PDF of Trial CTRI Website URL -
|
|
- Betty Fletcher
- 5 years ago
- Views:
Transcription
1 Clinical Trial Details (PDF Generation Date :- Sun, 10 Mar :52:14 GMT) CTRI Number Last Modified On 29/07/2016 Post Graduate Thesis Type of Trial Type of Study Study Design Public Title of Study Scientific Title of Study CTRI/2016/08/ [Registered on: 01/08/2016] - Trial Registered Retrospectively No Interventional Drug Randomized, Crossover Trial To compare the responses of pulse rate and blood pressure for electroconvulsive therapy in general anesthesia when dexmedetomidine, lignocaine and esmolol are used. A comparison of two doses of Dexmedetomidine, Esmolol and Lignocaine for the prevention of haemodynamic response to electroconvulsive therapy under general anaesthesia Secondary IDs if Any Secondary ID Identifier Details of Principal Investigator or overall Trial Coordinator (multi-center study) Details Contact Person (Scientific Query) Details Contact Person (Public Query) NIL NIL Details of Principal Investigator Sanchita Garg Phone Assistant Professor-Anesthesiology doc.sanchita@gmail.com Details Contact Person (Scientific Query) Devangi Parikh Phone ASSOCIATE PROFESSOR-ANAESTHESIOLOGY sdevangi10@gmail.com Details Contact Person (Public Query) Devangi Parikh ASSOCIATE PROFESSOR-ANAESTHESIOLOGY page 1 / 5
2 Source of Monetary or Material Support Primary Sponsor Details of Secondary Sponsor Countries of Recruitment Sites of Study Details of Ethics Committee Regulatory Clearance Status from DCGI Health Condition / Problems Studied Intervention / Comparator Agent Phone sdevangi10@gmail.com Source of Monetary or Material Support > Lokmanya tilak municipal medical college and lokmanya tilak municipal general hospital Type of Sponsor Dr Devangi Parikh List of Countries of Principal Investigator Dr Sanchita Garg Primary Sponsor Details Lokmanya Tilak Municipal General Hospital Lokmanya Tilak Municipal medical college and hospital Sulochana Shetty road Sion, - Government medical college Lokmanya Tilak Municipal medical college and hospital Sulochana Shetty road Sion, - of Site Site Phone// Lokmanya Tilak Municipal General Hospital Psychiatry OPD. Hospital OPD building,2nd floor, room number doc.sanchita@gmail.co m of Committee Approval Status Date of Approval Is Independent Ethics Committee? Institutional Ethics Committee, Staff research and society, Lokmanya Tilak Municipal Medical college and hospital Status Not Applicable Health Type Patients Approved 01/02/2012 No Date No Date Specified Condition patients suffering from various psychiatric disorders for whom electroconvulsive therapy (ECT)is advised by the psychiatrist Type Details Comparator Agent Normal saline as Placebo Each patient who is to receive five ECTs in five different sittings are enrolled in the study. Apart from the intervention listed below, each patient will receive normal saline as placebo. The patients will receive an intravenous infusion of 50 ml Normal Saline over 10 min followed by a bolus of 10 ml Normal saline over 15 seconds. Intervention Dexmedetomidine 1microgram/kg The patients will receive an intravenous infusion of page 2 / 5
3 Inclusion Criteria Intervention Dexmedetomidine 0.5microgram/kg Dexmedetomidine 1mcg/kg over 10 min followed by bolus of 10ml normal saline over 15 minutes before induction of anesthesia. The patients will receive an intravenous infusion of Dexmedetomidine 0.5mcg/kg over 10 min followed by a bolus of 10 ml NS over 15 seconds before induction of anesthesia Intervention Esmolol 1mg/kg The patients will receive an intravenous infusion of 50 ml NS over 10 min followed by a bolus of Esmolol (1mg/kg) in 10 ml NS over 15 seconds before induction of anaesthesia. Intervention Lignocaine 1mg/kg The patients will receive an intravenous infusion of 50 ml NS over 10 min followed by a bolus of lignocaine (1mg/kg) in 10 ml NS over 15 seconds before induction of anaesthesia. Age From Age To Gender Details Year(s) Year(s) Both Inclusion Criteria 1.ASA grade I/II 2.Patients of either sex. 3.Age between years. 4.Patients undergoing ECT in general anaesthesia who advised atleast five ECTS. 5.Patients consenting for the study Exclusion Criteria Method of Generating Random Sequence Method of Concealment Blinding/Masking Details Computer generated randomization Exclusion Criteria Sequentially numbered, sealed, opaque envelopes Participant, Investigator and Outcome Assessor Blinded 1.ASA grade III/IV 2.BMI>30 3.Known sensitivity to General Anaesthetic drugs. 4.Known allergy to study drugs. 5.Pregnant and lactating females. 6.Patients on beta blockers or calcium channel blockers. 7.Known Hypertensives on treatment. 8.Bronchospasm or bronchial asthma. 9.Systolic BP 10.Heart rate Primary Outcome Outcome Timepoints To compare the effects of two doses of Dexmedetomidine(0.5 and 1mic), Esmolol and Lignocaine during Electroconvulsive therapy under general anaesthesia in terms of Intraoperative hemodynamics (heart rate, blood pressure, rate pressure product). at baseline, after study drug, after induction of anaesthesia, and at 1, 3, 10 minutes after ECT. page 3 / 5
4 Secondary Outcome Outcome Timepoints 1.Duration of motor seizure. 2.Time to spontaneous breathing, eye opening and obeying commands. 3.Post-procedure sedation/agitation. 4.Readiness to discharge. 5.Propofol requirement. all this will be noted at the end of the ECT session upto discharge. Target Sample Size Phase of Trial Date of First Enrollment () Date of First Enrollment (Global) Estimated Duration of Trial Recruitment Status of Trial (Global) Recruitment Status of Trial () Publication Details Brief Summary Total Sample Size=30 Sample Size from =30 Post Marketing Surveillance 02/02/2012 No Date Specified Years=0 Months=3 Days=0 Not Applicable Completed 2. Begec Z., Toprak H. I., Demirbilek S. et al; Dexmedetomidine blunts acute hyperdynamic responses to electroconvulsive therapy without altering seizure duration; ActaAnaesthesiologicaScandinavica, February 2008; 52(2): Electroconvulsive therapy (ECT) is frequently used for treatment of psychiatric illness, primarily major affective disorders, and in certain cases of schizophrenia. This therapy works by electrically inducing grand mal seizures. ECT is known for its well-described, brief parasympathetic sequence followed by adrenergic outflow during the seizure, which markedly increases heart rate (HR), arterial blood pressure, and plasma levels of catecholamines. These haemodynamic effects can produce cardiovascular stress and could place a patient with coronary or cerebrovascular disease at the risk of myocardial ischaemia/infarction, congestive heart failure, cardiac arrest or cerebrovascular accidents. A number of drug regimens have been used to prevent or to attenuate the hemodynamic response to ECT. Few of these suggested regimens include NItroglycerin, Lignocaine, opioids such as Fentanyl, adrenoceptor antagonists such as Labetalol, Esmolol, centrally acting α-receptor agonists Clonidine and page 4 / 5
5 Powered by TCPDF ( Dexmedetomidine. ECTs are frequently performed on an outpatient basis; therefore, anaesthetic drugs used for the procedure should be short-acting with rapid recovery profiles. In addition, several of these drugs cause post-procedure sedation and can prolong time to discharge or cognitive recovery. Thus, although it is desirable to prevent the cardiovascular responses to ECT, the choice of a premedication to accomplish this should be appropriate. In the present study, we plan to compare the effects of Esmolol, lignocaine and two doses of Dexmedetomidine on hemodynamic response to Electroconvulsive therapy under general anaesthesia using a double blind, randomized, placebo-controlled, crossover design. Each patient will receive each of the treatments and will serve as his or her own control. page 5 / 5
PDF of Trial CTRI Website URL -
Clinical Trial Details (PDF Generation Date :- Mon, 11 Mar 2019 09:06:55 GMT) CTRI Number CTRI/2009/091/000725 [Registered on: 15/09/2009] - Last Modified On Post Graduate Thesis Type of Trial Type of
More informationComparison of Clonidine and Dexmedetomidine on Cardiovascular Stability in Laparoscopic Cholecystectomy
Original Article DOI: 10.17354/ijss/2016/185 Comparison of Clonidine and Dexmedetomidine on Cardiovascular Stability in Laparoscopic Cholecystectomy Devang Bharti 1, Juhi Saran 2, Chetan Kumar 3, H S Nanda
More informationStudy between clonidine and dexmedetomidine in attenuation of pressor response during endotracheal intubation
Original Research Article Study between clonidine and dexmedetomidine in attenuation of pressor response during endotracheal intubation K. Selvarju 1, Kondreddi Narayana Prasad 2*, Ajay Kumar Reddy Bobba
More informationDıfferent Doses Of Dexmedetomidine On Controllıng Haemodynamıc Responses To Tracheal Intubatıon
ISPUB.COM The Internet Journal of Anesthesiology Volume 27 Number 2 Dıfferent Doses Of Dexmedetomidine On Controllıng Haemodynamıc Responses To Tracheal Intubatıon A Sa??ro?lu, M Celik, Z Orhon, S Yüzer,
More informationStudy the Effect of Dexmedetomidine on Emergence Agitation after Nasal Surgeries
Original Research Article Study the Effect of Dexmedetomidine on Emergence Agitation after Nasal Surgeries G V Krishna Reddy 1*, S. Kuldeep 2, G. Obulesu 3 1 Assistant Professor, Department of Anaesthesiology,
More informationSynopsis. Takeda Pharmaceutical Company Limited Name of the finished product UNISIA Combination Tablets LD, UNISIA Combination Tablets
Synopsis Name of the sponsor Takeda Pharmaceutical Company Limited Name of the finished product UNISIA Combination Tablets LD, UNISIA Combination Tablets Name of active ingredient Title of the study Study
More informationA New Advancement in Anesthesia. Your clear choice for induction.
A New Advancement in Anesthesia Your clear choice for induction. By Kirby Pasloske When using Alfaxan, patients should be continuously monitored, and facilities for maintenance of a patent airway, artificial
More informationA Clinical Study of Dexmedetomidine under Combined Spinal Epidural Anaesthesia at a Tertiary Care Hospital
Original Research A Clinical Study of Dexmedetomidine under Combined Spinal Epidural Anaesthesia at a Tertiary Care Hospital Kamala GR 1, Leela GR 2 1 Assistant Professor, Department of Anaesthesiology,
More informationCorresponding author: V. Dua, Department of Anaesthesia, BJ Wadia Hospital for Children, Parel, Mumbai, India.
Comparative evaluation of dexmedetomidine as a premedication given intranasally vs orally in children between 1 to 8 years of age undergoing minor surgical procedures V. Dua, P. Sawant, P. Bhadlikar Department
More informationComparison of Intensive Care Unit Sedation Using Dexmedetomidine, Propofol, and Midazolam
Original Article Print ISSN: 2321-6379 Online ISSN: 2321-595X DOI: 10.17354/ijss/2017/24 Comparison of Intensive Care Unit Sedation Using Dexmedetomidine, Propofol, and Midazolam Gajendra Singh, Kakhandki
More informationDexmedetomidine. Dr.G.K.Kumar,M.D.,D.A., Assistant Professor, Madras medical college,chennai. History
Dexmedetomidine Dr.G.K.Kumar,M.D.,D.A., Assistant Professor, Madras medical college,chennai Dexmedetomidine is the most recently released IV anesthetic. It is a highly selective α 2 -adrenergic agonist
More informationStudy of Dexmedetomidine as intramuscular premedication in outpatient cataract surgery: A placebo controlled study
Original Research Article Study of Dexmedetomidine as intramuscular premedication in outpatient cataract surgery: A placebo controlled study D. Srinivasa Naik 1, K. Ravi Kumar 1, Surendra Babu 2, R. Pandu
More informationOriginal Article INTRODUCTION. Abstract
Original Article Print ISSN: 2321-6379 Online ISSN: 2321-595X DOI: 10.17354/ijss/2016/305 Comparison between 0.5 µg/kg Dexmedetomidine with 0.5% Lignocaine and 0.5% Lignocaine Alone in Intravenous for
More informationAssociate Professor, Department of Anaesthesiology, Government Thoothukudi Medical College, Thoothukudi, Tamil Nadu, India, 2
Original Article DOI: 10.17354/ijss/2016/295 Effect of Intravenous use of Dexmedetomidine on Anesthetic Requirements in Patients Undergoing Elective Spine Surgery: A Double Blinded Randomized Controlled
More informationPropofol vs Dexmedetomidine
Propofol vs Dexmedetomidine A highlight of similarities & differences Lama Nazer, PharmD, BCPS Critical Care Clinical Pharmacy Specialist King Hussein Cancer Center Outline Highlight similarities and differences
More informationParthasarathy et al. Sri Lankan Journal of Anaesthesiology: 25(2):76-81(2017)
Comparison of efficacy of intravenous dexmedetomidine with intravenous ketamine in allaying procedural discomfort during establishment of subarachnoid block S Parthasarathy 1*, AJ Charles 2, DR Singh 1,
More informationS Kumar, B B Kushwaha, R Prakash, S Jafa, A Malik, R Wahal, J Aggarwal, R Kapoor
ISPUB.COM The Internet Journal of Anesthesiology Volume 33 Number 1 Comparative Study Of Effects Of Dexmedetomidine And Clonidine Premedication In Perioperative Hemodynamic Stability And Postoperative
More informationDexmedetomidine and stress response Madhusudan et al
Original Article: Effect of intravenous dexmedetomidine on haemodynamic responses to laryngoscopy, tracheal intubation and anaesthetic and analgesic requirements: a randomized double-blind clinical efficacy
More informationHaemodynamic and anaesthetic advantages of dexmedetomidine
Haemodynamic and anaesthetic advantages of dexmedetomidine Abstract Rao SH, Assistant Professor Sudhakar B, Associate Professor Subramanyam PK, Professor Department of Anaesthesia and Critical Care, Dr
More informationInt. J. Pharm. Sci. Rev. Res., 36(1), January February 2016; Article No. 38, Pages: *Corresponding author s
Research Article Comparative Study Betweeen Dexmedetomidine and Remifentanyl for Efficient Pain and Ponv Management in Propofol Based Total Intravenous Anesthesia after Laparoscopic Gynaecological Surgeries
More informationRole of Dexmedetomidine as an Anesthetic Adjuvant in Laparoscopic Surgery
Role of Dexmedetomidine as an Anesthetic Adjuvant in Laparoscopic Surgery Vaishali Waindeskar, Munir Khan, Shankar Agarwal, M R Gaikwad Department of Anesthesiology, People s College of Medical Sciences
More informationComparison of dexmedetomidine and propofol for conscious sedation in inguinal hernia repair: A prospective, randomized, controlled trial
Research Report Comparison of dexmedetomidine and propofol for conscious sedation in inguinal hernia repair: A prospective, randomized, controlled trial Journal of International Medical Research 2017,
More informationA bispectral index guided study on the effect of dexmedetomidine on sevoflurane requirements during elective laparoscopic surgeries
Original Research Article A bispectral index guided study on the effect of dexmedetomidine on sevoflurane requirements during elective laparoscopic surgeries Nitesh Kabra 1, Nama Nagarjuna Chakravarthy
More informationComparison of two doses of intranasal dexmedetomidine as premedication in children
Comparison of two doses of intranasal dexmedetomidine as premedication in children V. Pavithra, M. N. Ramani, S. K. Shah Department of Anaesthesia, B. J. Medical College, Civil Hospital, Ahmedabad, Gujarat,
More informationPAIN Effect of intra-articular dexmedetomidine on postoperative analgesia after arthroscopic knee surgery
British Journal of Anaesthesia 101 (3): 395 9 (2008) doi:10.1093/bja/aen184 Advance Access publication June 20, 2008 PAIN Effect of intra-articular dexmedetomidine on postoperative analgesia after arthroscopic
More informationSusan Becker DNP, RN, CNS, CCRN, CCNS Marymount University, Arlington, VA
Susan Becker DNP, RN, CNS, CCRN, CCNS Marymount University, Arlington, VA Disclosures Study and presentation has no commercial bias or interests No financial relationship with a commercial interest, products,
More informationDr. PratekKoolwal, Dr.BribalBaj, DrKashif M Madani, Dr.MohitSomani, Dr. Vijay Mathur.
IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) e-issn: 2279-853, p-issn: 2279-861.Volume 14, Issue 7 Ver. VIII (July. 215), PP 84-9 www.iosrjournals.org "Dose related prolongation of hyperbaric
More informationPRESCRIPTION PATTERN OF ANTI HYPERTENSIVE DRUGS IN SHRI SATHYA SAI MEDICAL COLLEGE & RESEARCH INSTITUTE
Original Article PRESCRIPTION PATTERN OF ANTI HYPERTENSIVE DRUGS IN SHRI SATHYA SAI MEDICAL COLLEGE & RESEARCH INSTITUTE Annamalai Maduram 1, Harikrishna 2 INTRODUCTION High blood pressure, termed "hypertension,"
More informationSCIENTIFIC COOPERATIONS MEDICAL WORKSHOPS July, 2015, Istanbul - TURKEY
21-22 July, 2015, Istanbul - TURKEY PROSPECTIVE EVALUATION OF CORRELATION OF DEPTH OF DEXMEDETOMIDINE SEDATION AND CLINICAL EFFECTS FOR RECONSTRUCTIVE SURGERIES UNDER REGIONAL ANAESTHESIA Alma Jaunmuktane
More informationAshraf Darwish, Rehab Sami, Mona Raafat, Rashad Aref and Mohamed Hisham
Dexmedetomidine versus Propofol for Monitored Anesthesia Care In Patients Undergoing Anterior Segment Ophthalmic Surgery Under Peribulbar Medial Canthus Anesthesia Ashraf Darwish, Rehab Sami, Mona Raafat,
More informationHemodynamic effects of dexmedetomidine-- fentanyl vs. nalbuphine--propofol in plastic surgery
Hemodynamic effects of dexmedetomidine-- fentanyl vs. nalbuphine--propofol in plastic surgery Juan F. De la Mora-González *, José A. Robles-Cervantes 2,4, José M. Mora-Martínez 3, Francisco Barba-Alvarez
More informationASMIC 2016 DEXMEDETOMIDINE IN THE INTENSIVE CARE UNIT DR KHOO TIEN MENG
ASMIC 2016 DEXMEDETOMIDINE IN THE INTENSIVE CARE UNIT DR KHOO TIEN MENG PREAMBLE : EVOLUTION OF SEDATION IN THE ICU 1980s : ICU sedation largely extension of GA No standard approach, highly variable Deep
More informationBenefits of total intravenous anaesthesia in dogs and cats
Vet Times The website for the veterinary profession https://www.vettimes.co.uk Benefits of total intravenous anaesthesia in dogs and cats Author : KATHERINE ROBSON Categories : Vets Date : November 17,
More informationRajaclimax Kirubahar, Bose Sundari, Vijay Kanna*, Kanakasabai Murugadoss
International Journal of Research in Medical Sciences Kirubahar R et al. Int J Res Med Sci. 2016 Apr;4(4):1172-1176 www.msjonline.org pissn 2320-6071 eissn 2320-6012 Research Article DOI: http://dx.doi.org/10.18203/2320-6012.ijrms20160804
More informationDisclosures. Dexmedetomidine: The Good, The Bad and The Delirious. The Delirious. Objectives. Characteristics of Delirium. Definition of Delirium
Dexmedetomidine: The Good, The Bad and The Delirious Disclosures! I have no actual or potential conflict of interest in relation to this presentation. By John J. Bon, Pharm.D., BCPS Lead Clinical Pharmacist,
More informationWhat dose of methadone should I use?
What dose of methadone should I use? Professor Derek Flaherty BVMS, DVA, DipECVAA, MRCA, MRCVS RCVS and European Specialist in Veterinary Anaesthesia SPC dose rates for Comfortan dogs: 0.5-1.0 mg/kg SC,
More informationThe comparison of the effects of intravenous ketamine or dexmedetomidine infusion on spinal block with bupivacaine
Clinical Research Article Korean J Anesthesiol 2014 August 67(2): 85-89 http://dx.doi.org/10.4097/kjae.2014.67.2.85 The comparison of the effects of intravenous ketamine or dexmedetomidine infusion on
More informationComparison of dexmedetomidine v/s propofol used as adjuvant with combined spinal epidural anaesthesia for joint replacement surgeries
Comparison of dexmedetomidine v/s propofol used as adjuvant with combined spinal epidural anaesthesia for joint replacement surgeries Kuldeep Chittora 1 *; Ritu Sharma 2 ; Rajeev LochanTiwari 3 1 Department
More informationCase Report Dexmedetomidine as a Procedural Sedative for Percutaneous Tracheotomy: Case Report and Systematic Literature Review
Case Reports in Critical Care Volume 2012, Article ID 659415, 4 pages doi:10.1155/2012/659415 Case Report Dexmedetomidine as a Procedural Sedative for Percutaneous Tracheotomy: Case Report and Systematic
More informationReview Article The Effects of Intravenous Dexmedetomidine Injections on IOP in General Anesthesia Intubation: A Meta-Analysis
Hindawi BioMed Research International Volume 7, Article ID 68683, 6 pages https://doi.org/.55/7/68683 Review Article The Effects of Intravenous Injections on IOP in General Anesthesia Intubation: A Meta-Analysis
More informationThe Effects of 2-Adrenergic Receptor Agonist Dexmedetomidine on Hemodynamic Response in Direct Laryngoscopy
The Open Otorhinolaryngology Journal, 2007, 1, 5-11 5 The Effects of 2-Adrenergic Receptor Agonist Dexmedetomidine on Hemodynamic Response in Direct Laryngoscopy Berrin I ik, Mustafa Arslan *, Özgür Özsoylar
More informationPreliminary UK experience of dexmedetomidine, a novel agent for postoperative sedation in the intensive care unit
Preliminary UK experience of dexmedetomidine, a novel agent for postoperative sedation in the intensive care unit R. M. Venn, 1 C. J. Bradshaw, 1 R. Spencer, 2 D. Brealey, 3 E. Caudwell, 3 C. Naughton,
More informationPremedication with alpha-2 agonists procedures for monitoring anaesthetic
Vet Times The website for the veterinary profession https://www.vettimes.co.uk Premedication with alpha-2 agonists procedures for monitoring anaesthetic Author : Lisa Angell, Chris Seymour Categories :
More informationSUMMARY OF PRODUCT CHARACTERISTICS
SUMMARY OF PRODUCT CHARACTERISTICS 1. Name of the Veterinary Medicinal Product Vetofol 10mg/ml Emulsion for Injection for cats and dogs (AT, CY, EE, FI, DE, EL, LV, PT, ES) Norofol 10mg/ml Emulsion for
More informationA COMPARATIVE STUDY OF MIDAZOLAM, PROPOFOL AND DEXMEDETOMIDINE INFUSIONS FOR SEDATION IN ME- CHANICALLY VENTILATED PATIENTS IN ICU
ORIGINAL ARTICLE A COMPARATIVE STUDY OF MIDAZOLAM, PROPOFOL AND DEXMEDETOMIDINE INFUSIONS FOR SEDATION IN ME- CHANICALLY VENTILATED PATIENTS IN ICU Suresh Chandra Dulara 1, Pooja Jangid 2, Ashish Kumar
More informationSummary of Product Characteristics
Summary of Product Characteristics 1 NAME OF THE VETERINARY MEDICINAL PRODUCT Domitor 1 solution for injection 2 QUALITATIVE AND QUANTITATIVE COMPOSITION Active substance: Medetomidine hydrochloride (equivalent
More informationSUMMARY OF PRODUCT CHARACTERISTICS
SUMMARY OF PRODUCT CHARACTERISTICS 1. NAME OF THE VETERINARY MEDICINAL PRODUCT Anaestamine 100 mg/ml solution for injection Aniketam, 100 mg/ml solution for injection (EE/LT/LV) Aniketam vet., 100 mg/ml
More informationOriginal Article Effects of low dose midazolam on bradycardia and sedation during dexmedetomidine infusion
Int J Clin Exp Med 2016;9(6):11838-11844 www.ijcem.com /ISSN:1940-5901/IJCEM0020616 Original Article Effects of low dose midazolam on bradycardia and sedation during dexmedetomidine infusion Yun-Sic Bang
More informationComparison of dexmedetomidine and propofol in mechanically ventilated patients with sepsis: A pilot study
Original article Comparison of dexmedetomidine and propofol in mechanically ventilated patients with sepsis: A pilot study Mark B. Sigler MD, Ebtesam A. Islam MD PhD, Kenneth M. Nugent MD Abstract Objective:
More informationOriginal Article Dose-dependent effects of dexmedetomidine during one-lung ventilation in patients undergoing lobectomy
Int J Clin Exp Med 2017;10(3):5216-5221 www.ijcem.com /ISSN:1940-5901/IJCEM0012317 Original Article Dose-dependent effects of dexmedetomidine during one-lung ventilation in patients undergoing lobectomy
More informationEfficacy of dexmedetomidine in reducing postoperative morphine consumption in patients undergoing total abdominal hysterectomy
Original Article Brunei Int Med J. 2016; 12 (3): 97-103 Efficacy of dexmedetomidine in reducing postoperative morphine consumption in patients undergoing total abdominal hysterectomy Mazlilah ABDUL MALEK
More informationA comparative study between Dexmedetomidine infusion and Propofol infusion for maintenance
IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) e-issn: 2279-0853, p-issn: 2279-0861.Volume 15, Issue 3 Ver. II (Mar. 2016), PP 82-86 www.iosrjournals.org A comparative study between Dexmedetomidine
More informationInternational Journal of Health Sciences and Research ISSN:
International Journal of Health Sciences and Research www.ijhsr.org ISSN: 2249-9571 Original Research Article Intravenous Dexmedetomidine Premedication on Spinal Anaesthesia with Hyperbaric Bupivacaine
More informationAbstract. and Ahmed Mohamed Omar *
scientific articles PROSPECTIVE, RANDOMIZED STUDY TO ASSESS THE ROLE OF DEXMEDETOMIDINE IN PATIENTS WITH SUPRATENTORIAL TUMORS UNDERGOING CRANIOTOMY UNDER GENERAL ANAESTHESIA Rabie Nasr Soliman *, Amira
More informationISSN X (Print) Research Article. *Corresponding author S. Kiran Kumar
Scholars Journal of Applied Medical Sciences (SJAMS) Sch. J. App. Med. Sci., 2014; 2(5A):1517-1523 Scholars Academic and Scientific Publisher (An International Publisher for Academic and Scientific Resources)
More informationRETRACTED. Dexmedetomidine infusion is associated with enhanced renal function after thoracic surgery
Journal of Clinical Anesthesia (2006) 18, 422 426 Original contribution Dexmedetomidine infusion is associated with enhanced renal function after thoracic surgery Robert J. Frumento MS, MPH, Helene G.
More informationCOMPARATIVE STUDY OF INTRAVENOUS DEXMEDETOMIDINE PLUS INTRATHECAL BUPIVACAINE VS INTRATHECAL BUPIVACAINE ALONE FOR PROLONGATION OF SPINAL ANALGESIA
COMPARATIVE STUDY OF INTRAVENOUS DEXMEDETOMIDINE PLUS INTRATHECAL BUPIVACAINE VS INTRATHECAL BUPIVACAINE ALONE FOR PROLONGATION OF SPINAL ANALGESIA H. L. Rani 1, I. Upendranath 2 1Associate Professor,
More informationAlfaxan. (alfaxalone 10 mg/ml) Intravenous injectable anesthetic for use in cats and dogs. TECHNICAL NOTES DESCRIPTION INDICATIONS
Alfaxan (alfaxalone 10 mg/ml) Intravenous injectable anesthetic for use in cats and dogs. NADA 141-342, Approved by FDA ALFAXAN (Schedule: C-IV) (alfaxalone 10 mg/ml) Intravenous injectable anesthetic
More informationEffect of intravenous dexmedetomidine infusion on some proinflammatory cytokines, stress hormones and recovery profile in major abdominal surgery
Alexandria Journal of Medicine (2012) 48, 3 8 Alexandria University Faculty of Medicine Alexandria Journal of Medicine www.sciencedirect.com ORIGINAL ARTICLE Effect of intravenous dexmedetomidine infusion
More informationDOI /yydb medetomidine a review of clinical applications J. Curr Opin Anaesthesiol
1573 medetomidine a review of clinical applications J. Curr Opin Anaesthesiol 2008 21 4 457-461. 6 DAHMANI S PARIS A JANNIER V et al. Dexmedetom- 2. α 2 idine increases hippocampal phosphorylated extracellular
More informationA SYSTEMATIC REVIEW ON THE USE OF DEXMEDETOMIDINE AS A SOLE AGENT FOR INTRAVENOUS MODERATE SEDATION
A SYSTEMATIC REVIEW ON THE USE OF DEXMEDETOMIDINE AS A SOLE AGENT FOR INTRAVENOUS MODERATE SEDATION by Dr. Samuel Y. Toong A thesis submitted in conformity with the requirements for the degree of Master
More informationSUMMARY OF PRODUCT CHARACTERISTICS
SUMMARY OF PRODUCT CHARACTERISTICS 1. NAME OF THE VETERINARY MEDICINAL PRODUCT Medeson 1 mg/ml solution for injection for dogs and cats [AT, CY, CZ, DE, EL, ES, HR, IT, LT, LV, PL, PT, RO, SI, SK] Medeson,
More informationSingle Dose PK Study in Non-Naïve Beagle or Mixed Breed Dogs (Parallel Session)
Single PK Study in Non-Naïve Beagle or Mixed Breed Dogs (Parallel Session) Single PK Study in Non-Naïve Beagle or Mixed Breed Dogs (4 crossover Sessions) Repeat PK Study in Non-Naïve Beagle or Mixed Breed
More informationDISSOCIATIVE ANESTHESIA
DISSOCIATIVE ANESTHESIA Adarsh Kumar Dissociative anesthesia implies dissociation from the surrounding with only superficial sleep mediated by interruption of neuronal transmission from unconscious to
More informationQuality of MRI pediatric sedation: Comparison between intramuscular and intravenous dexmedetomidine
Egyptian Journal of Anaesthesia (2013) 29, 47 52 Egyptian Society of Anesthesiologists Egyptian Journal of Anaesthesia www.elsevier.com/locate/egja www.sciencedirect.com Research Article Quality of MRI
More informationIntraoperative Sedation During Epidural Anesthesia: Dexmedetomidine Vs Midazolam
ISPUB.COM The Internet Journal of Anesthesiology Volume 17 Number 2 Intraoperative Sedation During Epidural Anesthesia: Dexmedetomidine Vs Midazolam M Celik, N Koltka, B Cevik, H Baba Citation M Celik,
More informationDexmedetomidine infusion as a supplement to isoflurane anaesthesia for vitreoretinal surgery
British Journal of Anaesthesia 98 (4): 477 83 (2007) doi:10.1093/bja/aem040 Advance Access publication March 1, 2007 Dexmedetomidine infusion as a supplement to isoflurane anaesthesia for vitreoretinal
More informationA Comparative Evaluation of Intranasal Dexmedetomidine and Intranasal Midazolam for Premedication in Pediatric Surgery
Original Research Article A Comparative Evaluation of Intranasal Dexmedetomidine and Intranasal Midazolam for Premedication in Pediatric Surgery Dr. Shweta Nitturi 1*, Dr. Olvyna D souza 2 1 ICU Junior
More informationJMSCR Vol 05 Issue 03 Page March 2017
www.jmscr.igmpublication.org Impact Factor 5.84 Index Copernicus Value: 83.27 ISSN (e)-2347-176x ISSN (p) 2455-0450 DOI: https://dx.doi.org/10.18535/jmscr/v5i3.219 Comparative Study of Adverse Effect of
More informationA randomized control study of dexmedetomidine versus fentanyl as an anesthetic adjuvant in supratentorial craniotomies
ORIGINAL ARTICLE ANAESTHESIA, PAIN & INTENSIVE CARE www.apicareonline.com A randomized control study of dexmedetomidine versus fentanyl as an anesthetic adjuvant in supratentorial craniotomies Amrita Gupta,
More informationYuan Han 1,2, Liu Han 1, Mengmeng Dong 1, Qingchun Sun 1, Ke Ding 1, Zhenfeng Zhang 1, Junli Cao 1,2* and Yueying Zhang 1*
Han et al. BMC Anesthesiology (2018) 18:12 DOI 10.1186/s12871-018-0468-x RESEARCH ARTICLE Open Access Comparison of a loading dose of dexmedetomidine combined with propofol or sevoflurane for hemodynamic
More informationAppendix: Outcomes when Using Adjunct Dexmedetomidine with Propofol Sedation in
SUPPLEMENTAL CONTENT Appendix: Outcomes when Using Adjunct Dexmedetomidine with Propofol Sedation in Mechanically Ventilated Surgical Intensive Care Patients Table of Contents Methods Summary of Definitions
More informationSUMMARY OF PRODUCT CHARACTERISTICS
SUMMARY OF PRODUCT CHARACTERISTICS 1. NAME OF THE VETERINARY MEDICINAL PRODUCT Dormilan solution for injection for dogs and cats [FR] Dormilan 1 mg/ml solution for injection for dogs and cats [DE, ES,
More informationStudy of efficacy and safety of intravenous Dexmedetomidine infusion as an adjuvant to Bupivacaine spinal anaesthesia in Abdominal hysterectomy
ORIGINAL ARTICLE Study of efficacy and safety of intravenous Dexmedetomidine infusion as an adjuvant to Bupivacaine spinal anaesthesia in Abdominal hysterectomy Darshna Patel 1 *, Abdulrazak Saiyad 2,
More informationDEXMEDETOMIDINE ATTENUATES SYMPATHO AD RENAL RESPONSES TO TRACHEAL INTUBATION AND REDUCES THE NEED FOR THIOPENTONE AND PEROPERATIVE FENTANYL
British Journal of Anaesthesia 992; 68: 26- ORIGINAL ARTICLES DEXMEDETOMIDINE ATTENUATES SYMPATHO AD RENAL RESPONSES TO TRACHEAL INTUBATION AND REDUCES THE NEED FOR THIOPENTONE AND PEROPERATIVE FENTANYL
More informationMaduranthagam. 2 Associate Professor, Department Of Anesthesia, Karpagavinayaga Medical College And Hospital, Maduranthagam.
IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) e-issn: 2279-0853, p-issn: 2279-0861.Volume 14, Issue 8 Ver. V (Aug. 2015), PP 01-08 www.iosrjournals.org A Comparative Clinical Study Of 0.25% Bupivacaine
More informationDexmedetomidine and its Injectable Anesthetic-Pain Management Combinations
Back to Anesthesia/Pain Management Back to Table of Contents Front Page : Library : ACVC 2009 : Anesthesia/Pain Management : Dexmedetomidine Dexmedetomidine and its Injectable Anesthetic-Pain Management
More informationReview of local guidelines Contributes to CQC Regulation number: 9,11
Dexmedetomidine Infusions in Burns Intensive Care for Adults Clinical Guideline Register No: 15026 Status: Public Developed in response to: Best practice Review of local guidelines Contributes to CQC Regulation
More informationNon-invasive, mildly to moderately painful, procedures and examinations which require restraint, sedation and analgesia in dogs and cats.
1. NAME OF THE VETERINARY MEDICINAL PRODUCT Sedadex 0.1 mg/ml solution for injection for dogs and cats 2. QUALITATIVE AND QUANTITATIVE COMPOSITION 1 ml contains: Active substance: Dexmedetomidine hydrochloride
More informationAssociate Professor, Department of Anaesthesiology, Rangaraya Medical College, Kakinada, East Godavari, Andhra Pradesh, India, 2
Original Article Print ISSN: 3-6379 Online ISSN: 3-595X DOI: 0.7354/ijss/07/47 Bolus Doses of Ketofol versus Dexmedetomidine for the Prevention of Emergence Agitation in Children: A Prospective Randomized
More informationClinical applicability of dexmedetomidine for sedation, premedication and analgesia in cats 1 / 2007
1 / 2007 Clinical applicability of dexmedetomidine for sedation, premedication and analgesia in cats 1 5 Dexmedetomidine: a new 2-adrenoceptor agonist for modern multimodal anaesthesia in dogs and cats
More informationBabita Ghai, Divya Jain, Payal Coutinho, and Jyotsna Wig. Correspondence should be addressed to Divya Jain;
Anesthesiology Volume 2015, Article ID 617074, 7 pages http://dx.doi.org/10.1155/2015/617074 Clinical Study Effect of Low Dose Dexmedetomidine on Emergence Delirium and Recovery Profile following Sevoflurane
More informationIJBCP International Journal of Basic & Clinical Pharmacology. Adverse drug effects monitoring of amlodipine in a tertiary care hospital
Print ISSN: 2319-2003 Online ISSN: 2279-0780 IJBCP International Journal of Basic & Clinical Pharmacology DOI: http://dx.doi.org/10.18203/2319-2003.ijbcp20182069 Original Research Article Adverse drug
More informationCritical appraisal Randomised controlled trial questions
Critical appraisal Randomised controlled trial questions Korpivaara, M., Laapas, K., Huhtinen, M., Schoning, B., Overall, K. (2017) Dexmedetomidine oromucosal gel for noise-associated acute anxiety and
More informationComparison of anesthesia with a morphine lidocaine ketamine infusion or a morphine lidocaine epidural on time to extubation in dogs
Veterinary Anaesthesia and Analgesia, 2016, 43, 86 90 doi:10.1111/vaa.12273 SHORT COMMUNICATION Comparison of anesthesia with a morphine lidocaine ketamine infusion or a morphine lidocaine epidural on
More informationChronic subdural hematoma (CSDH) is one of the most
CLINICAL INVESTIGATION Comparison of Dexmedetomidine Versus Midazolam-Fentanyl Combination for Monitored Anesthesia Care During Burr-Hole Surgery for Chronic Subdural Hematoma Vinod Bishnoi, MD,* Bhupesh
More informationDexmedetomidine In The Prevention Of Emergence Delirium In Children
University of New England DUNE: DigitalUNE Nurse Anesthesia Capstones School of Nurse Anesthesia 6-2017 Dexmedetomidine In The Prevention Of Emergence Delirium In Children Lauren Anderson University of
More informationA comparison of the effectiveness of dexmedetomidine versus propofol target-controlled infusion for sedation during fibreoptic nasotracheal intubation
doi:10.1111/j.1365-2044.2009.06226.x ORIGINAL ARTICLE A comparison of the effectiveness of dexmedetomidine versus propofol target-controlled infusion for sedation during fibreoptic nasotracheal intubation
More informationANNEX I SUMMARY OF PRODUCT CHARACTERISTICS
ANNEX I SUMMARY OF PRODUCT CHARACTERISTICS 1 1. NAME OF THE VETERINARY MEDICINAL PRODUCT DEXDOMITOR 0.1 mg/ml solution for injection 2. QUALITATIVE AND QUANTITATIVE COMPOSITION Active substance: Excipients:
More informationJMSCR Vol 06 Issue 10 Page October 2018
www.jmscr.igmpublication.org Impact Factor (SJIF): 6.379 Index Copernicus Value: 79.54 ISSN (e)-2347-176x ISSN (p) 2455-0450 DOI: https://dx.doi.org/10.18535/jmscr/v6i10.02 The Beneficiary Effects of Intravenous
More informationANNEX I SUMMARY OF PRODUCT CHARACTERISTICS
ANNEX I SUMMARY OF PRODUCT CHARACTERISTICS 1 1. NAME OF THE VETERINARY MEDICINAL PRODUCT Cepedex 0.1 mg/ml solution for injection for dogs and cats. 2. QUALITATIVE AND QUANTITATIVE COMPOSITION 1 ml contains:
More informationA comparison of dexmedetomidine and midazolam for sedation in third molar surgery*
doi:10.1111/j.1365-2044.2007.05230.x A comparison of dexmedetomidine and midazolam for sedation in third molar surgery* C. W. Cheung, 1 C. L. A. Ying, 2 W. K. Chiu, 3 G. T. C. Wong, 1 K. F. J. Ng 4 and
More informationSuitability of Antibiotic Treatment for CAP (CAPTIME) The duration of antibiotic treatment in community acquired pneumonia (CAP)
STUDY PROTOCOL Suitability of Antibiotic Treatment for CAP (CAPTIME) Purpose The duration of antibiotic treatment in community acquired pneumonia (CAP) lasts about 9 10 days, and is determined empirically.
More informationPackage leaflet: Information for the user. Propofol 2 % (20 mg/1 ml) Fresenius emulsion for injection or infusion Propofol
Package leaflet: Information for the user Propofol 2 % (20 mg/1 ml) Fresenius emulsion for injection or infusion Propofol Read all of this leaflet carefully before you are given this medicine because it
More informationHealth Products Regulatory Authority
1 NAME OF THE VETERINARY MEDICINAL PRODUCT Ketamidor 100 mg/ml solution for injection 2 QUALITATIVE AND QUANTITATIVE COMPOSITION 1 ml contains: Active substance: Ketamine (as hydrochloride) Excipient:
More informationSUMMARY OF PRODUCT CHARACTERISTICS. Narcostart 1 mg/ml solution for injection for cats and dogs (NL, AT, BE, CZ, EL, HU, IS, LU, PL, SK)
SUMMARY OF PRODUCT CHARACTERISTICS Revised: September 2015 1. NAME OF THE VETERINARY MEDICINAL PRODUCT Narcostart 1 mg/ml solution for injection for cats and dogs (NL, AT, BE, CZ, EL, HU, IS, LU, PL, SK)
More information1. NAME AND ADDRESS OF THE MARKETING AUTHORISATION HOLDER AND OF THE MANUFACTURING AUTHORISATION HOLDER RESPONSIBLE FOR BATCH RELEASE, IF DIFFERENT
PACKAGE LEAFLET FOR: Dormilan solution for injection for dogs and cats [FR] Dormilan 1 mg/ml solution for injection for dogs and cats [DE, PT, UK] Reanest 1 mg/ml solution for injection for dogs and cats
More informationT u l a n e U n i v e r s i t y I A C U C Guidelines for Rodent & Rabbit Anesthesia, Analgesia and Tranquilization & Euthanasia Methods
T u l a n e U n i v e r s i t y I A C U C Guidelines for Rodent & Rabbit Anesthesia, Analgesia and Tranquilization & Euthanasia Methods Abbreviations: General Considerations IV = intravenous SC = subcutaneous
More informationTHE EFFECTS OF MIDAZOLAM AND DEXMEDETOMIDINE INFUSION ON Peri-OPERATIVE ANXIETY IN REGIONAL ANESTHESIA
THE EFFECTS OF MIDAZOLAM AND DEXMEDETOMIDINE INFUSION ON Peri-OPERATIVE ANXIETY IN REGIONAL ANESTHESIA Elif Şenses *, Alparslan Apan **, Emıne Arzu Köse ***, Gökşen Öz *** and Hatice Rezaki **** Abstract
More informationBritish Journal of Anaesthesia 83 (3): (1999)
British Journal of Anaesthesia 83 (3): 372 80 (1999) CLINICAL INVESTIGATIONS Effects of dexmedetomidine on isoflurane requirements in healthy volunteers. 1: Pharmacodynamic and pharmacokinetic interactions
More information