Geoffrey Coombs 1, Graeme Nimmo 2, Julie Pearson 1, Samantha Cramer 1 and Keryn Christiansen 1
|
|
- Logan Dawson
- 6 years ago
- Views:
Transcription
1 Community Onset MRSA Infections in Australia: A Tale of Two Clones Geoffrey Coombs 1, Graeme Nimmo 2, Julie Pearson 1, Samantha Cramer 1 and Keryn Christiansen 1 Community Associated MRSA First isolated in the Kimberley region of WA (199) in the aboriginal population. ST-MRSA-IV (WA MRSA ) [PVL NEGATIVE] Udo EE et al (1993) J Hosp Infect 2, 97-1 Genetic analysis of community strains of methicillin-resistant Staphylococcus aureus in Western Australia 1 Department of Microbiology and Infectious Diseases PathWest Laboratory Medicine WA Royal Perth Hospital Division of Microbiology Pathology Queensland Central Laboratory Antimicrobial 21 Australian Society for Antimicrobials 2 th February 21 Auckland Region (via Western Samoa) (1992) ST3-MRSA-IV (WSPP) [PVL POSITIVE] World-wide dissemination of community MRSA Community Associated MRSA Papua New Guinea Asia Europe United Kingdom Ireland Canada United States of America Central America South America Community Associated MRSA Lack risk factors associated with healthcare-associated MRSA Skin and soft tissue infections in young people Laboratory Findings - Susceptible to most non-β-lactam antimicrobials - Very rapid growth times - Clone types different from healthcare-associated MRSA - SCCmec IV (V, VII, VIII) - Panton Valentine leukocidin (PVL) [lukf and luks genes] - Greater clonal diversity 1
2 Community Associated MRSA Western Australia Clonal Complex 1 Clonal Complex Clonal Complex 72 ST1-MRSA-IV (WA1) ST-MRSA-IV (WA) *ST72-MRSA-IV (WA) ST73-MRSA-V (WA1) *ST-MRSA-IV (USA3) *ST772-MRSA-V (WA6) ST-MRSA-IV (WA67) Clonal Complex 7 ST72-MRSA-IV (WA) ST-MRSA-IV (WA) ST7-MRSA-IV (WA) ST1-MRSA-IV (WA7) ST-MRSA-V (WA3) ST7-MRSA-IV (WA79) ST-MRSA-V (WA77) ST13-MRSA-IV (WA72) ST-MRSA-VIII (WA16) Clonal Complex ST76-MRSA-IV (WA31) Clonal Complex ST-MRSA-IV (WA3) ST69-MRSA-IV (WA19) *ST-MRSA-IV (Euro) ST-MRSA-IV (WA1) ST612-MRSA-IV (WA2) *ST3-MRSA-IV (WA17) ST-MRSA-IV (WA21) *ST923-MRSA-IV (WA62) ST72-MRSA-IV (WA3) *ST-MRSA-IV (WA6) ST1173-MRSA-IV (WA) ST-MRSA-IV (WA71) Clonal Complex ST-MRSA-IV (WA7) Clonal Complex 9 ST7-MRSA-IV (WA2) ST-MRSA-IV (WA2) ST3-MRSA-IV (WA13) ST2-MRSA-IV ST-MRSA-V (WA11) ST-MRSA-V (WA1) Clonal Complex 12 Clonal Complex 97 ST-MRSA-V (WA3) ST12-MRSA-IV (WA69) ST93-MRSA-IV (WA) ST-MRSA-V (WA3) ST12-MRSA-novel (WA9) ST117-MRSA-IV (WA63) ST-MRSA-V (WA1) ST-MRSA-V (WA) Clonal Complex 3 Clonal Complex 121 ST-MRSA-V (WA6) *ST3-MRSA-IV (WSPP) ST77-MRSA-V (WA22) ST-MRSA-V T (WA) ST39-MRSA-IV (WA6) ST6-MRSA-IV (WA1) Clonal Complex 1 ST6-MRSA-IV (WA66) Clonal Complex ST1-MRSA-IV (WA3) ST73-MRSA-IV (WA) ST-MRSA-IV (WA23) ST1-MRSA-IV (WA7) ST73-MRSA-IV (WA6) ST-MRSA-IV (WA7) ST26-MRSA-IV (WA39) ST-MRSA-V (WA) Clonal Comples 361 ST7-MRSA-IV (WA2) ST-MRSA-V (WA) ST361-MRSA-VIII (WA2) ST77-MRSA-V (WA22) ST61-MRSA-V (WA61) Clonal Complex 9 Clonal Complex 39 ST3-MRSA-IV (WA) ST9-MR SA-IV (WA-1) ST39-MRSA-V ST3-MRSA-V (WA6) *ST9-MRSA-IV (WA-) ST3-MRSA-novel (WA) *ST9-MRSA-IV (WA6) Clonal Complex 672 ST3-MRSA-V (WA7) ST9-MRSA-IV (WA73) ST672-MRSA-IV (WA29) *ST9-MRSA-V T (Taiwan) ST672-MRSA-V (WA7) Undefined Clonal Complex ST7-MRSA-IV (WA2) ST133-MRSA-IV (WA76) *ST92-MRSA-V (WA2) Singletons *ST93-MRSA-IV (Qld) ST3-MRSA-IV (WA7) Notifications /7/23 to 3/6/29 1 clones 19 clonal clusters 2 singletons Year SCCmec IV clones 23 SCCmec V clones 2 SCCmec VIII clones 2 novel SCCmec clones 13 *PVL positive clones Five major global community-associated MRSA clones ST-MRSA IV (European MRSA) ST9-MRSA-V T (Taiwan MRSA) ST-MRSA-IV (USA3) ST1-MRSA-IV (USA) ST3-MRSA-IV (Oceania MRSA) Panton-Valentine leucocidin (lukf/luksluks genes) POSITIVE () 2-2 () Percentage of Staphylococcus aureus Identified as MRSA 2 27 public teaching hospitals private laboratories % MRSA % 1.% 1.3% 16.% 1.% Each institution collected 1 consecutive clinically significant S aureus isolates from 1 different outpatients (exclude dialysis and day surgery patients) Year of Survey Significant increase from 2 to 2 (p <.1) 2
3 () Percentage of Staphylococcus aureus Identified as MRSA by Region 3 % of S aureus Qld NSW ACT Vic Tas SA WA NT Aust () and as a Percentage of S aureus % of S aureus All MRSA 2 Community S aureus Surveillance Programme 2 Community S aureus Surveillance Programme Box Plot of Age of Patients Infected with and and Acquisition by Decade of Life Mean: years Median: 3 years Mean: 69 years Median: 7 years 1% % 6% % 2% %
4 2 Community S aureus Surveillance Programme 2 Community S aureus Surveillance Programme Box Plot of Age of Patients Infected with PVL Positive and PVL Negative PVL Status by Decade of Life of Patients Infected with PVL Positive and PVL Negative 1% PVL NEG Mean: 3 years Median: 6 years PVL POS Mean: 33 years Median: 3 years % 6% % 2% % PVL NEG PVL POS 2 Community S aureus Surveillance Programme s [3 isolates consisting of 22 clones,62% of MRSA] s [27 isolates consisting of clones, 3% of MRSA] ST93-MRSA-IV (Qld MRSA) [1] ST22-MRSA-IV (EMRSA-1) [112] 2 Community S aureus Surveillance Programme Qld (ST93-MRSA MRSA-IV) 27.% of MRSA EMRSA-1 (ST22-MRSA-IV) 2.% of MRSA ST1-MRSA-IV (WA MRSA-1) [63] ST239-MRSA-II (Aus2 and Aus3 EMRSA) [93] ST1-MRSA-V [1] ST-MRSA-II (New York Japan MRSA or USA1 ) [1] ST-MRSA-IV (WA MRSA-3) [2] ST36-MRSA-II (EMRSA-16 or USA2) [1] ST73-MRSA-IV (WA MRSA-6) [] ST-MRSA-IV [1] ST-MRSA-V [2] ST-MRSA-IV (WA MRSA-) ST-MRSA-IV (USA3) [1] ST3-MRSA-IV (WA MRSA-13) [1] ST3-MRSA-IV (WSPP) 7] ST-MRSA-V (WA MRSA-) [2] ST-MRSA-V (WA MRSA-) [7] ST-MRSA-IV (WA MRSA-23) [2] ST9-MRSA-IV (WA MRSA-1) [2] ST9-MRSA-V (Taiwan ) [1] ST72-MRSA-IV (WA MRSA-) [2] ST13 MRSA-IV (WA MRSA-72) [1] ST7-MRSA.-V (WA MRSA-2) [1] ST-MRSA-IV (European ) [2] ST-MRSA-V [1] ST27-MRSA-V [1] First identified in Caucasian patients in Ipswich Queensland (Munckhof et al 23) - boils, bacteraemia, pneumonia Epidemic potential Substantial outbreaks (causing boils) in aboriginals living in rural NSW (Gosbell et al 2) Multiple reports of severe infections Including necrotising pneumonia (including fatal cases), deep abscesses, osteomyeltis, septic arthritis and bacteraemia First identified in the Midlands and South- East England in the early 199s Major clone in United Kingdom, Ireland, several European countries, New Zealand, Singapore and Australia First reported in Australia in 1997 (Pearman et al 199) In Western Australia frequently isolated from patients in long term care facilities and pre-employment screening of healthcare workers from Ireland and the United Kingdom
5 2 Community S aureus Surveillance Programme EMRSA-1 (ST22-MRSA-IV) 2.% of MRSA 2 Community S aureus Surveillance Programme EMRSA-1 (ST22-MRSA-IV) 2.% of MRSA Antibiogram: Ciprofloxacin R % Erythromycin R 9% Tetracycline R 1% Mupirocin R % Fusidic Acid R % Rifampicin R % Gentamicin R % Cotrimoxazole R 1% Clindamycin R 3% Antibiogram: Ciprofloxacin R 1% Erythromycin R 63% Tetracycline R 3% Mupirocin R <1% Fusidic Acid R <1% Rifampicin R % Gentamicin R % Cotrimoxazole R % Regional Distribution as a Percentage of MRSA <1% Australia: 27.% Australia: 2.% 1-% 6-1% 11-2% 33.3% 21-% % 1.7% >% 6.%.% 1.% 2.% 1.6% 32.% 32.9% Panton Valentine Leucocidin: Panton Valentine Leucocidin: ACT 7.1% 12.1% ACT 1.3% 19.2% Positive Negative %.% 2 Community S aureus Surveillance Programme Regional Distribution 2 2 7% EMRSA-1 (ST22-MRSA-IV) 2.% of MRSA 2 Community S aureus Surveillance Programme EMRSA-1 (ST22-MRSA-IV) 2.% of MRSA Percentage of Staphylococcus aureus 6% 2 2 % % 3% All MRSA All MRSA Qld NSW ACT Vic Tas SA 2% 1% WA NT Aust Qld NSW ACT Percentage of MRSA Vic Tas SA WA NT Aust Qld EMRSA (SAP22 data not available)
6 2 Community S aureus Surveillance Programme EMRSA-1 (ST22-MRSA-IV) 2.% of MRSA Summary Percentage of S aureus infections identified as MRSA increasing in the Australian community Number of Isolates per decade of life Decade of Life Decade of Life Although polyclonal this increase is primarily a tale of two clones 1% % 6% % 2% % Qld Clone (ST93-IV) UK EMRSA-1 (ST22-IV) WA 1 (ST1-IV) PVL Positive PVL Negative AUS 2 WSPP (ST3-IV) AUS 3 WA 3 (ST-IV) WA 2 (ST7-IV) USA3 (ST-IV) Acknowledgments Nadishani Liyanage Kathaluwa Department of Microbiology and Infectious Diseases Gram-positive Bacteria Typing and Research Unit PathWest Royal Perth Hospital Frances O Brien Molecular Genetics Research Unit, Curtin University of Technology Lottery West State Biomedical Facility: Genomics, Dept of Clinical Immunology and Immunogenetics, Royal Perth Hospital. PathWest Laboratory Medicine - WA Australian Group for Antimicrobial Resistance () Australian Government Department of Health and Ageing 6
Staphylococcus aureus Programme 2007 (SAP 2007) Hospital Survey MRSA Epidemiology and Typing Report
AGAR The Australian Group on Antimicrobial Resistance http://antimicrobial-resistance.com Staphylococcus aureus Programme 2007 (SAP 2007) Hospital Survey MRSA Epidemiology and Typing Report PREPARED BY:
More informationEpidemiology of MRSA in Australia
Epidemiology of MRSA in Australia Graeme R Nimmo Director, Division of Microbiology Pathology Queensland Central Laboratory, Herston QLD 429 Tel: (7) 3636 8 Fax: (7) 3636 1336 Email: Graeme_Nimmo@health.
More informationStaphylococcus aureus Programme 2012 (SAP 2012) Community Survey MRSA Epidemiology and Typing Report
Staphylococcus aureus Programme 2012 (SAP 2012) Community Survey MRSA Epidemiology and Typing Report PREPARED BY: Dr Geoffrey Coombs Department of Microbiology and Infectious Diseases, PathWest Laboratory
More informationSurveillance Programme annual report, Abstract
Community-onset Staphylococcus aureus Surveillance Programme, 2012 Community-onset Staphylococcus aureus Surveillance Programme annual report, 2012 Geoffrey W Coombs, Denise A Daley, Julie C Pearson, Graeme
More informationAnnual survey of methicillin-resistant Staphylococcus aureus (MRSA), 2008
Annual survey of methicillin-resistant Staphylococcus aureus (MRSA), 2008 Each year ESR conducts a one-month survey of methicillin-resistant Staphylococcus aureus (MRSA) to provide ongoing information
More informationaureus isolated from hospital inpatients, 2009:
Antibiotic susceptibility of Staphylococcus aureus, 2009 Antimicrobial susceptibility of Staphylococcus aureus isolated from hospital inpatients, 2009: Report from the Australian Group on Antimicrobial
More informationStaphylococcus aureus Programme 2008 (SAP 2008) Community Survey Antimicrobial Susceptibility Report
AGAR The Australian Group on Antimicrobial Resistance http://antimicrobial-resistance.com Staphylococcus aureus Programme 2008 (SAP 2008) Community Survey Antimicrobial Susceptibility Report PREPARED BY:
More informationCommunity-onset Staphylococcus aureus infections presenting to general practices in South-eastern Australia
Epidemiol. Infect. (2014), 142, 501 511. Cambridge University Press 2013 doi:10.1017/s0950268813001581 Community-onset Staphylococcus aureus infections presenting to general practices in South-eastern
More informationMethicillin-resistant Staphylococcus aureus in the Australian community: an evolving epidemic
Methicillin-resistant Staphylococcus aureus in the Australian community: an evolving epidemic Graeme R Nimmo, Geoffrey W Coombs, Julie C Pearson, Francis G O'Brien, Keryn J Christiansen, John D Turnidge,
More informationAnnual reports AGAR Hospital-onset Staphylococcus aureus Surveillance Programme, 2011
Annual reports AGAR -onset Staphylococcus aureus Surveillance Programme, 2011 AGAR -onset Staphylococcus aureus Surveillance Programme, 2011 Australian Group on Antimicrobial Resistance -onset Staphylococcus
More informationStaphylococcus aureus Down Under : contemporary epidemiology of S. aureus in Australia, New Zealand, and the South West Pacific
REVIEW 10.1111/1469-0691.12702 Staphylococcus aureus Down Under : contemporary epidemiology of S. aureus in Australia, New Zealand, and the South West Pacific D. A. Williamson 1,2, G. W. Coombs 3,4 and
More informationAbstract. Australian Staphylococcus aureus Sepsis Outcome Programme, 2013 Australian Staphylococcus aureus Sepsis. Introduction
Australian Staphylococcus aureus Sepsis Outcome Programme, 2013 Australian Staphylococcus aureus Sepsis Outcome Programme annual report, 2013 Geoffrey W Coombs, Graeme R Nimmo, Denise A Daley, Tam T Le,
More informationStaphylococcus aureus Programme 2006 (SAP 2006) Community Survey Antimicrobial Susceptibility Report
AGAR The tralian Group on Antimicrobial Resistance ://antimicrobial-resistance.com Staphylococcus aureus Programme 2006 (P 2006) Community Survey Antimicrobial Susceptibility Report PREPARED BY: Associate
More informationAnnual survey of methicillin-resistant Staphylococcus aureus (MRSA), 2015
Annual survey of methicillin-resistant Staphylococcus aureus (MRSA), 2015 Helen Heffernan and Sarah Bakker Nosocomial Infections Laboratory, Institute of Environmental Science and Research Limited (ESR);
More informationPVL Staph aureusjust a skin/soft tissue problem? Layla Mohammadi Lead Pharmacist, Antimicrobials Lewisham Healthcare NHS Trust
PVL Staph aureusjust a skin/soft tissue problem? Layla Mohammadi Lead Pharmacist, Antimicrobials Lewisham Healthcare NHS Trust Neonatal Case History Neonate born at 26 +2 gestation Spontaneous onset of
More informationAnnual survey of methicillin-resistant Staphylococcus aureus (MRSA), 2014
Annual survey of methicillin-resistant Staphylococcus aureus (MRSA), 2014 Helen Heffernan, Sarah Bakker, Kristin Dyet, Deborah Williamson Nosocomial Infections Laboratory, Institute of Environmental Science
More informationCA-MRSA a new problem in Indonesia?
CA-MRSA a new problem in Indonesia? Latre Buntaran Clinical Microbiologist Consultant Indonesia Coordinator of ANSORP Study Secretary General of INASIC Community Associated MRSA Papua New Guinea Asia Europe
More informationMethicillin-Resistant Staphylococcus aureus
Methicillin-Resistant Staphylococcus aureus By Karla Givens Means of Transmission and Usual Reservoirs Staphylococcus aureus is part of normal flora and can be found on the skin and in the noses of one
More informationCa-MRSA Update- Hand Infections. Washington Hand Society September 19, 2007
Ca-MRSA Update- Hand Infections Washington Hand Society September 19, 2007 Resistant Staph. Aureus Late 1940 s -50% S.Aureus resistant to PCN 1957-80/81 strain- of S.A. highly virulent and easily transmissible
More informationStaphylococcus aureus Bacteremia, Australia
RESEARCH Staphylococcus aureus Bacteremia, Australia Peter Collignon,* Graeme R. Nimmo, Thomas Gottlieb, and Iain B. Gosbell, on behalf of the Australian Group on Antimicrobial Resistance 1 Staphylococcus
More informationPopulation dynamics of methicillin-susceptible and -resistant Staphylococcus aureus in remote communities
Journal of Antimicrobial Chemotherapy (2009) 64, 684 693 doi:10.1093/jac/dkp285 Advance Access publication 27 August 2009 Population dynamics of methicillin-susceptible and -resistant Staphylococcus aureus
More informationAnnual reports Australian Staphylococcus aureus Sepsis Outcome Programme, 2014
Australian Staphylococcus aureus Sepsis Outcome Programme, 2014 Australian Group on Antimicrobial Resistance Australian Staphylococcus aureus Sepsis Outcome Programme annual report, 2014 Geoffrey W Coombs,
More informationSafe Patient Care Keeping our Residents Safe Use Standard Precautions for ALL Residents at ALL times
Safe Patient Care Keeping our Residents Safe 2016 Use Standard Precautions for ALL Residents at ALL times #safepatientcare Do bugs need drugs? Dr Deirdre O Brien Consultant Microbiologist Mercy University
More informationStaphylococcus aureus
The National Reference Centre (NRC) for S. aureus of Université Libre de Bruxelles (ULB) provides the following tasks: - Identification and antimicrobial susceptibility testing of Staphylococcus sp. strains
More informationCHAPTER 1 INTRODUCTION
1 CHAPTER 1 INTRODUCTION The Staphylococci are a group of Gram-positive bacteria, 14 species are known to cause human infections but the vast majority of infections are caused by only three of them. They
More informationSource: Portland State University Population Research Center (
Methicillin Resistant Staphylococcus aureus (MRSA) Surveillance Report 2010 Oregon Active Bacterial Core Surveillance (ABCs) Office of Disease Prevention & Epidemiology Oregon Health Authority Updated:
More informationResearch Article Genotyping of Methicillin Resistant Staphylococcus aureus Strains Isolated from Hospitalized Children
International Pediatrics, Article ID 314316, 4 pages http://dx.doi.org/10.1155/2014/314316 Research Article Genotyping of Methicillin Resistant Staphylococcus aureus Strains Isolated from Hospitalized
More informationNational MRSA Reference Laboratory
Author: Gráinne Brennan Date: 23/02/2017 Date of Issue: 23/02/2017 National MRSA Reference Laboratory User s Manual NMRSARL Users Manual Page 1 of 12 Table of Contents Page 1. Location... 3 2. Contact
More informationHelen Heffernan and Sarah Bakker Nosocomial Infections Laboratory, Institute of Environmental Science and Research Limited (ESR); October 2018
2017 survey of methicillin-resistant Staphylococcus aureus (MRSA) Helen Heffernan and Sarah Bakker Nosocomial Infections Laboratory, Institute of Environmental Science and Research Limited (ESR); October
More informationAntimicrobial Use and Resistance in Australia
Antimicrobial Use and Resistance in Australia John Turnidge Senior Medical Advisor, ACSQHC Funding from July 2013 to June 2016 to establish antimicrobial resistance surveillance in Australia The National
More informationBacterial whole genome sequencing in clinical microbiology, infection control and public health. Julian Parkhill. FIS, Birmingham, November 2013
Bacterial whole genome sequencing in clinical microbiology, infection control and public health Julian Parkhill FIS, Birmingham, November 2013 Falling costs of genomics 2003 Cost/genome Throughput 60,000
More informationCommunity-associated methicillin-resistant Staphylococcus aureus infections
British Medical Bulletin Advance Access published April 1, 2010 Community-associated methicillin-resistant Staphylococcus aureus infections Fiona J. Cooke and Nicholas M. Brown * Clinical Microbiology
More informationStaphylococcus aureus and Health Care associated Infections
Staphylococcus aureus and Health Care associated Infections Common - but poorly measured Prof Peter Collignon The Canberra Hospital Australian National University What are health-care associated infections?
More informationPREVALENCE OF ANTIMICROBIAL RESISTANCE IN ENTEROCOCCUS ISOLATES IN AUSTRALIA, 2005:
PREVALENCE OF ANTIMICROBIAL RESISTANCE IN ENTEROCOCCUS ISOLATES IN AUSTRALIA, 25: REPORT FROM THE AUSTRALIAN GROUP ON ANTIMICROBIAL RESISTANCE Keryn J Christiansen, John D Turnidge, Jan M Bell, Narelle
More informationAntimicrobial Resistance and Molecular Epidemiology of Staphylococcus aureus in Ghana
Antimicrobial Resistance and Molecular Epidemiology of Staphylococcus aureus in Ghana Beverly Egyir, PhD Noguchi Memorial Institute for Medical Research Bacteriology Department, University of Ghana Background
More informationEuropean Antimicrobial Resistance Surveillance System (EARSS) in Scotland: 2004
European Antimicrobial Resistance Surveillance System (EARSS) in Scotland: 2004 SECOND ANNUAL REPORT MJ Coyne 1, SJ Dancer 1, G Edwards 2, 3, D Morrison 2. 1 Health Protection Scotland, 2 Scottish MRSA
More informationStaphylococcus aureus
Staphylococcus aureus Significant human pathogen. SSTI Biomaterial related infections Osteomyelitis Endocarditis Toxin mediated diseases TSST Staphylococcal enterotoxins Quintessential Pathogen? Nizet
More informationSignificant human pathogen. SSTI Biomaterial related infections Osteomyelitis Endocarditis Toxin mediated diseases TSST Staphylococcal enterotoxins
Staphylococcus aureus Significant human pathogen. SSTI Biomaterial related infections Osteomyelitis Endocarditis Toxin mediated diseases TSST Staphylococcal enterotoxins Quintessential Pathogen? Nizet
More informationMRSA Outbreak in Firefighters
MRSA Outbreak in Firefighters Angie Carranza Munger, MD Resident, Occupational and Environmental Medicine The University of Colorado, Denver and National Jewish Health Candidate, Masters of Public Health
More information"What's new in Infectious skin diseases"
"What's new in Infectious skin diseases" Prof. Dr. med. Kathrin Mühlemann Dep. of Infectious Diseases, Inselspital Institute for Infectious Diseases, University of Bern Disclosure Educational Grant with
More informationPrevalence & Risk Factors For MRSA. For Vets
For Vets General Information Staphylococcus aureus is a Gram-positive, aerobic commensal bacterium of humans that is carried in the anterior nares of approximately 30% of the general population. It is
More informationCommunity-Associated Methicillin-Resistant Staphylococcus aureus: Epidemiology and Clinical Consequences of an Emerging Epidemic
CLINICAL MICROBIOLOGY REVIEWS, July 2010, p. 616 687 Vol. 23, No. 3 0893-8512/10/$12.00 doi:10.1128/cmr.00081-09 Copyright 2010, American Society for Microbiology. All Rights Reserved. Community-Associated
More informationEpidemiology of community MRSA obtained from the UK West Midlands region.
Epidemiology of community MRSA obtained from the UK West Midlands region. J. Rollason a, L. Bastin b, A. C. Hilton a, D. G. Pillay c, T. Worthington a, C. Mckeon c, P. De c, K. Burrows c and P. A. Lambert
More information2015 Antimicrobial Susceptibility Report
Gram negative Sepsis Outcome Programme (GNSOP) 2015 Antimicrobial Susceptibility Report Prepared by A/Professor Thomas Gottlieb Concord Hospital Sydney Jan Bell The University of Adelaide Adelaide On behalf
More informationLA-MRSA in the Netherlands: the past, presence and future.
LA-MRSA in the Netherlands: the past, presence and future. Prof. Jaap Wagenaar DVM, PhD With input from Prof. Jan Kluytmans MD, PhD Department of Infectious Diseases and Immunology, Faculty of Veterinary
More informationMRSA in the United Kingdom status quo and future developments
MRSA in the United Kingdom status quo and future developments Dietrich Mack Chair of Medical Microbiology and Infectious Diseases The School of Medicine - University of Wales Swansea P R I F Y S G O L
More informationAntimicrobial Resistance and Papua New Guinea WHY is it important? HOW has the problem arisen? WHAT can we do?
Antimicrobial Resistance and Papua New Guinea WHY is it important? HOW has the problem arisen? WHAT can we do? John Ferguson, John Hunter Hospital, University of Newcastle, NSW, Australia Infectious Diseases
More informationMicrobiological Surveillance of Methicillin Resistant Staphylococcus aureus (MRSA) in Belgian Hospitals in 2003
Microbiological Surveillance of Methicillin Resistant Staphylococcus aureus (MRSA) in Belgian Hospitals in 3 Final report Olivier Denis and Marc J. Struelens Reference Laboratory for Staphylococci Department
More informationAntimicrobial Resistance Trends in the Province of British Columbia. August Epidemiology Services British Columbia Centre for Disease Control
Antimicrobial Resistance Trends in the Province of British Columbia August 2008 Epidemiology Services British Columbia Centre for Disease Control 5 Table of Contents Executive Summary...5 Objective...6
More informationDr Nata Menabde Executive Director World Health Organization Office at the United Nations Global action plan on antimicrobial resistance
Global action plan on antimicrobial resistance Dr Nata Menabde Executive Director World Health Organization Office at the United Nations Proportion of MDR among previously treated TB cases, 1994-2010 0-
More informationSCOTTISH MRSA REFERENCE LABORATORY
Title SCOTTISH MRSA REFERENCE LABORATORY LABORATORY PROCEDURE NUMBER / VERSION User Manual DATE OF ISSUE 17/05/2014 REVIEW INTERVAL AUTHORISED BY AUTHOR 2 Years Dr. B. Jones B. Cosgrove COPY 1 of 1 Master
More informationDoxycycline staph aureus
Search Search Doxycycline staph aureus Mercer infection is the one of the colloquial terms given for MRSA (Methicillin-Resistant Staphylococcus Aureus ) infection. Initially, Staphylococcal resistance
More informationChanging epidemiology of methicillin-resistant Staphylococcus aureus colonization in paediatric intensive-care units
Washington University School of Medicine Digital Commons@Becker Open Access Publications 2012 Changing epidemiology of methicillin-resistant Staphylococcus aureus colonization in paediatric intensive-care
More informationConsequences of Antimicrobial Resistant Bacteria. Antimicrobial Resistance. Molecular Genetics of Antimicrobial Resistance. Topics to be Covered
Antimicrobial Resistance Consequences of Antimicrobial Resistant Bacteria Change in the approach to the administration of empiric antimicrobial therapy Increased number of hospitalizations Increased length
More informationMID 23. Antimicrobial Resistance. Consequences of Antimicrobial Resistant Bacteria. Molecular Genetics of Antimicrobial Resistance
Antimicrobial Resistance Molecular Genetics of Antimicrobial Resistance Micro evolutionary change - point mutations Beta-lactamase mutation extends spectrum of the enzyme rpob gene (RNA polymerase) mutation
More informationAntimicrobial Resistance
Antimicrobial Resistance Consequences of Antimicrobial Resistant Bacteria Change in the approach to the administration of empiric antimicrobial therapy Increased number of hospitalizations Increased length
More informationAntimicrobial Resistance Acquisition of Foreign DNA
Antimicrobial Resistance Acquisition of Foreign DNA Levy, Scientific American Horizontal gene transfer is common, even between Gram positive and negative bacteria Plasmid - transfer of single or multiple
More informationEpidemiology of human MRSA in Europe and public health importance of animal strains
Epidemiology of human MRSA in Europe and public health importance of animal strains Carl Suetens, ECDC, 08/04/2008 ecdc.europa.eu Why was ECDC established? Emerging and re-emerging communicable diseases
More informationMethicillin Resistant Staphylococcus aureus:
Methicillin Resistant Staphylococcus aureus: Action-Oriented Guidance for Community-Based Prevention Jackie Dawson, PhD Public Health Epidemiologist Chelan, Douglas, Grant, Kittitas, & Okanogan Counties
More informationWHO s first global report on antibiotic resistance reveals serious, worldwide threat to public health
New WHO report provides the most comprehensive picture of antibiotic resistance to date, with data from 114 countries 30 APRIL 2014 GENEVA - A new report by WHO its first to look at antimicrobial resistance,
More informationAbstract. Introduction. Editor: M. Paul
ORIGINAL ARTICLE BACTERIOLOGY Knowing prior methicillin-resistant Staphylococcus aureus (MRSA) infection or colonization status increases the empirical use of glycopeptides in MRSA bacteraemia and may
More informationSkin & Soft Tissue Infections (SSTI) Skin & Soft Tissue Infections. Skin & Soft Tissue Infections (SSTI)
Skin & Soft Tissue Infections (SSTI) Skin & Soft Tissue Infections 2007 Abscess Cellulitis Bradley W Frazee, MD, FACEP Dept of Emergency Medicine Alameda County Medical Center - Highland Hospital Associate
More informationTyping of Methicillin Resistant Staphylococcus Aureus Using DNA Fingerprints by Pulsed-field Gel Electrophoresis
Published online: 16/07/2016 Published print:08/2016 ORIGINAL PAPER Typing of Methicillin Resistant Staphylococcus Aureus Using DNA Fingerprints by Pulsed-field Gel Electrophoresis Velma Rebic 1, Ana Budimir
More informationEDUCATIONAL COMMENTARY - Methicillin-Resistant Staphylococcus aureus: An Update
EDUCATIONAL COMMENTARY - Methicillin-Resistant Staphylococcus aureus: An Update Educational commentary is provided through our affiliation with the American Society for Clinical Pathology (ASCP). To obtain
More informationMethicillin-resistant Staphylococcus aureus (MRSA) on Belgian pig farms
Methicillinresistant Staphylococcus aureus (MRSA) on Belgian pig farms Dewaele I., De Man I., Stael A., Delputte P., Butaye P., Vlaemynck G., Herman L., Heyndrickx M., Rasschaert G. 1 ILVO: Institute for
More informationCampylobacter infections in EU/EEA and related AMR
Campylobacter infections in EU/EEA and related AMR Therese Westrell, ECDC EURL Campylobacter workshop, Uppsala, Sweden, 9 October 2018 Zoonoses Zoonotic infections in the EU, 2016 Campylobacteriosis (N
More information(Accepted 27 November 2009; first published online 22 January 2010)
Epidemiol. Infect. (2010), 138, 730 737. f Crown Copyright. Published by Cambridge University Press 2010 doi:10.1017/s0950268809991488 A comparison of risk factors associated with community-associated
More informationHealthcare-associated Infections Annual Report December 2018
December 2018 Healthcare-associated Infections Annual Report 2011-2017 TABLE OF CONTENTS INTRODUCTION... 1 METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS INFECTIONS... 2 MRSA SURVEILLANCE... 3 CLOSTRIDIUM
More informationGlobal Status of Antimicrobial Resistance with a Focus on Nepal
Global Status of Antimicrobial Resistance with a Focus on Nepal John Ferguson, John Hunter Hospital, University of Newcastle, NSW, Australia Infectious Diseases Physician and Medical Microbiologist SIMON
More informationMulti-drug resistant Acinetobacter (MDRA) Surveillance and Control. Alison Holmes
Multi-drug resistant Acinetobacter (MDRA) Surveillance and Control Alison Holmes The organism and it s epidemiology Surveillance Control What is it? What is it? What is it? What is it? Acinetobacter :
More informationSpread of a methicillin-resistant Staphylococcus aureus ST80 strain in the community of the northern Netherlands
Eur J Clin Microbiol Infect Dis (2007) 26:723 727 DOI 10.1007/s10096-007-0352-y CONCISE ARTICLE Spread of a methicillin-resistant Staphylococcus aureus ST80 strain in the community of the northern Netherlands
More informationThe Australian Group on Antimicrobial Resistance Enterococcus spp Survey 2005 Antimicrobial Susceptibility Report
AGAR The Australian Group on Antimicrobial Resistance http://antimicrobial-resistance.com Enterococcus spp Survey 2005 Antimicrobial Susceptibility Report A/Professor Keryn Christiansen Head of Department
More informationWhat do we know about multidrug resistant bacteria in New Zealand s pet animals?
What do we know about multidrug resistant bacteria in New Zealand s pet animals? Eve Pleydell Animal and Marine Biosecurity Response Team, Ministry for Primary Industries Formerly: Institute of Veterinary,
More informationRCH antibiotic susceptibility data
RCH antibiotic susceptibility data The following represent RCH antibiotic susceptibility data from 2008. This data is used to inform antibiotic guidelines used at RCH. The data includes all microbiological
More informationThe Australian Group on Antimicrobial Resistance. Enterococcus species Survey 2009 Antimicrobial Susceptibility Report
AGAR The Australian Group on Antimicrobial Resistance http://www.antimicrobial-resistance.com Enterococcus species Survey 2009 Antimicrobial Susceptibility Report Clinical Professor Keryn Christiansen
More informationOpening the Gates for Farmer Health National Center for Farm Health October 13, 2010
MRSA, MRSA, MRSA!!! An emerging infectious epidemic in people from livestock??? Kelley J Donham DVM Tara Smith PhD Abby Harper-Maples MPH Dwight Ferguson MS Kerry Leedom-Larson DVM, MPH, PhD Opening the
More informationSCOTTISH MRSA REFERENCE LABORATORY
Title SCOTTISH MRSA REFERENCE LABORATORY LABORATORY PROCEDURE NUMBER / VERSION User Manual DATE OF ISSUE 20/01/2017 REVIEW INTERVAL AUTHORISED BY AUTHOR 1 Year Dr. B. Jones Dr E. Dickson COPY 1 of 1 Master
More informationNorth West Neonatal Operational Delivery Network Working together to provide the highest standard of care for babies and families
Document Title and Reference : Guideline for the management of multi-drug resistant organisms (MDRO) Main Author (s) Simon Power Ratified by: GM NSG Date Ratified: February 2012 Review Date: March 2017
More informationClinical Guideline. District Infectious Diseases Management. Go to Guideline. District Infectious Diseases Management CG 18_24
Clinical Guideline District Infectious Diseases Management Sites where Clinical Guideline applies All facilities This Clinical Guideline applies to: 1. Adults Yes 2. Children up to 16 years Yes 3. Neonates
More informationCellulitis. Assoc Prof Mark Thomas. Conference for General Practice Auckland Saturday 28 July 2018
Cellulitis Assoc Prof Mark Thomas Conference for General Practice Auckland Saturday 28 July 2018 Summary Cellulitis Usual treatment flucloxacillin for 5 days Frequent recurrences consider penicillin 250mg
More informationThe Australian Group on Antimicrobial Resistance. Enterococcus species Survey 2007 Antimicrobial Susceptibility Report
AGAR The Australian Group on Antimicrobial Resistance http://www.antimicrobial-resistance.com Enterococcus species Survey 2007 Antimicrobial Susceptibility Report Clinical Professor Keryn Christiansen
More informationHealth Service Executive Parkgate St. Business Centre, Dublin 8 Tel:
Health Service Executive Parkgate St. Business Centre, Dublin 8 Tel: 01 635 2500 www.hse.ie Health Service Executive Oak House, Millennium Park, Naas, Co. Kildare Tel: 045 880 400 www.hse.ie The prevention
More informationHong-Kai Wang 1, Chun-Yen Huang 1 and Yhu-Chering Huang 1,2*
Wang et al. BMC Infectious Diseases (2017) 17:470 DOI 10.1186/s12879-017-2560-0 RESEARCH ARTICLE Open Access Clinical features and molecular characteristics of childhood communityassociated methicillin-resistant
More informationConcise Antibiogram Toolkit Background
Background This toolkit is designed to guide nursing homes in creating their own antibiograms, an important tool for guiding empiric antimicrobial therapy. Information about antibiograms and instructions
More informationCharacteristics of community- and hospitalacquired meticillin-resistant Staphylococcus aureus strains carrying SCCmec type IV isolated in Malaysia
Journal of Medical Microbiology (2009), 58, 1213 1218 DOI 10.1099/jmm.0.011353-0 Characteristics of community- and hospitalacquired meticillin-resistant Staphylococcus aureus strains carrying SCCmec type
More informationAntibacterial Resistance In Wales
A Report from Public Health Wales Antimicrobial Resistance Programme Surveillance Unit: Antibacterial Resistance In Wales 2005-2012 Authors: Maggie Heginbothom Robin Howe & Catherine Thomas Version: 1
More informationMolecular Characterization of Staphylococcus aureus Isolates from a Contemporary (2005) ACCEPTED
AAC Accepts, published online ahead of print on 18 June 2007 Antimicrob. Agents Chemother. doi:10.1128/aac.01588-06 Copyright 2007, American Society for Microbiology and/or the Listed Authors/Institutions.
More informationHow is Ireland performing on antibiotic prescribing?
European Antibiotic Awareness Campaign 2016 November Webinar Series on Antibiotic Prescribing How is Ireland performing on antibiotic prescribing? Dr Rob Cunney National Clinical Lead HCAI AMR Clinical
More informationAntibacterial Resistance In Wales
A Report from Public Health Wales Antimicrobial Resistance Programme Surveillance Unit: Antibacterial Resistance In Wales 2005-2013 Authors: Maggie Heginbothom and Robin Howe Version: 1 Antibacterial Resistance
More informationInfections caused by Methicillin-Resistant Staphylococcus
MRSA infections are no longer limited to hospitals. An infectious disease specialist offers insight on what this means for dermatologists. By Robert S. Jones, DO, Reading, PA Infections caused by Methicillin-Resistant
More informationGUIDE TO INFECTION CONTROL IN THE HOSPITAL
GUIDE TO INFECTION CONTROL IN THE HOSPITAL CHAPTER 43: Staphylococcus Aureus Authors J. Pierce, MD M. Edmond, MD, MPH, MPA M.P. Stevens, MD, MPH Chapter Editor Michelle Doll, MD, MPH) Topic Outline Key
More informationThe molecular epidemiology of methicillin-resistant Staphylococcus aureus (MRSA) in the major countries of East Asia
Boston University OpenBU Theses & Dissertations http://open.bu.edu Boston University Theses & Dissertations 2017 The molecular epidemiology of methicillin-resistant Staphylococcus aureus (MRSA) in the
More informationSUPPLEMENT ARTICLE. S114 CID 2001:32 (Suppl 2) Diekema et al.
SUPPLEMENT ARTICLE Survey of Infections Due to Staphylococcus Species: Frequency of Occurrence and Antimicrobial Susceptibility of Isolates Collected in the United States, Canada, Latin America, Europe,
More informationDeborah A. Williamson 1,2,3 *, Sally A. Roberts 2, Stephen R. Ritchie 1, Geoffrey W. Coombs 4,5, John D. Fraser 1, Helen Heffernan 3.
Clinical and Molecular Epidemiology of Methicillin- Resistant Staphylococcus aureus in New Zealand: Rapid Emergence of Sequence Type 5 (ST5)-SCCmec-IV as the Dominant Community-Associated MRSA Clone Deborah
More informationMonitoring gonococcal antimicrobial susceptibility
Monitoring gonococcal antimicrobial susceptibility The rapidly changing antimicrobial susceptibility of Neisseria gonorrhoeae has created an important public health problem. Because of widespread resistance
More informationAntimicrobial Resistance
Antimicrobial Resistance Consequences of Antimicrobial Resistant Bacteria Change in the approach to the administration of Change in the approach to the administration of empiric antimicrobial therapy Increased
More informationThe UK 5-year AMR Strategy - a brief overview - Dr Berit Muller-Pebody National Infection Service Public Health England
The UK 5-year AMR Strategy - a brief overview - Dr Berit Muller-Pebody National Infection Service Public Health England Chief Medical Officer - Annual Report 2013 Antimicrobial resistance poses catastrophic
More informationJ M e d A l l i e d S c i ; 6 ( 2 ) : w w w. j m a s. i n. P r i n t I S S N : O n l i n e I S S N : X
J M e d A l l i e d S c i 2 0 1 6 ; 6 ( 2 ) : 5 6-6 0 w w w. j m a s. i n P r i n t I S S N : 2 2 3 1 1 6 9 6 O n l i n e I S S N : 2 2 3 1 1 7 0 X Journal of M e d i cal & Allied Sciences Original article
More informationStaphylococcus aureus
The National Reference Centre (NRC) for S. aureus of Université Libre de Bruxelles (ULB) provides the following tasks: - Identification and antimicrobial susceptibility testing of Staphylococcus sp. strains
More information