*Adult hookworm (Ancylostoma caninum), adult roundworm (Toxocara canis and Toxascaris leonina), and adult whipworm (Trichuris vulpis)
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1 Main Message Trifexis (spinosad+milbemycin oxime) provides 3-in-1 parasite protection against heartworm, fleas and intestinal parasites. * *adult hookworm, roundworm and whipworm infections Description Convenient 3-in-1 parasite protection. Trifexis (spinosad + milbemycin oxime) is the monthly, beef-flavored tablet that kills fleas and prevents flea infestations, prevents heartworm disease, and treats and controls adult hookworm, roundworm and whipworm infections. This powerful protection is approved for use in dogs and puppies 8 weeks of age or older and 5 pounds of body weight or greater. Sample Headlines Trifexis for dogs: 3-in-1 parasite protection. Get three types of parasite protection in just one tablet every month. Protecting your dog from parasites is easy. Once a month, every month. Claims & Benefits Kills fleas and prevents infestations. Prevents heartworm disease. Treats and controls adult hookworm, roundworm and whipworm* infections. #1 Prescribed combo parasite protection. 1 A monthly, beef-flavored tablet that kills adult fleas and prevents flea infestations, prevents heartworm disease, and treats and controls adult hookworm, roundworm and whipworm* infections. Trifexis is proven safe in dogs and puppies 8 weeks and older and 5 pounds and greater. *Adult hookworm (Ancylostoma caninum), adult roundworm (Toxocara canis and Toxascaris leonina), and adult whipworm (Trichuris vulpis) 1 Elanco Animal Health. Data on file. When utilizing any copy noted in Main Message, Description, Sample Headlines, or Claims & Benefits, see RULES AND REGULATIONS section for mandatory copy inclusion. Product Comparison Chart Kills fleas and prevents infestations Prevents heartworm disease Treats and controls adult Hookworm Roundworm Whipworm Trifexis (spinosad + milbemycin oxime) Heartgard Plus (ivermectin/pyrantel) NexGard (afoxolaner) Bravecto TM (fluralaner) * ** NexGard and Bravecto also kill ticks. These comparisons are based on label information. *A. caninum **A. caninum, U. stenocephala, A. braziliense
2 Important Safety Information The use of ivermectin at higher than FDA-approved doses at the same time as Trifexis can result in serious side effects. Treatment with fewer than three monthly doses after the last exposure to mosquitoes may not provide complete heartworm prevention. Prior to administration, dogs should be tested for existing heartworm infection. Use with caution in breeding females. The safe use of Trifexis in breeding males has not been evaluated. Use with caution in dogs with preexisting epilepsy. The most common adverse reactions reported are vomiting, depression/lethargy, itching, decreased appetite, and diarrhea. To ensure heartworm prevention, observe your dog for one hour after administration. If vomiting occurs within one hour of administration, redose. Puppies less than 14 weeks of age may experience a higher rate of vomiting. Like all medications, keep Trifexis out of reach of children. See Trifexis label for complete safety information. Retail Information Trifexis is available in five tablet sizes. Each size is available in packages of six tablets per box. Spinosad Milbemycin oxime Material Code Dog Weight Pack Size UPC Code Per Tablet (mg) Per Tablet (mg) CA4332YO7AM 5-10 lbs 6 doses CA4333YO7AM lbs 6 doses CA4334YO7AM lbs 6 doses CA4335YO7AM lbs 6 doses CA4336YO7AM lbs 6 doses Administer the Administer the Administer the Over 120 lbs appropriate appropriate appropriate combination of combination of combination of tablets. tablets. tablets Rules & Regulations In order to comply with laws applicable to this product, you must do the following: 1. Must state the brand name, established name and dose form Trifexis (spinosad + milbemycin oxime) - on each piece, it must be clear what the dose form is (chewable [flavored] tablet). 2. Must include the full indication Trifexis kills fleas and prevents infestations, prevents heartworm disease, and treat and controls intestinal parasite infections (hookworm, roundworm and whipworm). Hookworm species (A. caninum) should be presented either immediately following hookworm or using an asterisk after hookworm directing to the species name. 3. Must include risk/safety information Important Safety Information (ISI) is required on all print (including electronic) full product advertising. If brand name/logo and brand use or benefit are present, ISI must be present. Must present benefit:risk information in a fair and balanced manner. In addition to content, also consider size, formatting, white space, background, coloring and placement of benefit and risk information to achieve balance and equal prominence. 4. Must include full product label active links for digital Label can be found at: exis_090740as_03b429_w1b_ws.pdf 5. Direct to consumer (DTC) assets, including but not limited to, digital banners, videos, blasts, direct mail and in-store merchandising pieces that have any Elanco product mentioned must be validated with Elanco if a piece needs approval prior to release. All FDA DTC pieces will need to be submitted to the FDA with first use date prior to first use.
3 Brand Assets Access to brand visuals, photography, art files, etc. is available upon request from your Elanco contact. Not actual size.
4 Campaign photography available upon request. MUST READ: Trifexis Photography Usage Rights Usage rights include global usage for Internet, Social Media and Point-of-Sale for a 3-yr. period from March 1, 2017 to March 1, Broadcast or print usage is excluded.
5
6 Trifexis and Elanco are trademarks of Elanco or its affiliates Elanco or its affiliates. USCACTFX01122(1)
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