Nystatin apollo

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1 Nystatin apollo Nystatin apollo Nystatin CAS Number : Molecular Weight : g/mol Molecular Formula : C47H75NO17 Systematic (IUPAC) : (21E,23E,25E,27E,31E,33E)- 20-{[(3S,4S,5S,6R)-4-amino-3,5-dihydroxy-6- methyloxan-2-yl]oxy}-4,6,8,11,12,16,18,36-octahydroxy- 35,37,38-trimethyl-2,14-dioxo-1-oxacyclooctatriaconta- 21,23,25,27,31,33-hexaene-17-carboxylic acid Type : small molecule

2 Description : Nystatin is a polyene antifungal drug to which many molds and yeasts are sensitive, including Candida spp. Nystatin has some toxicity associated with it when given intravenously, but it is not absorbed across intact skin or mucous membranes. It is considered a relatively safe drug for treating oral or gastrointestinal fungal infections. Categories Anti-Bacterial Agents Antifungal Agents Ionophores Taxonomy Kingdom : Organic Classes : Aminoglycosides Substructures Carboxylic Acids and Derivatives Aminoglycosides Hydroxy Compounds Alkanes and Alkenes Pyrans Acetates Acetals and Derivatives Lactones Aliphatic and Aryl Amines Ethers Amino Alcohols Alcohols and Polyols

3 Heterocyclic compounds Ketones Pharmacology Indication : For treatment of cutaneous or mucocutaneous mycotic infections caused by Candida species Pharmacodynamics : Nystatin is an antibiotic which is both fungistatic and fungicidal in vitro against a wide variety of yeasts and yeast-like fungi, including Candida albicans, C. parapsilosis, C. tropicalis, C. guilliermondi, C. pseudotropicalis, C. krusei,torulopsis glabrata, Tricophyton rubrum, T. mentagrophytes. Nystatin acts by binding to sterols in the cell membrane of susceptible species resulting in a change in membrane permeability and the subsequent leakage of intracellular components. On repeated subculturing with increasing levels of nystatin, Candida albicans does not develop resistance to nystatin. Generally, resistance to nystatin does not develop during therapy. However, other species of Candida (C. tropicalis, C. guilliermondi, C. krusei, and C. stellatoides) become quite resistant on treatment with nystatin and simultaneously become cross resistant to amphotericin as well. This resistance is lost when the antibiotic is removed. Nystatin exhibits no appreciable activity against bacteria, protozoa, or viruses. Mechanism of action : Nystatin exerts its antifungal activity by binding to ergosterol found in fungal cell membranes. Binding to ergosterol causes the formation

4 of pores in the membrane. Potassium and other cellular constituents leak from the pores causing cell death. Absorption : Nystatin is not absorbed from intact skin or mucous membrane. Affected organisms : Fungi Uses This medication is used to treat fungal infections of the mouth. Nystatin is an antifungal that works by stopping the growth of fungus.nystatin suspension should not be used to treat fungal infections of the blood. How To Use? Shake well before using, and use the provided medication dropper to carefully measure out the dose. Unless your doctor instructs you otherwise, use as follows: Place half of the dose in one side of the mouth. Swish it around the mouth, gargle, and swallow. Keep the liquid in your mouth for as long as possible before swallowing. Then repeat with the remaining half of the dose in the other side of the mouth. Avoid eating for 5-10 minutes after using this medication.use this medication 4 times a day or as directed by your doctor. It may take from several days to several months to complete treatment. Use this medication regularly in order to get the most benefit from it. Remember to use it at the same times each day. Dosage is based on your medical condition and response to therapy.continue to use this medication until the full prescribed amount is finished, even if symptoms disappear after a few days.

5 Stopping the medication too early may allow the infection to continue, resulting in a return of the infection.inform your doctor if your condition persists after several days of treatment or worsens at any time. Why is this medication prescribed? Nystatin is used to treat fungal infections of the skin, mouth, vagina, and intestinal tract. Fungal medicines will not work for colds, flu, or other viral infections. This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information. How should this medicine be used? Nystatin comes as a tablet, capsule, and a liquid to take by mouth; a soft lozenge (pastille) to be dissolved slowly in the mouth; a tablet and vaginal cream to be inserted into the vagina; and in powder, ointment, and cream to be applied to the skin. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Use nystatin exactly as directed. Do not use more or less of it or use it more often than prescribed by your doctor. Allow the lozenges (pastilles) to dissolve slowly in your mouth. Do not chew or swallow lozenges whole. Continue to use nystatin lozenges (pastilles) for at least 48 hours after symptoms of your mouth infection disappear. Nystatin liquid usually is used three to five times a day for mouth infections and three times a day for intestinal infections. Shake the bottle well before each use to mix the medication evenly. If you are using liquid nystatin for a mouth infection, place half of the dose in each side

6 of the mouth and hold it there or swish it throughout the mouth for several minutes before swallowing. Good oral hygiene, including proper care of dentures, is important for the cure of mouth infections. If you are using liquid nystatin for an intestinal infection, just swallow the liquid you measured from the dropper; there is no need to hold it or swish it in your mouth. Nystatin skin ointment or cream usually is used several times a day for skin infections. Wash the affected area thoroughly. Apply a small amount of cream or ointment and gently and thoroughly massage it into your skin. If you use this medication on your face, keep it out of your eyes. If you are using powder for infected feet, dust the powder inside your shoes and stockings as well as on your feet. Nystatin vaginal tablets and cream usually are used once or twice a day for vaginal infections. Nystatin vaginal tablets usually are used for 2 weeks in women who are not pregnant and for 3 to 6 weeks before delivery in pregnant women. Continue to use the vaginal tablets and cream even if symptoms improve after a few days. Insert the vaginal tablets or cream high into the vagina. They each come with a special applicator for inserting them and directions. Unwrap the vaginal tablets just before inserting them. Read the directions provided with the tablets or cream and follow these steps: Fill the special applicator to the level indicated. Lie on your back with your knees drawn upward and spread apart. Gently insert the applicator into your vagina and push the plunger to release the medication.

7 Withdraw the applicator and wash it with soap and warm water. Wash your hands promptly to avoid spreading the infection. You may wish to wear a sanitary napkin while using the vaginal cream to protect your clothing against stains. Do not use a tampon because it will absorb the drug. Do not douche unless your doctor tells you to do so. Continue using nystatin vaginal cream or tablets even if you get your period during treatment. What special precautions should I follow? Before using nystatin, tell your doctor and pharmacist if you are allergic to nystatin or any other drugs. tell your doctor and pharmacist what prescription and nonprescription medications you are taking, including vitamins. tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while using nystatin, call your doctor. What should I do if I forget a dose? Use the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not use a double dose to make up for a missed one. What side effects can this medication cause? Nystatin may cause side effects. Tell your doctor if any of these symptoms from the vaginal tablets and cream or skin ointment or cream are severe or do not go away: itching

8 irritation burning If you experience any of the following symptoms from the oral tablets and liquid, call your doctor immediately: diarrhea nausea stomach pain skin rash What storage conditions are needed for this medicine? Keep this medication in the container it came in, tightly closed, and out of reach of children. Store the tablets and liquid at room temperature and away from excess heat and moisture (not in the bathroom). Store nystatin powder, lozenges (pastilles), and vaginal tablets and cream in the refrigerator. Do not allow nystatin to freeze. Throw away any medication that is outdated or no longer needed. Talk to your pharmacist about the proper disposal of your medication. What other information should I know? Keep all appointments with your doctor and the laboratory. Your doctor will order certain lab tests to check your response to nystatin. Do not let anyone else use your medication. Your prescription is probably not refillable. If you still have symptoms of infection after you finish the nystatin, call your doctor. It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You

9 should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies. apollo asia Division APOLLO Pharmaceuticals API Manufacturer INDIA [P] Ltd. asia Division Mr.Vipin Saxena CEO Cellular: Cellular: Direct : FAX : Wireline Purchase HELPDESK: Wireline Sales HELPDESK: Wireless 24x7 HELPDESK: Blackberry Pin :

10 32E6500D 32E C Chat: MSN Hotmail:VipinrSaxena Skype NAME:VipinrSaxena Rocketmail:VipinrSaxena Google mail:vipinrsaxena BlackBerry:28415C58 Regd. Office :- 1104, Maker Chamber V, Nariman Point Mumbai, INDIA Pin: Industrial Office D-62, OIC India

11 Oshiwara Industrial Centre, New Link Road, Goregoan West, Mumbai, INDIA Pin: Manufacturing Unit Address: Plot No. 117A, Village: Chamble Near MonaTona Limited.Wada, Maharashtra, PIN : INDIA apollo@hotmail.co.in Sales@apollopharma.in Export@apollopharma.in purchase@apollopharma.in

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