OIE Quality Standard for Veterinary Laboratories
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1 OIE Quality Standard for Veterinary Laboratories Peter Wright Fisheries & Oceans Canada Gulf Fisheries Centre New Brunswick, Canada Mark Robinson US Dept of Agriculture Nat l Institute for Food & Agriculture Washington, DC OIE OIE Collaborating Centre for for ELISA and and Molecular Techniques in in Animal Disease Diagnosis 2nd Global Conference, Paris, June
2 Why Quality Management? As a testing laboratory: Instil confidence & create acceptance Sound management Technical competence Validity of results 2nd Global Conference, Paris, June
3 Quality management in veterinary testing laboratories A good introduction to QMS Terrestrial Manual Chapter Aquatic Manual Chapter nd Global Conference, Paris, June
4 OIE Quality Standard for Veterinary Laboratories 1 st Edition nd Edition nd Global Conference, Paris, June
5 OIE Quality Standard and Guidelines for Veterinary Laboratories: Infectious Diseases OIE Standard for Management and Technical Requirements for Laboratories Conducting Tests for Infectious Diseases OIE Guide 1: Validation of diagnostic assays for infectious diseases OIE Guide 2: Validation and quality control of polymerase chain reaction methods used for the diagnosis of infectious diseases OIE Guide 3: International reference antibody standards for antibody assays OIE Guide 4: Laboratory proficiency testing Glossary of Terms 2nd Global Conference, Paris, June
6 A Brief Historical Perspective ISO/IEC Guide 25:1990 (3 rd Edition) ISO/IEC Guide 25 (Period of Transition) ISO/IEC 17025:1999 (1 st Edition) OIE Quality Standard (1 st Edition:2002) OIE Quality Standard (2 nd Edition:2008) ISO/IEC 17025:2005 (2 nd Edition) 2nd Global Conference, Paris, June
7 OIE Standard for Management and Technical Requirements for Laboratories Conducting Tests for Infectious Diseases ISO/IEC 17025: General requirements for the competence of testing and calibration laboratories OIE Standard represents an interpretation of the generally stated requirements of the ISO Standard OIE Standard may be used by accreditation bodies Labs in compliance with the OIE Standard also operate in accordance with the ISO Standard Unique to laboratories conducting tests for infectious animal diseases Special emphasis on Clause 5 - Technical requirements 2nd Global Conference, Paris, June
8 Clause 5 - Technical requirements 5.4 Test Methods General Relevance of the test method and test results to a specific diagnostic interpretation or application: Suitability or fitness for purpose Acceptability by scientific and regulatory communities Acceptability to the client / customer Feasibility given laboratory resources 2nd Global Conference, Paris, June
9 Clause 5 - Technical requirements 5.4 Test Methods Validation of test methods Validation according to the principles outlined in the OIE Manual of Diagnostic Tests and Vaccines for Terrestrial Animals Analytical sensitivity & specificity Precision & accuracy Diagnostic sensitivity & specificity Other parameters 2nd Global Conference, Paris, June
10 Validation of Diagnostic Tests Principles of validation of diagnostic assays for infectious diseases Combined into one document Validation and quality control of polymerase chain reaction methods used for diagnosis of infectious diseases Terrestrial Manual Chapters & 5 Aquatic Manual Chapters & 3 OIE Ad hoc Group on Validation of diagnostic assays 2nd Global Conference, Paris, June
11 OIE Validation and Certification of Diagnostic Assays Validation Pathway for Diagnostic Test Methods Stage 1 - Analytical characteristics (Bench) Stage 2 - Diagnostic characteristics (Field) Stage 3 - Reproducibility (Ruggedness) Stage 4 - Applications (Repertoire) 2nd Global Conference, Paris, June
12 If one of your goals is to become accredited, just remember The difference between try and triumph is a little umph. 2nd Global Conference, Paris, June
13 Standards, Guidelines & Templates OIE Validation and Certification of Diagnostic Assays 2nd Global Conference, Paris, June
14 Quality Management Credo Say what you do & do what you say! 2nd Global Conference, Paris, June
15 Has persistence been rewarded? "Challenges are what make life interesting; overcoming them is what makes life meaningful. - Mark Twain 2nd Global Conference, Paris, June
16 Adopted as a Benchmark by the AAVLD REQUIREMENTS FOR AN ACCREDITED VETERINARY MEDICAL DIAGNOSTIC LABORATORY AMERICAN ASSOCIATION OF VETERINARY LABORATORY DIAGNOSTICIANS, INC. Version 4.3 2nd Global Conference, Paris, June
17 Recognized for qualification by NAHLN A.1 Evaluation Criteria The NAHLN Steering Committee develops criteria for entry into and maintenance of all veterinary diagnostic laboratories in the NAHLN. If a decision is made to introduce a laboratory into the NAHLN in a state, the laboratory must first meet the following criteria: 4. Licensure/ certification - Must be an American Association of Veterinary Laboratory Diagnosticians (AAVLD) accredited laboratory or other public, notfor-profit, animal disease diagnostic laboratory with an established quality assurance system meeting OIE/ISO standards and selected by the USDA. Excerpt from: Policy Regarding Evaluation of Veterinary Diagnostic Laboratories for Membership in the National Animal Health Laboratory Network - Version 2.0 (Rev. August 25, 2008) NAHLN- A State and Federal Partnership to Safeguard Animal Health 2nd Global Conference, Paris, June
18 Incorporated into a Veterinary Specialty by A2LA American Association for Laboratory Accreditation PRESS RELEASE A2LA adds new Veterinary Accreditation Program requirements.. Veterinary laboratories world-wide may choose to meet the ISO/IEC 17025:2005, General requirements for the competence of testing and calibration laboratories as a stand-alone requirement for accreditation or the combined criteria of ISO/IEC 17025:2005 and the OIE Quality Standard and Guidelines for Veterinary Laboratories: Infectious Diseases, (excerpt) Contact Information: Matthew Torres American Association for Laboratory Accreditation (A2LA) Phone: mtorres@a2la.org Web: 12/08/2008 2nd Global Conference, Paris, June
19 "All our dreams can come true... if we have the courage..." Walt Disney The race for quality has no finish line so technically, it s more like an elusive dream 2nd Global Conference, Paris, June
20 Quality Management is Central & Essential QM impacts many lab activities: Diagnostic testing Research & development Information management Biocontainment & biosecurity Health & safety 2nd Global Conference, Paris, June
21 The End Questions? JOURNEY A bend in the road is not the end of the road... unless you fail to make the turn! 2nd Global Conference, Paris, June
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