Medical Department PHYSIOLOGICAL EAR CLEANSER

Transcription

1 PHYSIOLOGICAL EAR CLEANSER

2 Their ears are fragile, take care! Structure of the external ear Pinna Ear canal External ear Border Collie Jack Russel Inner ear? Tympanic membrane Middle ear Bearded Collie Boxer

3 Their ears are fragile, take care! Microanatomy: epidermis and secretions Control of relative humidity Control of aural flora ecosystem Water exclusion Mp Mechanical protection of ear canal and tympanum Squamous epithelial cells Decrease of bacterial and yeast adhesion + Deep ceruminous gland Acid mucopolysaccharides Phospholipids + Trapping of small debris and foreign material : grass fragments dust, dirt dead cells Superficial sebaceous glands Neutral lipids = Cerumen

4 Their ears are fragile, take care! Factors that favour imbalances Climatic changes, bathing Breed predisposition to seborrhea, allergy Pendulous, hairy ears Cerumen accumulation, incubator effect Improper management: cotton-tipped applicators, irritating substances Impairment of natural clearing mechanisms Ear canal tightness, Man-driven selection on ear morphology Increased apocrine tissue, cerumen secretion

5 Their ears are fragile, take care! Dirty ears

6 Physio Ear Cleanser: product highlights Excellent cleansing power Micellar cleansing solution Emulsification of cerumen accumulated within the ear canal by the ear cleansing solution Epithelium of the ear canal lined by protective surface lipid film Epithelium of the ear canal coated by excess cerumen Micelles Non-irritant non-detergent cleansing Micelles loaded with cerumen Hydrophilic polar head Hydrophobic tail Cerumen Trapping Cerumen aggregate Surface lipid film

7 Physio Ear Cleanser: product highlights Application of the cleansing solution in ear Cleansing solution Epithelium of the auditory canal Cerumen coating High aural integument tolerance Useful ingredients only Ø additives, colorants, text. agents, perfume Hypotonic solution Hypertonic solution Isotonic solution Non-irritant, non-sensitizing remarkable safety profile Turgescence Plasmolysis Dynamic equilibrium Isotonic solution physiology respectful fluid/mineral balance Impairment of cellular integrity Minerals Water Perturbation of the aural environment Preservation of cellular integrity Respect of the aural environment Neutral ph = 7

8 Physio Ear Cleanser: product highlights Patented anti-odour technology Transformation by the bacterial flora Lipids Oxidation Cerumen accumulation, incubator effect Immediate effective disappearance of unpleasant smells Longer period of deodorising action Smelling compounds Unpleasant smells Aldehyde complex Neutralising action

9 Physio Ear Cleanser: product highlights Revolutionary packaging Heasy handling operate with one hand Adapted to anatomy of all ear conformations avoid injury, animal reaction Elastomere non-traumatic enlarged tip Spiked fins Precise control of fluid delivery press: 1 ml redirected noise free jet threat FACILITATE & OPTIMISE SECURE & COMFORT THE OWNERS THE ANIMALS

10 Studies to evaluate efficacy and safety Cerumen solubilisation: in vitro data 100 mg synthetic dog cerumen + 1 ml test solution (10 min., 37 C) agitation (10 sec.) Distilled water (control) Cerulane Otoclean Otolane Virbac Physio Ear Cleanser filtration > undissolved cerumen quantification macroscopy Emulsion formation

11 Studies to evaluate efficacy and safety Cerumen solubilisation: in vitro data mg/ml (dissolved cerumen) quantity of dissolved cerumen wetting power index Cerulane Otolane Distilled water Otoclean Better cerumen dissolution properties than competitors disperse dirt and debris g/l (wetting power) * Virbac Physiologic Ear Cleanser * vs distilled water (p<0.05) Higher ability to spread and being adsorbed on surfaces (wetting power index, ISO 8022) greasy dirt detachment

12 Studies to evaluate efficacy and safety Clinical trial in dogs: in vivo data 42 dogs cerumen at orifice of ear canal no otitis requiring med. treat. dirty ears no prior treat. 1 week D1 No concomitant treatment D15 Dog ears: random 1 Physio Ear Cleanser: 1 ml once a day 1 left untreated Blind evaluation Cerumen deposit Ear odour associated erythema graded 0-4 (severity) Ear swabbing cytology Mean nb. Malassezia/ hpf (x100 oil immersion obj.)

13 Studies to evaluate efficacy and safety Clinical trial in dogs: in vivo data Cerumen deposit score 3 Group treated ears untreated ears Odour score * % % 1 * Days Days Excellent cleansing and odour neutralising activity under field conditions in dogs

14 Studies to evaluate efficacy and safety Clinical trial in dogs: in vivo data Erythema score 2 Group treated ears untreated ears Nb Malassezia/hpf * % % 1 * Days Days helps reduce pre-existing erythema and yeast by removing excess cerumen

15 Studies to evaluate efficacy and safety Clinical trial in dogs: in vivo data Owners opinion 9.5% 2.4% 57.1% 33.3% Not satisfied Hardly satisfied Satisfied 52.4% 45.2% Very satisfied Cleansing efficacy Deodorising effect Tolerance no irritation no hypersensitivity no microbial proliferation

16 Studies to evaluate efficacy and safety Clinical trial in cats: in vivo data 25 cats cerumen at orifice of ear canal no infectious otitis 1 ml of physio cleanser in both ears once by vet acceptation and tolerance checking min. 2 days 24 Acceptation / Tolerance 4 cats: defence reaction (to fluid instillation in ear) no irritation no hypersensitivity no behaviour modification Number of cats Very poor Poor Good Very good Tolerance Investigators opinion

17 Conclusions The No. 1 product for routine ear cleaning in dogs and cats Exceptional cerumen removal properties Patented odour-neutralising technology Physiology-respecful activity, optimal tolerance Owner-friendly container and delivery system Ear care, it s their health!