Acinetobacter lwoffii h h

Transcription

1 hh Acinetobacter lwoffii h h h h hh MBL Acinetobacter lwoffii MBL A. lwoffii MBL MBL Acinetobacter lwoffii hh Staphylococcus pseudintermedius Pseudomonas aeruginosa h Escherichia coli, hhh ABCD Ambler B hhmbl MBL h MBL h MBL Acinetobacter lwoffii, g A. lwoffii A. lwoffii BTB VITEK GN bio Mérieux S.A., France TSI MBL Shibata SMA h h FAX hh miya@c-able.ne.jp 365

2 h h MBL Acinetobacter lwoffii IPM CAZ SMA IPM CAZ SMA IPM CAZ mm MBL Clinical and Laboratory Standards InstituteCLSI ABPCPIPC C/AMP CEZCTMLMOX CTRXCFPM MINOAMK LVFX IPM A. lwoffii MBL A. lwoffii MBL A. lwoffii A. lwoffii MBL A. lwoffii 366 MBL A. lwoffii A. lwoffii ABPCC/AMPCEZ CTM MINO AMK PIPC IPM MBL A. lwoffii MBL A. lwoffii MBL A. lwoffii CTRXCFPM LMOX MBL A. lwoffii LVFX MBL A. lwoffii MBL A. lwoffii Acinetobacter spp. Acinetobacter spp. Acinetobacter spp.

3 h SIR Acinetobacter lwoffii ABPC PIPC hh hh R R R R R R R R R R R S S S R R R R R R R CAMP CEZ R R R R R R R CTM R R R R R R R CTRX R R R I S S I CFPM R R R S S S S LMOX R R R I S I I IPM R R R R S S S MINO S S S S S S S AMK S S S S S S S LVFX R S S I S S S A. baumannii A. lwoffii Acinetobacter Acinetobacter spp. efflux pumpsh Acinetobacter spp. DNA DNA A. lwoffii MINO AMK LVFX A. lwoffii MBL A. lwoffii A. lwoffii A. lwoffii DNA Acinetobacter spp. MBL,, MBL A. lwoffii MBL A. lwoffii MBL h h MBL A. lwoffii IPM PIPC CTRX CFPM 367

4 MBL LMOX MBL MBL, MBL P. aeruginosa Acinetobacter spp., MBL A. lwoffii MBL MBL MBL MBL A. lwoffii MBL MBL MBL Scott Weese J : Antimicrobial resistance in companion animals, Anim Health Res Rev,, h () Gibson JS, Morton JM, Cobbold RN, Sidjabat HE, Filippich LJ, Trott DJ : Multidrughresistant E. coli and Enterobacter extraintestinal infection in Dogs, J Vet Intern Med,, h () Rubin J, Walker RD, Blickenstaff K, Bodeis-Jones S, Zhao S : Antimicrobial resistance and genetic characterization of fluoroquinolone resistance of Pseudomonas aeruginosa isolated from canine infections, Vet Microbiol,, h () Warren AL, Townsend KM, King T, Moss S, O Boyle D, Yates RM, Trott DJ : Multihdrug resistant Escherichia coli with extendedhspectrum hlactamase activity and fluoroquinolone resistance isolated from clinical infections in dogs, Aust Vet J,, h () Johnson JR, Miller S, Johnston B, Clabots C, Debroy C : Sharing of Escherichia coli sequence type ST and other multidrughresistant and urovirulent E. coli strains among dogs and cats within a household, J Clin Microbiol,, h () h hh MBL h hh h hh h Shibata N, Doi Y, Yamane K, Yagi T, Kurokawa H, Shibayama K, Kato H, Kai K, Arakawa Y : PCR typing of genetic determinants for metallohbetahlactamases and integrases carried by gramhnegative bacteria isolated in Japan, with focus on the class integron, J Clin Microbiol,, h () Clinical and Laboratory Standards Institute : Performance standards for antimicrobial susceptibility testing; th informational supplement, CLSI document MhS, Clinical and Laboratory Standards Institute, Wayne, Pa () Francey T, Gaschen F, Nicolet J, Burnens AP : The role of Acinetobacter baumannii as a nosocomial pathogen for dogs and cats in an intensive care unit, J Vet Intern Med,, h () Fishbain J, Peleg AY : Treatment of Acinetobacter infections, Clin Infect Dis,, h () A. baumanniib. cepacias. maltophilia h ESBL h Acinetobacter Stenotrophomonas maltophilia h h 368

5 Isolation of MetallohhLactamasehProducing Acinetobacter lwoffii from Three Dogs and a Cat Eriko SHIMADA, Tadashi MIYAMOTO and Shingo HATOYA Miyamoto Animal Hospital, 2265h8 Kurokawa, Yamaguchi, 753h0851, Japan Metallohhlactamase (MBL)hproducing Acinetobacter lwoffii was isolated from two dogs with pyoderma, a dog with subcutaneous abscess, and a cat with cystitis admitted to an animal hospital between May and August, All MBLhproducing A. lwoffii isolates were resistant to ampicillin, piperacillin, amoxicillinhclavulanic acid, cefazolin, cefotiam, and imipenem; and were susceptible to minocycline and amikacin. Because MBLh producing bacteria has been recognized as a public health problem, veterinary staff at animal hospitals should be concerned about possible infections of dogs and cats with MBLhproducing bacteria, including Acinetobacter. Key words : Acinetobacter lwoffii, Antimicrobial drug susceptibility, Metallohhlactamase. Correspondence to : Tadashi MIYAMOTO (Miyamoto Animal Hospital) 2265h8 Kurokawa, Yamaguchi, 753h0851, Japan TEL FAX 083h932h miya629@c-able.ne.jp J. Jpn. Vet. Med. Assoc.,, () 369