIMICROBIAL DRUGS OF SYSTEMIC ACTION CEBACTAL Suspension for injections Opaque light yellow liquid. 1 ml of the drug contains: active ingredient: cefquinome sulfate mg; excipients colza oil, propylparahydroxybenzoate, methylparahydroxybenzoate. АТСvet: QJ01. Antibacterials for systemic use. QJ01DE90. Cefquinome. Cefquinome is the fourth generation cephalosporin, which has a broad spectrum of antibacterial action against most gram-positive and gram-negative bacteria, particularly, including but not limited to Escherichia coli, Enterobacter spp., Staphylococcus aureus, Streptococcus spp., Clostridium spp., Actinobacillus spp., Citrobacter spp., Klebsiella spp., Pasteurella spp., Proteus spp., Salmonella spp., Serratia marcescens, Histophilus somni, Arcanobacterium pyogenes, Bacillus spp., Corynebacterium spp., Bacteroides spp., Fusobacterium spp., Prevotella spp. and Erysipelothrix rhusiopathiae as well as against β-lactamase producing strains. The mechanism of bactericidal effect consists in inhibition of cell membrane synthesis in microorganisms. After parenteral administration cefquinome penetrates into systemic circulation, reaching its maximum concentration in blood serum in minutes in cattle and minutes in swine and being maintained at therapeutic level for 24 hours. The level of binding of cefquinome with proteins of blood serum does not exceed 5%. Cefquinome is relatively easy eliminated from the body (half-life period makes hours in cattle and 9 hours in swine), primarily in unchanged form with urine. Cattle: treatment of animals against acute mastitis (including mastitis caused by Escherichia coli), escherichiosis (colibacillosis), respiratory diseases caused by Pasteurella multocida, P. haemolytica and other cefquinomesensitive microorganisms as well as panaritium, hoof sole ulcer, purulent pododermatitis, septicemia, bacterial interdigital dermatitis and necrobacillosis. Swine: treatment of animals against MMA (mastitis-metritis-agalactia) syndrome, meningitis, arthritis, dermatitis as well as diseases of respiratory organs caused by Pasteurella multocida, Haemophillus parasuis, Actinobacillus pleuropneumoniae, Streptococcus suis and other cefquinome-sensitive bacteria. Do not administer to animals sensitive to the drug and other β-lactam antibiotics. Do not prescribe in combination with bacteriostatics. Shake the vial intensely before every use. It is recommended that the injection site be changed throughout the treatment period to prevent local reaction. Avoid omission of regular drug administration as it may decrease therapeutic efficacy. In case a single dose is omitted, make injection as soon as possible with subsequent intervals between injections being unchanged. Animal slaughter for meat is possible in 8 days (cattle) and 4 days (swine) following the last administration of the drug. Milk may be consumed in 3 days following the last administration of the drug. Meat and milk obtained before the mentioned term shall be utilized or fed to non-productive animals depending on the statement of veterinary physician. Glass vials of 100 ml sealed with rubber stoppers and aluminum caps. Store in a dark place out of the reach of children at 2-30 С. Use the drug within 28 days following the initial sampling from the vial provided it is stored in a dry, dark place at 2-8 С. The drug is administered deep intramuscularly once daily in the following doses: Animal species Indications Daily drug dose Duration of (per 10 kg body treatment weight) 0.4 ml 3-5 days Cattle Diseases of respiratory organs, interdigital necrobacillosis or dermatitis Acute mastitis 0.4 ml 2 days Escherichiosis (colibacillosis) in calves 0.8 ml 3-5 days Swine Diseases of respiratory organs 0.8 ml 3 days MMA syndrome 0.8 ml 2 days Meningitis, arthritis, dermatitis 0.8 ml 5 days 4

7 ANTIMICROBIAL DRUGS OF SYSTEMIC ACTION DOXYTIL Water-soluble powder for oral administration Light yellow water-soluble powder. 1 g of the drug contains: active ingredients: doxycycline (in form of doxycycline hydrochloride) 100 mg; tylosin (in form of tylosin tartrate) 100 mg; ascorbic acid 100 mg; excipient glucose. АТС vet QJ01. Antibacterials for systemic use. QJ01RA90. Tetracyclines, combinations with other antibacterials. Doxycycline is a bacteriostatic broadspectrum antibiotic, which belongs to the tetracycline group. It is effective against gram-positive and gram-negative bacteria (Staphylococcus spp., Streptococcus spp., Bacillus аnthracis, Clostridium spp., Listeria spp., Actinomyces spp., Klebsiella spp., Shigella spp., Yersinia spp., Bordetella spp., Campylobacter spp., E. coli, Haemophilus spp., Pasteurella spp., Salmonella spp.) as well as chlamydia (Chlamydia spp.), mycoplasma (Mycoplasma spp.) and rickettsia (Rickettsia spp.). Its mechanism of action is related to inhibition of synthesis of proteins of microbial cell through binding of receptors of ribosomal 30S subunit of microorganisms. Doxycycline blocks attachment of aminoacyl trna to acceptor site preventing new amino acids from attachment to peptide chain and thus preventing synthesis of microbial proteins. Tylosin is an antibiotic of the macrolide group. It mostly acts upon gram-positive and certain gram-negative bacteria (Campylobacter spp., Pasteurella spp., Staphylococcus spp., Streptococcus spp., Treponema spp.) as well as large viruses. It demonstrates strong therapeutic effect upon Mycoplasma spp. The mechanism of action consists in binding with ribosomal 50S subunit of microbial cell, preventing translocation of peptides and thus inhibiting synthesis of proteins. Ascorbic acid, which is one of the ingredients of the drug, makes up the deficiency of vitamin С in the body during infection processes. Doxycycline penetrates well into lungs, hence, it is effective in treatment of respiratory infections. If administered orally, doxycycline is well absorbed from digestive tract and reaches peak concentration in blood serum in 2 hours. If there is any feed in digestive tract, it does not significantly influence the drug absorption. Bioavailability of doxycycline after oral administration makes 50-80%. Doxycycline is well dissolved in lipids, so it is well distributed in most tissues. Doxycycline is not considerably biotransformed before excretion. Half-life in calves makes 9.8 hours, in cows 14.2 hours, in chickens 4.8 hours, in swine 3.9 hours. Doxycycline, unlike other tetracyclines, is released to digestive tract in large quantities and inactivated. Out of 90% of the substance 16% eliminates with urine, <5% with bile, the rest is excreted intestinally. Maximum concentration of tylosin in blood serum after oral administration is reached in 2 hours. Due to the very high lipid dissolubility tylosin is widely distributed in the body and concentrations of the drug in tissues may significantly exceed concentrations in blood serum for 2-36 hours after administration of the drug. Tylosin is mostly eliminated from the body with bile (68%) and urine (24%), partially with feces. Ascorbic acid is well absorbed after oral administration, nevertheless, its quantity decreases proportionally according to the dose. Ascorbic acid is widely distributed in the body tissues. Its maximum concentrations may be found in liver, leukocytes, thrombocytes, endocrine glands. About 25% of ascorbic acid binds to proteins in plasma. It crosses the placental barrier well and is found in milk. Its half-life in plasma makes 16 days, but in case of excessive quantity may be reduced to several hours. Renal threshold makes about 14 μg/ ml for ascorbic acid, but this level may be changed individually. In case of excessive threshold concentrations of vitamin C in blood the ascorbic acid is eliminated from the body in unchanged form renally. On the contrary in case of deficiency there is no elimination with urine. Non-reactive metabolites (ascorbic acid-2-sulfate and oxalic acid) are eliminated with urine. Treatment of poultry (broiler chickens, breeding hens, pullets), piglets and calves (of up to 3 months of age) against diseases 5

8 ANTIMICROBIAL DRUGS OF SYSTEMIC ACTION of respiratory organs and digestive tract caused by doxycycline and tylosin-sensitive microorganisms. Administer orally with drinking water in the following doses: calves (up to 3 months of age): 5 g per 100 kg body weight twice daily for 3-5 days; piglets (up to 3 months of age), poultry (broiler chickens, breeding hens, pullets): 1 kg per 1 t of drinking water for 3-5 days. Do not administer to animals with hypersensitivity to doxycycline and tylosin, to animals with liver and kidney injuries. Do not prescribe in combination with penicillins, cephalosporins, quinolones and cycloserines. Do not administer to ruminants with functionally developed proventriculi and hens laying eggs for human consumption. Animal slaughter for meat is possible: calves in 14, piglets in 8 and poultry in 7 days following the last administration. Meat obtained before the mentioned term shall be utilized or fed to non-productive animals depending on the statement of veterinary physician. Do not prescribe Doxytil in sub-therapeutic doses. Allergic reactions are possible. Doxycycline, which is one of the ingredients of the drug, may cause structural changes in liver and kidneys, diarrhea. The drug solution must be the only source of water throughout the treatment period. Packages of film or foil materials of g. Store in a dark dry place out of the reach of children at 5-30 С. 24 hours after dissolution in water. 6

9 ANTIMICROBIAL DRUGS OF SYSTEMIC ACTION ENROL 10% Solution for oral administration Transparent yellow solution. 1 ml of the drug contains: active ingredient: enrofloxacin 100 mg; excipients potassium hydroxide, purified water. Enrofloxacin is a broad-spectrum antibiotic, which belongs to the group of fluoroquinolones. It prevents DNA synthesis in cells of microorganisms, makes bactericidal effect upon gram-positive and gram-negative microorganisms (Staphylococcus spp., Streptococcus spp., Clostridium spp., Listeria monocytogenes, Corynebacterium spp., Pseudomonas spp., E. coli, Haemophilus spp., Salmonella spp., Klebsiella spp., Proteus spp., Pasteurella spp. etc.) as well as mycoplasma (Mycoplasma spp.) and chlamydia (Chlamydia spp.). Treatment of broiler chickens against diseases of respiratory organs and digestive tract caused by enrofloxacin-sensitive microorganisms. Administer orally with drinking water in a dose of 10 mg of enrofloxacin per 1 kg body weight of broiler chickens or ml of the drug per 1 l of drinking water. Duration of treatment is 3 to 5 days. Do not administer to animals with hypersensitivity to enrofloxacin as well as to hens laying eggs for human consumption. Do not prescribe in combination with tetracycline drugs, erythromycin, chloramphenicol, theophylline, steroids. Slaughter of broiler chickens for meat is possible in 11 days following the last administration of the drug. Meat obtained before the mentioned term shall be utilized or fed to non-productive animals depending on the statement of veterinary physician. In case of preparation of stock solution add the drug to water. Water with the drug must be the only source of drinking water throughout the whole period of treatment! Do not prescribe Enrol 10% in subtherapeutic doses. Cardboard boxes with 10 vials of 10 ml each, plastic cans of 1000 ml. Store in a dry and dark place out of the reach of children at 5-30 С. 3 years. 24 hours after dissolution in drinking water. 7

10 ANTIMICROBIAL DRUGS OF SYSTEMIC ACTION FLOSAN Powder for oral administration White water-insoluble powder. 1 kg of the drug contains: active ingredient florfenicol 40 g; excipient semolina. ATCvet: QJ01BA90. Antibacterials for systemic use. Amfenicols. Florfenicol. Florfenicol is a synthetic broad-spectrum antibiotic, which is a derivative of thiamfenicol. It demonstrates effect against Pasteurella spp., Actinobacillus pleuropneumoniae, Bordetella bronchiseptica, Salmonella spp., Escherichia coli, Proteus spp., Haemophilus spp., Staphylococcus spp., Streptococcus spp., Shigella spp., Klebsiella spp., Enterobacter spp., Aeromonas salmonicida, Campylobacter spp., Edwardsiella ictaluri, Edwardsiella tarda, Flexibacter spp., Yersinia pseudotuberculosis, Vibrio spp., as well as mycoplasmas (Mycoplasma spp.). The mechanism of action is related to inhibition of activity of microbial cell peptidyl transferase, particularly in the area of 70S ribosomes. After oral administration florfenicol is well (about 90%) absorbed from digestive tract and distributed in organs and tissues, reaching concentrations of 4-8 μg/g in lungs, heart, pancreatic gland, skeletal muscles, spleen. Relatively high concentrations are found in bile, kidneys, small intestine, urine. Urinary metabolites are composed of florfenicolamine, florfenicol oxamic acid, monochloroflorfenicol. About 64% of florfenicol is biotransformed into florfenicol amine a metabolite, which is present in liver for the longest period. Half-life period of the drug makes hours on average. It is mostly (up to 50%) eliminated from the body with urine unchanged, the rest of the drug and its metabolites are eliminated with feces. Swine. Treatment of animals against pleuropneumonia (Actinobacillus pleuropneumoniae), atrophic rinitis (Pasteurella multocida, Bordetella bronchiseptica), hemophilic polyserositis (Haemophilus parasuis) as well as other diseases of respiratory organs caused by florfenicol-sensitive microorganisms. Fish (carps, salmons). Treatment of fish against aeromonosis (furunculosis, red spot disease, hemorrhagic septicemia), pasteurellosis, enterosepsis, vibriosis, pseudomonosis, streptococcosis caused by florfenicol-sensitive microorganisms. Administer orally with feed in the following doses: swine: 1.25 g of the drug per 10 kg body weight daily (5 mg of florfenicol per 1 kg body weight daily). Duration of treatment 7 days; fish (carps, salmons): 10 mg of florfenicol per 1 kg of fish daily (25 g of the drug per 100 kg of fish). Duration of treatment 10 days. Divide the daily dose in two feedings for small-size and juvenile fish. Recommended norm of ready medicated feed 0.5-3% of total fish weight. When treating swine against hemophilic polyserositis, administer the drug individually to every animal. Mix the drug thoroughly with feed. It is recommended to mix the drug with 3-10% of total feed quantity first and then blend the mixture obtained with the rest of the feed. When preparing medicated feed for fish, apply the drug on the surface or add it inside the feed before extrusion. In case of individual preparation of medicated feed prepare the mixture immediately before use. In this case use the required quantity of the feed and the drug and mix them thoroughly. Use fish oil or vegetable oil in amount of 2% of ready feed weight (2 l per 100 kg of the feed) as a binding component. For better mixing administer the drug to a small quantity of the feed first and then mix the drug with the rest of the feed thoroughly until homogeneous. Mechanical stirrer may be used for preparation. Do not administer to animals sensitive to florfenicol. Do not administer to pregnant and lactating animals and breeding boars. Do not feed the drug to fish if water temperature is below 5 C. Do not use in combination with antibiotics of the penicillin group, cephalosporins and fluoroquinolones as well as thiamfenicol and chloramfenicol. Swine slaughter for meat is possible in 1 day, fish may be used for eating in 16 days (if water temperature is 5-10 C) and 8 days (if water temperature is above 10 C) following the last administration of the drug. Meat obtained before the mentioned term shall be utilized or fed to non-productive animals depending on the statement of veterinary physician. Packages of film or foil materials of 1000 g. Store in a dark place out of the reach of children at 5-30 С. 8

11 ANTIMICROBIAL DRUGS OF SYSTEMIC ACTION FLOSAN 4% Solution for oral administration Transparent viscous solution. 1 ml of the drug contains: active ingredient: florfenicol 40 mg; excipient PEG-400. ATCvet: QJ01. Antibacterials for systemic use. QJ01BA90. Florfenicol. Florfenicol is a synthetic broad-spectrum antibiotic, which is a derivative of thiamphenicol. It demonstrates effect against Pasteurella spp., Actinobacillus pleuropneumoniae, Bordetella bronchiseptica, Salmonella spp., Escherichia coli, Proteus spp., Haemophilus spp., Staphylococcus spp., Streptococcus spp., Shigella spp., Klebsiella spp., Enterobacter spp., Aeromonas salmonicida, Campylobacter spp., Edwardsiella ictaluri, Edwardsiella tarda, Flexibacter spp., Yersinia pseudotuberculosis, Vibrio spp., as well as mycoplasma (Mycoplasma spp.). The meachanism of action is related to inhibition of activity of microbial cell peptidyl transferase, particularly in the area of 70S ribosomes. After oral administration florfenicol is well absorbed (up to 90%) from digestive tract and distributed in organs and tissues, reaching concentrations of 4-8 μg/g in lungs, heart, pancreatic gland, skeletal muscles, spleen. Relatively high concentrations are found in bile, kidneys, small intestine, urine. Half-life period of florfenicol makes hours on average. It is eliminated from the body primarily renally unchanged through glomerular filtration, as well as with bile, being inactivated through formation of chelate compounds, which are then eliminated with feces. Swine: treatment of animals against pleuropneumonia, atrophic rhinitis, Glasser s disease, infectious coryzae, mycoplasmosis and other diseases caused by florfenicolsensitive microorganisms (Actinobacillus pleuropneumoniae, Pasteurella multocida, Bordetella bronchiseptica, Haemophilus parasuis, Pasteurella multocida, Bordetella bronchiseptica). Poultry (broiler chickens, breeding hens, pullets): colisepticemia, pasteurellosis, mycoplasmosis as well as diseases of respiratory organs and digestive tract caused by florfenicol-sensitive microorganisms. Administer orally with drinking water in the following doses: swine: ml of the drug per 100 kg body weight (1.5-2 mf of florfenicol per 1 kg body weight) daily. Duration of treatment 7 days; poultry (broiler chickens, breeding hens, pullets): 50 ml of the drug per 100 kg body weight (20 mg of florfenicol per 1 kg body weight) daily. Duration of treatment: 3-5 days. Do not administer to animals sensitive to florfenicol. Do not administer to hens laying eggs for human consumption. Do not use in combination with thiamphenicol and chloramphenicol. Animal slaughter for meat is possible in 2 days following the last administration. Meat obtained before the mentioned term shall be utilized or fed to non-productive animals depending on the statement of veterinary physician. Changes in color of feces, diarrhea, redness or swelling of rectal perianal section, which disappear after withdrawal, are possible. Cardboard boxes with 10 vials of 10 ml each, plastic vials of 1 l. Store in a dry, dark, damp-proof place out of the reach of children at 5-30 С. 24 hours after dissolution in water. 9

12 ANTIMICROBIAL DRUGS OF SYSTEMIC ACTION FLOSAN 30% Solution for injections Light yellow or straw-colored transparent viscous solution. 1 ml of the drug contains: active ingredient: florfenicol 300 mg; excipients propylene glycol, PEG-400. ATCvet: QJ01. Antibacterials for systemic use. Florfenicol is a synthetic broad-spectrum antibiotic, which is a derivative of thiamfenicol. It demonstrates effect against Pasteurella spp., Actinobacillus pleuropneumoniae, Bordetella bronchiseptica, Salmonella spp., Escherichia coli, Proteus spp., Haemophilus spp., Staphylococcus spp., Streptococcus spp., Shigella spp., Klebsiella spp., Enterobacter spp., Aeromonas salmonicida, Campylobacter spp., Edwardsiella ictaluri, Edwardsiella tarda, Flexibacter spp., Yersinia pseudotuberculosis, Vibrio spp., as well as mycoplasmas (Mycoplasma spp.). The mechanism of action is related to inhibition of activity of microbial cell peptidyltransferase, particularly in the area of 70S ribosomes. After oral administration florfenicol penetrates into organs and tissues, reaching concentrations of 4-8 μg/g in lungs, heart, pancreatic gland, skeletal muscles, spleen. Relatively high concentrations are found in bile, kidneys, small intestine, urine. Urinary metabolites are composed of florfenicolamine, florfenicol oxamic acid, monochloroflorfenicol. About 64% of florfenicol is biotransformed into florfenicol amine a metabolite, which is present in liver for the longest period. Half-life period of the drug makes hours on average. It is mostly (up to 50%) eliminated from the body with urine unchanged, the rest of the drug and its metabolites are eliminated with feces. Cattle. Treatment of animals against interdigital necrobacillosis, keratoconjuctivitis as well as diseases of respiratory organs caused by florfenicolsensitive microorganisms. Swine. Treatment of animals against diseases of respiratory organs caused by florfenicol-sensitive microorganisms. Administer in the following doses: swine: 15 mg of florfenicol per 1 kg body weight intramuscularly (0.5 ml of the drug per 10 kg body weight). Repeat injection in 48 hours; cattle: 20 mg of florfenicol per 1 kg body weight intramuscularly (1 ml of the drug per 15 kg body weight) twice with an interval of 48 hours or 40 mg of florfenicol per 1 kg body weight subcutaneously (2 ml of the drug per 15 kg body weight) once. Administer maximum 10 ml of the drug per single injection site. Do not administer to animals sensitive to florfenicol. Do not administer to pregnant and lactating animals, stud bulls and breeding boars. Do not use in combination with antibiotics of the penicillin group, cephalosporins and fluoroquinolones as well as thiamfenicol and chloramfenicol. Animal slaughter for meat is possible as follows: swine in 14 days, cattle in case of intramuscular administration in 30 days, cattle in case of subcutaneous administration in 44 days following the last administration of the drug. Meat obtained before the mentioned term shall be utilized or fed to non-productive animals depending on the statement of veterinary physician. Glass vials of 100 ml sealed with rubber stoppers and aluminum caps. Store in a dark place out of the reach of children at 5-30 С. Do not freeze! 48 hours after initial opening (sampling) if stored a 2-8 С. 10

13 ANTIMICROBIAL DRUGS OF SYSTEMIC ACTION FORACOL Water-soluble powder for oral administration White powder. 1 g of the drug contains: active ingredients: ciprofloxacin hydrochloride 200 mg; trimethoprim 100 mg; colistin 2.4 m IU; excipient dextrose. АТСvet: QJ01. Antibacterials for systemic use. The drug contains combination of ciprofloxacin, trimethoprim and colistin, which has a synergic antimicrobial effect. Ciprofloxacin is a broad-spectrum antibiotic of the fluoroquinolone group. It demonstrates antimicrobial effect upon gram-positive and gram-negative microorganisms (Staphylococcus spp., Streptococcus spp., Clostridium spp., Listeria monocytogenes, Corynebacterium spp., Pseudomonas spp., E. coli, Haemophilus spp., Salmonella spp., Klebsiella spp., Proteus spp., Pasteurella spp. etc.) as well as mycoplasma (Mycoplasma spp.) and chlamydiae (Chlamydia spp.). The mechanism of action of ciprofloxacin is related to inhibition of bacterial DNA-gyrase, which results in violation of DNA replication in microorganisms. Trimethoprim is a broad-spectrum antibacterial of the diaminopiryrimidine group. It is effective against gram-positive and gram-negative microorganisms (E. coli, Klebsiella spp., Salmonella spp., Pasteurella spp., Enterobacter spp., Proteus spp., Shigella spp., Staphylococcus spp., Streptococcus spp., Haemophilus spp., Chlamydia spp.) as well as toxoplasma and coccidia. The mechanism of action of trimethoprim consists in inhibition of bacterial reductase of dihydrofolic acid. Colistin is an antibiotic of the polymyxin group, which demonstrates bactericidal effect against gram-negative microorganisms (E. сolі, Salmonella spp., Pasteurella spp., Haemophіlus spp., Bordetella spp.). The mechanism of action of colistin consists in violation of integrity of cytoplasmic membrane in bacteria. The antibiotic interacts with phospholipids and penetrates inside, destroying structure of cell membrane, the permeability of which changes immediately upon contact with the drug. Apart from antibacterial effect, colistin binds phospholipid А and neutralizes biological effect of bacterial endotoxin. Ciprofloxacin is quickly absorbed from digestive tract and well distributed in body tissues and fluids. Maximum concentration of the drug in blood is reached already in minutes. The feed in the stomach does not make any impact upon the drug absorption. Binding of ciprofloxacin to proteins makes 24%±2%. Its highest concentrations are observed in bile, kidneys, liver, lungs, reproductive organs. Ciprofloxacin is primarily excreted renally. Metabolites are eliminated with urine and feces. Trimethoprim is metabolized in liver and is primarily excreted renally through glomerular filtration and active tubular secretion. Its concentration in urine is essentially higher than in blood. Half-life period makes 8-10 hours. After oral administration colistin is poorly absorbed from digestive tract. In contrast to low concentrations of colistin in blood serum and tissues, its concentration in various segments of digestive tract is constantly high. Colistin is eliminated from the body with feces. Treatment of poultry against colibacteriosis, salmonellosis, necrotic enteritis, streptococcus, haemophillosis, mycoplasmosis and other infectious diseases caused by ciprofloxacin-, trimethoprim and colistin-sensitive microorganisms. Administer orally with drinking water in a dose of 0.5 g per 1 l of drinking water (500 g per 1 t of drinking water) for 4-6 days. In case the drug is given through dispenser, prepare the stock solution at the ratio at least 15 parts of water per 1 part of the drug. Medicated water must be the only source of drinking water throughout the whole treatment period. Do not prescribe to animals sensitive to the drug components. Do not administer to hens laying eggs for human consumption. Do not administer in combination with antibiotics of the tetracycline group, chloramphenicol, lincomycin. Do not prescribe the drug in sub-therapeutic doses. Poultry slaughter for meat is allowed in 11 days following the last administration of the drug. Meat obtained before the mentioned term shall be utilized or fed to non-productive animals depending on the statement of veterinary physician. Packages of g of film or foil materials. Store in a dry, dark place out of the reach of children at 5-30 С. 3 years. 24 hours after dissolution in drinking water. 11

14 ANTIMICROBIAL DRUGS OF SYSTEMIC ACTION SPELIMIX Solution for injections Transparent colorless solution. 1 ml of the drug contains: active ingredients: lincomycin (lincomycin hydrochloride) 50 mg; spectinomycin (spectinomycin sulfate) 100 mg; excipients benzyl alcohol, water for injections. АТСvet: QJ01. Antibacterials for systemic use. Lincomycin is an antibiotic of the lincosamides group. It inhibits synthesis of protein in microorganisms, binding ribosomal 50S subunits of bacterial cells. It demonstrates bacteriostatic or bactericidal action depending on concentration. It acts mostly upon grampositive (Staphylococcus spp., Streptococcus spp., Bacillus anthracis, Corynebacterium spp.) and gram-negative microorganisms (Actinobacillus spp., Bordetella spp., Nocardia spp., Actinomyces spp.) and is particularly effective against Serpulina hyodysenteriae and Mycoplasma spp. Spectinomycin is an antibiotic of tricyclic structure of the aminoglycosides group. Its efficacy is related to inhibition of synthesis of proteins in microbial cell through binding of ribosomal 30S subunit of microorganisms, which prevents elongation of polypeptide chain at translocation stage. It is mostly effective against gram-negative and gram-positive microorganisms (E. coli, Pasteurella multocida, Salmonella spp., Clostridium spp., Erysipelothrix rhusiopathiae, Haemophilus spp., Vibrio spp.) as well as mycoplasma (Mycoplasma spp.). After parenteral administration lincomycin is distributed in organs and tissues, particularly, in bone tissue. It binding to proteins makes 50%. Its concentration in blood reaches maximum in 2 hours following administration. Half-life period makes hours. Major quantities of lincomycin and its metabolites are excreted with urine and bile. Binding of spectinomycin to proteins does not exceed 10%. Its concentration in serum reaches maximum in 4 hours. Spectinomycin is scarcely biotransformed in the body and is eliminated intact with feces. Treatment of calves (of up to 3 months of age), swine, sheep, goats, dogs, cats, poultry (broiler chickens, turkeys) against diseases of digestive tract and respiratory organs caused by lincomycin and spectinomycin-sensitive microorganisms. Administer intramuscularly in the neck area in the following doses: swine: 1 ml of the drug per 10 kg body weight once daily for 3-7 days; calves of up to 3 months of age: 1 ml of the drug per 10 kg body weight once daily for 2-4 days; sheep, goats: 1 ml of the drug per 10 kg body weight once daily for 3 days; dogs, cats: 1 ml of the drug per 5 kg body weight once daily for 3-5 days (maximum treatment period 21 days). Administer subcutaneously in the following doses: broiler chickens, turkeys: 1 ml of the drug per 2.5 kg body weight once daily for 3 days. Do not administer to animals with hypersensitivity to lincomycin and spectinomycin. Do not administer to animals with blood or liver disorders. Do not administer to horses, rabbits, chinchillas as well as to hens laying eggs for human consumption. Do not administer Spelimix in combination with penicillin, quinolones, cephalosporins and erythromycin. Slaughter of mammals for meat is possible in 14 days and of poultry in 7 days following the last administration of the drug. Milk from sheep and goats may be consumed by people in 3 days following the last administration of the drug. Meat and milk obtained before the mentioned term shall be utilized or fed to non-productive animals depending on the statement of veterinary physician. Glass vials of 100 ml sealed with rubber stoppers and aluminum caps. Store in a dry, dark place out of the reach of children at С. Do not freeze! 48 hours after the initial opening (sampling) provided it is stored at 2-8 С. 12

15 ANTIMICROBIAL DRUGS OF SYSTEMIC ACTION SPELIMIX 44 Powder for oral administration White to yellowish powder. 1 g of the drug contains: active ingredients: lincomycin hydrochloride 22 mg; spectinomycin sulfate 22 mg; excipient semolina. Spelimix 44 is a complex drug, which is represents a combination of such antibiotics as lincomycin and spectinomycin with a broad spectrum of synergistic antimicrobial effect. Lincomycin is an antibiotic of the lincosamides group. It inhibits synthesis of protein in microorganisms, binding ribosomal 50S subunits of bacterial cells. It demonstrates bacteriostatic or bactericidal action depending on concentration. It acts mostly upon gram-positive (Staphylococcus spp., Streptococcus spp., Bacillus anthracis, Corynebacterium spp.) and gram-negative microorganisms (Actinobacillus spp., Bordetella spp., Nocardia spp., Actinomyces spp.) and is particularly effective against Serpulina hyodysenteriae and Mycoplasma spp. Spectinomycin is an antibiotic of tricyclic structure of the aminoglycosides group. Its efficacy is related to inhibition of synthesis of proteins in microbial cell through binding of ribosomal 30S subunit of microorganisms, which prevents elongation of polypeptide chain at translocation stage. It is mostly effective against gram-negative and grampositive microorganisms (E. coli, Pasteurella multocida, Salmonella spp., Clostridium spp., Erysipelothrix rhusiopathiae, Haemophilus spp., Vibrio spp.) as well as mycoplasma (Mycoplasma spp.). Treatment of hens (broiler chickens, breeding hens, pullets) ) and swine against enzootic pneumonia, salmonellosis, dysentery, MMA (mastitis-metritis-agalactia) syndrome, necrotic enteritis, colibacillosis, mycoplasmosis and other diseases of digestive tract and respiratory organs caused by lincomycin and spectinomycin-sensitive microorganisms. Administer orally with feed individually to every animal or by group method in the following doses: 2 kg of Spelimix 44 per 1 ton of feed for 5-7 days. It is recommended that the drug be mixed up with 3-10% of total feed quantity first and then the obtained blend be mixed with the rest of the feed. Do not administer to animals with hypersensitivity to lincomycin and spectinomycin as well as to hens laying eggs for human consumption. Do not administer in combination with penicillin, cephalosporins and macrolides. Slaughter of swine for meat is possible in 3 days and of poultry in 2 days following the last administration of the drug. Meat obtained before the mentioned term shall be utilized or fed to non-productive animals depending on the statement of veterinary physician. Do not prescribe Spelimix 44 in subtherapeutic doses. Bags of film or foil materials of g and paper bags of 25 kg. Store in a dry, dark place out of the reach of children at 0-30 С. 1 year. 13

16 ANTIMICROBIAL DRUGS OF SYSTEMIC ACTION SPELIMIX 100 Water-soluble powder for oral administration White powder. 150 g of the drug contains: active ingredients: lincomycin hydrochloride 33.3 g; spectinomycin sulfate 66.7 g; excipient: lactose. Spelimix 100 is a complex drug, which is represents a combination of such antibiotics as lincomycin and spectinomycin with a broad spectrum of synergistic antimicrobial effect. Lincomycin is an antibiotic of the lincosamides group. It inhibits synthesis of protein in microorganisms, binding ribosomal 50S subunits of bacterial cells. It demonstrates bacteriostatic or bactericidal action depending on concentration. It acts mostly upon gram-positive (Staphylococcus spp., Streptococcus spp., Bacillus anthracis, Corynebacterium spp.) and gram-negative microorganisms (Actinobacillus spp., Bordetella spp., Nocardia spp., Actinomyces spp.) and is particularly effective against Serpulina hyodysenteriae and Mycoplasma spp. Spectinomycin is an antibiotic of tricyclic structure of the aminoglycosides group. Its efficacy is related to inhibition of synthesis of proteins in microbial cell through binding of ribosomal 30S subunit of microorganisms, which prevents elongation of polypeptide chain at translocation stage. It is mostly effective against gram-negative and grampositive microorganisms (E. coli, Pasteurella multocida, Salmonella spp., Clostridium spp., Erysipelothrix rhusiopathiae, Haemophilus spp., Vibrio spp.) as well as mycoplasma (Mycoplasma spp.). Treatment of poultry (broilers, breeders, pullets) and swine against enzootic pneumonia, salmonellosis, dysentery, MMA (mastitis-metritis-agalactia) syndrome, necrotic enteritis, colibacillosis, mycoplasmosis and other diseases of digestive tract and respiratory organs caused by lincomycin and spectinomycin-sensitive microorganisms. Administer orally with drinking water in the following doses: piglets: 10 mg of active ingredients per 1 kg body weight daily (1.5 g of the powder per 100 kg body weight) or 150 g of the drug per 1,5 t of drinking water. Treatment period: 4-7 days; broilers, breeders, pullets: 150 g of the drug per l of drinking water for 5-7 days. The solution of the drug must be the only source of drinking water throughout the whole treatment period! Do not administer to animals with hypersensitivity to lincomycin and spectinomycin as well as to hens laying eggs for human consumption. Do not prescribe to pregnant or lactating sows. Do not administer in combination with penicillin, cephalosporins and macrolides. Slaughter of swine for meat is possible in 3 days and of poultry in 2 days following the last administration of the drug. Meat obtained before the mentioned term shall be utilized or fed to non-productive animals depending on the statement of veterinary physician. In some cases administration of the drug may cause redness of skin and mucous membranes in swine, though, no withdrawal is required then. Bags of film or foil materials of 150 g. Store in a dry, dark place out of the reach of children at 0-30 С. 24 hours after dissolution in drinking water. 14

17 ANTIMICROBIAL DRUGS OF SYSTEMIC ACTION SPELIMIX FORTE Powder for oral administration Yellow-grey powder. 1 g of the drug contains: active ingredients: florfenicol 40 mg; lincomycin (lincomycin hydrochloride) 44 mg; spectinomycin (spectinomycin sulfate) 44 mg; excipient: wheat groats АТСvet: QJ01. Antibacterials for systemic use. Spelimix Forte is a complex drug with a broad spectrum of anti-bacterial effect. The combination of florfenicol, lincomycin and spectinomycin makes potentiated synergistic effect upon bacteria. Florfenicol is a broad-spectrum synthetic antibiotic, which is the derivative of thiamfenicol. It is effective against Pasteurella spp., Actinobacillus pleuropneumoniae, Bordetella bronchiseptica, Salmonella spp., Escherichia coli, Proteus spp., Haemophilus spp., Staphylococcus spp., Streptococcus spp., Shigella spp., Klebsiella spp., Enterobacter spp., Aeromonas salmonicida, Campylobacter spp., Edwardsiella ictaluri, Edwardsiella tarda, Flexibacter spp., Vibrio spp. and makes effect upon mycoplasma (Mycoplasma spp.). The mechanism of action of florfenicol is related to inhibition of activity of peptidiltransferase of microbial cell, particularly in the section 70S of ribosomal subunit. Lincomycin is an antibiotic of the lincosamides group. It demonstrates bacteriostatic or bactericidal action depending on concentration. It acts mostly upon gram-positive (Staphylococcus spp., Streptococcus spp., Bacillus anthracis, Corynebacterium spp.) and gram-negative microorganisms (Actinobacillus spp., Bordetella spp.) and some species of Nocardia and Actinomyces. It is particularly effective against Serpulina hyodysenteriae and Mycoplasma spp. Lincomycin inhibit synthesis of protein in microorganisms binding ribosomal 50S subunits of bacterial cells. Spectinomycin is an antibiotic of tricyclic structure of the aminoglycosides group. It is mostly effective against gram-negative microorganisms, particularly, E. coli, Pasteurella multocida, Salmonella spp., Clostridium spp., Erysipelothrix rhusiopathiae, Haemophilus spp., Vibrio spp., as well as some gram-positive microorganisms and Mycoplasma spp. Its efficacy is related to inhibition of synthesis of proteins in microbial cell. It binds ribosomal 30S subunit of microorganisms, which prevents elongation of polypeptide chain at translocation stage. After oral administration florfenicol is well absorbed (up to 90%) from digestive tract and distributed in organs and tissues of the body, reaching concentration of 4-8 μg/g in lungs, heart, pancreas, skeletal muscles, spleen. Relatively high concentrations are found in bile, kidneys, small intestine, urine. Metabolites, which are eliminated with urine, contain florfenicolamine, florfenicol oxamic acid, monochloroflorfenicol. Florfenicol amine is the metabolite, which presence in liver is the longest. Biotransformation to florfenicolamin makes about 64%. Half-life of florfenicol makes on average hours. Florfenicol is primarily eliminated intact with urine (up to 50%). Florfenicol and its metabolites are also eliminated with feces. After oral administration lincomycin is well absorbed from digestive tract (almost 60%) and is distributed in organs and tissues, particularly, in bone tissue. It binding to proteins makes 50%. Its concentration in blood serum reaches maximum in 2 hours following administration. Half-life period makes hours. Major quantities of lincomycin and its metabolites are excreted with urine and bile. Minor quantities are eliminated with feces. Spectinomycin is poorly absorbed in digestive tract. In 24 hours following oral administration minor concentrations of the antibiotic are observed in kidneys, liver, lungs, muscles, fat tissue. Binding of spectinomycin to proteins does not exceed 10%. Its concentration in serum reaches maximum in 4 hours. Spectinomycin is scarcely biotransformed in the body and is eliminated intact with feces. Treatment of swine against enzootic pneumonia, salmonellosis, dysentery, actinobacillary pleuropneumonia, eperythzoonosis, MMA (mastitis-metritisagalactia) syndrome, necrotic enteritis, 15

18 ANTIMICROBIAL DRUGS OF SYSTEMIC ACTION colibacillosis, mycoplasmosis and other diseases of digestive tract and respiratory organs caused by lincomycin and spectinomycin-sensitive microorganisms. Administer orally with feed individually or by group method in a dose of kg of the drug per 1 t of feed for 5-7 days. If used with feed, it is necessary to mix the drug with the feed thoroughly. It is recommended that the drug be mixed with 3-10% of total feed quantity first and then blend the obtained mixture with the rest of the feed. Do not administer to animals with hypersensitivity to lincomycin and spectinomycin. Do not administer to rabbits, horses, cattle and laying hens. Do not administer to pregnant and lactating animals. Do not administer to animals with liver and kidney disorders. Do not administer in combination with erythromycin, antibiotics of the penicillin group, cephalosporins and fluoroquinolones as well as thiamfenicol and chloramfenicol. Do not prescribe the drug in sub-therapeutic doses. Animal slaughter for meat is possible in 14 days following the last administration of the drug. Meat obtained before the mentioned term shall be utilized or fed to non-productive animals depending on the statement of veterinary physician. Bags of film or foil materials of 1000 g and paper bags of 25kg. Store in a dark, damp-proof place out of the reach of children at 0-30 С. 1 year. 3 months after being mixed with feed. 16

19 ANTIMICROBIAL DRUGS OF SYSTEMIC ACTION SUPRIM 240 Solution for injections Transparent yellow oily liquid. 1 ml of the drug contains: active ingredients: sulfametoxazol 200 mg; trimethoprim 40 mg; excipient propylene glycol. АТСvet QJ01RA. Antibacterials for systemic use. Combinations of antibacterials. The drug composition includes the combination of sulfametoxazol and trimethoprim, which has a synergistic antimicrobial effect. Sulfametoxazol is a medium-lasting sulfanilamide. It initiates the process, which ensures acquisition of the required growth factors folic acid and other substances, the molecules of which contain paraaminobenzoic acid by microorganisms. Formation of methionine, purine and pyrimidine bases in a microbial cell is blocked under the effect of sulfametoxazol, which, in its turn, causes disturbance of synthesis of nucleic acids and nucleoproteins. Trimethoprim is an antibacterial of the diaminopyrimidines group. The drug is effective against gram-positive and gramnegative microorganisms (E. coli, Klebsiella spp., Salmonella spp., Pasteurella spp., Enterobacter spp., Proteus spp., Shigella spp., Staphylococcus spp., Streptococcus spp., Haemophilus spp., Chlamydia spp.) as well as toxoplasma and coccidia. Its mechanism of action is related to inhibition of bacterial reductase of dihydrofolic acid. Treatment of diseases of respiratory organs, digestive organs and urinary system caused by sulfametoxazol and trimethoprimsensitive microorganisms in cattle, sheep, goats, swine and rabbits. The drug is administered intramuscularly in the following doses: cattle (adult), sows: 1 ml of the drug per 20 kg body weight once daily for 3-5 days; calves, sheep, goats, piglets: 1 ml of the drug per 10 kg body weight once daily for 3-5 days; rabbits: 0.1 ml of the drug per 1 kg body weight once or twice with an interval of days. Do not prescribe to animals with individual hypersensitivity to trimethoprim and sulfametoxazol. Do not administer in combination with drugs, which cause sulfur removal (sodium sulfate), aminoglycosides (gentamicin, neomycin, streptomycin), as well as muscle relaxant and anesthetics as this may cause paralysis of respiratory muscles. Do not administer to animals with kidney and liver disorders as well as to animals with essential changes in hematological indices (in case of dyscrasia). Be cautious when administering the drug to goats as they are hypersensitive to sulfanilamides. Do not use Novocain solution for dissolution. Do not prescribe the drug in sub-therapeutic doses. Crystalluria, hematuria may be observed after long-term administration in high doses. Discontinue the administration immediately and prescribe sodium hydrocarbonate to increase solubility of sulfametoxazol in urine. Animal slaughter for meat is possible in 12 days and consumption of milk is possible in 4 days following the last administration of the drug. Meat and milk obtained before the mentioned term shall be utilized or fed to non-productive animals depending on the statement of veterinary physician. Glass vials of 100 ml sealed with rubber stoppers and aluminum caps. Store in a dry, dark place out of the reach of children at 5-30 С. 48 hours after the initial opening (sampling) provided it is stored at 2-8 С. 17

20 ANTIMICROBIAL DRUGS OF SYSTEMIC ACTION TIAKUR Water-soluble powder for oral administration Yellow water-soluble powder. 1 g of the drug contains: active ingredients: doxycycline hyclate 200 mg; tiamulin (tiamulin hydrogen fumarate) 66 mg; excipient glucose. АТС vet QJ01. Combined antibacterials of systemic action. QJ01RA90. Tetracyclines, combinations with other antibacterials, except trimethoprim. Doxycycline is a broad-spectrum bacteriostatic antibiotic of the tetracyclines group. It is effective against gram-positive and gram-negative bacteria (Staphylococcus spp., Streptococcus spp., Bac. аnthracis, Clostridium spp., Listeria spp., Actinomyces spp., Klebsiella spp., Shigella spp., Yersinia spp., Bordetella spp., Campylobacter spp., E. coli, Haemophilus spp., Pasteurella spp., Salmonella spp.), chlamydiae (Chlamydia spp.), mycoplasma (Mycoplasmaspp.) and rickettsiae (Rickettsia spp.). Doxycycline inhibits synthesis of proteins of microbial cell, binding receptors of ribosomal 30S subunit in microorganisms. It blocks attachment of aminoacyl trna to acceptor site, preventing attachment of new amino acids to peptide chain and preventing in such way synthesis of microbial proteins. Tiamulin is a semisynthetic antibiotic of the diterpenes group, which is effective against gram-positive (Staphylococcus spp., Streptococcus spp., Clostridium spp., Corynebacterium spp., Erysipelothrix spp., Listeria spp.) and certain gram-negative microorganisms (Haemophilus influenzae, Pasteurella multocida, Actinobacillus pleuropneumoniae, Campylobacter spp.), spirochetes (Serpulina hyodysenteriae, S. innocens, S. pilosicoli, S. suis) as well as Lawsonia intracellularis. The mechanism of its antibacterial activity consists in inhibition of synthesis of bacterial protein at the level of ribosomal 50S subunit. After oral administration, doxycycline is well absorbed from digestive tract and reaches maximum concentration in blood serum in 2 hours. It penetrates into lungs, thus, it is effective in treatment of respiratory infections. Feed in digestive tract does not make any impact upon absorption of doxycycline. Bioavailability of the antibiotic is %. Doxycycline is well dissolved in lipids, which causes its distribution in most tissues. It is subject to minor biotransformations before elimination. Half-life in chickens makes 4.8 hours, in swine 3,9 hours. Doxycycline, unlike other tetracyclines, is released into intestinal tract in large quantity and inactivated. Out of 90% of the substance 16% is eliminated with urine, about 5% with bile, the rest is eliminated intestinally. Swine. Treatment of dysentery, atrophic rhinitis, enzootic pneumonia, actinobacillosis pleuropneumonia, hemophilosis, intestinal spirochetosis, salmonellosis, colibacteriosis, necrotic enteritis, caused by microorganisms sensitive to tiamulin and doxycycline. Hens (chickens, broiler chickens) and turkeys. Treatment of diseases of digestive tract and respiratory organs caused by tiamulin and doxycycline-sensitive microorganisms (Mycoplasma gallisepticum, Mycoplasma synoviae and Mycoplasma meleagridis). Administer orally with feed or drinking water in the following doses: swine: kg of the drug per 1 t of feed or kg of the drug per 1 t of drinking water daily for 7 days; poultry (chickens, broiler chickens) and turkeys: kg of the drug per 1 t of feed or kg of the drug per 1 t of drinking water daily for 7 days. Do not administer to animals with hypersensitivity to tetracyclines and tiamulin as well as to animals with kidney and liver disorders. Avoid administration of drugs containing monensin, maduramycin, narasin, lasalocid or salinomycin at least in 7 days prior to, during and in 7 days following administration of Tiakur as this may cause deterioration in health condition or even death. Do not prescribe in combination with penicillins, cephalosporins, quinolones, erythromycin, sulfonamides, chloramphenicol and chlorpromazine as well as with drugs containing cations of magnesium, calcium, aluminum, as the latter are bound to doxycycline and prevent its absorption. Do not administer the drug to hens and turkeys laying eggs for human consumption. Do not administer the drug to pregnant or lactating animals. Animal slaughter for meat is possible in 10 days following the last administration. Meat obtained before the mentioned term shall be utilized or fed to non-productive animals depending on the statement of veterinary physician. Doxycycline as the drug component may cause structural changes in liver and kidneys, diarrhea. It is recommended to avoid administration of Tiakur in combination with antacids, oxidants and kaolin. Bags of g film or foil materials. Store in a dry, dark place out of the reach of children at 5-30 С. 18 months. 24 hours after dissolution in drinking water. 7 days after being mixed with feed. 18

21 ANTIMICROBIAL DRUGS OF SYSTEMIC ACTION TIAKUR 250 Solution for injections Transparent brown liquid. 1 ml of the drug contains: active ingredients: doxycycline hyclate 150 mg; tiamulin (tiamulin hydrogen fumarate) 100 mg; excipients 2-pyrrolidone, water for injections. Doxycycline is a broad-spectrum bacteriostatic antibiotic of the tetracyclines group. It is effective against gram-positive and gram-negative bacteria (Staphylococcus spp., Streptococcus spp., Bac. аnthracis, Clostridium spp., Listeria spp., Actinomyces spp., Klebsiella spp., Shigella spp., Yersinia spp., Bordetella spp., Campylobacter spp., E. coli, Haemophilus spp., Pasteurella spp., Salmonella spp.), chlamydiae (Chlamydia spp.), mycoplasma (Mycoplasma spp.) and rickettsiae (Rickettsia spp.). Doxycycline inhibits synthesis of proteins of microbial cell, binding receptors of ribosomal 30S subunit in microorganisms. It blocks attachment of aminoacyl trna to acceptor site, preventing attachment of new amino acids to peptide chain and preventing in such a way synthesis of microbial proteins. Tiamulin is a semisynthetic antibiotic of the diterpenes group, which is effective against gram-positive (Staphylococcus spp., Streptococcus spp., Clostridium spp., Corynebacterium spp., Erysipelothrix spp., Listeria spp.) and certain gram-negative microorganisms (Haemophilus influenzae, Pasteurella multocida, Actinobacillus pleuropneumoniae, Campylobacter spp.), spirochetes (Serpulina hyodysenteriae, S. innocens, S. pilosicoli, S. suis) as well as Lawsonia intracellularis. The mechanism of its antibacterial activity consists in inhibition of synthesis of bacterial protein at the level of ribosomal 50S subunit. Treatment of keratoconjuctivitis, colibacillosis, salmonellosis, pasteurellosis, staphilococcosis, gastroentherocolitis, mastitis, dysentery, atrophic rhinitis, enzootic pneumonia, actinobacillary pneumonia, haemophillosis, intestinal spirochetosis, necrotic enteritis in swine, cattle, sheep and goats. The drug is also effective in treatment of diseases of respiratory organs, urinary system, digestive tract, skin, musculoskeletal system, of post-surgical, wound and postpartum complications caused by doxycycline and tiamulin-sensitive microorganisms. Administer intramuscularly for 2-3 days in the following doses: cattle, sheep, goats, swine: ml per 10 kg body weight. Administer not more than 10 ml into a single site to adult cattle, not more than 2.5 ml to calves, sheep and goats, not more than 5ml to swine. In case the required dose exceeds the acceptable dose divide it and make injections to several sites. Do not administer to animals with hypersensitivity to tetracyclines and tiamulin as well as to animals with kidney and liver disorders. Avoid administration of drugs containing ionophoric antibiotics such as monensin, maduramycin, narasin, lasalocid or salinomycin during 7 days prior to, and during 7 days following administration of Tiakur 250. Do not use the drug in combination with penicillins, cephalosporins. Animal slaughter for meat is possible in 21 days following the last administration. Meat obtained before the mentioned term shall be utilized or fed to non-productive animals depending on the statement of veterinary physician. The drug is not prescribed in subtherapeutic doses. Allergic reactions are possible. Glass vials of 100 ml sealed with rubber stoppers and aluminum caps. Store in a dry, dark place out of the reach of children at 5-30 С. 28 hours after the initial opening (sampling) provided it is stored at 5-30 С in the original packaging. 19

22 ANTIMICROBIAL DRUGS OF SYSTEMIC ACTION TIAMIX Water-soluble powder for oral administration White powder. 1 g of the drug contains: active ingredients: tiamulin (as hydrogen fumarate) 225 mg; lincomycin (as lincomycin hydrochloride) 44 mg; spectinomycin (spectinomycin sulfate) 44 mg; excipient dextrose. ATCvet: QJ01. Antibacterials for systemic use. Tiamix is a complex drug with a broad spectrum of antimicrobial action. The combination of tiamulin, lincomycin and spectinomycin causes potentiated synergistic effect upon bacteria. Tiamulin is a semisynthetic antibiotic of the diterpenes group, which is effective against gram-positive (Staphylococcus spp., Streptococcus spp., Clostridium spp., Corynebacterium spp., Erysipelothrix spp., Listeria spp.) and certain gram-negative microorganisms (Haemophilus influenzae, Pasteurella multocida, Actinobacillus pleuropneumoniae, Campylobacter spp.), spirochetes (Serpulina hyodysenteriae, S. innocens, S. pilosicoli, S. suis) as well as Lawsonia intracellularis. The mechanism of its antibacterial activity consists in inhibition of synthesis of bacterial protein at the level of ribosomal 50S subunit. Lincomycin is an antibiotic of the lincosamides group. It demonstrates bacteriostatic or bactericidal action depending on concentration. It acts mostly upon gram-positive (Staphylococcus spp., Streptococcus spp., Bacillus anthracis, Corynebacterium spp.) and gram-negative microorganisms (Actinobacillus spp., Bordetella spp.) and certain species of Nocardia and Actinomyces. It is particularly effective against Serpulina hyodysenteriae and Mycoplasma spp. Lincomycin inhibits synthesis of protein in microorganisms, binding ribosomal 50S subunits of bacterial cells. Spectinomycin is an antibiotic of tricyclic structure of the aminoglycosides group. It is mostly effective against gram-negative microorganisms, particularly, E. coli, Pasteurella multocida, Salmonella spp., Clostridium spp., Erysipelothrix rhusiopathiae, Haemophilus spp., Vibrio spp., as well as certain gram-positive microorganisms and Mycoplasma spp. Its efficacy is related to inhibition of synthesis of proteins in microbial cell through binding of ribosomal 30S subunit of microorganisms, which prevents elongation of polypeptide chain at translocation stage. Tiamulin is quickly absorbed from digestive tract and penetrates into all organs and tissues of the body of swine. Its maximum concentration is observed in 2 hours following administration. The antibiotic is eliminated from the body primarily with feces. After oral administration lincomycin is well absorbed from digestive tract (almost 60%) and is distributed in organs and tissues, particularly, in bone tissue. It binding to proteins makes 50%. Its concentration in blood serum reaches maximum in 2 hours following administration. Half-life period makes hours. Major quantities of lincomycin and its metabolites are excreted with urine and bile. Minor quantities are eliminated with feces. Spectinomycin is poorly absorbed in digestive tract. In 24 hours following oral administration minor concentrations of the antibiotic are observed in kidneys, liver, lungs, muscles, fat tissue. Binding of spectinomycin to proteins does not exceed 10%. Its concentration in serum reaches maximum in 4 hours. Spectinomycin is scarcely biotransformed in the body and is eliminated in unchanged form with feces. Treatment of lawsoniosis, enzootic pneumonia, actinobacillary pleuropneumonia, salmonellosis, dysentery, MMA (mastitis-metritis-agalactia) syndrome, eperythrozoonosis, necrotic enteritis, colibacillosis, mycoplasmosis and other diseases of digestive tract and breathing organs caused by tiamulin-, lincomycin and spectinomycin-sensitive microorganisms in swine. Administer orally with feed individually or by group method in a dose of kg of Tiamix per 1 t of feed for 5-7 days or with drinking water in a dose of kg of Tiamix per 1 t of drinking water for 5-7 days. If administered with feed, mix the drug with 20

23 ANTIMICROBIAL DRUGS OF SYSTEMIC ACTION the feed thoroughly. It is recommended that the drug be used with 3-10% of total feed quantity first and then the obtained mixture be mixed with the rest of the feed. If administered with drinking water, the medicated solution must be the only source of drinking water throughout the whole treatment period. Do not administer to animals with hypersensitivity to tiamulin, lincomycin and spectinomycin. Do not administer to rabbits, horses, cattle and laying hens. Do not administer to pregnant and lactating animals. Avoid administration of drugs containing monensin, maduramycin, narasin, lasalocid or salinomycin at least in 7 days prior to, during and in 7 days following administration of Tiamix as this may cause deterioration in health condition or even death. Animal slaughter for meat is possible in 7 days following the last administration of the drug. Meat obtained before the mentioned term shall be utilized or fed to non-productive animals depending on the statement of veterinary physician. Bags of 1000 g film or foil materials. Store in a dark, damp-proof place out of the reach of children at 0-30 С. 3 months after being mixed with feed. 24 hours after dissolution in drinking water. 21

24 ANTIMICROBIAL DRUGS OF SYSTEMIC ACTION TILMICOL Solution for oral administration Yellowish solution. 1ml of the drug contains: active ingredient: tilmicosin base 250 mg; excipient propylene glycol. Tilmicosin is a semisynthetic antibiotic of the macrolide group. It has bacteriostatic effect in low concentrations and bactericidal effect in high concentrations against grampositive microorganisms, that is: Pasteurella spp., Haemophilus spp., Actinomyces spp., Corynebacterium spp., as well as mycoplasma (Mycoplasma spp.) and ornithobacteria (Ornithobacterium rhinotracheale). The mechanism of action of the drug consists in blocking of synthesis of proteins in bacterial cell through formation of complexes with ribosomal 50S subunits. Treatment of diseases of respiratory organs caused by tilmicosin-sensitive microorganisms in chickens, calves (of up to 6 months of age), piglets (of up to 3 months of age). Administer orally with drinking water or milk substitute in the following doses: chickens: 300 ml of the drug per 1 t of drinking water for the first 3 days of life. It is recommended that the administration be repeated on the 20 th -22 nd day of life (the duration and dose being the same); piglets (of up to 3 months of age): 80 ml of the drug per 100 l of drinking water for 5 days; calves (of up to 6 months of age): 1 ml of the drug per 20 kg body weight twice daily for 3-5 days. Do not administer to animals with hypersensitivity to tilmicosin. Do not administer to hens laying eggs for human consumption. Do not administer in combination with injections of macrolides. Do not prescribe to cows with functionally developed proventriculi. Do not administer with feed containing bentonites. For preparation of the stock solution add Tilmicol to water, but not to the contrary. The medicated water must be the only source of drinking water throughout the while treatment period! Do not feed the daily dose of the drug during single administration. Animal slaughter for meat is possible as follows: piglets in 14 days, chickens in 7 days, calves in 36 days following the last administration of the drug. Meat obtained before the mentioned term shall be utilized or fed to non-productive animals depending on the statement of veterinary physician. Plastic vials of ml. Store in a dry, dark place out of the reach of children at 5-30 С. 24 hours after dissolution. 22

25 ANTIMICROBIAL DRUGS OF SYSTEMIC ACTION TILOTRIN Solution for injections Transparent yellow solution. 1 ml of the drug contains: active ingredient: tylosin ( as tylosin tartrate) 50 mg; excipients propylene glycol, water for injections. АТС vet QJ01. Antibacterials for systemic use. QJ01FA90. Tylosin. Tylosin is a macrolide antibiotic, which inhibits bacterial synthesis of proteins by way of binding to ribosomal 50S subunits. The drug makes bacteriostatic effect upon grampositive (Actinomyces spp., Bacillus antracis, Clostridium spp., Corynebacterium spp., Erysipelothrix rhusiopathiae, Streptococcus spp.) and gram-negative microorganisms (Actinobacillus spp., Bordetella bronchiseptica, Fusobacterium spp., Haemophilus spp., Moraxella spp., Pasteurella spp., Proteus mirabilis, Salmonella spp.) as well as mycoplasma (Mycoplasma gallisepticum, M. hyopneumoniae, M. synoviae, M. meleagridis, M. agalactiae, M. bovigenitalium). After intramuscular administration the antibiotic is quickly distributed in organs and tissues and reaches its maximum concentrations in about 1 hour following administration. The therapeutic level of substances in tissues is maintained for over 20 hours. Tylosin is eliminated from the body primarily with urine and milk. The drug is used to treat animals against the following diseases caused by tylosinsensitive microorganisms: cattle: pneumonia, mastitis, pneumoenteritis, secondary bacterial infections in viral diseases; sheep, goat: bronchial pneumonia, infectious agalactia, secondary bacterial infections in viral diseases; swine: enzootic pneumonia, atrophic rhinitis, arthritis, dysentery, secondary bacterial infections in viral diseases; turkeys: diseases of respiratory organs. Administer intramuscularly once daily in the following doses: Animal species Drug doses (ml per 1 kg body weight) Cattle 0.1 Sheep, goats Swine 0.2 Turkeys Treatment period: 3-5 days. Do not administer to animals with hypersensitivity to tylosin. Do not administer to animals with kidney and liver disorders. Do not administer in combination with penicillins, cephalosporins and lincomycin. Do not administer to horses. Do not administer to animals in pregnancy as well as to animals of the first week of life. Consumption of milk is possible in 4 days and animal slaughter for meat is possible in 8 days following the last administration. Milk and meat obtained before the mentioned term shall be utilized or fed to non-productive animals depending on the statement of veterinary physician. Glass vials of 100 ml sealed with rubber stoppers and aluminum caps. Store in original packaging out of the reach of children at 0-30 С. 28 days after the initial sampling provided it is stored in original packaging at 0-30 С. 23

26 ANTIMICROBIAL DRUGS OF SYSTEMIC ACTION TRIFLON Solution for oral administration Transparent yellow solution. 1 ml of the drug contains: active ingredients: enrofloxacin 100 mg; trimethoprim 50 mg; excipient purified water. АТСvet: QJ01. Antibacterials for systemic use. Enrofloxacin is a broad-spectrum antibiotic of the fluoroquinolones group, which demonstrates activity against gram-positive and gram-negative microorganisms (Staphylococcus spp., Streptococcus spp., Clostridium spp., Listeria monocytogenes, Corynebacterium spp., Pseudomonas aeruginosa, E. coli, Haemophilus spp., Salmonella spp., Klebsiella spp., Proteus spp., Pasteurella spp. etc.) as well as mycoplasma (Mycoplasma spp.) and chlamydiae (Chlamydia spp.). Its mechanism of action is related to inhibition of bacterial DNA-gyrase, which results in violation of DNA replication in microorganisms. Trimethoprim is a broad-spectrum antibacterial of the diaminopyrimidines group. It is effective against gram-positive and gram-negative microorganisms (E. сolі, Klebsiella spp., Salmonella spp., Pasteurella spp., Enterobacter spp., Proteus spp., Shigella spp., Staphylococcus spp., Streptococcus spp., Haemophilus spp., Chlamydia spp.) as well as toxoplasma and coccidia. The mechanism of action of trimethoprim consists in inhibition of bacterial reductase of dihydrofolic acid. Enrofloxacin is quickly absorbed from digestive tract and is well distributed in the body tissues and fluids. Its maximum concentration in blood is reached already in minutes. Feed in the stomach does not make any impact upon absorption of the drug. Binding of enrofloxacin with proteins makes 24%±2%. Its highest concentrations are reached in bile, kidneys, liver, lungs, reproductive organs. Enrofloxacin is primarily excreted renally. Metabolites are eliminated with urine and feces. Trimethoprim is quickly absorbed from digestive tract and well distributed in all tissues and fluids of the body. Its concentrations in tissues are much higher than those in blood. High levels of the drug are observed in lungs, kidneys and liver. Concentration of trimethoprim in blood serum reaches its maximum in 1.5 hour following administration. Average half-life makes about 2.5 hours. Trimethoprim is primarily excreted renally. Its concentration in urine exceeds its concentration in blood by several times. Treatment of colibacillosis, salmonellosis, necrotic enteritis, streptococcosis, hemophillosis, mycoplasmosis and other infectious diseases caused by enrofloxacin and trimethoprim-sensitive microorganisms in poultry. Administer orally with drinking water in a dose of ml of the drug per 1 l of drinking water for 3-5 days. Hypersensitivity to enrofloxacin and trimethoprim. Do not administer to hens laying eggs for human consumption and pullets in 2 weeks prior to commencement of the laying period. Do not administer in combination with non-steroid antiinflammatory agents, antibiotics of the macrolides group, tetracycline and chloramphenicol. Animal slaughter for meat is possible in 11 days following the last administration. Meat obtained before the mentioned term shall be utilized or fed to non-productive animals depending on the statement of veterinary physician. For preparation of the stock solution add the drug to water. The medicated water must be the only source of the drinking water throughout the whole treatment period. Cardboard boxes with 10 plastic vials of 10 ml each and plastic vials of ml Store in a dry, dark place out of the reach of children at 5-30 С. 3 years. 24 hours after dissolution in drinking water. 24

27 ANTIMICROBIAL DRUGS OF SYSTEMIC ACTION TRIFLON 100 Solution for injections Transparent yellow solution. 1 ml of the drug contains: active ingredients: enrofloxacin 100 mg; trimethoprim 50 mg; excipient water for injections. АТСvet: QJ01. Antibacterials for systemic use. Enrofloxacin is a broad-spectrum antibiotic of the fluoroquinolones group, which demonstrates activity against gram-positive and gram-negative microorganisms (Staphylococcus spp., Streptococcus spp., Clostridium spp., Listeria monocytogenes, Corynebacterium spp., Pseudomonas aeruginosa, E. coli, Haemophilus spp., Salmonella spp., Klebsiella spp., Proteus spp., Pasteurella spp. etc.) as well as mycoplasma (Mycoplasma spp.) and chlamydia (Chlamydia spp.). Its mechanism of action id related to inhibition of bacterial DNA-gyrase, which results in violation of DNA replication in microorganisms. Trimethoprim is a broad-spectrum antibacterial of the diaminopyrimidines group. It is effective against gram-positive and gram-negative microorganisms (E. сolі, Klebsiella spp., Salmonella spp., Pasteurella spp., Enterobacter spp., Proteus spp., Shigella spp., Staphylococcus spp., Streptococcus spp., Haemophilus spp., Chlamydia spp.) as well as toxoplasma and coccidia. The mechanism of action of trimethoprim consists in inhibition of bacterial reductase of dihydrofolic acid. Treatment of diseases of digestive tract, respiratory organs and urinary system as well as skin and soft tissues caused by enrofloxacin and trimethoprim-sensitive microorganisms in cattle and swine. Cattle. Administer subcutaneously in a dose of 2.5 ml of the drug per 100 kg body weight once daily for 3-5 days. In salmonellosis and diseases of respiratory organs administer 5 ml of the drug per 100 kg body weight once daily for 5 days. Swine. Administer intramuscularly in a dose of 0.25 ml of the drug per 10 kg body weight once daily for 3 days. In salmonellosis and infections of respiratory organs administer 0.5 ml of the drug per 10 kg body weight once daily for 5 days. Hypersensitivity to enrofloxacin and trimethoprim. Do not administer to pregnant swine. Do not administer Triflon 100 in combination with tetracycline, chloramphenicol, theophylline and nonsteroidal anti-inflammatory agents. Animal slaughter for meat is possible in 14 days following the last administration. Consumption of milk is possible in 7 days following the last administration. Meat and milk obtained before the mentioned term shall be utilized or fed to non-productive animals depending on the statement of veterinary physician. Glass vials of 100 ml sealed with rubber stoppers and aluminum caps in cardboard boxes. Store in a dry, dark place out of the reach of children at 5-30 С. 3 years. 25

28 ANTIMICROBIAL DRUGS OF SYSTEMIC ACTION TRIMECOL Water-soluble powder for oral administration White water-soluble powder. 1 g of the drug contains: active ingredients: colistin sulfate IU; trimethoprim 50 mg; excipient glucose. АТСvet: QJ01. Antibacterials for systemic use. QJ01RA95. Polymyxins, combinations with other antibacterials. The drug composition includes the combination of trimethoprim and colistin, which has a synergistic antibacterial effect. Colistin is an antibiotic of the polymyxins group, which makes bactericidal effect upon gram-negative microorganisms (E. сolі, Salmonella spp., Pasteurella spp., Haemophіlus spp., Bordetella spp.). The mechanism of action of colistin consists in violation of integrity оf cytoplasmic membrane of microorganisms. The antibiotic interacts with phospholipids and penetrates inside, thus destroying the cell membrane structure, the permeability of which changes immediately after contact with the drug. Apart from antibacterial effect colistin binds phospholipid A and neutralizes toxic effect of bacterial endotoxin. Trimethoprim is a broad-spectrum antibacterial of the diaminopyrimidines group. It is effective against gram-positive and gram-negative microorganisms (E. сolі, Klebsiella spp., Salmonella spp., Pasteurella spp., Enterobacter spp., Proteus spp., Shigella spp., Staphylococcus spp., Streptococcus spp., Haemophilus spp., Chlamydia spp.) as well as toxoplasma and coccidia. The mechanism of action of trimethoprim consists in inhibition of bacterial reductase of dihydrofolic acid. Colistin is poorly absorbed from intestine in minor quantities, so it is effective in treatment of diseases of digestive organs. Its concentrations in blood serum are low, but its concentrations in various sections of digestive tract is constantly high. 60% of colistin binds to phospholipids and liposaccharides of gram-negative bacteria. Colistin is eliminated from the body primarily with feces. Trimethoprim is quickly absorbed from digestive tract and well distributed in all tissues and fluids of the body. Its concentrations in tissues are much higher than those in blood. High levels of the drug are observed in lungs, kidneys and liver. Concentration of trimethoprim in blood serum reaches its maximum in 1.5 hour following administration. Average half-life makes about 2.5 hours. Trimethoprim is primarily excreted renally. Its concentration in urine exceeds its concentration in blood by several times. Treatment of diseases of respiratory organs, urinary system and digestive tract caused by trimethoprim and colistin-sensitive microorganisms in calves, goats and lambs of up to 3 months of age, swine, rabbits, chickens and broiler chickens. Administer orally with drinking water or liquid feed in the following doses: calves, goatlings and lambs of up to 3 months of age, swine, rabbits: g of the drug per 10 kg body weight twice daily (maximum 30 g of the drug per animal daily) for 3 days; chickens and broiler chickens: g of the drug per 1 l of drinking water (young poultry maximum 1 g of the drug per 1 l of drinking water in the beginning of treatment) for 3 days. The drug solution must be the only source of drinking water throughout the whole treatment period! Do not administer to animals with hypersensitivity to colistin and trimethoprim as well as to animals with liver and kidney injuries. Do not administer in combination with aminoglycosides (gentamicin, neomycin), muscle relaxant and anesthetics. Resistance of strains of pathogenic bacteria to colistin and/ or trimethoprim belongs to contraindications for administration. Do not administer to hens laying eggs for human consumption as well as ruminants with functionally developed proventriculi. Animal slaughter for meat is possible in 7 days following the last administration. Meat obtained before the mentioned term shall be utilized or fed to non-productive animals depending on the statement of veterinary physician. Bags of g of film or foil materials. Store in a dry, dark place out of the reach of children at 5-30 С. 24 hours after dissolution in drinking water. 26

29 ANTIMICROBIAL DRUGS OF SYSTEMIC ACTION TRIMICOSIN Solution for oral administration Transparent yellow solution. 1 ml of the drug contains: active ingredients: tilmicosin 50 mg; enrofloxacin 50 mg; trimethoprim 25 mg; excipient purified water. АТСvet: QJ01. Antibacterials for systemic use. QJ01RA96. Quinolones, combinations with other antibacterials. The drug composition includes the combination of enrofloxacin, tilmicosin and trimethoprim, which has a synergistic antimicrobial effect. Enrofloxacin is a broad-spectrum antibiotic of the fluoroquinolones group, which demonstrates activity against gram-positive and gramnegative microorganisms (Staphylococcus spp., Streptococcus spp., Clostridium spp., Listeria monocytogenes, Corynebacterium spp., Pseudomonas aeruginosa, E. coli, Haemophilus spp., Salmonella spp., Klebsiella spp., Proteus spp., Pasteurella spp. etc.) as well as mycoplasma (Mycoplasma spp.) and chlamydiae (Chlamydia spp.). Its mechanism of action is related to inhibition of bacterial DNA-gyrase, which results in violation of DNA replication in microorganisms. Trimethoprim is a broad-spectrum antibacterial of the diaminopyrimidines group. It is effective against gram-positive and gram-negative microorganisms (E. сolі, Klebsiella spp., Salmonella spp., Pasteurella spp., Enterobacter spp., Proteus spp., Shigella spp., Staphylococcus spp., Streptococcus spp., Haemophilus spp., Chlamydia spp.) as well as toxoplasma and coccidia. The mechanism of action of trimethoprim consists in inhibition of bacterial reductase of dihydrofolic acid. Tilmicosin is a broad-spectrum antibiotic of the macrolides group, which is effective against agents of respiratory diseases (M. gallisepticum, M. synoviae, P. multocida і Ornithobacterium rhinotracheale). Tilmicosin inhibits synthesis of protein in microorganisms by way of interaction with ribosomes of bacterial cells. Enrofloxacin is quickly absorbed from digestive tract and well distributed in all tissues and fluids of the body. Its maximum concentration in blood is reached already in minutes. Feed in the stomach does not make any impact upon absorption of enrofloxacin. Binding of enrofloxacin to proteins makes 24%±2%. Its highest concentrations are observed in bile, kidneys, liver, lungs, reproductive organs. Enrofloxacin is primarily excreted renally. Metabolites are eliminated with urine and feces. Trimethoprim is metabolized in liver and eliminated primarily renally through glomerular filtration and active tubular secretion. Concentration of trimethoprim in urine is much higher than that in blood. Half-life period makes 8-10 hours. Tilmicosin is well absorbed from digestive tract. It accumulates in respiratory organs and macrophages in poultry in concentrations exceeding the concentration in blood serum by far. It is preserved in respiratory organs and tissues in therapeutic concentrations for over 2.5 days. It is metabolized with formation of several metabolites with antibacterial activity. It is primarily eliminated with feces. Treatment of mycoplasmosis, ornithobacteriosis, colibacillosis, salmonellosis, necrotic enteritis, streptococcosis as well as other diseases of digestive tract and respiratory organs caused by enrofloxacin-, tilmicosin and timetoprimsensitive microorganisms in poultry. Administer orally with drinking water in a dose of 1-2 ml of the drug per 1 l of drinking water for 3-5 days. In mycoplasmosis and ornithobacteriosis administer 2 ml per 1 l of drinking water for the first 3 days of life. It is recommended that the treatment is repeated in days in a dose of 1-2 ml per 1 l of drinking water during 3 days. Do not administer to poultry with hypersensitivity to the drug components. Do not administer to hens laying eggs for human consumption. Do not administer in combination with antibiotic of the tetracycline, chloramphenicol and lincomycine group. Do not administer to poultry with kidney and/or liver injuries. Do no prescribe Trimicosin in sub-therapeutic doses. For preparation of the stock solution it is necessary to add the drug to water first, but not on the contrary. The medicated water must be the only source of drinking water throughout the whole treatment period! Animal slaughter for meat is possible in 12 days following the last administration. Meat obtained before the mentioned term shall be utilized or fed to non-productive animals depending on the statement of veterinary physician. Cardboard boxes with 10 vials of 10 ml each, plastic vials of 1 l. Store in a dry, dark place out of the reach of children at 5-30 С. 24 hours after dissolution in water. 27

30 ANTIMICROBIAL DRUGS OF SYSTEMIC ACTION TRIMICOSIN М Water-soluble powder for oral administration Light yellow powder. 1 g of the drug contains: active ingredients: tilmicosin phosphate 100 mg; enrofloxacin 100 mg; trimethoprim 50 mg; excipient glucose. The drug composition includes the combination of enrofloxacin, tilmicosin and trimethoprim, which has a synergistic antimicrobial effect. Enrofloxacin is a broad-spectrum antibiotic of the fluoroquinolones group, which demonstrates activity against gram-positive and gram-negative microorganisms (Staphylococcus spp., Streptococcus spp., Clostridium spp., Listeria monocytogenes, Corynebacterium spp., Pseudomonas aeruginosa, E. coli, Haemophilus spp., Salmonella spp., Klebsiella spp., Proteus spp., Pasteurella spp. etc.) as well as mycoplasma (Mycoplasma spp.) and chlamydiae (Chlamydia spp.). Its mechanism of action is related to inhibition of bacterial DNA-gyrase, which results in violation of DNA replication in microorganisms. Trimethoprim is a broad-spectrum antibacterial of the diaminopyrimidines group. It is effective against gram-positive and gram-negative microorganisms (E. сolі, Klebsiella spp., Salmonella spp., Pasteurella spp., Enterobacter spp., Proteus spp., Shigella spp., Staphylococcus spp., Streptococcus spp., Haemophilus spp., Chlamydia spp.) as well as toxoplasma and coccidia. The mechanism of action of trimethoprim consists in inhibition of bacterial reductase of dihydrofolic acid. Tilmicosin is a broad-spectrum antibiotic of the macrolides group, which is effective against agents of respiratory diseases (M. gallisepticum, M. synoviae, P. multocida and Ornithobacterium rhinotracheale). Tilmicosin inhibits synthesis of protein in microorganisms by way of interaction with ribosomes of bacterial cells. Treatment of mycoplasmosis, ornithobacteriosis, colibacillosis, salmonellosis, necrotic enteritis, streptococcosis as well as other diseases of digestive tract and respiratory organs caused by enrofloxacin-, tilmicosin and timetoprim-sensitive microorganisms in poultry. Administer orally with drinking water in a dose of kg of the drug per 1 t of drinking water during the first 3-5 days of life. It is recommended that the treatment be repeated in 20 to 22 days in a dose of kg of the drug per 1 t of drinking water for 3 days. Do not administer to poultry with hypersensitivity to the drug components. Do not administer to hens laying eggs for human consumption. Do not administer in combination with antibiotic of the tetracycline, chloramphenicol and lincomycine group. Do no prescribe Trimicosin М in subtherapeutic doses. The medicated water must be the only source of drinking water throughout the whole treatment period! Animal slaughter for meat is possible in 12 days following the last administration. Meat obtained before the mentioned term shall be utilized or fed to non-productive animals depending on the statement of veterinary physician. Bags of g film or foil materials. Store in a dry, dark place out of the reach of children at 5-30 С. 24 hours after dissolution in water. 28

31 DRUGS AGAINST NECROTIC ENTERITIS BIOENRADIN Powder for oral administration Yellowish-white powder. 1 g of the drug contains: active ingredient: enramycin 20 mg; excipient semolina. Enramycin is an antibiotic of the polypeptides group, which makes bactericidal effect, mostly upon gram-positive microorganisms (Clostridium perfringens, Streptococcus spp., Staphylococcus spp.). It is not absorbed from the digestive tract; therefore, it makes impact exclusively upon intestinal microflora. It inhibits growth of bacteria producing ammonia, facilitating reduction of the ammonia level in digestive tract and blood. The mechanism of action is related with impairment of cell membrane function of microorganisms through inhibition of synthesis of peptidoglycan in bacterial cell walls. The resistance of bacteria to enramycin develops slowly. No resistance of Clostridium perfringens is observed. No cross-resistance between enramycin and other antibacterial preparations is observed in microorganisms. Treatment of poultry and swine against diseases of digestive tract caused by enramycin-sensitive microorganisms. The drug is applied by group method mixed with the feed in the following doses: young poultry: 500 g/t of feed throughout the growing period; laying hens and broiler parental stocks: g/t of feed. suckling and growing piglets: 800 g/t of feed; fattening piglets, main sows and boars: 600 g/t of feed; pregnant and lactating saws: 1200 g/t of feed. Do not use to treat animals with hypersensitivity to enramycin. Do not use the drug in sub-therapeutic doses. Packages of film or foil materials of g; bags of 25 kg. Store in a dry dark place out of the reach of children at 5-30 С. 29

32 DRUGS AGAINST NECROTIC ENTERITIS BIONON Powder for oral administration Brown powder. 1 g of the drug contains: active ingredient: nosiheptide 5 mg; excipient semolina up to 1 g. АТСvet: QA07A. Intestinal anti-infectives. Nosiheptide is an antibiotic of the polypeptides group. It makes bactericidal effect upon gram-positive microorganisms (Clostridium perfringens, Streptococcus spp., Staphylococcus spp.) as well as upon certain gram-negative microorganisms (Pasteurella multocida, Neisseria catarrhalis). Nosiheptide makes effect upon bacterial synthesis of proteins, that is upon 50S ribosomal subunits, and tightly binds the 23S-rRNA complex to the ribosomal protein L11. It is not absorbed from the digestive tract; therefore, it makes impact exclusively upon intestinal microflora. It inhibits growth of microorganisms producing ammonia, facilitating reduction of the ammonia level in digestive tract. The resistance of bacteria to the active ingredient develops slowly. No resistance of Clostridium perfringens is observed. No cross-resistance with other antibacterial preparations is observed in microorganisms. High concentration of nosiheptide formed in the digestive tract contributes to long-term antibacterial effect. It is not accumulated in body tissues and is eliminated from the body in unchanged form. Prevention and treatment of diseases of digestive tract (particularly of necrotic enteritis) caused by microorganisms sensitive to the active ingredient of the drug in poultry, swine, calves, rabbits. The drug is applied by group method mixed with the feed in the following doses: young poultry: 500 g/t of feed throughout the growing period; laying hens and broiler parental stocks: g/t of feed; suckling piglets, growing-fattening piglets, main sows and boars: g/t of feed; pregnant and lactating saws: g/t of feed; calves of up to 3 months of age: g/t of feed; rabbits: 1-2 g/kg of feed throughout the growing period. Do not use to treat animals with hypersensitivity to the active ingredient of the drug. Do not use Bionon in sub-therapeutic doses. Multilayer paper bags of 1 and 25 kg. Store in a dry dark place out of the reach of children at 5-30 С. 30

33 DRUGS AGAINST NECROTIC ENTERITIS GENTOVIT 10% Water-soluble powder for oral administration White water-soluble powder. 1 g of the drug contains: active ingredient: gentamicin sulfate 100 mg; excipient glucose. ATCvet: QJ01. Antibacterials for systemic use. QJ01GB03. Gentamicin. Gentamicin is an aminoglycoside antibiotic. It makes bactericidal effect upon gramnegative and, partially, upon gram-positive bacteria: Enterobacter aerogenes, E. coli, Klebsiella spp., Neisseria spp., Pasteurella multocida, Pseudomonas aeruginosa, Salmonella spp., Serratia marcescens, Shigella spp., Staphylococcus spp., certain Streptococcus species and Proteus species, Serpulina (Treponema) hyodysenteriae, Mycoplasma spp., Corynebacterium spp., Bacillus spp., Clostridium spp., Lysteria monocitigenes. Gentamicin penetrates into cell by way of oxygen-dependent active transport and passive diffusion. Then it binds to protein receptors at the level of ribosomal 30S subunits and blocks formation of a complex, which includes mrna, formylmethionine and trna. Consequently, there appears incorrect translation of trna, which results in formation of non-functional proteins. It is scarcely absorbed in blood and therefore acts only in organs of digestive system. Gentamicin does not demonstrate any toxic effect upon organisms of animals, does not cause any negative implications even in cases of major overdosing. Gentamicin is scarcely biotransformed in digestive tract and is eliminated from the body unchanged with feces. Treatment of swine, calves (of up to 3 months of age), poultry (broilers, breeders, pullets) against diseases of digestive tract (colibacteriosis, salmonellosis, dysentery, campylobacteriosis) caused by gentamicinsensitive microorganisms. Administer orally with drinking water or feed in the following doses: swine: 5 g per 100 kg body weight (5 mg of gentamicin sulfate per 1 kg body weight) daily (divide into 2 administrations). Duration of treatment: 3-5 days; poultry (broilers, breeders, pullets): 5 g per 100 kg body weight (5 mg of gentamicin sulfate per 1 kg body weight) daily. Duration of treatment: 5-7 days; calves (of up to 3 months of age): 5 g per 100 kg body weight (5 mg of gentamicin sulfate per 1 kg body weight) daily (divide into 2 administrations with interval of 12 hours). Duration of treatment: 3-5 days. Do not use to treat animals with hypersensitivity to gentamicin. Do not prescribe the drug concurrently with or subsequently to other oto or nephrotoxic drugs (streptomycin, kanamycin, apramycin, neomycin, chloramphenicol) as well as diuretic and muscle relaxants. Do not administer to cattle with functionally developed proventriculi and hens laying eggs for human consumption. Do not administer to animals with kidney function disorders, ear and labyrinth disorders. Animal slaughter is possible as follows: calves, swine in 10 days, broilers, breeders, pullets in 14 days following the last administration. Meat obtained before the mentioned term shall be utilized or fed to non-productive animals depending on the statement of veterinary physician. If used with feed, mix thoroughly. It is recommended to mix the powder with 3-10% of total feed quantity first and then blend the mixture obtained with the rest of the feed. Packages of film or foil materials of 1000 g. Store in a dark damp-proof place out of the reach of children at 0-30 C. 3 years. 24 hours after dissolution in drinking water. 31

34 ANTI-MASTITIS DRUGS FARMAST Suspension for intramammary administration Viscous yellow suspension with specific odor. 10 ml of the drug contains: active ingredients: amoxicillin (amoxicillin trihydrate) 670 mg; gentamicin (gentamicin sulfate) 75 mg; prednisolone (prednisolone acetate) 10 mg; excipient vegetable oil. Amoxicillin is a broad-spectrum bactericidal antibiotic of the penicillin group. It is effective against gram-positive (Staphylococcus spp., which do not produce penicillinase, Clostridium spp., Arcanobacterium spp., Bacillus anthracis, Listeria monocytogenes, Erysipelothrix rhusiopathiae) and gram-negative microorganisms (Pasteurella spp., Mannheimia haemolytica, Haemophillus spp., Actinobacillus spp., Escherichia coli, Salmonella spp., Moraxella spp. and Fusobacterium spp.). Amoxicillin inhibits synthesis of mucopeptide one of the components of bacterial cell wall, which ensures mechanical stability of microorganism, and thereby destroys bacteria in its growth stage. Gentamicin belongs to aminoglycoside antibiotics. It makes bactericidal effect against gram-negative microoganisms such as: Enterobacter aerogenes, Klebsiella pneumoniae, Pseudomonas aeruginosa, Escherichia coli, Salmonella spp. and Shigella spp. Gentamicin is also effective against such gram-positive bacteria as Treponema hyodysenteriae, Staphylococcus aureus and β-hemolytic Streptococcus. It makes direct effect upon ribosomes, where it inhibits biosynthesis of proteins and decreases accuracy of translation of genetic code. Penetration of gentamicin into bacterial cell intensifies as permeability of its wall increases under the effect of amoxicillin. Such a synergism makes it possible to use less aminoglycosides. Prednisolone is a dehydrogenated analogue of hydrocortisone. It has the properties inherent to other compounds of this group, that is: anti-inflammatory, desensitizing, anti-allergenic, antishock and anti-toxic. Through stimulation of steroid receptors the drug induces formation of special class of proteins lipoproteins, which have antiedemic activity, as well as reduces activity of hyaluronidase and reduces permeability of capillaries. The combination of amoxicillin and gentamicin creates a broad antibacterial spectrum of effect upon gram-positive (mainly streptococci, staphylococci and corynebacterium) and gram-negative microorganisms (particularly Escherichia coli, Pasteurella spp., Salmonella spp. and Pseudomonas spp.). This combination improves therapeutic properties of each of these antibiotics applied separately. Farmast is used to treat clinical and subclinical bacterial mastitis caused by microorganisms sensitive to the drug components in cattle. Administer the contents of a single syringe tube (10 ml) heated to body temperature into the teat canal of the injured quarter of the milked dry mammary gland once daily until complete clinical recovery (1-4 days). Do not administer to animals with hypersensitivity to the drug components. Consumption of milk and animal slaughter is possible in 7 days following the last administration of the drug. Milk and meat obtained before the mentioned term shall be utilized or fed to non-productive animals depending on the statement of veterinary physician. Plastic syringe tubes of 10 ml, 20 pcs. in package. Store in original packaging in a dry, dark place out of the reach of children at 5 30 С. 18 months. 32

35 ANTI-MASTITIS DRUGS MASTILEK Suspension for intramammary administration Yellow suspension. 10 ml of the drug (1 syringe tube) contains: active ingredients: cefquinome (equivalent to cefquinome sulfate) 75 mg; prednisolone 10 mg; excipient sunflower oil. АТСvet: QJ51. Antibacterials of systemic action. Antibacterials or intramammary use, other beta-lactam antibacterials for intramammary use. Cephalosporins of the 4 th generation. QJ01DE90. Cefquinome. Cefquinome is a cephalosporin of the 4 th generation, which has a broad spectrum of antibacterial action against most gram-positive and gram-negative bacteria (Escherichia coli, Enterobacter spp., Staphylococcus aureus, Streptococcus spp., Clostridium spp., Actinobacillus spp., Citrobacter spp., Klebsiella spp., Pasteurella spp., Proteus spp., Salmonella spp., Serratia marcescens, Histophilus somni, Arcanobacterium pyogenes, Bacillus spp., Corynebacterium spp., Bacteroides spp., Fusobacterium spp., Prevotella spp. and Erysipelothrix rhusiopathiae), particularly, upon strains producing β-lactamase. Mechanism of bactericidal effect of cefquinome consists in inhibition of synthesis of cell membrane of microorganisms. Prednisolone is a synthetic glucocorticoid, which demonstrates anti-inflammatory, antiallergic, immunosuppressive and antiproliferative action. The drug is used for treatment of clinical and subclinical mastitis in cattle during lactation caused by microorganisms sensitive to the drug components. Administer contents of a single syringe tube (10 ml) heated to the body temperature 3 times with intervals of 12 hours into the teat canal after thorough milking of the damaged quarter of mammary gland. of the drug to cows with hypersensitivity to cephalosporins and other β-lactam antibiotics, particularly cefquinome, is prohibited. Discontinue administration and conduct symptomatic therapy in case allergic reactions are observed. Avoid increase of intervals between administrations as this may cause decreased treatment effectiveness. Shake the syringe tube intensely before use. Do not use the drug with other antibacterials of bacteriostatic action. People may consume milk in 84 hours (7 milking sessions). Animal slaughter for meat is possible in 2 days following the last administration of the drug. Meat and milk obtained before the mentioned term shall be utilized or fed to non-productive animals depending on the statement of veterinary physician. Plastic syringe tubes of 10 ml, 20 pcs. in package. Store in original packaging in a dry, dark place out of the reach of children at 2-30 С. 33

36 ANTI-MASTITIS DRUGS MASTILEK FORTE Suspension for intramammary administration Yellow suspension. 10 ml of the drug contains: active ingredients: cefquinome (equivalent to cefquinome sulfate) 75 mg; prednisolone 10 mg; enrofloxacin 500 mg; excipients vegetable oil, propylparahydroxybenzoate, methylparahydroxybenzoate. АТСvet: QJ01. Antibacterials of systemic action. QJ01DE90. Cefquinome. Cefquinome is a cephalosporin of the 4 th generation, which has a broad spectrum of antibacterial action against most gram-positive and gram-negative bacteria (Escherichia coli, Enterobacter spp., Staphylococcus aureus, Streptococcus spp., Clostridium spp., Actinobacillus spp., Citrobacter spp., Klebsiella spp., Pasteurella spp., Proteus spp., Salmonella spp., Serratia marcescens, Histophilus somni, Arcanobacterium pyogenes, Bacillus spp., Corynebacterium spp., Bacteroides spp., Fusobacterium spp., Prevotella spp. and Erysipelothrix rhusiopathiae), particularly, upon strains producing β-lactamase. Mechanism of bactericidal effect of cefquinome consists in inhibition of synthesis of cell membrane of microorganisms. Enrofloxacin is a broad-spectrum antibiotic of the fluoroquinolone group. The drug is effective against gram-positive and gramnegative microorganisms (Staphylococcus spp., Streptococcus spp., Clostridium spp., Listeria monocytogenes, Corynebacterium spp., Pseudomonas spp., E. coli, Haemophilus spp., Salmonella spp., Klebsiella spp., Proteus spp., Pasteurella spp. etc.) as well as mycoplasma and chlamydia. The mechanism of action is related to inhibition of bacterial DNA-gyrase, which results in disturbance of replication of bacterials DNA. The drug is used for treatment of clinical and subclinical mastitis in cattle during lactation caused by microorganisms sensitive to the drug components. Administer contents of a single syringe tube (10 ml) heated to the body temperature 3 times with intervals of 12 hours into the teat canal after thorough milking of the damaged quarter of mammary gland. of the drug to cows with hypersensitivity to cephalosporins and other β-lactam antibiotics, particularly cefquinome, is prohibited. Discontinue administration and conduct symptomatic therapy in case allergic reactions are observed. Avoid increase of intervals between administrations as this may cause decreased treatment effectiveness. It is not recommended to use the drug with other antibacterials of bacteriostatic action. People may consume milk in 4 days. Animal slaughter for meat is possible in 2 days following the last administration of the drug. Meat and milk obtained before the mentioned term shall be utilized or fed to non-productive animals depending on the statement of veterinary physician. Plastic syringe tubes of 10 ml, 20 pcs. in package. Store in original packaging in a dry, dark place out of the reach of children at 2-30 С. 34

37 ANTI-MASTITIS DRUGS TRIMAST FORTE Solution for intramammary administration Transparent light yellow solution with specific odor. 1 syringe tube (10 ml) contains: active ingredients: enrofloxacin 200 mg; trimethoprim 100 mg; prednisolone 10 mg; excipient - purified water. АТСvet: QJ51. Antibacterials for intramammary use. QJ51RV01. Antibacerials and corticosteroids. Enrofloxacin is a broad-spectrum antibiotic of the fluoroquinolones group. It makes antibacterial effect upon gram-positive and gram-negative bacteria (Staphylococcus spp., Streptococcus spp., Clostridium spp., Listeria monocytogenes, Corynebacterium spp., Pseudomonas spp., E. coli, Haemophilus spp., Salmonella spp., Klebsiella spp., Proteus spp., Pasteurella spp. etc.) as well as mycoplasma and chlamydiae. Its mechanism of action is related to inhibition of bacterial DNA-gyrase, which causes violation in DNA replication in microorganisms. The drug is quickly distributed in organs and tissues. Therapeutic concentrations are reached in hours following administration and are maintained for 24 hours. Trimethoprim is a broad-spectrum antibacterial of the diaminopyridines group. It is effective against gram-positive and gram-negative bacteria (Escherichia coli, Klebsiella spp., Salmonella spp., Pasteurella spp., Enterobacter spp., Proteus spp., Shigella spp., Staphylococcus spp., Streptococcus spp., Haemophilus spp., Chlamydia spp.) as well as toxoplasma and coccidia. The mechanism of action consists in inhibition of bacterial reductase of dyhidrofolic acid. Prednisolone is a corticosteroid with antiinflammatory, antiallergenic, desensitizing and antiedemic activity. Treatment of clinical and subclinical forms of bacterial mastitis caused by microorganisms sensitive to the drug components in lactating cows. Heat the syringe tube on water bath before use to С and shake intensely. Administer the contents of a single syringe tube into the injured quarter of the mammary gland, having preliminarily milked dry and disinfected the gland. Massage the quarter for even distribution of the drug. Repeat the procedure twice daily. Continue treatment until clinical recovery (1-4 days). Do not administer to animals with individual hypersensitivity to any active ingredient of the drug as they may cause allergic reactions. Consumption of milk is possible in 3 days following the last administration. Milk obtained before the mentioned term shall be fed to non-productive animals or utilized depending on the statement of veterinary physician. Cardboard box with 20 polymer syringe tubes of 10 ml each. Store in a dark place out of the reach of children at С. 35

38 COCCIDIOSTATS DIAСOX 0.2% Powder for oral administration Water-insoluble light brown powder. 1 g of the drug contains: active ingredient: diclazuril 2 mg; excipient semolina. ATCvet: QP51. Antiprotozoals. QP51AJ01. Diclazuril. Diclazuril is an anticoccidial of the benzeneacetonitrile group. It makes effect upon all the eimeria species in poultry (Eimeria acervulina, Е. brunetti, Е. maxima, Е. mitis, Е. necatrix, Е. tenella, Е. adenoeides, Е. gallopavonis, Е. meleagrimitis etc.), rabbits (Е. flavescens, Е. intestinalis, Е. magna, Е. perforans, Е. stiedaе etc.), cattle, sheep, goats and swine causing disorders in energetic metabolism processes of endogenous cycle of development of coccidia. Asexual forms of endogenous cycle of development of eimeria are the most sensitive to the drug. Diclazuril is not accumulated in organs and tissues of animal bodies and does not cause any negative impact even in case of major overdosing (20-25 times of the recommended doses). Treatment and prevention of diseases in poultry (broiler chickens, young ducks, geese, pheasants, turkeys), cattle, goats, sheep, rabbits, swine caused by various Eimeria species. The drug is administered with feed in the following doses: Mix the drug thoroughly with feed: firstly with a small part (3-10% of total quantity), then mix the blend obtained with the rest of the feed. Do not administer to animals with hypersensitivity to diclazuril. Do not apply to treat females in early pregnancy. Do not apply to treat laying hens. Do not apply concurrently with other drugs against coccidia. Poultry slaughter for meat is allowed in 5 days following the last administration of Diaсoх 0.2%. Withdrawal period for cattle, sheep, goats, rabbits, swine is 0 days. Polymer or glass jars, packages of film or foil materials of 50 and g; bags of 25 kg. Store in original packaging in a dry, dark place out of the reach of children at 0-30 С. 1 year. Animal Poultry: hens (broiler chickens) Ducks, geese, pheasants Turkeys (young birds) Cattle, sheep, goats, swine, rabbits (young animals) Drug dose (Diaсox 0.2%) 0.5 kg/t of the ready feed 0.5 kg/t of the ready feed 0.5 kg/t of the ready feed 0.5 g/kg body weight Dose as per active ingredient (diclazuril) 1 mg/kg of the ready feed 1 mg/kg of the ready feed 1 mg/kg of the ready feed 1 mg/kg body weight Frequency of administration From the first day of life till the end of feeding From the first day of life till 16 th week of age From the first day of life till 14 th week of age Once according to indications, repeat in 3 weeks 36

39 COCCIDIOSTATS EIMERIX Microgranulate for oral administration Gray-brown fine granules with slight specific odor. 100 g of the drug contains: active ingredient: sodium monensin 20 g; excipient calcium carbonate. АТСvet: QP51. Antiprotozoals. QP51АН03. Monensin. Eimerix is an antiprotozoal containing sodium monensin (20%) of ionophore action as an active ingredient and excipients. It is effective against Eimeria tenella, E. acervulina, E. mivati, E. brunetti, E. necatrix, E. maxima, E. adenoeides, E. meleagrimitis, E. gallopavonis in chickens and turkeys. Monensin interrupts transport of monovalent ions of potassium and sodium in cells of the mentioned coccidia, which causes their swelling and vacuolization. Molecules of monesin increase intracellular sodium concentration. The parasite dies due to osmotic pressure disruption. Monensin acts upon eimeria in the states of sporozoites and trophozoites. Sodium monensin is ingested in chicken bodies and forms dimethyl oxidative and decarboxylized metabolites, which are found in feces and tissues, where the contents of either metabolite does not exceed 10% of total number of compounds. Monensin residue test in chickens and turkeys after administration demonstrated that the drug level was the highest in skin, fat and liver. Sodium monensin is eliminated fast from the body mainly with bile. Prevention and treatment of eimeriosis in chickens (broilers, pullets) and turkeys (of up to 16 weeks) caused by Eimeria: chickens: Еimeria necatrix, Е. tenella, E. acervulina, Е. maxima, Е. mivati, Е. brunetti; turkeys: E. adenoeides, Е. gallopavonis, Е. meleagrimitis. Eimerix is administered with feed. It is recommended to add it firstly to 3-10% of total feed quantity and then to mix the blend obtained with the rest of the feed. The drug shall be administered in the following doses: broiler chickens g of the drug per 1 t of feed ( g of sodium monensin per 1 t of feed) throughout the whole feeding period; chickens and pullets g of the drug per 1 t of feed ( g of sodium monensin per 1 t of feed) up to 16 weeks; turkey g of the drug per 1 t of feed ( g of sodium monensin per 1 t of feed) up to 16 weeks. Do not prescribe to laying hens and other adult poultries (particularly, waterfowl)! It is strictly prohibited to administer the drug to horses and other odd-toed animals! Slaughter of chickens and turkeys for meat is possible in 3 days following the last administration of the drug. Meat obtained before the mentioned term shall be utilized or fed to non-productive animals depending on the statement of veterinary physician. Sodium monensin is incompatible with certain drugs, particularly with tiamulin. Hence, products, which contain tiamulin, may be administered to broiler chickens, pullets of egg crosses and turkeys in 7 days to and 7 days after administration of Eimerix. In case of combination of this drugs severe complications and death of poultry is possible. When working with the drug, observe principal hygiene and safety requirements adopted for work with veterinary drugs, avoid inhalation of the drug and contact with open skin areas. In case of incidental contact with eyes rinse them immediately with flowing water. Polyethylene bags of 25 kg packed in paper bags. Store in original air tight packaging in a dry and well-ventilated place protected from direct sunlight at 0-30 С. 3 months after being mixed with feed. 37

40 COCCIDIOSTATS MADURO Powder for oral administration Light brown powder. 1 g of the drug contains: active ingredient: maduramycin ammonium 10 mg; excipient crushed wheat. ATCvet: QP51. Antiprotozoals. QP51AX10. Maduramycin. Maduramycin is an eimeriostatic of the ionophore group. It is active against eimeria (Eimeria tenella, E. acervulina, E. necatrix, E. mivati, E. maxima, E. brunetti) at the stages of sporozoites, trophozoites and schizoites of the first generation. The mechanism of action is based upon disruption of transportation of monovalent ions of Na + and К + through cell membrane of the parasite with its further death. Treatment and prevention of coccidiosis caused by various Eimeria species in hens (broiler chickens, pullets up to 16 weeks of age) and turkeys of up to 12 weeks of age. The drug is fed to poultry with feed in a dose of 500 g of the drug per 1 t of feed (0.5 g of the drug per 1 kg of feed). Maduro is thoroughly mixed with feed: firstly with minor part (3-10% of total quantity), then the blend obtained is mixed with the rest. Do not use in case of hypersensitivity to maduramycin. Do not administer to laying hens. Do not prescribe in combination with other anticoccidials. It is prohibited to feed Maduro in 7 days before, during and in 7 days after administration of tiamulin. Uneven mixing of the drug with feed, uneven eating of feed containing the drug (in case animals are hungry or ill), exceeding the recommended concentration of the drug in feed may in some cases result in decrease in productivity of animals and even in development of clinical signs of their intoxication. Slaughter of poultry for meat is possible in 5 days following the last administration of the drug. Paper or combined packages of 1 kg and bags of 25 kg. Store in original packaging in a dry, dark place out of the reach of children and animals at 0-30 С. 1 year. 38

41 COCCIDIOSTATS MADURO FORTE ATCvet: QP51. Antiprotozoals. QP51AX10. Maduramycin. QP51AJ03. Diclazuril. Powder for oral administration Properties of Maduro Forte are conditioned by the result of combination of active ingredients: maduramycin ammonium and diclazuril. Light brown powder. 1 g of the drug contains: active ingredients: maduramycin ammonium 9 mg; diclazuril 2 mg; excipient crushed wheat. Maduramycin is an eimeriostatic of the ionophore group. It is active against eimeria (Eimeria tenella, E. acervulina, E. necatrix, E. mivati, E. maxima, E. brunetti) at the stages of sporozoites, trophozoites and schizoites of the first generation. The mechanism of action is based upon disruption of transportation of monovalent ions of Na+ and К+ through cell membrane of the parasite with its further death. Diclazuril is an eimeriostatic of the triazine group. It is effective against all Eimeria species in poultry (Eimeria acervulina, Е. brunetti, Е. maxima, Е. mitis, Е. necatrix, Е. tenella, Е. adenoeides, Е. gallopavonis, Е. meleagrimitis etc.), rabbits (Е. flavescens, Е. intestinalis, Е. magna, Е. perforans, Е. stiedaе etc.), cattle, sheep, goats, swine and causes derangement in energetic metabolism processes of endogenic development of Eimeria. Asexual forms of endogenic cycle of development of coccidia exhibit the highest sensitivity to the drug. Treatment and prevention of coccidiosis caused by various Eimeria species in hens (broiler chickens, pullets of egg crosses of up to 16 weeks of age) and turkeys of up to 12 weeks of age. the drug per 1 kg of feed). Maduro Forte is thoroughly mixed with feed: firstly with minor part (3-10% of total quantity), then the blend obtained is mixed with the rest. Do not use in case of hypersensitivity to maduramycin and diclazuril. Do not administer to laying hens. Do not prescribe in combination with other anticoccidials. It is prohibited to feed Maduro Forte in 7 days before, during and in 7 days after administration of tiamulin. Uneven mixing of the drug with feed, uneven eating of feed containing the drug (in case animals are hungry or ill), exceeding the recommended concentration of the drug in feed may in some cases result in decrease in productivity of animals and even in development of clinical signs of their intoxication. Slaughter of poultry for meat is possible in 5 days following the last administration of the drug. Paper or combined packages of 1 kg and bags of 25 kg. Store in original packaging in a dry, dark place out of the reach of children and animals at 0-30 С. 1 year. The drug is fed to poultry with feed in a dose of 500 g of the drug per 1 t of feed (0.5 g of 39

42 COCCIDIOSTATS NICAMAX Powder for oral administration Yellow powder. 1 kg of the drug contains: active ingredients: maduramycin ammonium 7.5 g; nicarbazin 80 g; excipient corn fiber. АТСvet: QP51. Antiprotozoals. QP51AX30. Combinations of other antiprotozoal agents. Antiprotozoal effect of the drug is conditioned by synergism of active ingredients, which are present in its composition maduramycin ammonium (ionophoric antibiotic) and nicarbazin (derivative of dinitrocarbanilide), minor concentrations of which ensure effective anti-eimeriosis action. The use of Nicamax is more effective as compared to the separate use of maduramycin ammonium and nicarbazin. Maduramycin is an eimeriostatic of the ionophore group, which is active against eimeriae (Eimeria tenella, E. acervulina, E. necatrix, E. mivati, E. maxima, E. brunetti) in the stages of sporozoites, trophozoites and schizoites of the first generation. The mechanism of action of the drug consists in disruption of transport of monovalent ions of Na + and К + through cell membrane of the parasite with its further death. Nicarbazin is a synthetic agent, which represents a complex of 4,4 -dinitrocarbanilide (DNC) and 2-hydro- 4,6-dimethylpyrimidine (HDP), which inhibits energetic metabolism in the parasite body. Prevention and treatment of broiler chickens against coccidiosis caused by Eimeria: Е. tenella, E. acervulina, Е. maxima, Е. necatrix, Е. mivati and Е. brunetti. Administer Nicamax to broiler chickens with feed in a dose of 0.5 kg per 1 t of the feed from the first day of life throughout the growing period and exclude it from the diet in 5 days prior to slaughter. It is recommended to add it firstly to 3-10% of total feed quantity and then to mix the blend obtained with the rest of the feed. Do not administer to adult poultry and laying poultry. Do not administer in combination with other eimeriostatics. Do not administer the drug in 7 days prior to and 7 days following administration of tiamulin. Poultry slaughter for meat is possible in 5 days following the last administration of the drug. Meat obtained before the mentioned term shall be utilized or fed to non-productive animals depending on the statement of veterinary physician. Multilayer paper bags or packages of polymer film of 1 and 25 kg. Store in a dark place out of the reach of children at 5-30 С. 3 months after being mixed with feed. 40

43 COCCIDIOSTATS QUINOSAN Powder for oral administration Cream-colored or yellowish -white powder. 1 kg of the drug contains: active ingredient: decoquinate 60 g; excipient semolina. ATCvet: QP51. Antiprotozoals. QP51X14. Decoquinate. Decoquinate is an antiprotozoal compound, which belongs to the group of 4-hydroxyqionolinE. It is effective against Eimeria spp. and Toxoplasma spp. Decoquinate inhibits growth of eimeria in the beginning of their development cycle, which causes decrease in morbidity and mortality rates among animals. If administered orally, the drug makes effect primarily in digestive tract. It poorly absorbs and is eliminated unchanged primarily with feces; therefore, the residues of the drug in blood are minor and are quickly eliminated. Treatment and prevention of the following Eimeria damage in: calves: Eimeria bovis, E. zuernii, E. ellipsoidalis, E. cylindrical; lambs: Eimeria arloingi, E. ninaekohljakmovae, E. intricate, E. faurei; broiler chickens: Eimeria acervulina, E. maxima, E. tenella, E. necatrix, E. brunetti, E. mivati. Quinosan is administered orally in the following doses: treatment of eimeriosis in lambs and calves: 1.67 kg per 1 t of compound feed (1 mg of decoquinate per 1 kg body weight daily) for 28 days. The duration of treatment may be extended if required. The drug is mixed with ready compound feed and fed to animals; prevention of eimeriosis in broiler chickens: kg per 1 t of feed throughout the whole feeding period (from the 1st day of life). of the drug to broiler chickens is terminated in 3 days prior to slaughter. Do not administer the drug to female animals (cows, ewes) during lactation if their milk is used for human consumption. Withdrawal period: cattle and sheep 0 days, broiler chickens 3 days. Meat obtained before the mentioned term shall be utilized or fed to non-productive animals depending on the statement of veterinary physician. The staff involved into any operations with the drug must follow principal hygiene and safety requirements adopted for operations with veterinary drugs. Packages of film materials of g, paper bags of 25 kg. Store in original packaging in a dry place out of the reach of children at С. 1 year; 3 months after original package opening. 3 months in ready feed. 41

44 COCCIDIOSTATS RONICOX Powder for oral administration Light brown powder. 100 g of the drug contains: active ingredient: robenidine hydrochloride 6.6 g; excipient semolina. АТСvet: QP51. Antiprotozoals. QP51AX13. Robenidine. Robenidine hydrochloride is eimeriostatic, which is effective against eimeriae of the following species: Еimeria necatrix, E. tenella, E. acervulina, E. maxima, E. adenoeides, E. gallopavonis, E. meleagrimitis at the stage of schizonites of the first and second generations. It quickly passes the digestive tract of poultry and has a low absorption level (20-40%). It is primarily eliminated with feces. The elimination volume makes 60-65% of the administered dose. Treatment and prevention of Eimeria lesions in broiler chickens and turkeys: broiler chickens Eimeria tenella, E. acervulina, E. mivati, E. brunetti, E. maxima, E. necatrix; turkeys (up to 16 weeks of age) Eimeria adenoeides, E. meleagrimitis and E. gallopavonis. Ronicox is fed to broiler chickens and turkeys with feed in a dose of g per 1 t of the feed, which corresponds to g of robenidine hydrochloride per 1 t of the feed. The drug is administered to turkeys from the first days of life up to 16 weeks, to broiler chickens from the first days of life throughout the growing period. Do not administer to laying hens. Animal slaughter for meat is possible in 5 days following the last administration. Meat obtained before the mentioned term shall be utilized or fed to non-productive animals depending on the statement of veterinary physician. When working with the drug it is recommended that protective clothes, respirator, gloves and tightly fitting goggles be used. In case of contact with eyes wash them with plenty of water for 15 minutes. Bags of heat sealable film materials or double PET-bags of g; multilayer paper bags of 25 kg. Store in a dry, dark place out of the reach of children at С. 42

45 COCCIDIOSTATS SALIMIX ATCvet: QP51. Antiprotozoals. QP51AH01. Salinomycin. Powder for oral administration Salinomycin is an eimeriostatic of the ionophore group, which is effective against eimeriae (E. acervulina, E. tenella, E. brunetti, E. maxima, E. necatrix, E. mivati, E. meleagridis, E. meleagrimitis, E. bovis) in the stages of sporozoites, trophozoites and schizoites of the first generation. The drug inhibits transport of monovalent ions of Na+ and К+ through cell membrane of a single-cell parasite, which causes its death. Salinomycin is also effective against grampositive (Clostridium spp.) and gram-negative microorganisms (Serpulina (Treponema) hyodysenteriae). It increases weight gaining ratio and feed conversion ratio in ruminants and swine. Light brown powder. 1 g of the drug contains: active ingredient: salinomycin sodium 120 mg; excipient calcium carbonate. Treatment and prevention of coccidiosis in hens (broiler chickens, pullets) up to 12 weeks of age, in cattle and sheep (calves and lambs with developed proventriculi), swine. The drug is fed with feed in the following doses: hens (broiler chickens, pullets): 500 g of the drug per 1 t of the feed (0.5 g of the drug per 1 kg of the feed); swine of up to 4 months of age: g of the drug per 1 t of the feed; swine of 4 to 6 months of age: 250 g of the drug per 1 t of the feed; young cattle stock and sheep (3 months old and above: g of the drug per 1 t of the feed. Mix Salimix thoroughly with the feed. In order to ensure even mixing it s recommended to mixed firstly with minor part of the feed (3-10% of total quantity), then the blend obtained is mixed with the rest of the feed. Hypersensitivity to salinomycin. Do not administer to laying hens. Do not administer to calves and lambs with undeveloped proventriculi. Do not prescribe in combination with other anticoccidial drugs. It is forbidden to administer Salimix in combination with tiamulin as well as in 7 days prior to and in 7 days following administration of tiamulin. Do not administer to horses and other odd-toed animals. Uneven mixing of the drug with feed, uneven consumption of the medicated feed (hungry, ill animals) as well as excess of recommended concentrations of the drug in feed may in certain cases result to decrease in productivity of animals and even in occurrence of clinical signs of intoxication. Poultry slaughter for meat is possible in 1 day following the last administration of the drug. Slaughter of swine, calves, lambs is possible unrestricted. Paper and combined bags of 1 kg, bags of 25 kg. Store in original packaging in a dry, dark place out of the reach of children and animals at 0-30 C. 43

46 COCCIDIOSTATS SALIMIX PLUS Powder for oral administration Light brown powder. 1 g of the drug contains: active ingredients: salinomycin sodium 110 mg; diclazuril 2 mg; excipient calcium carbonate. ATCvet: QP51. Antiprotozoals. QP51AH01. Salinomycin. QP51AJ03. Diclazuril The effect of Salimix Plus is conditioned with properties of salinomycin sodium and diclazuril. Salinomycin is an eimeriostatic of the ionophore group, which is effective against eimeriae (E. acervulina, E. tenella, E. brunetti, E. maxima, E. necatrix, E. mivati, E. meleagridis, E. meleagrimitis, E. bovis) in the stages of sporozoites, trophozoites and schizoites of the first generation. Salinomycin is also effective against grampositive microorganisms, anaerobics and Serpulina (Treponema) hyodysenteriae. The drug inhibits transport of monovalent ions of Na + and К + through cell membrane of a single-cell parasite, which causes its death. It increases weight gaining ratio and feed conversion ratio in swine and ruminants. Diclazuril is an eimeriostatic agent of the triazines group. It is effective against all the Eimeria species in poultry (E. acervulina, Е. brunetti, Е. maxima, Е. mitis, Е. necatris, Е. tenella, Е. adenoeides, Е. gallopavonis, Е. meleagrimitis etc.), rabbits (Е. flavescens, Е. intestinalis, Е. magna, Е. perforans, Е. stiedai etc.), cattle, sheep, goats inhibiting metabolic processes of their endoenic development. Asexual forms of endogenic cycle of development of coccidia are the most sensitive to diclazuril. Treatment and prevention of eimeriaecaused coccidiosis in hens (broiler chickens, pullets up to 12 weeks of age), in cattle and sheep (calves and lambs with developed proventriculi), swine. The drug is fed with feed throughout the feeding period in the following doses: hens (broiler chickens, pullets): 500 g of the drug per 1 t of the feed (0.5 g of the drug per 1 kg of the feed); swine of up to 4 months of age: g of the drug per 1 t of the feed; swine of 4 to 6 months of age: 250 g of the drug per 1 t of the feed; young cattle stock and sheep (calves and lambs from 3 months and above): g of the drug per 1 t of the feed. Mix Salimix Plus thoroughly with the feed. Its recommended to mixed firstly with minor part of the feed (3-10% of total quantity), then the blend obtained is mixed with the rest of the feed. Hypersensitivity to salinomycin and diclazuril. Do not administer to laying hens. Do not administer to calves and lambs with undeveloped proventriculi. Do not prescribe in combination with other anticoccidial drugs. It is forbidden to administer Salimix Plus in combination with tiamulin as well as in 7 days prior to and in 7 days following administration of tiamulin. Do not administer to horses and other odd-toed animals. Uneven mixing of the drug with feed, uneven consumption of the medicated feed (hungry, ill animals) as well as excess of recommended concentrations of the drug in feed may in certain cases result to decrease in productivity of animals and even in occurrence of clinical signs of intoxication. Animal slaughter for meat is possible in 5 days following the last administration of the drug. Paper or combined bags of 1 kg or bags of 25 kg. Store in original packaging in a dry, dark place out of the reach of children and animals at 0-30 C. 1 year. 44

47 COCCIDIOSTATS SOLICOX ATCvet: QP51A. Antiprotozoals. QP51AJ03. Diclazuril. young cattle stock E. bovis, E. zuernii; Solution for oral administration Diclazuril is a chemically synthesized non-ionophore antibiotic of the benzeneacetonitrile class. It is effective against all species of eimeriae in poultry (E. acervulina, Е. brunetti, Е. maxima, Е. mitis, Е. necatrix, Е. tenella, E. adenoeides, Е. gallopavonis, Е. meleagrimitis etc.), rabbits (Е. flavescens, Е. intestinalis, Е. magna, Е. perforans, Е. stiedae etc.), cattle, sheep, goats and swine due to inhibition of energetic metabolism processes of endogenic cycle of development of coccidia. Eimeria in asexual stages of endogenic cycle of development ae the most sensitive to the drug. The drug is fed with feed or drinking water in the following doses: Transparent colorless or yellowish solution. 1 ml of the drug contains: active ingredient: diclazuril 2.5 mg; excipient polyethyleneoxide up to 1 ml. Diclazuril does not cause any side effects even if the administered dose is times higher than the recommended dose. The drug does not have any mutagenic, carcinogenic or teratogenic action and may be combined with other drugs. It is thermostable, effective in minor doses and does not accumulate in organs and tissues of animals. Prevention and treatment of eimeriosis in poultry (hens, turkeys, geese, ducks), swine, rabbits, young catеle stock, sheep and goats caused by the following species: poultry: hens E. acervulina, E. brunetti, E. tenella, E. maxima, E. necatrix, E. mitis; turkeys E. adenoeides, E. meleagrimitis; geese, ducks E. anseris, E. truncata; young sheep and goats E. сrandallis, E. ovinoidalis, E. arloingi, E. intricata. poultry: 0.4 ml per 1 kg body weight daily for 2 days, which is approximately equal to 2 ml of the drug per 1 l of water, or 1 mg of active ingredient (diclazuril) per 1 kg body weight daily; rabbits, young cattle stock, sheep, goats: 0.4 ml per 1 kg body weight daily, which is equal to 1 mg of the active ingredient (diclazuril) per 1 kg body weight daily. Duration of treatment (with drinking water or feed) is 2 consecutive days. piglets: 2 ml per 1 kg body weight to each animal individually once. Do not prescribe to animals with sensitivity to the drug. Watering the daily dose of the drug with drinking water for at least 12 hours daily. Do not administer to pregnant and lactating animals and laying poultry. The withdrawal period for meat and internal organs is 5 days. Cardboard boxes with 10 vials of 10 ml, plastic vials of 1 l. Store in a dark, damp-proof place out of the reach of children at 5-30 С. rabbits Е. flavescens, Е. intestinalis, Е. magna, Е. perforans, Е. stiedae; piglets Isospora suis; 24 hours after dissolution in water. 45

48 PARASITICIDES FENOTAL 22 Powder for oral administration White powder. 100 g of the drug contains: active ingredient: fenbendazole 22.2 g; excipient starch. АТСvet: QP52. Antihelmintics. QP52AC13. Fenbendazole. Fenbendazole is a broad-spectrum antihelmintic of helminthagogue action. Fenbendazole is highly effective against most types of gastrointestinal and lung nematodes, certain cestodes, trematodes, acantocephala (at every development stage). It has an ovocidal action. The active ingredient fenbendazole (group of benzimidazoles) inhibits polymerization of proteins of tubulins in microtubules, decreases activity of energetic enzymes. The drug causes disruption of metabolism in helminths, which causes reduction of glucose uptake, mitochondrial reactions and disruption of cell mitosis. As a result, complete devastation of parasites occurs, which causes their death. Orally administered fenbendazole is primarily eliminated in unchanged form with feces as metabolites. About 1% is eliminated with urine. Resorbed fenbendazole accumulates primarily in liver and fat tissues. Half-life makes 26 hours in sheep, 25 hours in cattle and 10 hours in swine. Prevention and treatment of the following parasite invasions in cattle, sheep, goats, horses, swine, poultry (hens, turkeys, geese, ducks), rabbits, fur animals (Arctic foxes, foxes), carnivores (dogs, cats): cattle, sheep, goats: Haemonchus spp., Nematodirus spp., Bunostomum spp., Oesophagostomum spp., Trichostrongylus spp., Ostertagia spp., Cooperia spp., Сhabertia ovina, Trichuris spp., Strongyloides spp., Dictyocaulus spp., Protostrongylus spp., Moniezia spp., Avitellina centripunctata, Dicrocoelium lanceatum, Paramphistomum spp., Liorchis scotia, Gastrothylax crumenifer; horses: Parascaris equorum, Oxyuris equi, Strongylus spp., Triodonthophorus spp., Сiathostomum spp., Cylicocyclus spp., Strongyloides spp., Anoplocephala magna, A. perfoliata, Paranoplocephala mamillana; swine: Ascaris suum, Trichuris suis, Oesophagostomum dentatum, Ollulanus spp., Strongyloides ransomi, Metastrongylus spp.; poultry: Ascaridia spp., Heterakis gallinarum, Syngamus trachea, Capillaria spp., Ganguleterakis dispar, Amidostomum anseris, Tetrameres fissispina, Hymenolepis spp., Drepanidotaenia spp., Polymorphus spp., Filicollis anatis; rabbits: Passalurus ambiquus, Trichostrongulus spp.; fur animals: Toxocara spp., Ascaris spp., Toxascaris spp., Ancylostoma caninum, Uncinaria stenocephala, Capillaria spp., Strongyloides spp., Molineus patens; dogs: Toxocara canis, Toxascaris leonina, Ancylostoma caninum, Uncinaria stenocephala, Trichuris vulpis, Taenia spp., Oslerus osleri, Protozoa Giardia (Lamblia) spp.; cats: Toxocara mystax, Ancylostoma tubaeforme, Taenia spp., Aelurostrongylus abstrusus. (See next page) Do not administer to emaciated animals and animals with infectious diseases Do not administer the drug to emaciated animals and animals with infectious diseases. Do not administer the drug in combination with anti fascioliasis drugs as well as in 7 days following treatment with bromsalans. Slaughter of cattle, sheep, goats, horses, swine for meаt is possible in 10 days, following the last administration. Poultry after 3 days. Consumption of milk is possible in 2 days following the last administration. Meat obtained before the mentioned term shall be utilized or fed to carnivores or processed into meat-bone four. Polyethylene or laminated bags of g. Store on a dark place out of the reach of children at 5-30 С. 46

49 PARASITICIDES Administer the drug orally as a single dose, having preliminarily mixed it with feed, better during the morning feeding in the following doses: Animal species, disease Cattle Single dose (g/kg body weight) Fenotal powder, 22.2% Frequency and duration of treatment Fenbendazol Nematodosis, cestodosis 0, Once daily for 2-3 days Dicroceliosis, Once daily for 6 days paramphistomatidosis Dictiocaulosis, Protostrongyloidosis, trichuriasis Once daily for 2-3 days Sheep, goats Gastrointestinal strongyloidosis, strongyloidosis, Once daily for 2 days cestodosis Dicroceliosis, paramphistomatidosis Once daily for 6 days Horses Parascarosi, oxiurosis, anoplocephalidosis Once daily for 2 days Gastrointestinal strongylatosis Once daily for 5-6 days Colts of 1-2 months: diarrhea caused by Strongyloides westeri Once daily for 2 days Swine ascorydosis, metastrongylosis, trichurrosis, Once daily for 5-6 days esophagostomosis olulanosis, strongyloidosis Once daily for 2-3 days Hens, turkeys: mixed nematodic invasion Once daily for 5-6 days Nematodosis, cestodosis (mixed invasion) Once Geese, ducks Acantocephaliasis Once daily for 5-6 days Rabbits: mixed nematodic invasion Once daily for 3 days Fur animals (Arctic foxes, foxes): mixed nematodic invasion Once daily for 5 days Dogs, cats: nematodosis, cestodosis Once daily for 3 days Puppies and kittens of the age of minimum of 3 weeks: protosoosis giardiasis (lambliasis) as well as nematodosis, cestodosis days in every 12 hours 47

50 PARASITICIDES INTRAMEK Solution for injections Transparent yellow solution. 1 ml of the drug contains: active ingredient: ivermectin 10 mg; excipient water for injections. ATCvet: QP54. Endectocides (QР54AА01. Ivermectin). Ivermectin belongs to the group of compounds produced by soil microorganisms Streptomyces avermitilis. Ivermectin strengthens binding of GABA (gammaaminobutyric acid) to special receptors on nerve endings of parasites, which results in violation of neurotransmission, paralytic stroke and death. The drug forms a kind of subcutaneous deposition of active ingredient, ensuring parasitocidal effect for days. Ivermectin is cytocidal for the following types of parasites: nematodes (imago and larvae): Ascaris, Hyostrongylus, Nematodirus, Oesophagostomum, Bunostomum, Strongyloides, Metastrongylus, Strongylus, Trichostrongylus, Ostertagia, Haemonchus, Cooperia, Chabertia, Trichuris etc.; nematodes (mature): Dictyocaulus viviparus, Nematodirus, Protostrongylus; arthropods: Otodectes, Haematopinus, Sarcoptes, Demodex, Gastrophilus, Hypoderma, Linognathus, Damalina, Solenopotes, Haematobia, Psoroptes, Oestrus, Melophagus etc. Dehelminthization of animals as well as insect and mite control in cattle, sheep, goats, swine. Applied in cases of parasite affection: cattle: nematodes in digestive tract (mature and larvae of the 4 th stage): Nematodirus helvetianus, Ostertagia ostertagі, О. lyrata, Bunostomum trigonocephalum, B. phlebotomum, Haemonchus placeі (particularly, larvae of the 3 rd stage), Trichostrongylus ахeі, T. colubriformis, Cooperia реctinata, C. punctata; lung helminthes: Dictyocaulus viviparus (mature and larvae of the 4 th stage); cavity helminthes: Setaria labiatopapillosa (at microsetaria stage); skin helminths: Paraphilaria bovicola (mature); larvae of warble fly (1 st and 2 nd stage): Hypoderma bovis, H. lineatum; itch mites: Psoroptes bovis, Sarcoptes bovis, Chorioptes bovis; mites: Demodex bovis; louses: Bovicola bovis; lices: Haematopinus eurysternus, Linognathus vituli; small cattle: nematodes in digestive tract: Bunostomum trigonocephalum, Haemonchus contortus (mature and larvae of the 3 rd and 4 th stage), Ostertagia сіrcumcincta, О. trifurcata, Oesophagostomum venulosum, О. columbianum (mature and larvae of the 3 rd and 4 th stage), Chabertia ovina, Trichostrongylus ахei (mature), Trichostrongylus colubriformis (mature and larvae of the 4 th stage), Trichuris ovis; lung helminthes: Dictyocaulus filaria (mature and larvae of the 4 th stage), Protostrongylus rufescens; larvae of sheep fly: Oestrus ovis (any larvae stage); itch mites: Psoroptes ovis, Sarcoptes bovis, S. carpe, Chorioptes ovis, Ch. caprae; louses: Bovicola ovis, В. сарrае; lices: Linognathus ovillus, L. реdalis, L. caprae; swine: nematodes in digestive tract (mature and larvae of the 4 th stage): Ascaris suum, Oesophagostomum dentatum, Strongyloides ransomi (mature), Trichuris suis; lung helminthes: Metastrongylus spp.; kidney helminthes: Stefanurus dentatus (mature and larvae of the 4 th stage); louses: Haematopinus suis; mites: Sarcoptes suis, S. parvula, Demodex phylloides. Treatment of animals against nematodes is performed before stalling and in spring before depasturing, against larvae of warble flies in the end of summer, against agents of arachnoentomosi as per indications. INTRAMEK is administered subcutaneously in a single dose, in cases of severe sarcoptosis double treatment with an interval of 8-10 days is needed. The drug doses are the following: cattle, sheep and goats: 1 ml per 50 kg body weight. Administer the drug in the skin fold in the front of or behind the shoulder blade with sterile instruments. The needle gauge of 16, 15 or 10 mm is recommended. swine: 1 ml per 33 kg body weight. 48

51 PARASITICIDES Administer subcutaneously in the neck area. Accurate dosage for swine with body weight of up to 16 kg is extremely important. Do not administer to animals with infectious diseases and emaciated animals! Do not administer to cows during lactation and female animals during pregnancy in a month before parturation! Do not administer the drug in subtherapeutic doses. Do not use to treat animals with hypersensitivity to ivermectin. In case of hypersensitivity to ivermectin increased salivary discharge, frequent defecation and urination, ataxia may be observed in some animals. The mentioned symptoms disappear spontaneously, without application of therapeutic agents. Animal slaughter for meat is possible in 28 days following the last administration of the drug. Meat obtained before the mentioned term shall be utilized or fed to non-productive animals depending on the statement of veterinary physician. Package Cardboard boxes with 10 glass vials of 10 ml each and 100 ml sealed with rubber stoppers and aluminum caps. Store in original packaging out of the reach of children at 5-30 С. 3 years. 49

52 PARASITICIDES NEOVERM Solution for oral administration Transparent light yellow solution. 1 ml of the drug contains: active ingredient: ivermectin 10 mg; excipient purified water. ATCvet: QP54. Endectocides. QР54AА01. Ivermectin. Ivermectin belongs to the group of compounds produced by soil microorganisms Streptomyces avermitilis. Ivermectin strengthens binding of GABA (gammaaminobutyric acid) to special receptor on nerve endings of parasites, which results in violation of neurotransmission, paralysis and death of helminths. The drug forms kind of deposition of active ingredient in subcutaneous tissue, ensuring parasitocidal effect for days. Ivermectin is destructive to the following types of parasites: nematodes (imago and larvae): Ascaris, Hyostrongylus, Nematodirus, Oesophagostomum, Bunostomum, Strongyloides, Metastrongylus, Strongylus, Trichostrongylus, Ostertagia, Haemonchus, Cooperia, Chabertia, Trichuris etc.; nematodes (adult): Dictyocaulus viviparus, Nematodirus, Protostrongylus; arthropods: Otodectes, Haematopinus, Sarcoptes, Demodex, Gastrophilus, Hypoderma, Linognathus, Damalina, Solenopotes, Hematobia, Psoroptes, Oestrus, Melophagus etc. Dehelmintization of animals as well as insect and mite control in cattle, sheep, goats, swine, poultry (hens, turkeys). The drug is used to treat the following parasite lesions: cattle: nematodes in digestive tract (adults and larvae of the fourth stage): Nematodirus helvetianus, Ostertagia ostertagі, О. lyrata, Bunostomum trigonocephalum, B. phlebotomum, Haemonchus placeі (particularly, larvae of the third stage), Trichostrongylus ахeі, T. colubriformis, Cooperia реctinata, C. punctata; lung helminths: Dictyocaulus viviparus (adults and larvae of the fourth stage); cavity helminths: Setaria labiatopapillosa (at the stage of microsetaria); skin helminths: Paraphilaria bovicola (mature); larvae of warble flies (of the first and second stages): Hypoderma bovis, H. lineatum; itch mites: Psoroptes bovis, Sarcoptes bovis, Chorioptes bovis; mites: Demodex bovis; louses: Bovicola bovis; lices: Haematopinus eurysternus, Linognathus vituli; small cattle: nematodes in digestive tract: Bunostomum trigonocephalum, Haemonchus contortus (mature and adults of the third and fourth stages), Ostertagia сіrcumcincta, О. trifurcata, Oesophagostomum venulosum, О. columbianum (adults and larvae of the third and fourth stages), Chabertia ovina, Trichostrongylus ахei (mature), Trichostrongylus colubriformis (mature and larvae of the fourth stage), Trichuris ovis; lung helminths: Dictyocaulus filaria (mature and larvae of the fourth stage), Protostrongylus rufescens; larvae of sheep botfly: Oestrus ovis (of any larvae stage); itch mites: Psoroptes ovis, Sarcoptes bovis, S. carpe, Chorioptes ovis, Ch. caprae; louses: Bovicola ovis, В. сарrае; lices: Linognathus ovillus, L. реdalis, L. caprae; swine: nematodes in digestive tract (mature and larvae of the fourth stage): Ascaris suum, Oesophagostomum dentatum, Strongyloides ransomi (mature), Trichuris suis; lung helminths: Metastrongylus spp.; kidney helminths: Stefanurus dentatus (mature and larvae of the fourth stage); lices: Haematopinus suis; mites: Sarcoptes suis, S. parvula, Demodex phylloides; poultry: mites: Knemidocoptes spp. Treatment of animals against nematodes is performed before stabling and in spring before pasturing, against warble flies in the end of summer, against agents of arachnoentomoses as per indications. Administer the drug orally with drinking water in the following doses: cattle, goats and sheep: 0.2 ml / 10 kg body weight (0.2 mg of ivermectin / kg body weight) once; swine (particularly piglets): 0.25 ml / 10 kg body weight (0.25 mg of ivermectin / kg body weight) twice with an interval of 24 hours; 50

53 PARASITICIDES poultry: 0.04 ml / kg body weight (0.4 mg of ivermectin / kg body weight) once, against arachnoentomoses twice with an interval of 24 hours. Do not administer to emaciated animals and animals with infectious diseases. Do not prescribe to pregnant females in a month before parturation. Do not administer to lactating cows. Do not administer to laying hens in 20 days prior to the egg laying period. Do not prescribe the drug in sub-therapeutic doses. Do not administer to animals with individual hypersensitivity to ivermectin as the following symptoms may be observed: increased salivations, frequent defecations and urinations, ataxia. The symptoms disappear spontaneously without use of any therapeutic agents. Animal slaughter for meat is possible as follows: cattle in 24 dayssheep and goats in 14 days, swine in 12 days, poultry in 8 days following the last administration of the drug. Meat obtained before the mentioned term shall be utilized or fed to carnivore animals depending on the statement of veterinary physician. Cardboard boxes with 10 plastic vials of 10 ml each, plastic vials of 100 and ml. Store in a dry, dark place out of the reach of children at 5-30 С. 3 years. 51

54 PARASITICIDES PRAFEN PLUS Round light beige tablets. 1 tablet contains: active ingredients: prasiquantel 50 mg; fenbendazole 500 mg; excipients potato starch, calcium stearate. ATCvet: QP52A. Antihelminthics; antitrematodes, antinematodes and anticestodic veterinary drugs. Prafen Plus makes complex antihelmintic effect upon nematodes and cestodes of carnivores. Prasiquantel, which is present in the drug, causes death to cestodes, which belong to Alveococcus, Echinococcus, Dipylidium, Taenia, Multiceps, Mesocestoides species. Fenbendazole causes death to nematodes, which belong to Тохосаrа, Toxascaris, Uncinaria, Ancylostoma, Trichuris species, as well as potentiates the effect of prasiquantel upon cestodes. Co-effect of prasiquantel and fenbendazole causes antihelmintic action upon most helminths parasitizing in carnivores. Treatment and prevention of nematodic and cestodic lesions in dogs and cats: Toxocara canis, T. leonina, Uncinaria stenocephala, Ancylostoma caninum, Dipylidium caninum, Diphyllobothrium spp., Taenia pisiformis, T. hydatigena, Echinococcus granulosus, Alveococcus multilocularis, Multiceps multiceps, M. serialis. Animal body weight, kg Up to ¼ ½ Over 50 6 Prafen Plus, tablet N\A Individual hypersensitivity to the drug components. None. Box with 10 blisters of 10 tablets each. Store in original packaging in a dry, dark place out of the reach of children at 0-30 С. 3 years. 52

55 PARASITICIDES PRAFEN PLUS UNIOR Round light beige tablets. 1 tablet contains: active ingredients: prasiquantel 25 mg; fenbendazole 250 mg; excipients potato starch, calcium stearate. ATCvet: QP52A. Antihelminthics; antitrematodes, antinematodes and anticestodic veterinary drugs. Prafen Plus Unior makes complex antihelmintic effect upon nematodes and cestodes of carnivores. Prasiquantel, which is present in the drug, causes death to cestodes, which belong to Alveococcus, Echinococcus, Dipylidium, Taenia, Multiceps, Mesocestoides species. Fenbendazole causes death to nematodes, which belong to Тохосаrа, Toxascaris, Uncinaria, Ancylostoma, Trichuris species, as well as potentiates the effect of prasiquantel upon cestodes. Co-effect of prasiquantel and fenbendazole causes antihelmintic action upon most helminths parasitizing in carnivores. Treatment and prevention of nematodic and cestodic lesions in dogs and cats: Toxocara canis, T. leonina, Uncinaria stenocephala, Ancylostoma caninum, Dipylidium caninum, Diphyllobothrium spp., Taenia pisiformis, T. hydatigena, Echinococcus granulosus, Alveococcus multilocularis, Multiceps multiceps, M. serialis. Animal body weight, kg Up to 1 Prafen Plus Unior, tablet ¼ ½ Over 20 N/A Individual hypersensitivity to the drug components. None. Polymer jars, vials of 10 tablets. Store in original packaging in a dry, dark place out of the reach of children at 0-30 С. 3 years. 53

56 VITAMINS AND GROWTH PROMOTERS HEPATONIC Solution for oral administration Transparent pink solution. 1 ml of the drug contains: active ingredients: carnitine hydrochloride 50.0 mg; cyanocobalamin (vitamin В 12 ) 0.03 mg; calcium pantothenate 7.5 mg; nicotinamide 20.0 mg; magnesium sulfate mg; sorbitol mg; excipient purified water. Hepatonic is a complex stimulating drug, which effect is aimed to improve metabolic body functions in animals, increase body resistance, prevent fatty liver syndrome, increase in feed conversion factors, general metabolic rate etc. Carnitine is a product of biosynthesis of lysine and methionine. Carnitine stimulates processes of utilization of excess of fatty acids and intracellular energy transport, facilitates increase in secretion and activity of digestive glands enzymes, improves appetite, facilitates increase of body weight. Cyanocobalamin has a pronounced lipotropic effect, prevents fatty liver infiltration, makes positive impact upon synthesis of labile methyl groups, activates production of methionine, choline, nucleic acids. It demonstrates anabolic effect: enhances synthesis of proteins and facilitates their accumulation. It also boosts immunity due to increase of phagocytic activity of leukocytes and promotion of reticuloendothelial system activity. Calcium pantothenate in the body transforms into pantethine, which composes coenzyme А, which, in its turn, is involved in metabolism of proteins, lipids and carbohydrates. It accelerates processes of oxidation and biosynthesis of fatty acids, synthesis of acetylcholine, steroid hormones and mucopolysaccharides. Nicotinamide stimulate synthesis of nicotinamide adenine dinucleotide (NAD) and nicotinamide adenine dinucleotide phosphate (NADP), which are cofactors of numerous enzymes. It is present in oxidation reduction reactions in forms of NAD and NADP, where it ensures normal course of different types of metabolism, particularly energetic metabolism. Magnesium sulfate regulates metabolism processes, neurochemical transmission and muscular irritability. In minor doses it increases appetite and improves digestion. It demonstrates strong choleretic action. Sorbitol is an energetic agent, which facilitates increase of glycogen in liver. Hepatonic is used to increase total body resistance, stimulate metabolism in order to reduce risk of fatty liver syndrome, reduce negative impact of stresses during transportation, vaccination, dietary changes etc., as well as to accelerate growth during fattening. The drug increases feed digestion and stimulates digestion processes, thus, improves the feed conversion ratio. Administer orally with drinking water or feed for 5-10 days in the following doses: poultry of any species and age group: 1-2 ml of the drug per 1 l of drinking water daily; swine: young pigs 1-2 ml of the drug per 1 animal daily; adults ml of the drug per 1 animal daily. The duration of treatment may be extended up to 21 days if required. Do not prescribe concurrently with tetracycline antibiotics and during vaccination with oral vaccines. Do not use to treat animals with hypersensitivity to the drug components. No precautions. Cardboard boxes with 10 vials of 10 ml each, plastic vials of 1 l and cans of 5 l. Store in original packaging in a dry, dark place out of the reach of children at С. 24 hours after dissolution in water. 54

57 VITAMINS AND GROWTH PROMOTERS HEPATONIC FORTE Solution for injections Transparent pink solution. 100 ml of the drug contains: active ingredients: carnitine hydrochloride 5 g; cyanocobalamin (vitamin В 12 ) 3 mg; calcium pantothenate 0.75 g; nicotinamide 2 g; thiamine hydrochloride 1 g; pyridoxine hydrochloride 0.3 g; biotin 12.5 mg; excipient water for injections. ATC vet: QA11AB. Multivitamins, other combinations. Hepatonic Forte is a complex stimulating drug, which effect is aimed to improve metabolic body functions in animals, increase body resistance, prevent fatty liver syndrome, increase in feed conversion factors, general metabolic rate etc. Carnitine is a product of biosynthesis of lysine and methionine. Carnitine stimulates processes of utilization of excess fatty acids and intracellular energy transport, facilitates increase in secretion and activity of digestive glands enzymes, improves appetite, facilitates increase of body weight. Cyanocobalamin has a pronounced lipotropic effect, prevents fatty liver infiltration, makes positive impact upon synthesis of labile methyl groups, activates production of methionine, choline, nucleic acids. It demonstrates anabolic effect: enhances synthesis of proteins and facilitates their accumulation. It also boosts immunity due to increase of phagocytic activity of leukocytes and promotion of reticuloendothelial system activity. Calcium pantothenate in the body transforms into pantethine, which composes coenzyme А, which, in its turn, is involved in metabolism of proteins, lipids and carbohydrates. It accelerates processes of oxidation and biosynthesis of fatty acids, synthesis of acetylcholine, steroid hormones and mucopolysaccharides. Nicotinamide stimulate synthesis of nicotinamide adenine dinucleotide (NAD) and nicotinamide adenine dinucleotide phosphate (NADP), which are cofactors of numerous enzymes. It is present in oxidation reduction reactions in forms of NAD and NADP, where it ensures normal course of different types of metabolism, particularly energetic metabolism. Thiamine (vitamin B 1 ) is required for oxidation decarboxylation of keto acids, synthesis of acetylcholine, carbohydrate, energetic, lipid, protein, water-salt metabolisms; it regulates functioning of nervous system, takes part in blood formation, increases body mass growth and gaining rates and increases appetite. Pyridoxine (vitamin В 6 ) is involved into proteins, lipids and carbohydrates metabolism, synthesis of adrenaline, serotonin and other neurotransmitters, breakdown of glycogen and metabolism of amino acids. Biotin makes impact upon processes of metabolism, takes part in carboxylation, decarboxylation, deamination of proteins and carbohydrates and lipid metabolism and is a component required for neurotrophic processes and cell differentiation. Hepatonic Forte is used to increase total body resistance, stimulate metabolism, reduce risk of fatty liver syndrome, reduce negative impact of stresses during transportation, vaccination, dietary changes etc., as well as to accelerate growth during fattening. The drug increases feed digestion and stimulates digestion processes, thus, improves the feed conversion ratio. Administer intramuscularly in the following doses: cattle: 1 ml per kg body weight daily for 5-10 days; swine: 1 ml per kg body weight daily for 5-10 days. Do not prescribe to animals with hypersensitivity to the drug components. No precautions. Withdrawal period 0 days. Glass vials with sealed rubber stoppers and aluminum cap of 100 ml. Store in original packaging in a dark place out of the reach of children at 5-30 С. 72 hours after vial opening. 55

58 VITAMINS AND GROWTH PROMOTERS MIXOVIT А Solution for oral administration Dark brown solution. 100 ml of the additive contains: active ingredients: vitamin А IU; vitamin D IU; vitamin Е mg; vitamin B mg; vitamin B mg; vitamin B mg; vitamin B μg; vitamin C mg; vitamin K mg; calcium pantothenate 800 mg; nicotinamide mg; excipient purified water up to 100 ml. The effect of the feed additive Mixovit А is a collective effect of its components. Vitamin В 1 is required for oxidative decarboxylation of keto acids, synthesis of acetylcholine, carbohydrate, energy, lipid, protein, water-salt metabolisms, it regulates functioning of nervous system, participates in hematopoiesis, increases growth and weight gaining rates, improves appetite. Vitamin B 2 is a part of the oxidation-reducing enzymes of the processes of biological oxidation and energy formation. Vitamin В 6 participates in metabolism of proteins, lipids and carbohydrates, synthesis of adrenaline, serotonin and other neurotransmitters; breakdown of glycogen and metabolism of amino acids. Vitamin В 12 has a lipotropic effect. It increases cell oxygen consumption during acute and chronic hypoxia, boosts immunity and regulates functions of blood hematopoietic organs. Vitamin С is a natural antioxidant. It participates in regulation of oxidation reduction processes, regulates the blood clotting capacity, normalizes capillary permeability and has anti-inflammatory and antiallergenic effects. Vitamin К 3 regulates blood clotting processes in the body; is required for regular functioning of liver cells. Calcium pantothenate participates in metabolism of carbohydrates and lipids and synthesis of acetylcholine. Nicotinamide is present in hydrogentransferring enzymes, which causes its involvement into cell breathing reactions and metabolism. Vitamin А participates in oxidation-reduction processes, regulates protein synthesis, facilitates metabolism normalization, functioning of cell and subcell membranes. It is important for formation of bones and teeth as well as fat deposits; is required for growth of new cells and aging mitigation. Primary function of vitamin D 3 consists in support of normal bone growth and development, prevention of rickets and osteoporosis. It regulates mineral metabolism and facilitates deposition of calcium in bone tissue and dentine, thereby preventing osteomalacia (softening) of bones, participates in biosynthesis of heme and proteins, proliferation of cells, cellular respiration and other metabolic processes in cells. The additive is prescribed to supplement animal diet with vitamins, to increase general body resistance, to stimulate metabolism in stresses during transportation, dietary changes, vaccination etc., to increase growth and weight gaining rate during fattening. The feed additive improves the feed conversion ratio due to stimulation of digestion processes and increases uptake of nutrients. Administer orally to hens, turkeys, cattle and small cattle, swine, horses with drinking water or feed in the following doses: ml of the feed additive per 1 l of drinking water (0.5-1 l of the feed additive per 1 t of water) daily for 3-7 days; 1-2 ml of the feed additive per 1 kg of feed (1-2 l of the feed additive per 1 t of feed) daily for 3-7 days. No contraindications. Do not prescribe Mixovit А to animals with hypersensitivity to its components. It is necessary that the vitamin contents in dietary components be taken into account throughout the whole administration period. Cardboard boxes with 10 vials of 10 ml each, plastic vials of 1000 ml, plastic cans of 5 l. Store in transportation packaging in covered warehouses. Store in a dry, dark place at 5-30 С. 24 hours after dissolution in water or addition to feed. 56

59 VITAMINS AND GROWTH PROMOTERS MIXOVIT АDЕ Se The effect of the feed additive Mixovit АDЕ Se is a collective effect of its components. Solution for oral administration Vitamin А participates in formation of structure of mucous membranes of digestive organs, respiratory organs, urinary system, oil and sweat glands, in functioning of visual organs, in protein-lipid interaction in cell membranes. Vitamin А ensures reproductive function in animals: spermiogenesis and oogenesis, growth of embryos, onset of sexual maturity, synthesis of sex hormones. It stimulates growth and development of young animals, non-specific resistance, prevents respiratory and gastrointestinal diseases. Transparent yellow viscous liquid. 100 ml of the additive contains: active ingredients: vitamin А IU; vitamin D IU; vitamin Е mg; biotin 30 mg; sodium selenite 5 mg; excipient purified water. The additive is prescribed to supplement diet of animals with vitamins during deficiencies of vitamins A, D, Е and H, rickets and osteodystrophy, respiratory, gastrointestinal, and gynecologic diseases, encephalomalacia and muscle dystrophy, white-muscle disease; to increase total resistance of animals, to stimulate metabolism and growth during growing and fattening, to reduce stress effect during transportation. The additive is administered to hens, turkeys, cattle and small cattle, swine, horses orally with drinking water or feed in the following doses: Vitamin D3 stimulates synthesis of proteins of organic matrix of bone tissue and its mineralization, intestinal uptake of calcium and phosphor and their reabsorption from primary urine and mobilization from the bone tissue, supports homeostasis of both macronutrients, activates synthesis of calcitonin in thyroid gland and inhibits parathormone secretion ml of feed additive per 1 l of drinking water (0.5-1 l of feed additive per 1 t of drinking water) daily for 5-7 days; Vitamin Е composes lipoprotein structure of membranes of all cells, ensures their functional stability, prevents peroxidation of polyunsaturated fatty acids, stimulates synthesis of heme and formation of hemoglobin and myoglobin, reproductive function in females, prevents embryonic mortality, ensures embryo development. Do not administer the feed additive to animals with hypersensitivity to its components. It is necessary that the vitamin contents in dietary components be taken into account throughout the whole administration period. Selenium is present in amino acids (selenomethionine and selenocysteine) and enzyme of glutathione peroxidase, which has pronounced antioxidant properties, prevents muscle dystrophy, hepato- and myocardiodystrophy. Biotin is present in enzymes, which participate in regulation of metabolism of proteins, lipids and carbohydrates, carboxylation reactions and formation of high-energy compounds, prevents development of dermatitis. 1-2 ml of feed additive per 1 kg of feed (1-2 l of feed additive per 1 t of feed) daily for 5-7 days. No contraindications. Cardboard boxes with 10 plastic vials of 10 ml each, plastic vials of 1000 ml, plastic cans of 5 l. Store in transportation packagin g in covered warehouses. Store in a dry, dark place at 5-30 С. 24 hours after dissolution in water or addition to feed. 57

60 VITAMINS AND GROWTH PROMOTERS MIXOVIT B Water-soluble powder Yellow water-soluble powder. 100 g of the additive contains: active ingredients: vitamin В mg; vitamin В mg; vitamin В mg; vitamin В μg; vitamin С mg; vitamin К mg; calcium pantothenate mg; nicotinamide mg; folic acid 30 mg; excipient sorbitol up to 100 g. The effect of the feed additive Mixovit B is a collective effect of its components. Vitamin B 1 is required for oxidative decarboxylation of keto acids, synthesis of acetylcholine, carbohydrate, energy, lipid, protein, water-salt metabolisms; it regulates functioning of nervous system, participates in hematopoiesis, increases growth and weight gaining rates, improves appetite. Vitamin B 2 is a part of the oxidation-reducing enzymes of the processes of biological oxidation and energy formation. Vitamin В 6 participates in metabolism of proteins, lipids and carbohydrates, synthesis of adrenaline, serotonin and other neurotransmitters, breakdown of glycogen and synthesis of amino acids. Vitamin В 12 has a lipotropic effect. It increases cell oxygen consumption during acute and chronic hypoxia, boosts immunity and regulates functions of blood hematopoietic organs. Vitamin С is a natural antioxidant. It participates in regulation of oxidation and reduction processes, regulates the blood clotting capacity, normalizes capillary permeability and has anti-inflammatory and antiallergenic effects. Vitamin К 3 regulates blood clotting processes in the body; is required for regular functioning of liver cells. Calcium pantothenate participates in metabolism of carbohydrates and lipids and synthesis of acetylcholine. Nicotinamide is present in hydrogentransferring enzymes, which causes its involvement into cell breathing reactions and metabolism. Folic acid participates in processes of regulation of functions of hematopoietic organs, synthesis of nucleic acids (RNA and DNA) and methionine; stimulates secretion of hydrochloric acid in stomach. The additive is prescribed to supplement animal diet with vitamins, to increase general body resistance, simulate metabolism in stresses during transportation, dietary changes, vaccination etc., as well as to increase growth and weight gaining rate at fattening. The feed additive improves the feed conversion ratio due to stimulation of digestion processes and increases uptake of nutrients. Administer to hens, turkeys, cattle and small cattle, swine, horses orally with drinking water or feed in the following doses: g of the feed additive per 1 l of drinking water (0.5-1 kg of the feed additive per 1 t of water) daily for 3-7 days; 1-2 g of the feed additive per 1 kg of feed (1-2 kg of the feed additive per 1 t of feed) daily for 3-7 days. No contraindications. Do not prescribe Mixovit B to animals with hypersensitivity to its components. It is necessary that the vitamin contents in dietary components be taken into account throughout the whole administration period. Packages of 1 kg of film or foil materials. Store in transportation packages in covered warehouses. Store in a dry, dark place at 5-30 С. 24 hours after dissolution in water or addition to feed. 58

61 ANTIANEMIC DRUGS BIOFERON Solution for injections Brown liquid. 100 ml of the drug contain: active ingredient: iron dextran (bound iron) 10%; excipients phenol, purified water. The drug demonstrates anti-anemic properties due to the iron retention complex. Bioferon is quickly absorbed and easily released in the body ensuring effective prevention and treatment of iron-deficiency anemia. Treatment and prevention of iron-deficiency anemia in sows, piglets, calves and lambs. Administer the drug orally or intramuscularly into the thing or neck area in the following doses: prevention (ml per one animal): piglets (starting from the 3 rd -4 th day of life): 1.0 intramuscularly; calves (on the 1 st day of life): orally with the first colostrum portion; lambs (on the 5 th -6 th day of life): 1.0 intramuscularly; if necessary use the drug in the same doses also on the 10 th -14 th day of life; treatment (ml per one animal): piglets: 1.5 intramuscularly; lambs: 1.0 intramuscularly; sows (in days prior to farrowing): 6.0 intramuscularly. Treat animals based on presence of clinical features of anemia as well as unsatisfactory clinical and hematological factors (hemoglobin and hematocrit levels). The drug may be used in combination with other therapeutic products of other pharmacological effect. No contraindications. Allergic reactions may develop. Do not prescribe the drug in sub-therapeutic doses and do not administer to animals with hypersensitivity to the drug components. Glass vials of 100 ml. Store in a dry dark place out of the reach of children at 5-30 С. 3 years. 59

62 DRUGS FOR EXTERNAL APPLICATION UNISAN Ointment White ointment with specific odor. 1 g of the drug contains: active ingredients: chlorhexidine bigluconate 10 mg; zinc oxide 50 mg; excipients dimethyl sulfoxide, PEG-1500, distilled water. ATCvet: QD08AC52. Chlorhexidine, combinations. The drug has a pronounced antiseptic effect. The components of ointment are effective against vegetative forms of gram-positive (Staphylococcus spр., Streptococcus spр., Mycobacterium spр., Corynebacterium xerosis, Micrococcus spр., Sarcina lutea, Clostridium spр., Bacillus subtilis) and gram-negative bacteria (Escherichia coli, Salmonella spр., Shigella spр., Klebsiella spр., Enterobacter spр., Serratia marcescens, Providencia spр., Proteus spр., Pseudomonas spр., Neisseria spр.) as well as yeasts (Candida spр.), dermatophytes (Dermatophytes, Microsporum, Trichophyton, Trichoderma), lipophilic viruses, chlamydiae. Moreover, the drug makes anti-inflammatory, astringent, local analgesic effect. Apply externally to treat skin diseases caused by bacterial and fungal microflora, that is: skin staphylococcus, pyodermia, impetigo eczema, skin candidosis, trichophytosis, microsporia, seborrhea, external otitis, septic wounds, superficial abscesses and burns in cattle, sheep, goats, horses, swine, rabbits, poultry, dogs and cats. The ointment is applied with a thin layer on the injured skin area once or twice daily until complete recovery. Treatment period is conditioned by the type of pathological process. In any case it is necessary to apply ointment for at least 2-3 days after disappearance of clinical features of disease. In case of fungal diseases continue treatment for 7-10 days after disappearance of clinical symptoms of disease. To treat septic wounds and abscesses, permeate gauzes with the ointment and apply the gauzes to wounds or abscess cavities. Apply dressings every day until complete recovery from septic and necrotic masses. Do not apply in case of individual hypersensitivity to chlorhexidine. Avoid contact with mucous membranes. Do not prescribe in combination with iodine drugs. Utilize unused product in accordance with requirements of national legislation. Polymer jars, vials and aluminum tubes of 15 g and 200 g. Store in a dark place out of the reach of children at 0-25 С. 60

63 ACIDIFIERS ACIMIX Solution for oral administration Transparent blue liquid. 1 l of the feed supplement contains: active ingredients: zinc acetate 10 g; copper sulfate 10 g; formic acid 260 g; propionic acid 100 g; lactic acid 120 g; excipient purified water up to 1 l. Acimix is a mixture of organic acids and their salts, compounds of zinc and copper, which ensures antimicrobial and antifungal effect of the acidifier. The acidifier facilitates optimization of digestive processes in swine and poultry, prevents growth of fungus and bacteria (Salmonella spp., E. coli etc.) in drinking water and feeds. It reduces ph of drinking water, which makes it possible to maintain purity in water supply systems (removal of biological film and prevention of its formation). The acidifier is used to protect drinking water against yeast, mold, pathogenic bacteria and to destroy biological film in water supply systems (particularly, following application of drugs and vaccines with drinking water), to improve balance of digestive tract microflora and to prevent development of diarrhea in swine and poultry, to reduce ph of contents of digestive tract, to facilitate more effective intake of nutrients due to improvement of activity of digestive enzymes and appetite. Administer orally with drinking water (swine, broiler chickens, laying hens) in doses of 1-2 l of the acidifier per 1 t of drinking water. This solution is fed for at least 12 hours per day in the dose of 1 l of the acidifier per 1 t of drinking water and for at least 8 hours in the dose of 2 l of the acidifier per 1 t of drinking water. The duration of feeding makes 5-10 days. Pour 1% acidifier solution into the water supply system for cleaning (exposure period at least 12 hours). Wash the system with cold flowing water upon application. Do not use the water to feed animals during cleaning of water supply system. No contraindications. Do not use concurrently with drugs and vaccines. Acimix causes irritation to eyes, respiratory system and skin; it is dangerous if swallowed. In case of contact with skin or eyes rinse them immediately with plenty of water. Do not inhale evaporations. If you feel unwell, seek medical advice immediately (present the label of the acidifier to the doctor). Plastic cans of 5 l. Store in a dark place out of the reach of children at 0-30 С. 24 hours following dissolution in drinking water. 61

64 NONSTEROIDAL ANTI-INFLAMMATORY DRUGS APIRON Water-soluble powder for oral administration White powder. 1 g of the drug contains: active ingredient: acetylsalicylic acid 400 mg; excipient glucose up to 1 g. Acetylsalicylic acid is an antipyretic, antiinflammatory, analgesic, antiaggregant agent, which is a derivative of salicylic acid. Anti-inflammatory effect of acetylsalicylic acid is caused by impact upon processes taking place at the site of inflammation: it reduces capillary permeability, decreases the activity of hyaluronidase, restricts energetic support of inflammatory process through inhibition of ATP formation etc. The inhibition of biosynthesis of prostaglandins makes importance in the mechanism of anti-inflammatory impact. Antipyretic effect is also related to impact upon hypothalamic thermoregulation centers. Analgesic effect is caused with impact upon pain sensitivity centers as well as capability to reduce algogenic effect of bradykinin. Treatment of inflammations, infection syndromes, pain syndromes of musculoskeletal system in animals, thermal stress in calves, swine and broiler chickens. Poultry, swine, calves: 40 mg of acetylsalicylic acid per 1 kg body weight (100 mg of the drug per 1 kg body weight) daily orally with liquid feed or drinking water. Do not use to treat animals with diagnosed dehydration or digestive tract complications. Do not prescribe to animals during lactation period. Do not administer to hens laying eggs for human consumption. Do not use the drug to treat animals with hypersensitivity to acetylsalicylic acid. Animal slaughter for meat is allowed unrestricted. Packages of film or foil materials of 1000 g. Store in a dry dark place out of the reach of children at 5-30 С. 3 years. 24 hours following dissolution in drinking water. 62