Assessment of Antibiotics Misuse among People in Erbil City

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1 Assessment of Antibiotics Misuse among People in Erbil City تقيم شيىع استعمال المضادات الحيىية و تأثيراتها السلبية على االشخاص في مذينة اربيل Aza Bahadeen Taha / Ph.D. in Medical Microbiology, College of Nursing, Hawler Medical University Kazhal Hassan Hama /High Diploma in Biology, College of Nursing, Hawler Medical University Ismail Bilal Ismail/ M.Sc. in Pharmacology, College of Nursing, Hawler Medical University Sadiya Abdullah Mawlud/ M.Sc. in Microbiology, College of Nursing, Hawler Medical University E. mail: tahaaza@yahoo.com. الخالصة خلفية البحث : رعذ ان ضبداد انح خ احذح ي اكثش االد خ اسزخذايب ي قجم االشخبص نهقضبء عه نالنز بثبد انجكزش خ. ا اسزع بل ان ضبداد انح خ رحزبج ان دقخ ف االسزخذاو ان ع انك رحذ ذ ان ذح انضي خ انالصيخ الخز ان ضبداد انح خ, ف ز ان ضبداد انح خ رسجت يشبكم عذح نه شض اال ى ي رنك ر نذ يقب يخ نه ضبداد انح خ ا زشبس ز ان قب يخ. الهذف : ا ان ذف ي ز انذساسخ رق ى ظب شح اسزخذاو ان ضبداد انح خ ي قجم االشخبص ثشكم عبو يعشفخ يذ دقخ اسزخذاي ب يعه يبد ان سزخذو ح ل ان ضبداد انح خ ثذ اسزشبسح االطجبء. المنهجية: ف ز انذساسخ رى اخز 055 ع خ ثشكم عش ائ ع ع طش ق اخشاء يقبثالد يع االشخبص انجبنغ ي يخزهف ان بطق ف اسث م. النتائج: زبئح ز انذساسخ اظ شد ا يب قبسة صف ان سزخذي )5..%0( نه ضبداد انح خ نى ك نذ ى ا يعه يبد ع االعشاض اندب ج خ ا 3..%8 ي ان شبسك ف انجحث كب ذ نذ ى فكشح خبطئخ ع اسزخذاو ان ضبداد انح خ نعالج انصذاع. ا %80.3 ي ان شبسك نى ك نذ ى فكشح عه ا ان ضبداد انح خ قذ رقض رسبعذ ف قزم انجكز ش ب ان ف ذح نهدسى. ا...%0 ي ان شبسك نى ك نذ ى ا فكشح ح ل اصد بد يقب يخ انجكزش ب نه ضبداد انح خ ع ذ كثشح اسزخذاي ب. اظ شد ز انذساسخ ا %58 ي ان شبسك كب ا سزخذي ان ضبداد انح خ ثذ اسزشبسح االطجبء ا انص بدنخ ا..%58 ي ى سزخذي ب نعالج اال فه ضا ا 5..%0 ي ان سزخذي فضه اسزخذاو ان ضبداد انح خ ع شكم حج ة ا انكجس الد. االستنتاجات : أظ شد ز انذساسخ يذ ا زشبس اسزخذاو ان ضبداد انح خ ثشكم غ ش عه دق ق ي ب سجت يشبكم عذ ذح اعشاض خب ج خ نذ ان سزخذي. التىصيات: ر ص ز انذساسخ عه عذو صشف ان ضبداح انح خ ي ثذ اسزشبسح االطجبء ي قجم انص ذن بد. Abstract Background: Antibiotics are only useful for treating bacterial infections. Inadequate use of includes overuse, inappropriate type, dose, duration and/or frequency of administration had been a major problem. Antibiotic use has been identified as a major contributor to the development and spread of antibiotic resistance. Objectives: Assessment self-medication and inappropriate of were used among people in Erbil city. To find out the associations between the antibiotic use and knowledge related antibiotic consumption. Methods: The study was used a cross-sectional study, which conducted on 500 randomly, selected adult residents in Erbil by using a face-to-face questionnaire. Results: About half of the study samples (52.40%) did not know that has adverse effect on humans body, 37.80% were agree to used antibiotic for headache treatment, 65.80% of them did not know that kill normal flora, and 57.20% were did not know that bacteria become resistant to. In addition, 46.00% were used on advice of someone other than a physician or pharmacist, 46.20% of peoples were some time used against colds and flu, 52.40% of peoples were some time used as injection, and 57.20% of peoples were some time used antibiotic as one capsule when needed. Conclusion: Self-medication and inappropriate use of were problems among people in the community. Recommendation: Strict precautions should be taken about use and sale without prescriptions. Keywords: Antimicrobials, antibiotic resistance, self-medication 0

2 INTRODUCTION Antibiotics are among the most common drugs prescribed. The spread of antibiotic resistance is a major threat to public health (1, 2). A direct relationship between excessive antibiotic use and increasing microbial resistance had been documented also influenced by how are used by the patient (3,4). Moreover, levels of bacterial resistance occur in proportion to the volume of community antibiotic use (5, 6). Many commensal and pathogenic bacteria have developed resistance to (7). Antibiotics should be used with care as antibiotic resistance is correlated with antibiotic use (8). The emergence of antibiotic resistance has been recognised as an important health problem because discovery of new is no longer keeping pace with the spread of highly resistant bacteria (9). The resistance to any antibiotic is promoted by excessive prescribing of broad-spectrum, because this overprescribing promotes resistance to agents that are commonly used to complicated infections (10, 11). The increasing use, overused and abused of to treat illness is the greatest factor causing spread of drug resistance. Antibiotics are misused because many patients do not take according to prescription instructions (12). Misuse of antibiotic therapy, including failure to complete therapy, skipping of doses, or reuse of leftover, can potentially exposed patients to suboptimal doses of antibiotic therapy (13-15). Antibiotics do not have any effect on viral infections. The treatment for a cold is normally getting rest (16). Misuse of antibiotic therapy has ramifications on treatment failures in patients with antibiotic resistant infections, wasted medication, hospitalisation time, and increased return visits to the physician (13, 14). Self-medication with may increase the risk of inappropriate use and the selection of resistant bacteria (17). Unnecessary prescription of is the main driver for the development of antibiotic resistance (18, 19). Physicians may overprescribe because they want to prevent potential infections or simply because they believe that is what patients want (20). The consequences of overuse are striking, every year; millions of people are directly exposed to the side effects of (21). Increased treatment options, more variable benefits and risks, higher financial costs, and the growth of consumerism appear to be central contributors to a growing role for patients in the decision making process (22). In low-income countries showed that the cost of medical consultation and low attitudes and behaviour of health personnel might reinforce use of self-medication with (23). The widespread consumption of inappropriate and inadequate doses of in developing countries is of a major concern of which resistance to has been linked to level of consumption (5). Many countries increasingly implement actions to control antibiotic resistance through rational use (24). The objective of the presented study was to evaluate the awareness toward antibiotic usage among the peoples. METHODS The cross-sectional study conducted on people in Erbil city. Home visits were conducted a randomly selected households in Erbil quarter from June 2012 to July Only one member of the household was selected randomly by alphabetically of the names who those above 18 and able to understand and answer the questionnaire. Participants were given information by completed the questionnaire face to face. Informed consent was obtained from 500 participants in the study. Setting of study: the present study was conducted Erbil city. Instruments composition: Study tool was prepared through literatures review, which involved two parts; Part I: demographic characteristics were include age, gender, marital status, and level of education. Part II: this part composed of the questionnaire toward awareness (11 items) and attitudes (10 items) of participants about antibiotic use. 1

3 Validity of questionnaire: Five experts from different related specialties were evaluated the questionnaires. Statistical methods: Data was analyzed using SPSS 19.0 software. Qualitative variables were compared using the Chi-square (X 2 ). All p-values with p < 0.05 were considered significant. RESULTS Table 1: Demographic characteristics of 500 household members Age Group Gender Marital status Level of education Characteristics n % Male Female Married Single Illiterate Primary 40 8 Intermediate Institute College Post-graduate This table shows that the demographic characteristic of 500 population-studded shows that the majority (50.8%) of ages were 18 to 24 of which males were 68.2%, while females were 31.8% and the married status were 44.2%. According to the educational status, high percentage 59.6% of the population was in the level 7-12 (Table 1). Table 2: Association between antibiotic use and demographic characteristics Antibiotics used in the past Characteristics 1 weeks 2 weeks 3 weeks 4 weeks 5 weeks Total P-value n % n % n % n % n % n % Age Group Gender Male Female Marital Married status Single Illiterate Primary Intermediate Level of Institute education College Postgraduate Total = Significant, = Not significant

4 Table 2 shows that there is high significant (P = 0.02) relation between antibiotic taken and level of education, while there are no significant with age (P = 0.48), gender (P = 0.11), and marital status (P = 0.25) (Table 2). Table 3: Association between awareness of the study sample toward antibiotic use and age groups Statements Used on advice of someone other than a physician or pharmacist Total p- n % value Never Some time Every time Never Selection of Some time depending on the price Every time Selection of Never according to their colour Some time and shape Every time Never Used old prescription of Some time Every time Stop taking the Never antibiotic when feeling Some time better Every time Change the antibiotic if Never do not feel better Some time immediately Every time Never Used against Some time colds and flu Every time Never Used as Some time injection Every time Never Antibiotic used as one Some time capsule when needed Every time Never Used overdose of Some time Every time Never Some time prescribing Every time = Significant, = Not significant Table 3 show that there are significant differences between age group and stop taking of the antibiotic when feeling better (P = 0.04). However, there are no statistical differences with others statements under table 3. 3

5 Table 4: Attitudes of study sample regarding antibiotic use and their age groups Statements Taking has adverse effect on your body Unnecessary use of has adverse effect on your body Total p- value n % Total agree Total disagree Don t know Total agree Total disagree Don t know prescribing and avoid cutting the course of treatment Antibiotics kill normal flora Antibiotic is a fever lowering agent Antibiotics effective against colds and flu Antibiotic used for headache treatment All are similar in the same activity and way of use Used overdose of Total agree Total disagree Don t know Total agree Total disagree Don t know Total agree Total disagree Don t know Total agree Total disagree Don t know Total agree Total disagree Don t know Total agree Total disagree Don t know Total agree Total disagree Don t know Bacteria become resistant to = Significant, = Not significant Total agree Total disagree Don t know Table 4 shows that positive relation were found between age group with following statements; complete the course of prescribing and avoid cutting the course of treatment (P = 0.02); antibiotic effective against cold and flu (P = 0.01); Antibiotic used for headache treatment (P ), and; all antibiotic are similar in same activity and way of use (P = 0.04) (Table 4). 4

6 Table 5: Association between awareness of the study samples toward antibiotic use among gender respondent Used on advice of someone other than a physician or pharmacist Selection of depending on the price Selection of according to their colour and shape Used old prescription of Stop taking the antibiotic when feeling better Change the antibiotic if do not feel better immediately Used against colds and flu Used as injection Antibiotic used as one capsule when needed Used overdose of Statements Male Female Total n % Never Some time Every time Never Some time Every time Never Some time Every time Never Some time Every time Never Some time Every time Never Some time Every time Never Some time Every time Never Some time Every time Never Some time Every time Never Some time Every time Never prescribing Some time Every time = Significant, = Not significant P-value Table 5 shows that there were significant relations were found between gender and most of statements, while no significant relations were found in statements; Used old prescription of (P =0.78); stop taking antibiotic when feeling better (P=0.27); Change the antibiotic if do not feel better immediately (P = 0.843), and; used overdose of (P= 0.28) (Table 5). 5

7 Table 6: Attitudes of the study sample awareness toward antibiotic use among gender Statements Taking has adverse effect on your body Unnecessary use of has adverse effect on your body prescribing and avoid cutting the course of treatment Antibiotics kill normal flora Antibiotic is a fever lowering agent Antibiotics effective against colds and flu Antibiotic used for headache treatment All are similar in the same activity and way of use Used overdose of Male Female Total n % Total agree Total disagree Don t know Total agree Total disagree Don t know Total agree Total disagree Don t know Total agree Total disagree Don t know Total agree Total disagree Don t know Total agree Total disagree Don t know Total agree Total disagree Don t know Total agree Total disagree Don t know Total agree Total disagree Don t know P-value 0.11 <0.01 < <0.01 <0.01 Bacteria become resistant to = Significant, = Not significant Total agree Total disagree Don t know Table 6 present there were no difference between male and female in the statements; taking antibiotic has adverse effect on your body (P = 0.11); Antibiotic kill normal flora (P = 0.57), and; bacteria become resistant to antibiotic (P = 0.10) (Table 6). 6

8 Illiterate Primary Intermediate Institute College Postgraduate Table 7: Association between awareness of the study samples toward antibiotic use and education levels Statements Total p-value Used on advice of someone other than a physician or pharmacist Selection of depending on the price Selection of according to their colour and shape Used old prescription of Stop taking the antibiotic when feeling better Change the antibiotic if do not feel better immediately Used against colds and flu Used as injection Antibiotic used as one capsule when needed Used overdose of n % Never Some time Every time Never Some time Every time Never Some time Every time Never Some time Every time Never Some time Every time Never Some time Every time Never Some time Every time Never Some time Every time Never Some time Every time Never Some time Every time Never prescribing Some time Every time = Significant, = Not significant Table 7 reveals that there were significant relations between level of education and following statements; Used on advice of someone other than a physician or pharmacist (P= 0.02); Antibiotic used as one capsule when needed (P= 0.01); Used overdose of (P= 0.01) (Table 7). 7

9 Illiterate Primary Intermediate Institute College Postgraduate Table 8: Attitudes of awareness toward antibiotic use among different education levels Statements Total p-value Taking has adverse effect on your body Unnecessary use of has adverse effect on your body prescribing and avoid cutting the course of treatment Antibiotics kill normal flora Antibiotic is a fever lowering agent Antibiotics effective against colds and flu Antibiotic used for headache treatment All are similar in the same activity and way of use Used overdose of n % Total agree Total disagree Don t know Total agree Total disagree Don t know Total agree Total disagree Don t know Total agree Total disagree Don t know Total agree Total disagree Don t know Total agree Total disagree Don t know Total agree Total disagree Don t know Total agree Total disagree Don t know Total agree Total disagree Don t know Total agree Bacteria become resistant to Total disagree Don t know = Significant, = Not significant Table 8 shows that there were statistical associated between level of education with the following statements; Taking has adverse effect on your body (P= 0.01); Unnecessary use of has adverse effect on your body (P ); Complete the course of prescribing and avoid cutting the course of treatment (P= 0.02) Antibiotics kill normal flora (P ); Antibiotic is a fever lowering agent (P ); Antibiotics effective against colds and flu (P ); Antibiotic used for headache treatment (P ); All are similar in the same activity and way of use (P ); used overdose of antibiotic (P= 0.02), and; Bacteria become resistant to (P ) (Table 8). 8

10 DISCUSSION Antibiotic resistance is a serious and growing problem in nations around the globe (25). A direct relationship between rates of antibiotic use and misuse with the rising bacterial resistance has been reported (6). The current study was assessed the antibiotic abuse in community of Erbil city, this study investigate the prevalence of self medication among population of which, 62.3% used for headache, 49.8% for fever and 48.3% for cold and flu. The result found that about half of the people use on advice of someone other than a physician or pharmacist, in compared with others studies, 46% of the community uses without prescription in Jordan (26). While in Greek population, the level of use of non-prescribed antibiotic was as high as 74.6% (27). This difference in results may be attributable to the public awareness, different cultures, and health system. Antibiotics resistances are affected not only by over dose of it but also by the way of used, which emphasizing pharmacists role and responsibility in stopping antibiotic sale without prescription. The prescribing practices of practitioners are not regulated (28). The study found about half of participants declared about the price of which some of the people may not have enough money to go to physicians or have time. In addition, the study found that some of the people choose antibiotic according to the colour and shape thus, it is necessary to raise awareness about the threat of antibiotic resistance and the importance of prudent antibiotic use. The study were conclusion that weak awareness and irrational of used among people in Erbil city. CONCLUSION Self-medication and irrational use of is common among the people in the community in Erbil city. Education increases attitudes of awareness toward antibiotic use. RECOMMENDATION The development of management and the promotion of the role of the pharmacist in prescribing, also improved strategies for prescribing. REFERENCES 1. Besser RE. Antimicrobial prescribing in the United States: good news, bad news. Ann Intern Med 2003; 138(7): Rogues AM, Placet-Thomazeau B, Parneix P, Vincent I, Ploy MC, Marty N, et al. Use of in hospitals in south-western France. J Hosp Infect 2004; 58(3): Malhotra-Kumar S, Lammens C, Coenen S, Van Herck K, Goossens H. Effect of azithromycin and clarithromycin therapy on pharyngeal carriage of macrolide-resistant streptococci in healthy volunteers: a randomised, double-blind, placebo-controlled study. Lancet 2007; 369(9560): Metlay JP, Shea JA, Crossette LB, Asch DA. Tensions in antibiotic prescribing: pitting social concerns against the interests of individual patients. J Gen Intern Med 2002; 17(2): Austain DJ, Kristinsson KJ, Anderson RM. The relationship between the volume of antimicrobial consumption in human communities and frequency of resistance. Proc Natl Acad Sci USA 1999; 96(3): Goossens H, Ferech M, Vander Stichele R, Elseviers M, ESAC Project Group. Outpatient antibiotic use in Europe and association with resistance: a cross-national database study. Lancet 2005; 365(9459): Lipsitch M, Samore MH. Antimicrobial use and antimicrobial resistance: a population perspective. Emerg Infect Dis 2002; 8(4): Levy SB, Marshall B. Antibacterial resistance worldwide: causes, challenges and responses. Nat Med 2004; 10(12):

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