Thermo Scientific Sensititre Plate Guide. for Antimicrobial Susceptibility Testing

Transcription

1 Thermo Scientific Sensititre Plate uide for ntimicrobial Susceptibility Testing

2 Table of ontents Introduction 3 Thermo Scientific Sensititre System The Value of a True MI for ST 5 Sensititre MI Plates uman 6 ram Negative 7 ram Positive 7 Yeast Myco Veterinary 3 Surveillance 6 Quality ontrol 57 ustom apabilities 5 ustomer Service and Installation 60 lossary 6

3 INTROUTION In 9, the discovery of penicillin revolutionized medicine. ver since, the use of antibiotics to treat and prevent bacterial infections has saved innumerable lives, enabled advancements in medical procedures like surgery and chemotherapy, and helped slow the spread of deadly infections. owever, after nearly 00 years of widespread antibiotic use, the threat posed by evolving bacteria possessing resistance to common antibiotics has emerged as one of the most significant global health issues of the st century. ntimicrobial resistance is present in every country, increases healthcare costs, and is accelerating due to the misuse and overuse of antibiotics in both people and animals. ntimicrobial resistance is a global health emergency that will seriously jeopardize progress in modern medicine. ¹ r. Tedros dhanom hebreyesus irector-eneral, WO The ability to treat infections quickly and accurately with the information obtained from antimicrobial susceptibility testing (ST) is of the utmost importance for combating resistance. ccess to an ST device with the most up-to-date antimicrobials is vital to expanding patient treatment options and improving patient outcomes. ¹World ealth Organization. (07, September 0). The world is running out of antibiotics, WO report confirms [Press Release]. Retrieved from: 3

4 T TRMO SINTII SNSITITR SYSTM To effectively combat antimicrobial resistance, you need the right antimicrobials at the right dose. To improve patient care outcomes, you need faster, more reliable ST devices. Whether you prefer manual or automated solutions, you ll find the right fit for your specific susceptibility testing needs and volume requirements with the Thermo Scientific Sensititre I/ST System. ustomizable testing options are also available, and all solutions are designed to maximize accuracy and reproducibility. The Sensititre System utilizes both in vitro diagnostic (IV) and research use only (RUO), 96-well microtitre plates. With over 0 antimicrobials available in extended dilution ranges on a wide variety of formats, the Sensititre System allows you to consolidate confirmatory tests while meeting, LSI and UT breakpoint requirements. onsolidate your susceptibility testing on a single platform The Sensititre System is a scalable and flexible solution, accommodating microbiology laboratories of all sizes: Inoculate Incubation Read Interpret Thermo Scientific Sensititre Nephelometer a simple solution to standardize inoculum density. Thermo Scientific Sensititre -hannel Programmable Pipette quick and accurate manual inoculation of microtitre plates, with enhanced ergonomics. Thermo Scientific Sensititre IM utomated Inoculation elivery System quickly and accurately doses Sensititre 96-well plates, eliminating both skipped wells and costly repeat tests. Thermo Scientific Sensititre RIS X Instrument includes a heated carousel to individually incubate 6 MI, breakpoint or identification plates, ensuring optimal growth conditions and eliminating repeat tests. Thermo Scientific Sensititre Manual Viewer perform simple visual reads of your 96-well microtitre plates with our mirrored viewbox. Thermo Scientific Sensititre Vizion igital MI Viewing System combines automation with visual results, to consolidate all offline testing on a single instrument, with the benefits of xpert System software and LIS connectivity. Thermo Scientific Sensititre OptiRead utomated luorometric Plate Reading System utilizes fluorescence technology to provide fast, accurate plate reads, and eliminate manual reading. Thermo Scientific Sensititre SWIN Software System, omplete combines results from manual, semi-automated and fully automated read options on a single software platform, to easily consolidate your entire test program and enhance data entry. Thermo Scientific Sensititre SWIN Software pidemiology Module allows users to generate complete, real-time reports and bar graphs in just minutes, including multiple search options to create comprehensive reports specific to your patient population to fully support antimicrobial stewardship programs. Thermo Scientific Sensititre RIS X Instrument a fully automated, benchtop incubating and reading system that facilitates efficient workflow, with the benefits of xpert System software and LIS connectivity. Not available in urope.

5 T VLU O TRU MI OR ST urrent ST methods are based on assessing the ability of an antimicrobial to inhibit bacterial growth. The minimum inhibitory concentration (MI) is the level of antimicrobic required to achieve inhibition against the tested pathogen. owever, some ST systems calculate the MI value by extrapolating growth curves and applying dedicated algorithms. The Sensititre System generates true MI results based on actual growth of the organism. true MI reveals the difference between whether a bacterial isolate is susceptible, how susceptible the organism is against a particular drug, and the exact point at which the isolate becomes resistant. When comparing your MI results against the latest clinical breakpoints from UT and LSI, you can trust the value of a true MI to deliver the accuracy required for optimal patient outcomes, and to track emerging resistance. To be able to get an accurate measurement of MI for very specific drugs like vancomycin, for me, is wonderfully valuable. r. James McKinnell, ssistant Professor of Medicine, avid effen School of Medicine, University of alifornia, Los ngeles The Vizion igital MI Viewing System produces easy-to-read digital plate images, allowing users to easily read and record MI results while eliminating the potential for manual reading errors. 5

6 UMN s the threat of antimicrobial resistance escalates, faster, more accurate testing and identification of an ever-increasing range of infections is vital to improving patient outcomes. With over 300 antimicrobials in extended dilution ranges, the Sensititre I/ST System offers earlier access to the most up-to-date antimicrobials in a complete solution with true MI results, providing confidence when time is critical. Our latest antimicrobial offerings include delafloxacin, meropenem/vaborbactam, ceftazidime/avibactam, and ceftolozane/ tazobactam, with updated breakpoints for an off-the-shelf, true MI solution. xpand treatment options using our broad range of species-specific antimicrobials in standard and customizable formats. ram Negative ram Positive astidious Yeast Mycobacteria Single rug 6

7 uman Sensititre ram Negative N Plate ntimicrobial susceptibility plate for testing non-fastidious ram negative isolates roth Type Mcarland Standard (0) Sensititre Mueller inton roth (T36) IV, LSI [WW] utoread or Manual Sensititre RIS X (V3090) Sensititre OptiRead (V3030) Sensititre Vizion (V0) (V007) Put 3-5 colonies into measure a Mcarland using the Nephelometer, Mix μl*, 0 μl**, or 30 μl*** of suspension into M 50 μl volume per well of the suspension using the Sensititre IM or Multi-hannel Pipette incubate at 3-36 o in a non-o incubator or Sensititre RIS X for - hours utomatically read with RIS X or OptiRead or manually read with ntimicrobics 6 3 P/T / P/T 6/ P/T 3/ P/T 6/ P/T / TIM / TIM 6/ TIM 3/ TIM 6/ 3 6 OR OR OR OR TP TP TP TP TP TP /3 /76 PIP 6 PIP 3 PIP 6 Z Z Z Z Z 6 6 /S / /S / /S 6/ ZT ZT ZT ZT ZT P/T TIM OR TP PIP Z /S ZT mikacin Piperacillin / Tazobactam constant Tigecyline Ticarcillin / lavulanic acid constant Levofloxacin Nitrofurantoin Tetracycline oripenem Minocycline rtapenem Trimethoprim / Sulfamethoxazole Impenem Piperacillin Meropenem entamicin eftazidime Tobramycin eftazidime mpicillin / Sulbactam : ratio ztreonam micillin efepime iprofloxacin eftriaxone *or Proteus spp. **or nterobacteriaceae and Non-nterobacteriaceae. ***or aid in detection of resistance mechanisms for nterobacteriaceae and Non-nterobacteriaceae. Not available in urope. 7

8 uman Sensititre ram Negative N6 Plate with eftazidime/vibactam and eftolozane/tazobactam ntimicrobial susceptibility plate for testing non-fastidious ram negative isolates roth Type Mcarland Standard (0) Sensititre Mueller inton roth (T36) IV, LSI [WW] utoread or Manual Sensititre RIS X (V3090) Sensititre OptiRead (V3030) Sensititre Vizion (V0) (V007) Put 3-5 colonies into measure a Mcarland using the Nephelometer, Mix μl*, 0 μl**, or 30 μl*** of suspension into M 50 μl volume per well of the suspension using the Sensititre IM or Multi-hannel Pipette incubate at 3-36 o in a non-o incubator or Sensititre RIS X for - hours utomatically read with RIS X or OptiRead or manually read with ntimicrobics 6 3 P/T / P/T 6/ P/T 3/ P/T 6/ P/T / /T / /T / /T / /T 6/ 3 6 OR OR OR OR TP TP TP TP TP TP /3 /76 Z / Z / Z / Z 6/ Z Z Z Z Z 6 6 /S / /S / /S 6/ ZT ZT ZT ZT ZT /S ZT Z Z /T OR TP P/T mikacin mpicillin mpicillin / Sulbactam : ratio ztreonam efazolin efepime eftazidime eftazidime / vibactam eftolozane / Tazobactam eftriaxone iprofloxacin oripenem rtapenem entamicin Imipenem Levofloxacin Meropenem Minocycline Nitrofurantoin Piperacillin / Tazobactam constant Tetracycline Tigecycline Tobramycin Trimethoprim / Sulfamethoxazole *or Proteus spp. **or nterobacteriaceae and Non-nterobacteriaceae. ***or aid in detection of resistance mechanisms for nterobacteriaceae and Non-nterobacteriaceae. Not available in urope.

9 uman Sensititre ram Negative NX Plate with olistin ntimicrobial susceptibility plate for testing non-fastidious ram negative isolates roth Type Mcarland Standard (0) Sensititre Mueller inton roth (T36) RUO LSI [WW] utoread or Manual Sensititre RIS X (V3090) Sensititre OptiRead (V3030) Sensititre Vizion (V0) (V007) Put 3-5 colonies into measure a Mcarland using the Nephelometer, Mix μl*, 0 μl**, or 30 μl*** of suspension into M 50 μl volume per well of the suspension using the Sensititre IM or Multi-hannel Pipette incubate at 3-36 o in a non-o incubator or Sensititre RIS X for - hours utomatically read with RIS X or OptiRead or manually read with ntimicrobics 6 3 TIM 6/ TIM 3/ TIM 6/ ZT ZT ZT ZT 6 P/T / P/T 6/ P/T 3/ /9.5 /9 /3 /76 6 OT TP OR 0. OL POL OT TP OR OL POL OT TP OR OL POL OT TP OR OL POL OT 6 TP OR OL POL 6 OT 3 TIM ZT P/T OT TP OR OL POL mikacin Ticarcillin / lavulanic acid constant ztreonam Piperacillin / Tazobactam constant Trimethoprim / Sulfamethoxazole entamicin efepime Tobramycin Levofloxacin oxycycline iprofloxacin Minocycline Meropenem efotaxime Tigecycline rtapenem Imipenem oripenem olistin Polymixin eftazidime TIM / P/T 6/ 6 6 *or Proteus spp. **or nterobacteriaceae and Non-nterobacteriaceae. ***or aid in detection of resistance mechanisms for nterobacteriaceae and Non-nterobacteriaceae. Not available in urope. 9

10 Meet the latest antimicrobials on our new single-drug plate Introducing the Sensititre elafloxacin LXN Plate a new single-drug, multi-isolate MI plate for both ram negative and ram positive organisms ombating emergent multi-drug resistance and expanding patient treatment options requires faster access to an ST device with the most up-to-date antimicrobials. iscover the latest broad spectrum antimicrobial addition to our ST portfolio with the Sensititre elafloxacin LXN plate. Indicated for the treatment of acute bacterial skin and skin structure infections (SSSI), the Sensititre elafloxacin Plate provides true MI results that meet both and LSI requirements in an off-the-shelf, standard format, as well as: One of the latest -cleared antimicrobials ull dilution ranges for both ram negative and ram positive organisms Surveillance data in early stages of drug adoption to combat emerging resistance Not all products are available for sale in all territories. Please inquire. 0

11 uman Sensititre elafloxacin LXN Plate ntimicrobial susceptibility plate for testing non-fastidious ram negative isolates roth Type Mcarland Standard (0) Sensititre Mueller inton roth (T36) IV [US] Manual Sensititre Vizion (V0) (V007) Put 3-5 colonies into measure a Mcarland using the Nephelometer, Mix μl*, 0 μl**, or 30 μl*** of suspension into M 50 μl volume per well of the suspension using the Sensititre IM or Multi-hannel Pipette incubate at 3-36 o in a non-o incubator or Sensititre RIS X for - hours Manually read with ntimicrobics elafloxacin *or Proteus spp. **or nterobacteriaceae and Non-nterobacteriaceae. ***or aid in detection of resistance mechanisms for nterobacteriaceae and Non-nterobacteriaceae. Not available in urope.

12 Meet the latest antimicrobials on our new dual-drug plate Introducing the Sensititre Meropenem/Vaborbactam V Plate a new dual-drug, multi-isolate MI plate for ram negative organisms Mitigating carbepenem resistance and expanding patient treatment options requires faster access to an ST device with the most up-to-date antimicrobials. iscover our latest standard format addition for ram negative organisms with the Sensititre Meropenem/Vaborbactam V plate. dual component drug granted fast-track approval by the, meropenem/vaborbactam is indicated for the treatment of serious ram negative infections, such as complicated urinary tract infections. The Sensititre Meropenem/Vaborbactam Plate provides true MI results that meet both and LSI requirements in an off-the-shelf, standard format, as well as: xpanded treatment options with the latest antimicrobial combination Standardized, direct comparison of meropenem and meropenem/vaborbactam for better susceptibility results, and to help physicians understand the clinical benefit of vaborbactam as a treatment option Supports antimicrobial stewardship efforts by providing surveillance data even in early stages of drug adoption Not all products are available for sale in all territories. Please inquire.

13 uman Sensititre Meropenem/Vaborbactam V Plate ntimicrobial susceptibility plate for testing non-fastidious ram negative isolates roth Type Mcarland Standard (0) Sensititre Mueller inton roth (T36) IV [US] Manual Sensititre Vizion (V0) (V007) Put 3-5 colonies into measure a Mcarland using the Nephelometer, Mix μl*, 0 μl**, or 30 μl*** of suspension into M 50 μl volume per well of the suspension using the Sensititre IM or Multi-hannel Pipette incubate at 3-36 o in a non-o incubator or Sensititre RIS X for - hours Manually read with ntimicrobics MV 0.00/ MV 0.05/ MV 0.00/ MV 0.05/ MV 0.00/ MV 0.05/ MV Meropenem Meropenem / Vaborbactam MV / 0.05 MV / 0.05 MV / 0.05 MV / MV / MV / MV 0./ MV 6/ MV 0./ MV 6/ MV 0./ MV 6/ MV / MV / 0. MV / MV / 0. MV / MV / 0. MV / MV / MV / MV / MV / MV / MV / MV / MV / MV / MV / MV / *or Proteus spp. **or nterobacteriaceae and Non-nterobacteriaceae. ***or aid in detection of resistance mechanisms for nterobacteriaceae and Non-nterobacteriaceae. Not available in urope. 3

14 uman Sensititre ram Negative NX3 Plate with olistin ntimicrobial susceptibility plate for testing non-fastidious ram negative isolates roth Type Mcarland Standard (0) Sensititre Mueller inton roth (T36) RUO LSI [WW] utoread or Manual Sensititre RIS X (V3090) Sensititre OptiRead (V3030) Sensititre Vizion (V0) (V007) Put 3-5 colonies into measure a Mcarland using the Nephelometer, Mix μl*, 0 μl**, or 30 μl*** of suspension into M 50 μl volume per well of the suspension using the Sensititre IM or Multi-hannel Pipette incubate at 3-36 o in a non-o incubator or Sensititre RIS X for - hours utomatically read with RIS X or OptiRead or manually read with ntimicrobics /9.5 /9 /3 /76 ZT ZT ZT ZT 6 6 OL POL OT /S / OR P/T / OL POL OT /S / OR P/T 6/ OL POL OT /S 6/ OR P/T 3/ OL POL OT 6 /S 3/6 OR P/T 6/ OL POL 6 OT 3 /S 6/3 ZT OL POL OT /S OR P/T TIM mikacin oxycycline entamicin Minocycline Tobramycin Tigecycline iprofloxacin Trimethoprim / Sulfamethoxazole Levofloxacin ztreonam Imipenem efepime Meropenem olistin Polymixin eftazidime efotaxime mpicillin / Sulbactam : ratio oripenem Piperacillin / Tazobactam constant Ticarcillin / lavulanic acid constant 6 6 TIM 6/ TIM 3/ TIM 6/ TIM / *or Proteus spp. **or nterobacteriaceae and Non-nterobacteriaceae. ***or aid in detection of resistance mechanisms for nterobacteriaceae and Non-nterobacteriaceae. Not available in urope.

15 uman Sensititre ram Negative KMN Plate with olistin, eftazidime/vibactam and eftolozane/tazobactam ntimicrobial susceptibility plate for testing non-fastidious ram negative isolates roth Type Mcarland Standard (0) Sensititre Mueller inton roth (T36) IV, UT [U] Manual Sensititre Vizion (V0) (V007) Put 3-5 colonies into measure a Mcarland using the Nephelometer, Mix μl*, 0 μl**, or 30 μl*** of suspension into M 50 μl volume per well of the suspension using the Sensititre IM or Multi-hannel Pipette incubate at 3-36 o in a non-o incubator or Sensititre RIS X for - hours Manually read with ntimicrobics 0. U / OL 0. U / OL U 6/ OL U 3/ OL U 6/ OL ZT /T / OL /9 ZT P/T / /T / OT /3 6 ZT P/T / /T / OT /76 ZT P/T / /T / OT /5 ZT P/T / /T / OT 6 ZT 6 P/T 6/ /T 6/ OT 3 ZT 3 P/T 3/ /T 3/ U OL ZT /T P/T OT Z TP Meropenem entamicin iprofloxacin moxicillin / lavulanic acid constant olistin Tigecycline eftazidime Imipenem ztreonam eftolozane / Tazobactam Trimethoprim / Sulfamethoxazole Piperacillin / Tazobactam constant efotaxime eftazidime / vibactam rtapenem mikacin Tobramycin 6 Z / Z / Z / Z / Z / Z 6/ 6 TP 0. TP TP TP TP *or Proteus spp. **or nterobacteriaceae and Non-nterobacteriaceae. ***or aid in detection of resistance mechanisms for nterobacteriaceae and Non-nterobacteriaceae. Not available in urope. 5

16 uman Sensititre ram Negative URNOL Plate with olistin, eftazidime/vibactam and eftolozane/tazobactam ntimicrobial susceptibility plate for testing non-fastidious ram negative isolates roth Type Mcarland Standard (0) Sensititre Mueller inton roth (T36) IV, UT [U] Manual Sensititre Vizion (V0) (V007) Put 3-5 colonies into measure a Mcarland using the Nephelometer, Mix μl*, 0 μl**, or 30 μl*** of suspension into M 50 μl volume per well of the suspension using the Sensititre IM or Multi-hannel Pipette incubate at 3-36 o in a non-o incubator or Sensititre RIS X for - hours Manually read with ntimicrobics OL OL P/T / P/T / /T / /T / OL OL P/T / P/T / /T / /T / OL OL P/T / P/T / /T / /T / OL P/T /T Z olistin Piperacillin / Tazobactam constant eftolozane / Tazobactam eftazidime / vibactam Meropenem OL P/T 6/ Z / OL P/T 6/ Z / OL P/T 6/ Z / OL P/T 3/ Z / OL P/T 3/ Z / OL P/T 3/ Z / OL /T / Z / OL /T / Z / OL /T / Z / OL /T / Z / OL /T / Z / OL /T / Z / P/T / /T / Z 6/ P/T / /T / Z 6/ P/T / /T / Z 6/ P/T / /T / 0. 6 P/T / /T / 0. 6 P/T / /T / 0. 6 *or Proteus spp. **or nterobacteriaceae and Non-nterobacteriaceae. ***or aid in detection of resistance mechanisms for nterobacteriaceae and Non-nterobacteriaceae. Not available in urope. 6

17 uman Sensititre Streptococcus NS Plate with Oritavancin, albavancin, and Tedizolid ntimicrobial susceptibility plate for testing Streptococcus species roth Type Mcarland Standard (0) Sensititre Mueller inton roth 5 ml (T3605) Sensititre Mueller inton roth w/lysed orse lood - manual read (P-0) or Sensititre Mueller inton roth w/lysed orse lood - autoread (P0) IV [US] utoread or Manual Sensititre RIS X (V3090) Sensititre OptiRead (V3030) Sensititre Vizion (V0) (V007) Put 3-5 colonies into measure a Mcarland using the Nephelometer, Mix 00 μl of suspension into M w/ L Tube 00 μl volume per well of the suspension using the Sensititre IM or Multi-hannel Pipette incubate at 3-36 o in a non-o incubator or Sensititre RIS X for 0- hours utomatically read with RIS X or OptiRead or manually read with ntimicrobics ORI TZ 0.00 PT 0.00 L 0.00 ORI 0.00 TZ 0.00 PT 0.00 L 0.00 ORI 0.00 TZ 0.00 PT 0.05 L 0.00 ORI 0.00 TZ 0.05 PT L 0.00 ORI 0.00 TZ PT L 0.05 ORI 0.05 TZ PT 0. L ORI TZ 0. PT L ORI TZ PT L 0. ORI 0. TZ PT L ORI TZ PT L ORI TZ PT L ORI TZ PT L PT L TS ORI TL TZ lindamycin eftaroline albavancin Test rythromycin Linezoid Oritavancin Telavancin Tedizolid Vancomycin TL 0.00 TL 0.00 TL 0.00 TL 0.00 TL 0.05 TL TL TL 0. TL TL TL TL TS 0. Not available in urope. 7

18 uman Sensititre Streptococcus species STP6 Plate ntimicrobial susceptibility plate for testing Streptococcus species roth Type Mcarland Standard (0) Sensititre Mueller inton roth 5 ml (T3605) Sensititre Mueller inton roth w/lysed orse lood - manual read (P-0) or Sensititre Mueller inton roth w/lysed orse lood - autoread (P0) IV, LSI [WW] utoread or Manual Sensititre RIS X (V3090) Sensititre OptiRead (V3030) Sensititre Vizion (V0) (V007) Put 3-5 colonies into measure a Mcarland using the Nephelometer, Mix 00 μl of suspension into M w/ L Tube 00 μl volume per well of the suspension using the Sensititre IM or Multi-hannel Pipette incubate at 3-36 o in a non-o incubator or Sensititre RIS X for 0- hours utomatically read with RIS X or OptiRead or manually read with ntimicrobics 0.05 UR 0. OT 0. UR OT 0. UR OT UR OT TP U / OT TP U / OT 0. TP U / 0. U 6/ TP /9.5 /9 /3 /76 UR OT TP U LZ Moxifloxacin Levofloxacin Tetracycline efuroxime eftriaxone efotaxime aptomycin hloramphenicol Penicillin Meropenem rtapenem moxicillin / lavulanic acid : ratio Linezolid lindamycin efepime Tigecycline zithromycin rythromycin Trimethoprim / Sulfamethoxazole Vancomycin Not available in urope.

19 uman Sensititre aemophilus and Streptococcus pneumoniae P Plate ntimicrobial susceptibility plate for testing Streptococcus pneumoniae and aemophilus influenzae isolates roth Type Mcarland Standard (0) Sensititre Mueller inton roth 5 ml (T3605) Sensititre TM (T370)* or Sensititre Mueller inton roth w/lysed orse lood - manual read (P-0)** IV, LSI [WW] Manual Sensititre Vizion (V0) (V007) Put 3-5 colonies into measure a Mcarland using the Nephelometer, Mix 50 μl* or 00 μl** of suspension into TM* or M w/ L Tube** 00 μl volume per well of the suspension using the Sensititre IM or Multi-hannel Pipette incubate at 3-36 o in a non-o incubator or Sensititre RIS X for 0- hours Manually read with ntimicrobics SPX SPX SPX SPX 0. SPX SPX /3 /9 /9.5 /.75 0./.3 0. /.9 UR UR UR UR UR IX 0. IX IX U 6/ U / U / U / IX /S U IX UR SPX mpicillin / Sulbactam : ratio mpicillin moxicillin / lavulanic cid : ratio eftriaxone hloramphenicol larithromycin Trimethroprim / Sulfamethoxazole rythromycin efaclor efepime efixime efuroxime Impenem Levofloxacin Meropenem Penicillin Sparfloxacin Tetracycline /S / /S / 0. 6 *or aemophilus. **or S. pneumaniae/streptococcus. Not available in urope. 9

20 uman Sensititre ram Positive PLL Plate ntimicrobial susceptibility plate for testing non-fastidious ram positive isolates roth Type Mcarland Standard (0) Sensititre Mueller inton roth (T36) IV, LSI [WW] utoread or Manual Sensititre RIS X (V3090) Sensititre OptiRead (V3030) Sensititre Vizion (V0) (V007) Put 3-5 colonies into measure a Mcarland using the Nephelometer, Mix 0 μl or 30 μl* of suspension into M 50 μl volume per well of the suspension using the Sensititre IM or Multi-hannel Pipette incubate at 3-36 o in a non-o incubator or Sensititre RIS X for - hours utomatically read with RIS X or OptiRead or manually read with ntimicrobics /9.5 /9 /3 6 6 /76 6 OX+ 0. OX+ 0. OX+ 0. OX+ OX T 6 6 N T S 6 3 OX+ T T S N hloramphenicol aptomycin entamicin Linezolid Rifampin Trimethoprim / Sulfamethoxazole Quinupristin / alfopristin Tetracycline rythromycin Oxacillin + % Nal mpicillin Penicillin Vancomycin Levofloxacin Tigecycline Moxifloxacin lindamycin Streptomycin iprofloxacin Nitrofurantoin Test Test efoxitin screen Negative control *or aid in detection of resistance mechanisms for ram positive organisms. Not available in urope. 0

21 uman Sensititre ram Positive PLL3 Plate with eftaroline and Telavancin ntimicrobial susceptibility plate for testing non-fastidious ram positive isolates roth Type Mcarland Standard (0) Sensititre Mueller inton roth (T36) IV, LSI [WW] utoread or Manual Sensititre RIS X (V3090) Sensititre OptiRead (V3030) Sensititre Vizion (V0) (V007) Put 3-5 colonies into measure a Mcarland using the Nephelometer, Mix 0 μl or 30 μl* of suspension into M 50 μl volume per well of the suspension using the Sensititre IM or Multi-hannel Pipette incubate at 3-36 o in a non-o incubator or Sensititre RIS X for - hours utomatically read with RIS X or OptiRead or manually read with ntimicrobics PT PT PT PT 6 PT 0. PT 6 OX+ 3 OX+ 6 TL 0.05 OX+ 3 TL OX+ 6 TL /3 500 T 6 TL 0. / N T S 6 TL PT OX+ TL T T S N eftaroline hloramphenicol lindamycin Linezolid Penicillin Moxifloxacin Rifampin Tetracycline Tigecycline entamicin rythromycin etriaxone Vancomycin Levofloxacin Oxacillin + % Nal mpicillin Telavancin w/ Tween mimic Nitrofurantoin iprofloxacin aptomycin Trimethoprim / Sulfamethoxazole Test Test Streptomycin efoxitin screen Negative control *or aid in detection of resistance mechanisms for ram positive organisms. Not available in urope.

22 uman Sensititre ram Positive USTP Plate with eftaroline and Telavancin ntimicrobial susceptibility plate for testing non-fastidious ram positive isolates roth Type Mcarland Standard (0) Sensititre Mueller inton roth (T36) IV, UT [U] utoread or Manual Sensititre RIS X (V3090) Sensititre OptiRead (V3030) Sensititre Vizion (V0) (V007) Put 3-5 colonies into measure a Mcarland using the Nephelometer, Mix 0 μl or 30 μl* of suspension into M 50 μl volume per well of the suspension using the Sensititre IM or Multi-hannel Pipette incubate at 3-36 o in a non-o incubator or Sensititre RIS X for - hours utomatically read with RIS X or OptiRead or manually read with ntimicrobics PT PT PT PT US US US US /9 /3 /76 / TI TI TI TI TI 6 NOR NOR NOR 6 T T TL TL TL 0. TL TL TL 6 S 6 0. MUP MUP MUP MUP MUP MUP 56 N S PT T T US MUP NOR TI TL N efoxitin efoxitin screen eftaroline lindamycin Test Test aptomycin rythromycin usidate entamicin Levofloxacin Linexolid Moxifloxacin Mupirocin Norfloxacin Rifampin Teicoplanin Telavancin Tetracycline Tobramycin Trimethoprim / Sulfanethoxazole Vancomycin Negative control *or aid in detection of resistance mechanisms for ram positive organisms. Not available in urope.

23 uman Sensititre ram Positive NP Plate with Oritavancin, albavancin, and Tedizolid ntimicrobial susceptibility plate for testing non-fastidious ram positive isolates roth Type Mcarland Standard (0) Sensititre Mueller inton roth (T36) IV [US] utoread or Manual Sensititre RIS X (V3090) Sensititre OptiRead (V3030) Sensititre Vizion (V0) (V007) Put 3-5 colonies into measure a Mcarland using the Nephelometer, Mix 0 μl or 30 μl* of suspension into M 50 μl volume per well of the suspension using the Sensititre IM or Multi-hannel Pipette incubate at 3-36 o in a non-o incubator or Sensititre RIS X for - hours utomatically read with RIS X or OptiRead or manually read with ntimicrobics ORI 0.00 TL 0.00 PT L 0.00 ORI 0.00 TL 0.00 PT 0. L 0.05 ORI 0.00 TL 0.00 PT L ORI 0.05 TL 0.00 PT L ORI TL 0.05 PT L 0. ORI TL PT L ORI 0. TL PT 6 L ORI TL 0. PT 3 L ORI TL PT 6 6 L ORI TL PT 3 ORI TL PT 6 T ORI TL S 6 T S PT T T L ORI OX+ TZ TL N efoxitin screen hloramphenicol lindamycin Test Test albavancin rythromycin Linezolid Oritavancin Oxacillin + % Nal Tedizolid Telavancin Vancomycin Negative control TZ TZ TZ 0. TZ TZ TZ TZ TZ 6 3 N OX+ 0. OX+ OX+ OX+ OX+ OX+ *or aid in detection of resistance mechanisms for ram positive organisms. Not available in urope. 3

24 uman Sensititre YeastOne YOIV Plate ntimicrobial susceptibility plate for testing andida species roth Type Mcarland Standard (0) Sensititre YeastOne roth (Y36) IV, LSI [WW] Manual Sensititre Vizion (V0) (V007) Put 3-5 colonies into measure a Mcarland using the Nephelometer, Mix 0 μl of suspension into Sensititre YeastOne roth 00 μl volume per well of the suspension using the Sensititre IM or Multi-hannel Pipette incubate at 35 o in a non-o incubator for -5 hours Manually read with ntimicrobics lucytosine luconazole 0. 6 aspofungin Voriconazole Itraconazole

25 uman Sensititre YeastOne YO3IV Plate with Micafungin ntimicrobial susceptibility plate for testing andida species roth Type Mcarland Standard (0) Sensititre YeastOne roth (Y36) IV, LSI [WW] Manual Sensititre Vizion (V0) (V007) Put 3-5 colonies into measure a Mcarland using the Nephelometer, Mix 0 μl of suspension into Sensititre YeastOne roth 00 μl volume per well of the suspension using the Sensititre IM or Multi-hannel Pipette incubate at 35 o in a non-o incubator for -5 hours Manually read with ntimicrobics M 5-lucytosine luconazole aspofungin Voriconazole Itraconazole Micafungin M 0.00 M 0.05 M M M 0. M M M M M M M 6 5

26 uman Sensititre YeastOne YO9 Plate with nidulafungin and Micafungin ntimicrobial susceptibility plate for testing andida species roth Type Mcarland Standard (0) Sensititre YeastOne roth (Y36) RUO LSI [US] Manual Sensititre Vizion (V0) (V007) Put 3-5 colonies into measure a Mcarland using the Nephelometer, Mix 0 μl of suspension into Sensititre YeastOne roth 00 μl volume per well of the suspension using the Sensititre IM or Multi-hannel Pipette incubate at 35 o in a non-o incubator for -5 hours Manually read with ntimicrobics M N 0.05 M N M N M N 0. M N M N M N M N M 6 N M 3 N M 6 0. N M PZ nidulafungin mphotericin Micafungin aspofungin 5-lucytosine Posaconazole Voriconazole Itraconazole luconazole PZ 0.00 PZ 0.05 PZ PZ PZ 0. PZ PZ PZ PZ PZ PZ

27 uman Sensititre YeastOne YO0 Plate with nidulafungin and Micafungin ntimicrobial susceptibility plate for testing andida species roth Type Mcarland Standard (0) Sensititre YeastOne roth (Y36) IV, LSI [OUS] Manual Sensititre Vizion (V0) (V007) Put 3-5 colonies into measure a Mcarland using the Nephelometer, Mix 0 μl of suspension into Sensititre YeastOne roth 00 μl volume per well of the suspension using the Sensititre IM or Multi-hannel Pipette incubate at 35 o in a non-o incubator for -5 hours Manually read with ntimicrobics M N 0.05 M N M N M N 0. M N M N M N M N M 6 N M 3 N M 6 0. N M PZ nidulafungin mphotericin Micafungin aspofungin 5-lucytosine Posaconazole Voriconazole Itraconazole luconazole PZ 0.00 PZ 0.05 PZ PZ PZ 0. PZ PZ PZ PZ PZ PZ

28 uman Sensititre Mycobacterium tuberculosis MYOT Plate eterminiation of MIs to first and second-line anti-tuberculosis drugs for Mycobacterium tuberculosis isolates roth Type Mcarland Standard (0) Sensititre Saline Tween with lass eads (T390) Sensititre Middlebrook 79 with O (T30) RUO [US] Manual Sensititre Vizion (V0) (V007) Put 3-5 colonies into Saline Tween with lass eads to reach Mcarland Standard, Mix 00 μl into Sensititre Middlebrook 79 with O 00 μl volume per well of the suspension using the Sensititre IM or Multi-hannel Pipette incubate at o in a non-o incubator for 0- days Manually read with ntimicrobics OL 3 OL 6 OL OL OL R 6 R R R R PS 6 PS 3 PS 6 PS PS T 0 T 0 T 0 T 5 T.5 Y 56 Y Y 6 Y 3 Y 6 IN IN IN IN IN KN 0 KN 0 KN 0 KN 5 KN.5 M 3 M 6 M M M OL R PS T Y IN KN M Ofloxacin Moxifloxacin Rifampin mikacin Streptomycin Rifabutin Para-aminosalicylic acid thionamide ycloserine Isoniazid Kanamycin thambutol OL R PS T. Y IN 0. KN. M OL 0. R PS T 0.6 Y IN KN 0.6 M OL R 0. PS T 0.3 Y IN

29 uman Sensititre Mycobacterium tuberculosis MYOTI Plate eterminiation of MIs to first and second-line anti-tuberculosis drugs for Mycobacterium tuberculosis isolates roth Type Mcarland Standard (0) Sensititre Saline Tween with lass eads (T390) Sensititre Middlebrook 79 with O (T30) IV [OUS] Manual Sensititre Vizion (V0) (V007) Put 3-5 colonies into Saline Tween with lass eads to reach Mcarland Standard, Mix 00 μl into Sensititre Middlebrook 79 with O 00 μl volume per well of the suspension using the Sensititre IM or Multi-hannel Pipette incubate at o in a non-o incubator for 0- days Manually read with ntimicrobics OL 3 OL 6 OL OL OL R 6 R R R R PS 6 PS 3 PS 6 PS PS T 0 T 0 T 0 T 5 T.5 Y 56 Y Y 6 Y 3 Y 6 IN IN IN IN IN KN 0 KN 0 KN 0 KN 5 KN.5 M 3 M 6 M M M OL R PS T Y IN KN M Ofloxacin Moxifloxacin Rifampin mikacin Streptomycin Rifabutin Para-aminosalicylic acid thionamide ycloserine Isoniazid Kanamycin thambutol OL R PS T. Y IN 0. KN. M OL 0. R PS T 0.6 Y IN KN 0.6 M OL R 0. PS T 0.3 Y IN 9

30 uman Sensititre Rapid rowing Myco RPMYO Plate Susceptibility testing of rapidly growing mycobacteria, Nocardia spp., and other aerobic actinomycetes roth Type Mcarland Standard (0) Sensititre M with TS (T36) RUO [US] Manual Sensititre Vizion (V0) (V007) Put 3-5 colonies into measure a Mcarland using the Nephelometer, Mix 50 μl of suspension into Sensititre M with TS 00 μl volume per well of the suspension using the Sensititre IM or Multi-hannel Pipette incubate at 30 o in a non-o air incubator for 7 hours* Manually read with ntimicrobics / /9.5 /9 6 /3 3 / /5 3 U / 6 U / U / 6 U 6/ U 3/ U 6/3 6 U Trimethoprim / Sulfamethoxazole iprofloxacin Moxifloxacin efoxitin mikacin oxycycline Tigecycline larithromycin Linezolid Imipenem efepime moxicillin / lavulanic acid : ratio eftriaxone Minocycline Tobramycin *or Nocardia spp. and other aerobic actinomycetes, incubate at 35 in a non-o incubator for -3 days. 30

31 uman Sensititre Rapid rowing Myco RPMYOI Plate Susceptibility testing of rapidly growing mycobacteria, Nocardia spp., and other aerobic actinomycetes roth Type Mcarland Standard (0) Sensititre M with TS (T36) IV [OUS] Manual Sensititre Vizion (V0) (V007) Put 3-5 colonies into measure a Mcarland using the Nephelometer, Mix 50 μl of suspension into Sensititre M with TS 00 μl volume per well of the suspension using the Sensititre IM or Multi-hannel Pipette incubate at 30 o in a non-o air incubator for 7 hours* Manually read with ntimicrobics / /9.5 /9 6 /3 3 / /5 3 U / 6 U / U / 6 U 6/ U 3/ U 6/3 6 U Trimethoprim / Sulfamethoxazole iprofloxacin Moxifloxacin efoxitin mikacin oxycycline Tigecycline larithromycin Linezolid Imipenem efepime moxicillin / lavulanic acid : ratio eftriaxone Minocycline Tobramycin *or Nocardia spp. and other aerobic actinomycetes, incubate at 35 in a non-o incubator for -3 days. 3

32 uman Sensititre Slow rowing Myco SLOMYO Plate Susceptibility testing of slow growing non-tuberculosis mycobacteria (NTM) roth Type Mcarland Standard (0) Sensititre M with O (T005) RUO [US] Manual Sensititre Vizion (V0) (V007) Put 3-5 colonies into measure a Mcarland using the Nephelometer, Mix 50 μl of suspension into Sensititre M with O 00 μl volume per well of the suspension using the Sensititre IM or Multi-hannel Pipette Seal plate and incubate at 35 o in non-o incubator for 7- days Manually read with ntimicrobics 6 R R R 0. 3 M 6 M M 6 IN IN IN /5 /76 /3 / T 0 T 0 T 5 T.5 T. R M IN T larithromycin Rifabutin thambutol Isoniazid Moxifloxacin Rifampin Trimethoprim / Sulfamethoxazole mikacin Linezolid iprofloxacin Streptomycin oxycycline thionamide R M IN /9.5 T 0.6 R M IN /.75 T 0.3 R M IN /

33 uman Sensititre Slow rowing Myco SLOMYOI Plate Susceptibility testing of slow growing non-tuberculosis mycobacteria (NTM) roth Type Mcarland Standard (0) Sensititre M with O (T005) IV [OUS] Manual Sensititre Vizion (V0) (V007) Put 3-5 colonies into measure a Mcarland using the Nephelometer, Mix 50 μl of suspension into Sensititre M with O 00 μl volume per well of the suspension using the Sensititre IM or Multi-hannel Pipette Seal plate and incubate at 35 o in non-o incubator for 7- days Manually read with ntimicrobics 6 R R R 0. 3 M 6 M M 6 IN IN IN /5 /76 /3 / T 0 T 0 T 5 T.5 T. R M IN T larithromycin Rifabutin thambutol Isoniazid Moxifloxacin Rifampin Trimethoprim / Sulfamethoxazole mikacin Linezolid iprofloxacin Streptomycin oxycycline thionamide R M IN /9.5 T 0.6 R M IN /.75 T 0.3 R M IN /

34 VTRINRY Offering true MI results for over 0+ veterinaryspecific antimicrobials and the broadest portfolio of host animal-specific ST plates, the Sensititre System bolsters your ability to improve animal outcomes. mergent diseases and evolving multidrug resistance demand earlier intervention with the latest antimicrobials. To effectively treat animal and zoonotic infections, you need a microbiology offering that delivers relevant, more accurate results every time. or standard and custom solutions formulated specifically for veterinary microbiology laboratories, choose the Sensititre I/ST System. Our latest offering is the Thermo Scientific Sensititre ovine OPO7 Plate the only standard microbroth dilution ST to include gamithromycin and tildipirosin in the fight against bovine respiratory disease. ost animal-specific ST formats ensure compliance with veterinary LSI recommendations. vian Mastitis ovine/porcine Urine ompanion Topical quine 3

35 Veterinary Sensititre Vet vian VIN Plate ntimicrobial susceptibility plate for testing non-fastidious ram positive and ram negative isolates of veterinary origin roth Type Mcarland Standard (0) Sensititre Mueller inton roth (T36) Veterinary LSI [WW] utoread or Manual Sensititre RIS X (V3090) Sensititre OptiRead (V3030) Sensititre Vizion (V0) (V007) Put 3-5 colonies into measure a Mcarland using the Nephelometer, Mix μl*, 0 μl, or 30 μl** of suspension into M 50 μl volume per well of the suspension using the Sensititre IM or Multi-hannel Pipette incubate at 3-36 o in a non-o incubator or Sensititre RIS X for - hours*** utomatically read with RIS X or OptiRead or manually read with ntimicrobics NO 3 OXY NO 6 OXY NO OXY NO OXY 0. NO OXY SP 6 SP 3 SP 6 SP 0. OXY SM 56 SM SM 6 SM 3 /3 /9 /9.5 N N N N STZ 56 STZ STZ NOV NOV NOV NOV TYLT 0 TYLT 0 TYLT 5 N NO OXY MOX SP SM N STZ NOV TYLT N nrofloxacin entamicin eftiofur Neomycin rythromycin Oxytetracycline Tetracycline moxicillin Spectinomycin Sulphadimethoxine Trimethoprim / Sulfamethoxazole lorfenicol Sulphathiazole Penicillin Streptomycin Novobiocin Tylosin tartrate lindamycin Negative control MOX 6 MOX MOX MOX MOX MOX MOX STZ 3 TYLT.5 *or Proteus spp. **nsure detection of hetero-resistant isolates among Staphylococcus and nterococcus spp. ***Incubate for hours to ensure detection of oxacillin-resistant Staphylococcus and vancomycin-resistant nterococcus spp. Not available in urope. 35

36 Veterinary Sensititre Vet quine QUIN Plate ntimicrobial susceptibility plate for testing non-fastidious ram positive and ram negative isolates of veterinary origin (or Streptococcus pneumoniae and ctinobacillus pleuropneumoniae isolates, contact your local Thermo isher Scientific Microbiology respresentative for protocol specifications) roth Type Mcarland Standard (0) Sensititre Mueller inton roth (T36) Veterinary LSI [WW] utoread or Manual Sensititre RIS X (V3090) Sensititre OptiRead (V3030) Sensititre Vizion (V0) (V007) Put 3-5 colonies into measure a Mcarland using the Nephelometer, Mix μl*, 0 μl, or 30 μl** of suspension into M 50 μl volume per well of the suspension using the Sensititre IM or Multi-hannel Pipette incubate at 3-36 o in a non-o incubator or Sensititre RIS X for - hours*** utomatically read with RIS X or OptiRead or manually read with ntimicrobics OX+ OX OX+ 3 3 OX+ OX+ Z Z Z 6 /9.5 /9 6 6 /3 3 3 / OX+ TI TIM Z mikacin zithromycin eftiofur hloramphenicol nrofloxacin Oxacillin + % Nal Penicillin Ticarcillin mpicillin larithromycin entamicin Ticarcillin / lavulanic acid constant efazolin eftazidime rythromycin Trimethoprim / Sulfamethoxazole oxycycline Imipenem Rifampin Tetracycline Positive ontrol TI TI 6 TI 3 TI 6 TIM / TIM 6/ TIM 3/ TIM 6/ *or Proteus spp. **nsure detection of hetero-resistant isolates among Staphylococcus and nterococcus spp. ***Incubate for hours to ensure detection of oxacillin-resistant Staphylococcus and vancomycin-resistant nterococcus spp. Not available in urope. 36

37 Veterinary Sensititre Vet ovine/swine OPO6 Plate ntimicrobial susceptibility plate for testing non-fastidious ram positive and ram negative isolates of veterinary origin (or Mannheimia hemolytica, Pasteurella multocida, ordetella bronchiseptica, Streptococcus pneumoniae, istophilus somni, and ctinobacillus pleuropneumoniae isolates, contact your local Thermo isher Microbiology respresentative for protocol specifications) roth Type Mcarland Standard (0) Sensititre Mueller inton roth (T36) Veterinary LSI [WW] utoread or Manual Sensititre RIS X (V3090) Sensititre OptiRead (V3030) Sensititre Vizion (V0) (V007) Put 3-5 colonies into measure a Mcarland using the Nephelometer, Mix μl*, 0 μl, or 30 μl** of suspension into M 50 μl volume per well of the suspension using the Sensititre IM or Multi-hannel Pipette incubate at 3-36 o in a non-o incubator or Sensititre RIS X for - hours*** utomatically read with RIS X or OptiRead or manually read with ntimicrobics TI 3 TI 6 TI TI TI TI TI OXY OXY OXY OXY OXY 6 6 NO NO NO NO 0. NO 3 NO 6 /3 SP 6 SP 3 SP 6 SP TYLT 3 TYLT TYLT TYLT TYLT TUL 6 TUL 3 TUL TUL TUL TIL 6 TIL 3 TIL 6 6 SM TI N OXY NO SM NO SP TYLT TUL TIL eftiofur Tiamulin hlortetracycline entamicin lorfenicol Oxytetracycline Penicillin mpicillin anofloxacin Sulphadimethoxine Neomycin Trimethoprim / Sulfamethoxazole Spectinomycin Tylosin tartrate Tulathromycin Tilmicosin lindamycin nrofloxacin 0. NO TYLT 6 TUL 6 TIL N N N N N N NO TYLT TUL TIL *or Proteus spp. **nsure detection of hetero-resistant isolates among Staphylococcus and nterococcus spp. ***Incubate for hours to ensure detection of oxacillin-resistant Staphylococcus and vancomycin-resistant nterococcus spp. Not available in urope. 37

38 The latest antimicrobials to combat bovine respiratory disease Introducing the Sensititre ovine OPO7 Plate the only host animal-specific ST solution to include gamithromycin and tildipirosin in a standard format emand for rigorous testing of animals and livestock with the latest antimicrobials has escalated due to emergent diseases like bovine respiratory disease (R) and evolving multidrug resistance. R presents significant economic challenges to the animal production industry, reinforcing the need for earlier tests and faster results. s the first standard format ST solution to include gamithromycin and tildipirosin for bovine/porcine applications, the Sensititre ovine OPO7 Plate delivers host animal-specific results on a single plate, enabling faster, more effective therapy intervention and improved animal outcomes. The Sensititre ovine OPO7 Plate features: amithromycin and tildipirosin, two of the latest antimicrobials approved for the treatment of R Updated breakpoint ranges* for tilmicosin, tulathromycin and tiamulin to meet the latest standards designated by LSI, and consolidation of tetracycline agents for more efficient ST True MI results from a host animal-specific format *ontact Thermo isher Scientific Microbiology Technical Support to add new breakpoint updates to your Thermo Scientific Sensititre SWIN Software. Not all products are available for sale in all territories. Please inquire. 3

39 Veterinary Sensititre Vet ovine OPO7 Plate ntimicrobial susceptibility plate for testing non-fastidious ram positive and ram negative isolates of veterinary origin (or Mannheimia hemolytica, Pasteurella multocida, ordetella bronchiseptica, Streptococcus pneumoniae, istophilus somni, and ctinobacillus pleuropneumoniae isolates, contact your local Thermo isher Microbiology respresentative for protocol specifications) roth Type Mcarland Standard (0) Sensititre Mueller inton roth (T36) Veterinary LSI [US, N] utoread or Manual Sensititre RIS X (V3090) Sensititre OptiRead (V3030) Sensititre Vizion (V0) (V007) Put 3-5 colonies into measure a Mcarland using the Nephelometer, Mix μl*, 0 μl, or 30 μl** of suspension into M 50 μl volume per well of the suspension using the Sensititre IM or Multi-hannel Pipette incubate at 3-36 o in a non-o incubator or Sensititre RIS X for - hours*** utomatically read with RIS X or OptiRead or manually read with ntimicrobics 0. TI TYLT NO TI TYLT NO 6 TI TYLT NO 3 TI TYLT TUL TI TYLT TUL 6 TI 6 TYLT 6 TUL 3 6 TI 3 TYLT 3 TUL 6 6 M TIP TIL 0. NO 0. M TIP TIL NO M TIP TIL NO M TIP TIL 6 NO SM 56 6 TIP 6 NO M NO N NO SP SM TI TIP TIL TUL TYLT amithromycin mpicillin eftiofur lindamycin anofloxacin nrofloxacin lorfenicol entamicin Neomycin Penicillin Spectinomycin Sulphadimethoxine Tetracycline Tiamulin Tildipirosin Tilmicosin Trimethoprim / Sulfamethoxazole Tulathromycin Tylosin tartrate N N N N N N SP SP 6 SP 3 SP 6 /3 *or Proteus spp. **nsure detection of hetero-resistant isolates among Staphylococcus and nterococcus spp. ***Incubate for hours to ensure detection of oxacillin-resistant Staphylococcus and vancomycin-resistant nterococcus spp. Not available in urope. 39

40 More choice. More performance. Sensititre Veterinary MI Plates for ompanion nimals expand treatment options with the latest veterinary LSI recommendations The Sensititre Vet ompanion nimal ram Positive OMPP Plate and Sensititre Vet ompanion nimal ram Negative OMPN Plate represent our commitment to providing the most comprehensive species-specific drug ranges, including the newest compounds that comply with the latest veterinary LSI recommendations. Increase the range of Sensititre ST achieve maximum performance across a number of animal species and surveillance purposes. Scalable flexible instrumentation options designed to be modular in order to meet unique needs of individual lab space, workload, and budget requirements Robust superior reproducibility for accurate results the first time, thereby, reducing unnecessary testing and protocols Up-to-date comply to the latest LSI veterinary guidelines for companion animal ram positive and ram negative ST to ensure relevant results based on real-time epidemiology trends Tailor-made design your own plate to meet specific formulary and surveillance requirements from a selection of more than 50 veterinary-specific agents 0

41 Veterinary Sensititre Vet ompanion nimal ram Positive OMPP Plate with Pradofloxacin ntimicrobial susceptibility plate for testing non-fastidious ram positive isolates of veterinary origin roth Type Mcarland Standard (0) Sensititre Mueller inton roth (T36) Veterinary LSI [WW] utoread or Manual Sensititre RIS X (V3090) Sensititre OptiRead (V3030) Sensititre Vizion (V0) (V007) Put 3-5 colonies into measure a Mcarland using the Nephelometer, Mix 0 μl or 30 μl* of suspension into M 50 μl volume per well of the suspension using the Sensititre IM or Multi-hannel Pipette incubate at 3-36 o in a non-o incubator or Sensititre RIS X for - hours** utomatically read with RIS X or OptiRead or manually read with ntimicrobics P 6 PO P 0. 3 PO Z 6 PO Z 3 OV /3 6 OV 0. 6 /76 OV OX+ U /0. / U U / 6 OV OX+ 3 OV OX+ PR 0. OV OX+ U / MR PR OV U / MR PR 6 OV U / MR PR N U Z OV PO P MR OX+ PR N mikacin moxicillin / lavulanic acid : ratio mpicillin efazolin efovecin efopodoxime ephalothin hloramphenicol lindamycin oxycycline nrofloxacin rythromycin entamicin Impenem Marbofloxacin Minocycline Nitrofurantoin Oxacillin + % Nal Penicillin Pradofloxacin Rifampin Tetracycline Trimethoprim / Sulfamethoxazole Vancomycin Negative control *nsure detection of hetero-resistant isolates among Staphylococcus and nterococcus spp. **Incubate for hours to ensure detection of oxacillin-resistant Staphylococcus and vancomycin-resistant nterococcus spp. Not available in urope.

42 Veterinary Sensititre Vet ompanion nimal ram Negative OMPN Plate with Pradofloxacin ntimicrobial susceptibility plate for testing non-fastidious ram negative isolates of veterinary origin roth Type Mcarland Standard (0) Sensititre Mueller inton roth (T36) Veterinary LSI [WW] utoread or Manual Sensititre RIS X (V3090) Sensititre OptiRead (V3030) Sensititre Vizion (V0) (V007) Put 3-5 colonies into measure a Mcarland using the Nephelometer, Mix μl* or 0 μl of suspension into M 50 μl volume per well of the suspension using the Sensititre IM or Multi-hannel Pipette incubate at 3-36 o in a non-o incubator or Sensititre RIS X for - hours utomatically read with RIS X or OptiRead or manually read with ntimicrobics PO OV LX Z 0. PO OV LX Z PO OV LX Z PO OV LX Z PR OV LX OR Z 6 PR OV LX 6 OR Z 3 U /0. / U U / PR OR MR 0. PR OR MR /9.5 MR U / /9 MR 6 U / /3 6 MR 3 U / /76 3 MR U Z OV PO LX MR OR P/T PR mikacin moxicillin / lavulanic acid : ratio mpicillin efazolin efovecin efopodoxime eftazidime ephalexin hloramphenicol oxycycline nrofloxacin entamicin Impenem Marbofloxacin Orbifloxacin Piperacillin / Tazobactam contant Pradofloxacin Tetracycline Trimethoprim / Sulfamethoxazole P/T / P/T 6/ P/T 3/ P/T 6/ 6 6 *or Proteus spp. Not available in urope.

43 Veterinary Sensititre Vet Mastitis MVM Plate ntimicrobial susceptibility plate for testing non-fastidious ram positive and ram negative isolates of veterinary origin (or Streptococcus pneumoniae isolates, contact your local Thermo isher Scientific Microbiology representative for protocol specifications) roth Type Mcarland Standard (0) Sensititre Mueller inton roth (T36) Veterinary LSI [WW] utoread or Manual Sensititre RIS X (V3090) Sensititre OptiRead (V3030) Sensititre Vizion (V0) (V007) Put 3-5 colonies into measure a Mcarland using the Nephelometer, Mix μl*, 0 μl, or 30 μl** of suspension into M 50 μl volume per well of the suspension using the Sensititre IM or Multi-hannel Pipette incubate at 3-36 o in a non-o incubator or Sensititre RIS X for - hours*** utomatically read with RIS X or OptiRead or manually read with ntimicrobics PIRL PIRL PIRL PIRL PIRL PIRL PIRL PIRL OX+ PIRL P/N P SM mpicillin Penicillin rythromycin Oxacillin +% Nal Pirlamycin Penicillin / Novobiocin Tetracycline ephalothin eftiofur Sulphadimethoxine P/N /6 P 6 SM 56 P/N /6 P 6 SM 56 P/N / P SM P/N / P SM OX+ P/N / P SM 6 OX+ P/N / P SM OX+ P/N / P SM OX+ P/N / P SM 3 *or Proteus spp. **nsure detection of hetero-resistant isolates among Staphylococcus and nterococcus spp. ***Incubate for hours to ensure detection of oxacillin-resistant Staphylococcus and vancomycin-resistant nterococcus spp. Not available in urope. 3

44 Veterinary Sensititre Urinary MVUR Plate ntimicrobial susceptibility plate for testing non-fastidious ram positive and ram negative isolates of veterinary origin roth Type Mcarland Standard (0) Sensititre Mueller inton roth (T36) Veterinary LSI [WW] utoread or Manual Sensititre RIS X (V3090) Sensititre OptiRead (V3030) Sensititre Vizion (V0) (V007) Put 3-5 colonies into measure a Mcarland using the Nephelometer, Mix μl*, 0 μl, or 30 μl** of suspension into M 50 μl volume per well of the suspension using the Sensititre IM or Multi-hannel Pipette incubate at 3-36 o in a non-o incubator or Sensititre RIS X for - hours*** utomatically read with RIS X or OptiRead or manually read with ntimicrobics 56 /5 /76 6 LX 56 LX 6 U 56/ U /6 U 6/3 56 /5 /76 6 LX 56 LX 6 U 56/ U /6 U 6/3 LX U Trimethoprim / Sulfamethoxazole eftiofur Tetracycline ephalexin mpicillin moxicillin / lavulanic acid : ratio nrofloxacin /3 3 LX 6 3 U 3/6 /3 3 LX 6 3 U 3/6 6 LX 3 6 U 6/ 6 LX 3 6 U 6/ LX 6 U / 0. LX 6 U / 0. LX U / LX U / LX U / LX U / *or Proteus spp. **nsure detection of hetero-resistant isolates among Staphylococcus and nterococcus spp. ***Incubate for hours to ensure detection of oxacillin-resistant Staphylococcus and vancomycin-resistant nterococcus spp. Not available in urope.

45 Veterinary Sensititre reakpoint ye Two-Isolate JOY Plate Product Use Perform accurate ST with this dual-isolate plate for breakpoint testing of topical compounds roth Type Mcarland Standard (0) Sensititre Mueller inton roth (T36) Veterinary LSI [WW] Manual Sensititre Vizion (V0) (V007) Put 3-5 colonies into measure a Mcarland using the Nephelometer, Mix 0 μl of suspension into M 50 μl volume per well of the suspension using the Sensititre IM or Multi-hannel Pipette incubate at 3-36 o in a non-o incubator or Sensititre RIS X for - hours Manually read with ntimicrobics OXY OL 0. OXY OL OXY 6 OL OXY TI 6 OL NO 6 TI 3 POL 5 NO 3 TI 6 6 POL 0 OXY OL 0. OXY OL OXY 6 OL OXY TI 6 OL NO 6 TI 3 POL 5 NO 3 TI 6 6 POL 0 OXY OL TI NO POL Z rythromycin Oxytetracycline entamicin hloramphenicol Ofloxacin acitracin oxycycline iprofloxacin eftiofur Ticarcillin Tobramycin Moxifloxacin Neomycin mikacin Polymixin efazolin Trimethoprim / Sulfamethoxazole Z Z 6 Z Z 6 0. /3 0. /3 Not available in urope. 5

46 SURVILLN Identifying antimicrobial resistance patterns is vital to your ability to better understand key pathogenic drivers and more effectively respond to emerging resistance. To do so, your lab needs modular, customizable testing options that meet, LSI and UT requirements. The Sensititre System provides a standardized MR surveillance tool to support public health and national reference laboratories, enabling you to comply with government surveillance mandates while streamlining workflow. armonize your surveillance ST with the method of choice for global MR programs, including: US National ntimicrobial Resistance Monitoring System (NRMS), coordinated via /VM, US and the US ntibiotic Resistance Lab Network U Monitoring System of Zoonoses - U Mandate 03/65/U 6

47 Surveillance Sensititre NRMS ram Negative MV3N Plate ntimicrobial susceptibility plate for testing Salmonella and scherichia coli isolates as part of The National ntimicrobial Resistance Monitoring System (NRMS) program in the United States roth Type Mcarland Standard (0) Sensititre Mueller inton roth (T36) Surveillance [WW] utoread or Manual Sensititre RIS X (V3090) Sensititre OptiRead (V3030) Sensititre Vizion (V0) (V007) Put 3-5 colonies into 0 to measure a Mcarland using the Nephelometer, Mix 0 μl of suspension into M 50 μl volume per well of the suspension using the Sensititre IM or Multi-hannel Pipette incubate at 3-36 o in a non-o incubator or Sensititre RIS X for hours utomatically read with RIS X or OptiRead or manually read with ntimicrobics U 3/6 U 6/ U / U / 0. 6 NL 6 NL NL NL NL 0. IS 3 IS 6 /76 /3 / N U NL IS N efoxitin zithromycin hloramphenicol Tetracycline eftriaxone moxicillin / lavulanic acid : ratio iprofloxacin entamicin Nalidixic cid eftiofur Sulfisoxazole Trimethoprim / Sulfamethoxazole mpicillin Streptomycin Negative control 6 U / NL IS 56 / U / IS / NL 3 IS 6 0./.3 3 Not available in urope. 7

48 Surveillance Sensititre NRMS ram Negative MVN Plate ntimicrobial susceptibility plate for testing Salmonella and scherichia coli isolates as part of The National ntimicrobial Resistance Monitoring System (NRMS) program in the United States roth Type Mcarland Standard (0) Sensititre Mueller inton roth (T36) Surveillance [WW] utoread or Manual Sensititre RIS X (V3090) Sensititre OptiRead (V3030) Sensititre Vizion (V0) (V007) Put 3-5 colonies into 0 to measure a Mcarland using the Nephelometer, Mix 0 μl of suspension into M 50 μl volume per well of the suspension using the Sensititre IM or Multi-hannel Pipette incubate at 3-36 o in a non-o incubator or Sensititre RIS X for hours utomatically read with RIS X or OptiRead or manually read with ntimicrobics U 3/6 U 6/ U / U / 0. 6 NL 6 NL NL NL NL 0. IS 3 IS 6 /76 /3 / N U NL IS N moxicillin / lavulanic acid : ratio mpicillin zithromycin efoxitin eftriaxone hloramphenicol iprofloxacin entamicin Meropenem Nalidixic cid Streptomycin Sulfisoxazole Tetracycline Trimethoprim / Sulfamethoxazole Negative control 6 U / NL IS 56 /9.5 U / IS / NL 3 IS 6 0./.3 3 Not available in urope.

49 Surveillance Sensititre NRMS ram Positive MV3P Plate ntimicrobial susceptibility plate for testing nterococcus isolates as part of the National ntimicrobial Resistance Monitoring System (NRMS) program in the United States roth Type Mcarland Standard (0) Sensititre Mueller inton roth (T36) Surveillance [WW] utoread or Manual Sensititre RIS X (V3090) Sensititre OptiRead (V3030) Sensititre Vizion (V0) (V007) Put 3-5 colonies into 0 to measure a Mcarland using the Nephelometer, Mix 0 μl of suspension into M 50 μl volume per well of the suspension using the Sensititre IM or Multi-hannel Pipette incubate at 3-36 o in a non-o incubator or Sensititre RIS X for hours* utomatically read with RIS X or OptiRead or manually read with ntimicrobics TYLT 0 TYLT 0 TYLT 0. 6 TYLT 6 3 TYLT 3 TYLT TYLT 6 3 TYLT TYLT KN LIN N Tigecycline Tetracycline hloramphenicol aptomycin Streptomycin Tylosin tartarte Quinupristin / alfoprisitn Linezolid Nitrofurantoin Penicillin Kanamycin rythromycin iprofloxacin Vancomycin Linocomycin entamicin Negative control 6 3 LIN LIN LIN LIN N KN KN 56 KN 5 KN 0 *Linezolid and nitrofurantoin should be read manually at hours and vancomycin should be read manually at hours. Not available in urope. 9

50 Surveillance Sensititre NRMS ram Positive MVP Plate ntimicrobial susceptibility plate for testing nterococcus isolates as part of the National ntimicrobial Resistance Monitoring System (NRMS) program in the United States roth Type Mcarland Standard (0) Sensititre Mueller inton roth (T36) Surveillance [WW] Manual Sensititre Vizion (V0) (V007) Put 3-5 colonies into 0 to measure a Mcarland using the Nephelometer, Mix 0 μl of suspension into M 50 μl volume per well of the suspension using the Sensititre IM or Multi-hannel Pipette incubate at 3-36 o in a non-o incubator for hours* Manually read with ntimicrobics VL N Tigecycline aptomycin rythromycin entamicin iprofloxacin Vancomycin mpicillin Quinupristin / alfopristin hloramphenicol Tetracycline Streptomycin Linezolid Nitrofurantoin vilamycin Negative control 6 3 VL VL VL 6 VL N *Linezolid and nitrofurantoin should be read manually at hours and vancomycin should be read manually at hours. 50

51 Surveillance Sensititre U Surveillance ampylobacter U Plate ntimicrobial susceptibility plate for testing ampylobacter isolates as part of a surveillance program roth Type Mcarland Standard (0) Sensititre Mueller inton roth 5 ml (T3605) Sensititre Mueller inton roth w/lysed orse lood (P-0) Surveillance [U] Manual Sensititre Vizion (V0) (V007) Put 3-5 colonies into Sensititre M 5 ml to reach a Mcarland Standard, Mix 00 μl into Sensititre M w/ L 50 μl volume per well of the suspension using the Sensititre IM or Multi-hannel Pipette incubate in a microaerophillic atmosphere* at 35-37º for hours or at º for hours** Manually read with ntimicrobics NL 6 NL 3 NL NL 6 NL 3 NL 6 6 NL rythromycin iprofloxacin Tetracycline entamicin Nalidixic cid Streptomycin 6 NL 6 NL NL NL NL NL NL NL *5% N, 0% O, 5% O. **o not stack plates more than four high. 5

52 Surveillance Sensititre ampylobacter Y Plate ntimicrobial susceptibility plate for testing ampylobacter isolates as part of a surveillance program roth Type Mcarland Standard (0) Sensititre Mueller inton roth 5 ml (T3605) Sensititre Mueller inton roth w/lysed orse lood (P-0) Surveillance [WW] Manual Sensititre Vizion (V0) (V007) Put 3-5 colonies into Sensititre M 5 ml to reach a Mcarland Standard, Mix 00 μl into Sensititre M w/ L 50 μl volume per well of the suspension using the Sensititre IM or Multi-hannel Pipette incubate in a microaerophillic atmosphere* at 35-37º for hours or at º for hours** Manually read with ntimicrobics N NL TL zithromycin iprofloxacin rythromycin Tetracycline lorfenicol Nalidixic cid Telithromycin lindamycin entamicin N N N 0. N N N N N N N 6 N 3 N 6 NL NL NL 6 NL 3 NL 6 TL 0.05 TL TL TL 0. TL TL TL TL TL TL 0. 6 *5% N, 0% O, 5% O. **o not stack plates more than four high. 5

53 Surveillance Sensititre U Surveillance Staphylococcus UST Plate ntimicrobial susceptibility plate for testing Staphylococcus isolates as part of a surveillance program roth Type Mcarland Standard (0) Sensititre Mueller inton roth (T36) Surveillance [U] Manual Sensititre Vizion (V0) (V007) Put 3-5 colonies into 0 to measure a Mcarland using the Nephelometer, Mix 0 μl of suspension into M 50 μl volume per well of the suspension using the Sensititre IM or Multi-hannel Pipette incubate at 3-36 o in a non-o incubator for - hours* Manually read with ntimicrobics 0. US 0. US 6 US US 3 TI 6 6 TI TI TI MUP MUP 6 6 MUP SMX 6 SMX 56 6 MUP 56 SMX SMX 5 US KN TI TMP MUP SMX N lindamycin Tetracycline Rifampin Streptomycin usidate Penicillin hloramphenicol Kanamycin Tiamulin Quinupristin / alfopristin Vancomycin entamicin Trimethoprim rythromycin iprofloxacin efoxitin Linezolid Mupirocin Sulfamethoxazole Negative control KN KN KN 6 KN 3 KN 6 TMP TMP TMP TMP 6 TMP 3 N *Incubate for hours to ensure detection of oxacillin-resistant Staphylococcus and vancomycin-resistant nterococcus spp. 53

54 Surveillance Sensititre U Surveillance nterococcus UVN Plate ntimicrobial susceptibility plate for testing nterococcus isolates as part of a surveillance program roth Type Mcarland Standard (0) Sensititre Mueller inton roth (T36) Surveillance [U] Manual Sensititre Vizion (V0) (V007) Put 3-5 colonies into 0 to measure a Mcarland using the Nephelometer, Mix 0 μl of suspension into M 00 μl volume per well of the suspension using the Sensititre IM or Multi-hannel Pipette incubate at 3-36 o in a non-o incubator for - hours* Manually read with ntimicrobics TI 6 TI 3 TI 6 TI TI TI Vancomycin Teicoplanin Quinupristin / alfopristin Tetracycline aptomycin iprofloxacin rythromycin Tigecycline Linezolid entamicin mpicillin hloramphenicol TI 0. 3 TI 6 TI 0. *Incubate for hours to ensure detection of oxacillin-resistant Staphylococcus and vancomycin-resistant nterococcus spp. 5

55 Surveillance Sensititre U Surveillance Salmonella/. coli UVS Plate ntimicrobial susceptibility plate for testing Salmonella and scheria coli isolates as part of a surveillance program roth Type Mcarland Standard (0) Sensititre Mueller inton roth (T36) Surveillance [U] Manual Sensititre Vizion (V0) (V007) Put 3-5 colonies into 0 to measure a Mcarland using the Nephelometer, Mix 0 μl of suspension into M 50 μl volume per well of the suspension using the Sensititre IM or Multi-hannel Pipette incubate at 3-36 o in a non-o incubator for hours Manually read with ntimicrobics SMX 0 SMX 5 SMX 56 SMX SMX 6 TMP 3 TMP 6 TMP TMP TMP NL NL 6 NL 3 NL 6 NL OL 6 OL OL OL OL SMX TMP NL OT OL Sulfamethoxazole Trimethoprim iprofloxacin Tetracycline Meropenem zithromycin Nalidixic cid efotaxime hloramphenicol Tigecycline eftazidime olistin mpicillin entamicin SMX 3 TMP NL OT SMX 6 TMP 0. OT OT SMX TMP OT OT 55

56 Surveillance Sensititre U Surveillance SL UVS Plate ntimicrobial susceptibility plate for testing SL isolates as part of a surveillance program roth Type Mcarland Standard (0) Sensititre Mueller inton roth (T36) Surveillance [U] Manual Sensititre Vizion (V0) (V007) Put 3-5 colonies into 0 to measure a Mcarland using the Nephelometer, Mix 0 μl of suspension into M 50 μl volume per well of the suspension using the Sensititre IM or Multi-hannel Pipette incubate at 3-36 o in a non-o incubator for hours Manually read with ntimicrobics TP TP TP 0. TP 0. TP 6 TP 3 TP 6 TP 6 OT OT OT 6 OT OT OT 3 6 OT OT OT 6 TRM TRM TRM 6 TRM 3 TRM 6 TP / T/ OT TRM efoxitin rtapenem Imipenem Meropenem eftazidime efepime efotaxime / lavulanic acid eftazidime / lavulanic acid efotaxime Temocillin TRM TRM TRM TRM / / / 0./ / / / / / / / / / / / / / 6/ / 3/ / 6/ T/ 0./ T/ / T/ / T/ / T/ / T/ / T/ / T/ 6/ T/ 3/ T/ 6/ T/ / 56

57 QULITY ONTROL Perform Sensititre quality control testing with the most comprehensive range of microorganism strains recommended by LSI and UT. Thermo Scientific ulti-loops enable quick and safe preparation of T cultures for Q testing. They are ready-to-use bacteriological loops containing gel-stabilised micro-organisms. ach loop is individually packaged in a foil pouch and each pack contains 5 loops. elow is a list of ulti-loops containing the recommended T Strains for the UT and LSI test methods: ulti-loops Part Number escription T Strain R6050 acteroides fragilis 55 R6060 acteroides thetaiotaomicron 97 R6099 ampylobacter jejuni subsp. Jejuni R6095 lostridium ifficiles R6095 ggerthella lenta 3055 R nterococcus faecalis 9 R60996 nterococcus faecalis 599 R scherichia coli 59 R6097 scherichia coli 35 R6030 aemophilus influenza 0 R60330 aemophilus influenza 97 R60306 aemophilus influenza 9766 R60307 Klebsiella pneumoniae R6093 Klebsiella pneumoniae -705 R60935 Klebsiella pneumoniae -706 R Neisseria gonorrhoeae 96 R Pseudomonas aeruginosa 753 R60939 Staphylococcus aureus -70 R60700 Staphylococcus aureus subsp. aureus 593 R6070 Staphylococcus aureus subsp. aureus 93 R6090 Staphylococcus aureus subsp. aureus 3300 R6065 Staphylococcus aureus subsp. aureus -976 R60653 Staphylococcus aureus subsp. aureus -977 R60905 Streptococcus pneumoniae 969 Routine Testing UT xtended Testing Routine Testing LSI xtended Testing The T Licensed erivative mblem, the T Licensed erivative word mark and the T catalog marks are trademarks of T. Remel Inc. is licensed to use these trademarks and to sell products derived from T cultures. The identity, purity, and authenticity of the Licensed Products are exclusively the responsibility of Remel Inc., and not T. The uropean ommittee on ntimicrobial Susceptibility Testing. Routine and extended internal quality control for MI determination and disk diffusion as recommended by UT. Version.0, 0. linical and Laboratory Standards Institute (LSI). Performance Standards for ntimicrobial Susceptibility Testing. 7th ed. LSI supplement M00. linical and Laboratory Standards Institute, 950 West Valley Road, Suit 500, Wayne, Pennsylvania 907 US, 07 57

58 USTOM PILITIS Though the size and workload demands of microbiology laboratories vary, a challenge for each remains in expediting susceptibility testing to facilitate more informed treatment decisions, and improve patient care. The Sensititre System s custom plate capabilities enable you to design a plate format tailored to your formulary for both clinical and veterinary applications. Let us help you identify the custom ST solution that fits the needs of your lab. reater flexibility Performance ustom design Scalable Over 0 antimicrobials available for clinical and veterinary applications; available as frozen or dried format Superior reproducibility for accurate results the first time; consolidate testing onto one format to reduce unnecessary testing protocols asily adapt formulary requirements and prescription protocols to monitor local resistance hoose from a variety of flexible instrumentation options to streamline your workflow and meet your specific workload and budget requirements 5

59 USTOM PILITIS It s not enough to have access to one of the widest, most up-to-date selections of antimicrobials if you can t specifically address the needs of your formulary or patient population. With dilution ranges of your choice and the ability to update formats conveniently, Sensititre ustom Plate capabilities allow you to create the ultimate test program with the flexibility to address the challenges of each individual microbiology laboratory. Offering tailor-made ST with the latest antimicrobials, our custom capabilities lead to relevant results that are based on real-time resistance trends and local epidemiology, allowing you to improve clinical outcomes and effectively manage resistance in your institution. our simple steps to designing your custom plate Our team of microbiology experts will guide you through the Sensititre custom plate process from design to delivery. esign hoose antimicrobials and dilution ranges tailored to your formulary requirements and local patient or animal populations pproval ustom plate designs are rigorously reviewed and approved based on quality and regulatory standards ensuring your plate meets your exact specifications and industry standard guidelines Order ollowing approval and receipt of a purchase order, your Sensititre custom plates will be scheduled for manufacture. ontact us for current lead times* elivery very custom plate comes complete with the required Thermo Scientific Sensititre SWIN Software script specific to your design to ensure results are reported with correct interpretive criteria. Plates may also be read manually subject to configuration *Minimum order quantities apply 59

60 USTOMR SRVI N INSTLLTION Thermo isher Scientific is committed to providing industry-leading customer service. n important part of this service is provided by our dedicated technical support experts. Our team of friendly, experienced microbiologists and engineers are available to give product advice or to help with any technical questions or issues you may have, in your local language. We provide an end-to-end solution for instrument installation, support and servicing through a network of fully trained ield Service ngineers. nd, we can help you set your laboratory up for success and ensure maximum productivity with a Thermo Scientific xtended Service greement. Thermo isher Scientific is equipped to deliver a variety of global services to keep you up and running. rom preventative maintenance and corrective services to continued application assistance provided by technical scientists, get tailored solutions and exceptional support from the experts in microbiology. When you choose Thermo Scientific products for your microbiology needs, consider it the start of a valuable partnership. Whether you need assistance with protocols, product transitions or troubleshooting, our team of experts is ready to help. or more information on how to find solutions perfectly matched for your ST program, please contact your local Thermo isher Scientific Microbiology representative or visit us at thermofisher.com/st 60