Burkholderia cepacia. Clinica Veterinaria Vezzoni - Cremona, Italy

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1 Burkholderia cepacia Clinica Veterinaria Vezzoni - Cremona, Italy

2 Clinical experience of epidemic outbreak Positive culture for Burkholderia cepacea in the surgical site end of surgery Repeatedly positive for several months Negative culture for BCC from the surgical environment (walls, floor, drapes, gloves, air conditioned, staff, etc.) No systemic signs in the post-op

3 Clinical experience of epidemic outbreak Positive culture at the end of surgery Saprophyte bug? Lab bug? Positive culture at the surgical approach Positive culture of synovial taps before THR

4 Clinical experience of epidemic outbreak Several symptomatic cup loosening 2 to 10 months after surgery

5 Aerobic Gram-negative bacteria Different species (at least nine) Found in aquatic environments Low virulence, but induction of inflammation Causing pneumonia in people with underlying cystic fibrosis Specific media for its culture No reports (yet) in veterinary medicine

6 Agricultural use of BCC as a biopesticide Tap water contamination Human and animal health hazard Colonizer of fluids used in the hospital Colonization of body fluids Wide documentation in the web

7 Clinical experience of epidemic outbreak Bacterial sensitivity Amikacine Amoxi+clav. ac. Cefadroxile Cefalexine Cefazoline Ceftazidime Ceftriaxone Ciprofloxacine Enrofloxacine Gentamicine S R R R R S S S S S

8 Clinical experience of epidemic outbreak Where was the bug coming from? Check the pipe water! Human Hospital Dept. of Infectious Dieseases

9 Clinical experience of epidemic outbreak Positive culture from the tap water in the Hospital

10 Clinical experience of epidemic outbreak How did the bug contaminate the patient? In surgery? All cultures were negative in surgery!

11 Clinical experience of epidemic outbreak Occasional observation at the end of one day

12 Clinical experience of epidemic outbreak Positive culture of diluted fentanyl in the intravenous pump set Negative culture of fentanyl vials

13 Pathway of contamination

14 Pathway of the contamination from tap water to patient: washed hands of nurses and anesthetists contamination of intravenous lines bacterial replication inside solutions anesthesia induction blood stream Pathway of contamination

15 Pathway of contamination Conservation of diluted drugs and intravenous lines increases bacterial replication

16 Clinical experience of epidemic outbreak Low morbidity, but: local inflammation inhibition of osteointegration affecting the cup, not the stem cup more susceptible no observed consequences on other surgical procedures

17 Clinical experience - cup revisions

18 Clinical experience - cup revisions Positive culture for BCC in both the synovial fluid and the loose cup membrane up to 3 months after surgery Positive culture for BCC in the loose cup membrane only from 3 to 8 months after surgery Negative culture for BCC in the synovial fluid and in the loose cup membrane from 8 months after surgery

19 Clinical experience - cup revisions Surgical revision for cup loosening Septocoll

20 Clinical experience - cup revisions Surgical revision for cup loosening Revision cup

21 Counter measures Disposable gloves for handling animal and infusion set, frequent change Hydro-alcoholic antiseptic gel

22 Counter measures

23 Counter measures Discard any remnants Individual pump solution and IV lines and/or fluids

24 Counter measures Individual scrub can, steam sterilized Individual prep solutions

25 Counter measures Effective to counteract other bacteria with the same possible pathway of contamination: other gram neg. bacteria: Serratia marcescens Pseudomonas aeruginosa Stenotrophomonas maltophilia

26 Conclusions Awareness of BCC potential risk Focused on the HANDS Especially for THR (unforgiving any contamination) Effectiveness of prevention measures No more BCC culture in our cases since over one year

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