A hypothetical case of nasal microbiome transplantation
|
|
- Holly Morris
- 6 years ago
- Views:
Transcription
1 A hypothetical case of nasal microbiome transplantation Katherine P. Lemon, MD, PhD Institute & Boston Children s Hospital Mary-Claire Roghmann, MD, MS University of Maryland Microbiota-transplantation Working Group December 12, 2016
2 The Problem: repeated Staphylococcus aureus infections Child with a complex medical condition Dependent on a central venous catheter S. aureus (MSSA) brain abscess Later a S. aureus (MSSA) bacteremia S. aureus nasal & skin decolonization failed A third S. aureus (MSSA) infection
3 What next? Risk for repeat S. aureus infections Repeat decolonization, which might fail There is no vaccine against S. aureus
4 Staphylococcus aureus colonizes the human nose, skin and throat nostrils throat segments back of nose back of mouth lower throat Wertheim LID 2005 (rev) Mertz CID 2007
5 Staphylococcus aureus lives in the noses of ~25% of humans Colonization increases the risk of infection Gorwitz JID 2008
6 Most Staphylococcus aureus interactions with humans are harmless Harmless Infection
7 Staphylococcus aureus also causes infection Harmless Infection
8 Staphylococcus aureus kills up to 10,000 people per year in the U.S. CDC. Active Bacterial Core Surveillance Report,
9 S. aureus causes a range of infections Skin & soft tissue Bone Joint Blood stream Heart valve Pneumonia Medical devices
10 Some people experience repeated S. aureus infections USA300 clone of MRSA Reports of multiple recurrences Reports of multiple MRSA infections, e.g., SSTIs, within a household
11 Why are 75% of people are free of Staphylococcus aureus? and have a lower risk of infection
12 Our genetics has little influence on whether Staphylococcus aureus lives in our nose Andersen et al. JID 2012
13 other bacteria in the nose likely do Liu et al. Sci Adv 2015
14 Studies have identified bacterial genera/species inversely correlated with S. aureus Frank et al. PONE 2010 Wos-Oxley et al. ISME J 2010 Yan et al. CHM 2013
15 Can other members of the nasal microbiome keep S. aureus out? Benign or beneficial S. aureus
16 The Problem: repeated Staphylococcus aureus infections Child with a complex medical condition Dependent on a central venous catheter S. aureus (MSSA) brain abscess Later a S. aureus (MSSA) bacteremia S. aureus nasal & skin decolonization failed A third S. aureus (MSSA) infection
17 Hypothesis: the nasal microbiome can be replaced by one resistant to S. aureus Repeat decolonization to perturb the ecosystem Community will repopulate secondary succession Guide repopulation: Nasal Microbiota Transplant Donor: long-term S. aureus non-carrier Goal: to prevent S. aureus infection by eradicating S. aureus colonization
18 S. aureus nasal and skin decolonization First 5 days of every month for 3-4 cycles Topical antibiotic to both nostrils twice daily mupirocin Topical microbicide wash/bath once daily Chlorhexidine Dilute bleach Decolonize the household (all S. aureus carriers) Limit sharing of S. aureus via household surfaces (e.g., avoid sharing towels) e.g., Fritz et al. CID 2012
19 Risks of S. aureus decolonization Generally well tolerated Localized reaction to the topic mupirocin or microbicide Potential to select for resistant S. aureus Mupirocin resistance The protocol may fail
20 Theoretical Nasal Microbiota Transplant Harvest microbiota with nostril swab(s) Donor: healthy and repeatedly negative for S. aureus colonization for >1 year Nostril, throat, axilla, inguinal fold and maybe GI Swab the nostrils of the recipient immediately after decolonization protocol Topical decolonization only? Oral antibiotics included in the decolonization? What about other carriers in the household? How long to monitor for recurrence/reacquisition of S. aureus?
21 The Lemon Lab at Developing new and sustainable ways to manage the bacterial microbiome in the nose and on the skin to prevent and treat infections. Boston Children s Hospital
22 Discussion
23 Why study bacteria that live in noses?
24 Bacterial interactions with humans range from beneficial to harmless to infection Beneficial Infection (pathogen)
25 We think about nasal bacteria in terms of how they affect humans Commensal Harmless Mutualist Beneficial Pathobiont Can cause severe disease
26 What keeps Staphylococcus aureus behaving harmlessly? Harmless Infection
27 A systems level view of a complex microbial community (microbiota)
28 Goal: identify molecular mechanisms that drive community composition/function Metabolites or Signals Antagonism Synergy
Responders as percent of overall members in each category: Practice: Adult 490 (49% of 1009 members) 57 (54% of 106 members)
Infectious Diseases Society of America Emerging Infections Network 6/2/10 Report for Query: Perioperative Staphylococcus aureus Screening and Decolonization Overall response rate: 674/1339 (50.3%) physicians
More informationSuccess for a MRSA Reduction Program: Role of Surveillance and Testing
Success for a MRSA Reduction Program: Role of Surveillance and Testing Singapore July 13, 2009 Lance R. Peterson, MD Director of Microbiology and Infectious Disease Research Associate Epidemiologist, NorthShore
More informationPrevalence & Risk Factors For MRSA. For Vets
For Vets General Information Staphylococcus aureus is a Gram-positive, aerobic commensal bacterium of humans that is carried in the anterior nares of approximately 30% of the general population. It is
More informationSixth Plague of Egypt. Community MRSA. Epidemiology. Basic Features of Community MRSA. Populations with CA-MRSA
Community MRSA Henry F. Chambers, M.D. University of California San Francisco San Francisco General Hospital Sixth Plague of Egypt (~ 1200 BCE) So they took soot from a kiln, and stood before Pharaoh;
More informationCommunity Methicillin- Resistant Staphylococcus aureus. Sixth Plague of Egypt. Epidemiology
Community Methicillin- Resistant Staphylococcus aureus Henry F. Chambers, M.D. University of California San Francisco San Francisco General Hospital Sixth Plague of Egypt (~ 1200 BCE) So they took soot
More informationHOSPITAL-ACQUIRED INFECTION/MRSA EYERUSALEM KIFLE AND GIFT IMUETINYAN OMOBOGBE PNURSS15
HOSPITAL-ACQUIRED INFECTION/MRSA EYERUSALEM KIFLE AND GIFT IMUETINYAN OMOBOGBE PNURSS15 INTRODUCTION DEFINITIONS SIGNS AND SYMPTOMS RISK FACTORS DIAGNOSIS COMPLICATIONS PREVENTIONS TREATMENT PATIENT EDUCATION
More informationReplaces:04/14/16. Formulated: 1997 SKIN AND SOFT TISSUE INFECTION
Effective Date: 04/13/17 Replaces:04/14/16 Page 1 of 7 POLICY To standardize the clinical management and housing of offenders with skin and soft tissue infections, thereby reducing the transmission and
More informationA patient s guide to. MRSA - Methicillin Resistant Staphylococcus Aureus
A patient s guide to MRSA - Methicillin Resistant Staphylococcus Aureus 1 What is MRSA? There are lots of micro-organisms (germs) on our skin. They are in the air we breathe, the water we drink, and the
More informationIs biocide resistance already a clinical problem?
Is biocide resistance already a clinical problem? Stephan Harbarth, MD MS University of Geneva Hospitals and Faculty of Medicine, Geneva, Switzerland Important points Biocide resistance exists Antibiotic
More informationCase: Family D. Staphylococcus aureus. Outline. Staphylococcus aureus Timeline. Newborn Nursery Epidemic: 1950s
Evolution, Epidemiology, and Eradication of Contemporary Staphylococcus aureus Stephanie Fritz, MD, MSCI Assistant Professor of Pediatrics Washington University School of Medicine September 6, 2012 Case:
More informationRisk factors? Insect bites? Hygiene? Household crowding Health literacy
Recurrent boils Commonest sites face, neck, armpits, shoulders, and buttocks (bottom) infection of the hair root or sweat pore Occur in otherwise healthy people (higher rates in diabetics, eczema, iron
More informationMethicillin Resistant Staphylococcus Aureus (MRSA) The drug resistant `Superbug that won t die
Methicillin Resistant Staphylococcus Aureus (MRSA) The drug resistant `Superbug that won t die Michael A. Miller, MD Assistant Professor of Pediatrics -Jacksonville OBJECTIVES 1. Understand the basic microbiology
More informationMulti-Drug Resistant Organisms (MDRO)
Multi-Drug Resistant Organisms (MDRO) 2016 What are MDROs? Multi-drug resistant organisms, or MDROs, are bacteria resistant to current antibiotic therapy and therefore difficult to treat. MDROs can cause
More informationEvaluating the Role of MRSA Nasal Swabs
Evaluating the Role of MRSA Nasal Swabs Josh Arnold, PharmD PGY1 Pharmacy Resident Pharmacy Grand Rounds February 28, 2017 2016 MFMER slide-1 Objectives Identify the pathophysiology of MRSA nasal colonization
More informationMRSA Background. New Challenges From an Old Foe. MRSA Demographics. Comparison of Types of MRSA CA-MRSA HA-MRSA
Winter Clinical 2017 : MRSA Update Whitney A. High, MD, JD, Meng whitney.high@ucdenver.edu Associate Professor, Dermatology & Pathology Director of Dermatopathology University of Colorado School of Medicine
More informationMethicillin Resistant Staphylococcus aureus:
Methicillin Resistant Staphylococcus aureus: Action-Oriented Guidance for Community-Based Prevention Jackie Dawson, PhD Public Health Epidemiologist Chelan, Douglas, Grant, Kittitas, & Okanogan Counties
More informationPVL Staph aureusjust a skin/soft tissue problem? Layla Mohammadi Lead Pharmacist, Antimicrobials Lewisham Healthcare NHS Trust
PVL Staph aureusjust a skin/soft tissue problem? Layla Mohammadi Lead Pharmacist, Antimicrobials Lewisham Healthcare NHS Trust Neonatal Case History Neonate born at 26 +2 gestation Spontaneous onset of
More informationMethicillin-Resistant Staphylococcus aureus (MRSA) Infections Activity C: ELC Prevention Collaboratives
Methicillin-Resistant Staphylococcus aureus (MRSA) Infections Activity C: ELC Prevention Collaboratives John Jernigan, MD, MS Alex Kallen, MD, MPH Division of Healthcare Quality Promotion Centers for Disease
More informationPreventing Multi-Drug Resistant Organism (MDRO) Infections. For National Patient Safety Goal
Preventing Multi-Drug Resistant Organism (MDRO) Infections For National Patient Safety Goal 07.03.01 2009 Methicillin Resistant Staphlococcus aureus (MRSA) About 3-8% of the population at large is a carrier
More informationGUIDE TO INFECTION CONTROL IN THE HOSPITAL
GUIDE TO INFECTION CONTROL IN THE HOSPITAL CHAPTER 43: Staphylococcus Aureus Authors J. Pierce, MD M. Edmond, MD, MPH, MPA M.P. Stevens, MD, MPH Chapter Editor Michelle Doll, MD, MPH) Topic Outline Key
More informationHosted by Dr. Jon Otter, Guys & St. Thomas Hospital, King s College, London A Webber Training Teleclass 1
Andreas Voss, MD, PhD Professor of Infection Control Radboud University Nijmegen Medical Centre & Canisius-Wilhelmina Hospital Nijmegen, Netherlands Hosted by Dr. Jon O0er Guys & St. Thomas NHS Founda
More informationStaphylococcus Aureus
GUIDE TO INFECTION CONTROL IN THE HOSPITAL CHAPTER 43: Staphylococcus Aureus Authors J. Pierce, MD M. Edmond, MD, MPH, MPA M.P. Stevens, MD, MPH Chapter Editor Michelle Doll, MD, MPH) Topic Outline Key
More informationTHE HUMAN MICROBIOME: THE INFECTION PREVENTIONIST S BEST FRIEND
THE HUMAN MICROBIOME: THE INFECTION PREVENTIONIST S BEST FRIEND Michigan Communicable Disease Conference May 4, 2017 Richard A. Van Enk, Ph.D., CIC Director, Infection Prevention and Epidemiology vanenkr@bronsonhg.org
More informationSource: Portland State University Population Research Center (
Methicillin Resistant Staphylococcus aureus (MRSA) Surveillance Report 2010 Oregon Active Bacterial Core Surveillance (ABCs) Office of Disease Prevention & Epidemiology Oregon Health Authority Updated:
More informationMRSA What We Need to Know Sharon Pearce, CRNA, MSN Carolina Anesthesia Associates
MRSA What We Need to Know Sharon Pearce, CRNA, MSN Carolina Anesthesia Associates What is MRSA? Methicillin-resistant Staphylococus aureus This hardy bacterium has developed resistance to every antibiotic
More informationOpening the Gates for Farmer Health National Center for Farm Health October 13, 2010
MRSA, MRSA, MRSA!!! An emerging infectious epidemic in people from livestock??? Kelley J Donham DVM Tara Smith PhD Abby Harper-Maples MPH Dwight Ferguson MS Kerry Leedom-Larson DVM, MPH, PhD Opening the
More informationToday s Agenda: 9/30/14
Today s Agenda: 9/30/14 1. Students will take C List Medical Abbreviation Quiz. 2. TO: Discuss MRSA. MRSA MRSA Methicillin Resistant Staphylococcus Aureus Methicillin Resistant Staphylococcus Aureus What
More informationPreventing Surgical Site Infections. Edward L. Goodman, MD September 16, 2013
Preventing Surgical Site Infections Edward L. Goodman, MD September 16, 2013 Outline NHSN Reporting and Definitions Magnitude of the Problem Risk Factors Non Pharmacologic Interventions Pharmacologic Interventions
More informationM R S A. Methicillin-Resistant Staphylococcus aureus. The Facts
M R S A Methicillin-Resistant Staphylococcus aureus The Facts Michael Parry, M.D. Director of Infectious Diseases and Microbiology Stamford Hospital January 24, 2008 Introduction to Staph aureus Staphylococcus
More informationLindsay E. Nicolle University of Manitoba Winnipeg, CANADA
Lindsay E. Nicolle University of Manitoba Winnipeg, CANADA Long Term Care Facilities: Spectrum low acuity assisted living mobile independent Not LTAC high acuity complete functional disability dialysis
More informationDevelopment of Drugs for Eradication of Nasal Carriage of S. aureus to Reduce S. aureus Infections in Vulnerable Surgical Patients
Development of Drugs for Eradication of Nasal Carriage of S. aureus to Reduce S. aureus Infections in Vulnerable Surgical Patients Richard Bax Transcrip Partners Bax - Eradication of carriage - EMA 25-26
More informationCan you treat mrsa with amoxicillin
Can you treat mrsa with amoxicillin 15-8-2017 Community-associated MRSA You can pick up MRSA outside the hospital, especially if you :. (a related drug developed to treat these germs). Amoxicillin and
More informationAntibiotic stewardship in long term care
Antibiotic stewardship in long term care Shira Doron, MD Associate Professor of Medicine Division of Geographic Medicine and Infectious Diseases Tufts Medical Center Boston, MA Consultant to Massachusetts
More informationStanding Orders for the Treatment of Outpatient Peritonitis
Standing Orders for the Treatment of Outpatient Peritonitis 1. Definition of Peritonitis: a. Cloudy effluent. b. WBC > 100 cells/mm3 with >50% polymorphonuclear (PMN) cells with minimum 2 hour dwell. c.
More informationSurveillance of Multi-Drug Resistant Organisms
Surveillance of Multi-Drug Resistant Organisms Karen Hoffmann, RN, MS, CIC Associate Director Statewide Program for Infection Control and Epidemiology (SPICE) University of North Carolina School of Medicine
More informationHorizontal vs Vertical Infection Control Strategies
GUIDE TO INFECTION CONTROL IN THE HOSPITAL Chapter 14 Horizontal vs Vertical Infection Control Strategies Author Salma Abbas, MBBS Michael Stevens, MD, MPH Chapter Editor Shaheen Mehtar, MBBS. FRC Path,
More informationFM - Male, 38YO. MRSA nasal swab (+) Due to positive MRSA nasal swab test, patient will be continued on Vancomycin 1500mg IV q12 for MRSA treatment...
Jillian O Keefe Doctor of Pharmacy Candidate 2016 September 15, 2015 FM - Male, 38YO HPI: Previously healthy male presents to ED febrile (102F) and in moderate distress ~2 weeks after getting a tattoo
More informationMethicillin-Resistant Staphylococcus aureus
Methicillin-Resistant Staphylococcus aureus By Karla Givens Means of Transmission and Usual Reservoirs Staphylococcus aureus is part of normal flora and can be found on the skin and in the noses of one
More informationStanding Orders for the Treatment of Outpatient Peritonitis
Standing Orders for the Treatment of Outpatient Peritonitis 1. Definition of Peritonitis: a. Cloudy effluent. b. WBC > 100 cells/mm3 with >50% polymorphonuclear (PMN) cells with minimum 2 hour dwell. c.
More informationA Prospective Investigation of Nasal Mupirocin, Hexachlorophene Body Wash, and Systemic
AAC Accepts, published online ahead of print on 14 November 2011 Antimicrob. Agents Chemother. doi:10.1128/aac.01608-10 Copyright 2011, American Society for Microbiology and/or the Listed Authors/Institutions.
More informationActive Bacterial Core Surveillance Site and Epidemiologic Classification, United States, 2005a. Copyright restrictions may apply.
Impact of routine surgical ward and intensive care unit admission surveillance cultures on hospital-wide nosocomial methicillin-resistant Staphylococcus aureus infections in a university hospital: an interrupted
More informationImpact of a Standardized Protocol to Address Outbreak of Methicillin-resistant
Impact of a Standardized Protocol to Address Outbreak of Methicillin-resistant Staphylococcus Aureus Skin Infections at a large, urban County Jail System Earl J. Goldstein, MD* Gladys Hradecky, RN* Gary
More informationHealthcare-associated Infections Annual Report December 2018
December 2018 Healthcare-associated Infections Annual Report 2011-2017 TABLE OF CONTENTS INTRODUCTION... 1 METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS INFECTIONS... 2 MRSA SURVEILLANCE... 3 CLOSTRIDIUM
More informationKeeping Antibiotics Working: Nursing Leadership in Action
Keeping Antibiotics Working: Nursing Leadership in Action Pat McLaine, DrPH, MPH, RN Robyn Gilden, PhD, RN Department of Family and Community Health Maryland Nurses Association October 2016 US 2 million
More informationMRSA Screening (Elective Patients)
What is MRSA? MRSA stands for Meticillin resistant Staphylococcus aureus. It is a type of Staphylococcus aureus bacteria (germ) that is very resistant to antibiotics so infections due to MRSA can be quite
More informationApproval Signature: Original signed by Dr. Michel Tetreault Date of Approval: July Review Date: July 2017
WRHA Infection Prevention and Control Program Operational Directives Admission Screening for Antibiotic Resistant Organisms (AROs): Methicillin Resistant Staphylococcus aureus (MRSA) and Vancomycin Resistant
More informationJoint scientific report of ECDC, EFSA and EMEA on meticillin resistant Staphylococcus aureus (MRSA) in livestock, companion animals and food 1.
16 June 2009 Joint scientific report of ECDC, EFSA and EMEA on meticillin resistant Staphylococcus aureus (MRSA) in livestock, companion animals and food 1. Summary of the scientific Opinion of the Panel
More informationA LONGITUDINAL STUDY OF COMMUNITY-ASSOCIATED METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS COLONIZATION IN COLLEGE SPORTS PARTICIPANTS
A LONGITUDINAL STUDY OF COMMUNITY-ASSOCIATED METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS COLONIZATION IN COLLEGE SPORTS PARTICIPANTS By Natalia Jiménez Truque Dissertation Submitted to the Faculty of the
More informationIn-Service Training Program. Managing Drug-Resistant Organisms in Long-Term Care
In-Service Training Program Managing Drug-Resistant Organisms in Long-Term Care OBJECTIVES 1. Define the term antibiotic resistance. 2. Explain the difference between colonization and infection. 3. Identify
More informationPrinciples of Antimicrobial Therapy
Principles of Antimicrobial Therapy Doo Ryeon Chung, MD, PhD Professor of Medicine, Division of Infectious Diseases Director, Infection Control Office SUNGKYUNKWAN UNIVERSITY SCHOOL OF MEDICINE CASE 1
More informationYour Guide to Managing. Multi Drug-resistant Organisms (MDROs)
Agency for Integrated Care 5 Maxwell Road #10-00 Tower Block MND Complex Singapore 069110 Singapore Silver Line: 1800-650-6060 Email: enquiries@aic.sg Website: www.silverpages.sg Facebook: www.facebook.com/carerssg
More informationTreatment of Surgical Site Infection Meeting Quality Statement 6. Prof Peter Wilson University College London Hospitals
Treatment of Surgical Site Infection Meeting Quality Statement 6 Prof Peter Wilson University College London Hospitals TEG Quality Standard 6 Treatment and effective antibiotic prescribing: People with
More informationMulti-drug resistant microorganisms
Multi-drug resistant microorganisms Arzu TOPELI Director of MICU Hacettepe University Faculty of Medicine, Ankara-Turkey Council Member of WFSICCM Deaths in the US declined by 220 per 100,000 with the
More informationMRSA Outbreak in Firefighters
MRSA Outbreak in Firefighters Angie Carranza Munger, MD Resident, Occupational and Environmental Medicine The University of Colorado, Denver and National Jewish Health Candidate, Masters of Public Health
More informationMultidrug-Resistant Organisms: How Do We Define them? How do We Stop Them?
Multidrug-Resistant Organisms: How Do We Define them? How do We Stop Them? Roberta B. Carey, PhD Centers for Disease Control and Prevention Division of Healthcare Quality Promotion Why worry? MDROs Clinical
More informationMrsa abscess and cellulitis
Search Mrsa abscess and cellulitis An abscess is a collection of pus that has built up within the tissue of the body. Signs and symptoms of abscesses include redness, pain, warmth, and swelling. The. Staph
More informationDoes Screening for MRSA Colonization Have A Role In Healthcare-Associated Infection Prevention Programs?
Does Screening for MRSA Colonization Have A Role In Healthcare-Associated Infection Prevention Programs? John A. Jernigan, MD, MS Division of Healthcare Quality Promotion Centers for Disease Control and
More informationHand washing/hand hygiene reduces the number of microorganisms on the hands and is the most important practice to prevent the spread of infection.
1. Hand Hygiene Quick Reference Chart Hand washing/hand hygiene reduces the number of microorganisms on the hands and is the most important practice to prevent the spread of infection. WHEN Before: Direct
More information8/17/2016 ABOUT US REDUCTION OF CLOSTRIDIUM DIFFICILE THROUGH THE USE OF AN ANTIMICROBIAL STEWARDSHIP PROGRAM
Mary Moore, MS CIC MT (ASCP) Infection Prevention Coordinator Great River Medical Center, West Burlington REDUCTION OF CLOSTRIDIUM DIFFICILE THROUGH THE USE OF AN ANTIMICROBIAL STEWARDSHIP PROGRAM ABOUT
More informationSafe Patient Care Keeping our Residents Safe Use Standard Precautions for ALL Residents at ALL times
Safe Patient Care Keeping our Residents Safe 2016 Use Standard Precautions for ALL Residents at ALL times #safepatientcare Do bugs need drugs? Dr Deirdre O Brien Consultant Microbiologist Mercy University
More informationTHE BOVINE MILK MICROBIOME. Mark McGuire
THE BOVINE MILK MICROBIOME Mark McGuire FLOW OF MILK FROM A FARM TO PROCESSOR HOW TO ASSESS PRESENCE OF BACTERIA? Culture-dependent methods Culture-independent methods Rely on molecular techniques and
More informationCONFLICT OF INTEREST ANTIMICROBIAL LOCK SOLUTIONS INCREASE BACTEREMIA
CONFLICT OF INTEREST ANTIMICROBIAL LOCK SOLUTIONS INCREASE BACTEREMIA NONE Vandana Dua Niyyar, MD Associate Professor of Medicine, Division of Nephrology, Emory University. OBJECTIVES Role of biofilm in
More informationAntimicrobial Resistance and Molecular Epidemiology of Staphylococcus aureus in Ghana
Antimicrobial Resistance and Molecular Epidemiology of Staphylococcus aureus in Ghana Beverly Egyir, PhD Noguchi Memorial Institute for Medical Research Bacteriology Department, University of Ghana Background
More informationLA-MRSA in the Netherlands: the past, presence and future.
LA-MRSA in the Netherlands: the past, presence and future. Prof. Jaap Wagenaar DVM, PhD With input from Prof. Jan Kluytmans MD, PhD Department of Infectious Diseases and Immunology, Faculty of Veterinary
More informationInfection Prevention Highlights for the Medical Staff. Pamela Rohrbach MSN, RN, CIC Director of Infection Prevention
Highlights for the Medical Staff Pamela Rohrbach MSN, RN, CIC Director of Infection Prevention Standard Precautions every patient every time a. Hand Hygiene b. Use of Personal Protective Equipment (PPE)
More informationCommunity-Associated Methicillin-Resistant Staphylococcus aureus: Epidemiology and Clinical Consequences of an Emerging Epidemic
CLINICAL MICROBIOLOGY REVIEWS, July 2010, p. 616 687 Vol. 23, No. 3 0893-8512/10/$12.00 doi:10.1128/cmr.00081-09 Copyright 2010, American Society for Microbiology. All Rights Reserved. Community-Associated
More informationCommunity Associated MRSA Dr. Rachel Gorwitz, CDC A Webber Training Teleclass
Community-Associated MRSA: What s Up and What s Next? Rachel Gorwitz, MD, MPH Division of Healthcare Quality Promotion Centers for Disease Control and Prevention Learning Objectives Describe the changing
More informationCa-MRSA Update- Hand Infections. Washington Hand Society September 19, 2007
Ca-MRSA Update- Hand Infections Washington Hand Society September 19, 2007 Resistant Staph. Aureus Late 1940 s -50% S.Aureus resistant to PCN 1957-80/81 strain- of S.A. highly virulent and easily transmissible
More informationImpact of Systemic Antibiotics on Staphylococcus aureus Colonization and Recurrent Skin Infection
Clinical Infectious Diseases MAJOR ARTICLE Impact of Systemic Antibiotics on Staphylococcus aureus Colonization and Recurrent Skin Infection Patrick G. Hogan, 1 Marcela Rodriguez, 2 Allison M. Spenner,
More informationThe Bug Stops Here: Treating Resistant Staph Infections Holly Roberts, DVM, MS, DACVD Blue Pearl Veterinary Specialists San Antonio, TX
The Bug Stops Here: Treating Resistant Staph Infections Holly Roberts, DVM, MS, DACVD Blue Pearl Veterinary Specialists San Antonio, TX 1. Staphylococcus bacteria a. Gram positive b. Opportunistic pathogens
More informationoriginal article infection control and hospital epidemiology october 2009, vol. 30, no. 10
infection control and hospital epidemiology october 2009, vol. 30, no. 10 original article 5 Years of Experience Implementing a Methicillin-Resistant Staphylococcus aureus Search and Destroy Policy at
More informationMRSA: How to Keep This Deadly Super Bug From Infecting You
MRSA: How to Keep This Deadly Super Bug From Infecting You DR. MERCOLA $9.97 Mercola.com is the world s #1-ranked natural health website, with over one million subscribers to its free newsletter. Millions
More informationInfection Control Priorities for Antibiotics Resistance - The Search and Destroy Strategy. WH Seto Hong Kong China
Infection Control Priorities for Antibiotics Resistance - The Search and Destroy Strategy WH Seto Hong Kong China WHD 2011 slogan Tier 1 Education Surveillance Environment Administration Usage IC isolation
More informationEpidemiology of Community- Associated (CA) Methicillin-Resistant Staphylococcus aureus (MRSA) in the United States
Epidemiology of Community- Associated (CA) Methicillin-Resistant Staphylococcus aureus (MRSA) in the United States R. M. Klevens, DDS, MPH Division of Healthcare Quality Promotion Acknowledgements CDC
More informationHealth Service Executive Parkgate St. Business Centre, Dublin 8 Tel:
Health Service Executive Parkgate St. Business Centre, Dublin 8 Tel: 01 635 2500 www.hse.ie Health Service Executive Oak House, Millennium Park, Naas, Co. Kildare Tel: 045 880 400 www.hse.ie The prevention
More informationAuthor - Dr. Josie Traub-Dargatz
Author - Dr. Josie Traub-Dargatz Dr. Josie Traub-Dargatz is a professor of equine medicine at Colorado State University (CSU) College of Veterinary Medicine and Biomedical Sciences. She began her veterinary
More informationIsolation of MRSA from the Oral Cavity of Companion Dogs
InfectionControl.tips Join. Contribute. Make A Difference. https://infectioncontrol.tips Isolation of MRSA from the Oral Cavity of Companion Dogs By: Thomas L. Patterson, Alberto Lopez, Pham B Reviewed
More informationOverview of Infection Control and Prevention
Overview of Infection Control and Prevention Review of the Cesarean-section Antibiotic Prophylaxis Program in Jordan and Workshop on Rational Medicine Use and Infection Control Terry Green and Salah Gammouh
More informationNHS GRAMPIAN MRSA POLICY FOR COMMUNITY SETTINGS JUNE 2003
NHS GRAMPIAN MRSA POLICY FOR COMMUNITY SETTINGS JUNE 2003 Grampian NHS Board Grampian University Hospitals Trust Grampian Primary Care Trust TABLE OF CONTENTS Aim 3 1 Introduction 4 2 Control of MRSA in
More informationHealthcare-associated infections surveillance report
Healthcare-associated infections surveillance report Methicillin-resistant Staphylococcus aureus (MRSA) Update, Q3 of 2017/18 Summary Table Q3 2017/18 Previous quarter (Q2 2017/18) Same quarter of previous
More informationStaph Cases. Case #1
Staph Cases Lisa Winston University of California, San Francisco San Francisco General Hospital Case #1 A 60 y.o. man with well controlled HIV and DM presents to clinic with ten days of redness and swelling
More informationStaphylococcus aureus Blood Stream Infection (Bacteraemia) Surveillance. Ceredigion and Mid Wales Trust Data per Bed Days
Staphylococcus aureus Blood Stream Infection (Bacteraemia) Surveillance Ceredigion and Mid Wales Trust Data per 100 000 Bed Days Commentary: Staphylococcus aureus is a bacterium that a proportion (up to
More information22/10/2013. antibiotic resistance an ecological problem. this part of the session. an ecological perspective. selection pressure and evolution
antibiotic resistance an ecological problem Jon Iredell critical.infection@sydney.edu.au NHMRC Centre for Research Excellence in Critical Infection Marie Bashir Institute Westmead Millennium Institute
More informationGet Smart For Healthcare
Get Smart For Healthcare Know When Antibiotics Work Marry Bardin, Quality Improvement Advisor June 9, 2015 Why We Need to Improve In-patient Antibiotic Use Antibiotics are misused in hospitals Antibiotic
More informationLiving with MRSA Learning how to control the spread of Methicillin-Resistant Staphylococcus Aureus (MRSA)
Living with MRSA Learning how to control the spread of Methicillin-Resistant Staphylococcus Aureus (MRSA) IMPORTANT MRSA is a serious infection that can become life-threatening if left untreated. If you
More informationA Randomized, Double-Blinded Study for the Prevention of Exit Site Infections in Pediatric Peritoneal Dialysis Patients
A Randomized, Double-Blinded Study for the Prevention of Exit Site Infections in Pediatric Peritoneal Dialysis Patients Joshua Zaritsky, MD PhD, Barbara Gales, RN, Georgina Ramos, and Isidro B. Salusky,
More informationSkin & Soft Tissue Infections (SSTI) Skin & Soft Tissue Infections. Skin & Soft Tissue Infections (SSTI)
Skin & Soft Tissue Infections (SSTI) Skin & Soft Tissue Infections 2007 Abscess Cellulitis Bradley W Frazee, MD, FACEP Dept of Emergency Medicine Alameda County Medical Center - Highland Hospital Associate
More informationConflict of interest: We have no conflict of interest to report on this topic of SSI reduction for total knees.
Reducing SSI- Knees TIFFANY KENNERK MBA, MSN, RN, NE -BC, ONC CYNTHIA SEAMAN BSN, RN, ONC, CMSRN ~COMMUNITY HOSPITALS AND WELLNESS CENTERS~ Conflict of interest: We have no conflict of interest to report
More informationNasal Antisepsis Methods: Povidone-Iodine vs Alcohol Based Solutions
University of Wyoming Wyoming Scholars Repository Honors Theses AY 16/17 Undergraduate Honors Theses Spring 5-12-2017 Nasal Antisepsis Methods: Povidone-Iodine vs Alcohol Based Solutions Mackenzie McCoy
More informationWhat Is Thought To Be The Problem?
Do We Need an Alternative Approach to the Management of Osteomyelitis? Jeffrey C. Karr DPM, CWS, ABLES, FAPWCA, FCCWS Founder, Central Florida Limb Salvage Alliance Chairman, Founder: The Osteomyelitis
More informationON-DEMAND. Converging pressures encourage rapid MRSA/SA testing
CEPHEID ON-DEMAND REPORT A Quarterly Publication by Cepheid Volume 2, Issue 1 IN THIS ISSUE Cover Story: The Decolonization Decision In A New Healthcare Paradigm Inside: Rapid Results Pay Off for Patients
More informationAntibiotics & Emerging Resistance
Antibiotics & Emerging Resistance Some points to consider : A. Overview WHO and World Economic Forum say emerging antibiotic resistance is one of the greatest challenges facing mankind, we know what causes
More informationOther Enterobacteriaceae
GUIDE TO INFECTION CONTROL IN THE HOSPITAL CHAPTER NUMBER 50: Other Enterobacteriaceae Author Kalisvar Marimuthu, MD Chapter Editor Michelle Doll, MD, MPH Topic Outline Topic outline - Key Issues Known
More informationScreening for MRSA / MSSA and CPO within the Kent Kidney Care Centre
Screening for MRSA / MSSA and CPO within the Kent Kidney Care Centre Information for patients from the Infection Prevention and Control Team and the Renal Team This leaflet is not meant to replace the
More informationResearch Article Evaluation of Central Venous Catheter Associated Blood Stream Infections: A Microbiological Observational Study
Pathogens Volume 2013, Article ID 936864, 6 pages http://dx.doi.org/10.1155/2013/936864 Research Article Evaluation of Central Venous Catheter Associated Blood Stream Infections: A Microbiological Observational
More informationMeropenem for all? Midge Asogan ICU Fellow (also ID AT)
Meropenem for all? Midge Asogan ICU Fellow (also ID AT) Infections Common reason for presentation to ICU Community acquired - vs nosocomial - new infection acquired within hospital environment Treatment
More information11/10/2016. Skin and Soft Tissue Infections. Disclosures. Educational Need/Practice Gap. Objectives. Case #1
Disclosures Selecting Antimicrobials for Common Infections in Children FMR-Contemporary Pediatrics 11/2016 Sean McTigue, MD Assistant Professor of Pediatrics, Pediatric Infectious Diseases Medical Director
More informationTaking Action to Prevent and Manage Multidrug-resistant Organisms and C. difficile in the Nursing Home: Part 2 Understanding the spread
Taking Action to Prevent and Manage Multidrug-resistant Organisms and C. difficile in the Nursing Home: Part 2 Understanding the spread Nimalie D. Stone, MD,MS Division of Healthcare Quality Promotion
More informationWound Management. Elof Eriksson MD PhD Professor Emeritus, Harvard Medical School Chief Medical Officer, Applied Tissue Technologies LLC
Wound Management The use of a Platform Wound Device for Topical Treatment of Infections and for Delivery of Negative Pressure Elof Eriksson MD PhD Professor Emeritus, Harvard Medical School Chief Medical
More information