Update on the Diagnosis and Management of O33s Media. Leslie Herrmann MD, FAAP Pediatrician

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1 Update on the Diagnosis and Management of O33s Media Leslie Herrmann MD, FAAP Pediatrician

2 Disclosures I have no financial disclosures.

3 Objec3ves Understand the new diagnos3c criteria for OM Know when to treat vs when to watch and wait Know appropriate an3bio3cs to use in different clinical scenarios

4 Main Source Pediatrics Mar;131(3):e doi: /peds Epub 2013 Feb 25. The diagnosis and management of acute o11s media. Lieberthal AS, Carroll AE, Chonmaitree T, Ganiats TG, Hoberman A, Jackson MA, Joffe MD, Miller DT, Rosenfeld RM, Sevilla XD, Schwartz RH, Thomas PA, Tunkel DE. American Academy of Pediatrics and American Academy of Family Physicians Clinical Prac1ce Guideline Last revised in 2004 Commi=ee: pediatrics, family medicine, ENT, epidemiology, ID, EM, and guideline methology

5 Changes Since the 2004 Guidelines Stricter diagnos3c criteria Emphasis on watch and wait when appropriate Slightly different an3bio3cs recommended

6 Target Popula3on Ages 6 months to 12 years 6-23 months 2-12 years We extrapolate the recommenda3ons in our popula3on.

7 How is our popula3on different? Higher rates of o33s media, perfora3ons, and myringotomy tube placement Theories: Poverty, less educated parents, crowded housing, tobacco smoke, hea3ng smoke Pneumococcal vaccine-resistant serotypes are more common Anatomical differences in the bony segment of the eustachian tube

8 Pathogenesis 1. Nasopharyngeal infec3on with an otopathogen. 2. Inflamma3on and edema à obstruc3on of the eustachian tube. 3. Nega3ve pressure à accumula3on of secre3ons. hfp://lolatbio.wikispaces.com/the%2bear&docid=yu5lqmio2i-8xm&imgurl=hfp://lolatbio.wikispaces.com/file/view/earanatomy.jpg/ /earanatomy.jpg&w=525&h=386&ei=7zc- UfG7Bo-AqwGGzIGgBQ&zoom=1&iact=hc&vpx=2&vpy=431&dur=3315&hovh=192&hovw=262&tx=125&ty=139&page=1&tbnh=141&tbnw=192&start=0&ndsp=50&ved=1t:429,r:20,s:0,i:146

9 Most Common Pathogens Streptococcus pneumoniae (~50%) Non-typeable Haemophilus influenzae (~45%) Moraxella catarrhalis (~10%) Other: GAS, Staph, anaerobes (Pseudomonas) Viruses: RSV, rhinovirus, enterovirus, coronaviruses, flu, adenovirus, HMPV

10 Complica3ons Hearing loss Balance problems Cholesteatoma Mastoidi3s Intracranial complica3ons Infec3on: meningi3s, epidural/brain abscess Thrombosis: sinus, caro3d artery

11 Defini3ons AOM: rapid onset of inner ear inflamma3on Uncomplicated AOM: no otorrhea Severe AOM: moderate-to-severe otalgia OR fever 39 C (102.2 F) Nonsevere AOM: mild otalgia and temperature < 39 C (102.2 F) OME: OM with effusion, also called serous OM fluid in the middle ear without signs of infec3on

12 Diagnos3c Signs

13 Diagnosis

14 Diagnosis Normal! mild bulging + recent onset of ear pain moderate-tosevere bulging Dx AOM

15 Who to treat? All children with severe AOM unilateral or bilateral moderate-to-severe otalgia fever 39 C (102.2 F) Children younger than 24 months with BILATERAL nonsevere AOM mild otalgia temperature < 39 C (102.2 F)

16 Watch and Wait Children younger than 24 months with UNILATERAL nonsevere AOM mild otalgia temperature < 39 C (102.2 F) Children older than 2 years with nonsevere AOM unilateral or bilateral mild otalgia temperature < 39 C (102.2 F)

17 Treat vs Watch and Wait

18 Watch and Wait MUST have mechanism in place to provide treatment in hours if needed. WILL NOT increase complica3ons if there is appropriate follow-up. Reduces mul3drug resistant organisms. NOTE: con3nue to provide pain control in this group.

19 Treatment

20 Most Common Pathogens Streptococcus pneumoniae (~50%) Non-typeable Haemophilus influenzae (~45%) Moraxella catarrhalis (~10%) Other: GAS, Staph, anaerobes (Pseudomonas) Viruses: RSV, rhinovirus, enterovirus, coronaviruses, flu, adenovirus, HMPV

21 S pneumo Mechanism of resistance: penicillin-binding protein can be overwhelmed by satura3ng it with an3bio3c high-dose amoxicillin Drugs: high-dose amoxicillin: 84-92% efficacy in vitro cephalosporins: 70-80% efficacy in vitro

22 Nontypeable H flu Mechanism of resistance: beta-lactamase use beta-lactamase inhibitor amoxicillin-clavulanate Drugs: amoxicillin: 58% efficacy in vitro amoxicillin-clavulanate: 100% efficacy in vitro cephalosporins: 98% efficacy in vitro

23 M catarrhalis Mechanism of resistance: beta-lactamase use beta-lactamase inhibitor amoxicillin-clavulanate Very high rate of spontaneous clinical resolu3on Very rarely causes complica3ons

24 Treatment

25 Treatment 1 st -line: high-dose amoxicillin 2 nd -line: high-dose amoxicillin-clavulanate 3 rd -line: 3 rd -genera3on cephalosporin ± clindamycin

26 Treatment: First Episode of OM 1. high-dose amoxicillin (90 mg/kg/day twice daily) 2. Symptoms resolve. 3. Two weeks later, symptoms return. 4. What to use? 5. amoxicillin-clavulanate (90 mg/kg/day of amox component twice daily)

27 Treatment: Second Episode of OM 1. OM diagnosed day course of amoxicillin prescribed. 3. Symptoms resolved days a{er ini3al an3bio3c course started, symptoms return 5. What to use? 6. amoxicillin-clavulanate (90 mg/kg/day of amox component twice daily)

28 Treatment: First Episode of OM 1. high-dose amoxicillin (90 mg/kg/day twice daily) 2. No improvement hours later. 3. amoxicillin-clavulanate (90 mg/kg/day twice daily) 4. No improvement hours later. 5. clindamycin + 3 rd -genera3on cephalosporin 6. Refer to ENT.

29 Special Situa3ons O33s-conjunc3vi3s syndrome: commonly caused by nontypeable Haemophilus influenzae à may start with amoxicillinclavulanate.

30 And last Two Hot-Bufon Issues

31 Macrolides WARNING & DISCLAIMER: LESLIE HATES Z-PAKS. FDA-approved for the treatment of OM NOT recommended by the AAP or the AAFP for treatment of OM S pneumo: 25-35% resistance H flu: minimal efficacy

32 Penicillin Allergies NEVER TRUE ALLERGIES!! Highly over-reported. The literature consistently shows that only 10-20% of pa3ents who report a penicillin allergy have posi3ve skin tes3ng which does not equal anaphylaxis. Challenge the allergy!

33 References Lieberthal AS, et al. The Diagnosis and Management of Acute O33s Media. Pediatrics 2013; 131: e Bluestone CD. Epidemiology and pathogenesis of chronic suppura3ve o33s media: implica3ons for preven3on and treatment. Interna:onal Journal of Pediatric Otolaryngology 1998; 42: Curns AT, et al. Outpa3ent and Hospital Visits Associated With O33s Media Among American Indian and Alaska Na3ve Children Younger Than 5 Years. Pediatrics 2002; 109: e Singleton RJ, et al. Trends in O33s Media and Myringotomy With Tube Placement Among American Indian/Alaska Na3ve Children and the US General Popula3on of Children. The Pediatric Infec:ous Disease Journal 2009; 28(2): Klein JO, et al. Acute o33s media in children: Epidemiology, microbiology, clinical manifesta3ons, and complica3ons. Up-to-Date Online. 4/25/13. Accessed 6/16/13. Klein JO, et al. Acute o33s media in children: Treatment. Up-to-Date Online. 12/29/12. Accessed 6/16/13. Salkind AR, Cuddy PG, Foxworth JW. Is This Pa3ent Allergic to Penicillin? An Evidence-Based Analysis of the Likelihood of Penicillin Allergy. JAMA 2001; 285: Raja AS, et al. The Use of Penicillin Skin Tes3ng to Assess the Prevalence of Penicillin Allergy in an Emergency Department Seng. Annals of Emergency Medicine 2009; 54:

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