Clinical Usefulness of Multi-facility Microbiology Laboratory Database Analysis by WHONET

Size: px
Start display at page:

Download "Clinical Usefulness of Multi-facility Microbiology Laboratory Database Analysis by WHONET"

Transcription

1 Special Articles Journal of General and Family Medicine 2015, vol. 16, no. 3, p Clinical Usefulness of Multi-facility Microbiology Laboratory Database Analysis by WHONET Sachiko Satake, PhD, 1 Singaku Kaneko, 2 Ikuyo Yokozawa, 2 Mayumi Shibasaki, 3 Osamichi Mita, 4 Mayumi Takase, 5 Sakiko Miyashita, 6 Yoshiro Fujita, MD, 7 John Stelling, MD, MPH, 8 and Yasuharu Tokuda, MD, MPH 9 1 School of Health Sciences, Gunma University, Japan 2 Maebashi Red Cross Hospital, Japan 3 JCHO Gunma Central Hospital, Japan 4 Kiryu Kosei General Hospital, Japan 5 Gunmaken Saiseikai Maebashi Hospital, Japan 6 Fujioka General Hospital, Japan 7 Chubu Rosai Hospital, Japan 8 WHO Collaborating Centre for Surveillance of Antimicrobial Resistance, Brigham and Women s Hospital, USA 9 Japan Community Healthcare Organization, Tokyo, Japan Clinically important issues might be addressed more comprehensively by analyzing microbiological data assembled from several institutions instead of from a single one. Microbiology laboratory databases collected from six collaborative hospitals (A F) between 2003 and 2013 were converted into WHONET files and analyzed. Three important areas of investigation are presented in this article including early warning of the emergence of resistant bacteria, evaluation of a new susceptibility testing method, and establishment of strategies for identifying patients harboring resistant organisms. Combined databases from microbiology laboratories of a collaborative hospital network might help in developing integrated responses to prevent infection, decrease transmission, and ensure that appropriate antibiotics are selected for patients with infectious diseases. Keywords: antimicrobial susceptibility, antibiogram, multidrug-resistant Pseudomonas aeruginosa, methicillinresistant Staphylococcus aureus, minocycline, infection control Corresponding author: Sachiko Satake, PhD Gunma University, Showa-machi, Maebashi , Japan satake@gunma-u.ac.jp Received for publication 30 October 2014 and accepted in revised form 18 February Japan Primary Care Association 138

2 Clinical Usefulness of Multi-facility Microbiology Laboratory Database Analysis by WHONET Table 1. Antimicrobial resistance rates of Pseudomonas aeruginosa isolated during 2005 Antibiotics Total Piperacillin ND Ceftazidime Aztreonam Imipenem Gentamicin Amikacin Levofloxacin Total patients (n) ND, not done. Background The antimicrobial susceptibility rate and the distribution of resistant bacteria are important for infectious disease clinics and infection control in supporting and evaluating therapy guidelines and containment interventions. 1,2 Useful strategies for the analysis and presentation of antimicrobial susceptibility test results are available in CLSI documents, 3 for example addressing the issue of repeat isolations of a microbial strain from a given patient through the analysis of first isolates of a given species from a patient. For monitoring incidence of infection, then analyzing one phenotype strain per patient may be more appropriate. Analyses of multicenter data might permit the data analysis to explore issues that cannot be addressed through separate analyses of data from individual institutions. Analyses of multicenter data might also clarify systematic problems in laboratory testing methods or in database analysis. The software WHONET 5.6 is a database for microbiology laboratory management that was developed and provided by the World Health Organization (WHO) Collaborating Centre for Surveillance of Antimicrobial Resistance, Boston. Six laboratory databases with information collected between 2003 and 2013 were converted to the WHONET file structure, and analyzed at Gunma University. Antimicrobial susceptibility was tested using the Vitek system (SYSMEX biomérieux) at the laboratory of Hospital A, and the MicroScan WalkAway (Siemens) at those of hospitals B, C, D, E and F. The laboratory of Hospital A is located in Aichi Prefecture (400 km west of Tokyo) and the other five are located in Gunma Prefecture (100 km north of Tokyo). The analytical findings of the individual databases are described with comments on each laboratory. In this study, we explore a number of ways to analyze data which would have benefits to clinicians, policy-makers, and infection control staff in the management of patients with resistant infections and in the tracking and containing of resistant microbes. Spread of Multidrug-Resistant Pseudomonas Aeruginosa The first isolate of Pseudomonas aeruginosa per patient in 2005 was analyzed. The rates of antibiotic resistance to ceftazidime (CAZ), aztreonam (AZT), imipenem (IPM) gentamicin (GM), amikacin (AMK), levofloxacin (LVFX) were statistically significantly different in hospital F compared with the other laboratories (Table 1). Resistance profiles were analyzed using WHONET to detect multidrug-resistant P. aeruginosa (MDRP). The rate of MDRP resistance to IPM, AMK, LVFX, was 1.8% in five laboratories and 13.0% in hospital F. However, the rate of MDRP in hospital F decreased to that of the other hospitals in 2007 (Table 2). Deviation of Antimicrobial Susceptibility Test Results between Two Machines The annual resistance rates to minocycline (MINO) of methicillin-resistant Staphylococcus aureus (MRSA) 139

3 Journal of General and Family Medicine 2015, vol. 16, no. 3 Table 2. Multidrug-resistant Pseudomonas aeruginosa (MDRP) isolated between 2003 and 2007 Ratio (%) of MDRP Number of patients Year Hospital F Other hospitals Hospital F Other hospitals MDRP Non-MDRP MDRP Non-MDRP , , , Table 3. Minocycline resistance rates of methicillin-resistant Staphylococcus aureus isolated between 2003 and 2013 Years Total ND ND ND ND, not done. isolated from all six hospitals between 2003 and 2013 were analyzed using WHONET. Analyses were based on the first isolate with antibiotic findings per patient per year. The resistance rates of MINO between 2005 and 2007 at hospitals B, C, D, E and F ranged from 0.0% to 1.0%, whereas the rates at hospital A between 2005 and 2007 ranged from 26.8% to 41.4%. The resistance rates of MINO did not significantly differ among the six hospitals by 2010 (Table 3). Analytical Method That Does Not Miss Emergence of Resistant Bacteria Clinical microbiology laboratory data from six hospitals in 2009 were analyzed. When several strains with the same species were repeatedly isolated from the same patient, we compared results obtained when analyzing 1) the first isolate per patient per 365 days versus 2) the most resistant finding for each antibiotic per patient. The rates of P. aeruginosa resistance to imipenem in the per-patient analysis using the first isolate did not differ significantly among the six hospitals. However, when the imipenem resistance rates of P. aeruginosa were analyzed using the most resistant test results, the rates at hospitals D and E were higher than those in the others. The rates of S. aureus resistance to oxacillin were higher for isolates from hospital F than at the others when the data were analyzed per patient with the first isolate or per patient with the most resistant result. The oxacillin resistance rates of isolates from hospitals B, D, E were higher than others when analyzed per strain (Table 4). The average numbers of MRSA isolates per patient at 140

4 Clinical Usefulness of Multi-facility Microbiology Laboratory Database Analysis by WHONET Table 4. Analysis of resistance rates during 2009 Analytical method Imipenem resistance rate of Pseudomonas aeruginosa By patient, first isolate with antibiotic results By patient, most resistant result against each antibiotic By isolate Oxacillin resistance rate of Staphylococcus aureus By patient, first isolate with antibiotic results By patient, most resistant result against each antibiotic By isolate Table 5. Average numbers of MRSA isolates per patient Number of MRSA isolates (A) MRSA-positive patients number (B) Ratio (A/B) hospitals B, D and E were 2.4, 2.9 and 2.8, respectively (Table 5). Discussion The higher rate of MDRP in hospital F compared in early 2006 with the other hospitals in 2005 was communicated to the hospital infection control and link nurse committees. This information improved staff awareness, and the infection control team evaluated the management of urethral catheter, and UTI surveillance was initiated in June By 2007, these aggressive interventions decreased the rate of MDRP. The resistance rates to MINO of MRSA considerably differed among the hospitals in 2005, but the cause could not initially be defined. Three years later, Siemens informed their clients that the results of MINO resistance were misreported by the MicroScan Pos series because the minimum inhibitory concentrations (MIC) were two- to four-fold lower than that of the standardized method of Clinical and Laboratory Standards Institute (CLSI). 4 Subsequently, Siemens reported that good MIC agreement could be obtained using the standard method and modification by an improved panel. The improved panel was adopted at all five hospitals between November 2008 and March 2009 and this immediately changed the rate of resistance to MINO. This finding led to an error being identified by a recently introduced method of testing minocycline susceptibility. Thus, the cause of the significantly different MINO resistance rate of MRSA among hospitals was established and the MINO database of S. aureus accumulated using the Micro- Scan Pos series before 2008 should be used as epidemiological information with care. To guide clinical decisions regarding empirical therapy for initial infections, antibiograms that comprise only the first isolate of a given species per patient should be analyzed according to the CLSI. 3 However, basing summaries only on the first isolate per patient might result in changes related to the emergence of new resistance patterns being overlooked. Analysis of the complete database is recommended to detect such resistant strains. When strains of the same species have been isolated repeatedly from the same patient, WHONET can be analyzed using the highest resistance value per antibiotic per patient. For example, an IPM- 141

5 Journal of General and Family Medicine 2015, vol. 16, no. 3 resistant strain emerged during IPM therapy for P. aeruginosa infection, and a first isolate approach omits this isolate from consideration. Analysis using the highest resistance result per antibiotic per patient can facilitate monitoring the spread of resistant bacteria among hospitalized patients. Therefore, this is considered to be a useful analytical method from the viewpoint of infection control. The analysis of combined data showed that knowing the number of patients harboring resistant organisms was more valuable than simply counting the number of isolates of resistant organisms to understand the epidemiological spread of resistant bacteria in patients at a single hospital. Acknowledgments We thank the medical technologists at each hospital laboratory who were responsible for sending the microbiological data to us for 11 years. Research reported in this publication was supported by the National Institute of General Medical Sciences of the National Institutes of Health under award number R01GM The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Conflict of interest None. Conclusion Providing feedback to a hospital that the rate of multiple-drug-resistant bacteria was statistically higher than that of other hospitals triggered an appropriate intervention to control infection. An analysis of multicenter data confirmed that the MINO resistance rate of MRSA before 2009 measured using MicroScan should be used carefully as epidemiological information. Analysis using the highest resistance value per antibiotic per patient is a useful appropriate method for infection control purposes as it is not affected by the number of isolates per patient, and it can improve detection of rare resistance phenotypes and identification of novel phenotypes among hospitalized patients. References 1 Trevino S: Antibiotic resistance monitoring: a laboratory perspective. Mil Med. 2000;165: Murray PR, Baron EJ, Landry ML, Jorgensen JH, Pfaller MA: Manual of clinical microbiology, 9th ed. ASM press, 2007, Clinical and Laboratory Standards Institute: Analysis and presentation of cumulative antimicrobial susceptibility test data; Approved Guideline, 3rd ed. CLSI document M39-A3. Wayne: Clinical and Laboratory Standards Institute, 2009, Clinical and Laboratory Standards Institute: Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically; Approved standard, 7th ed. CLSI document M7-A7. Wayne: Clinical and Laboratory Standards Institute, 2006,

Educating Clinical and Public Health Laboratories About Antimicrobial Resistance Challenges

Educating Clinical and Public Health Laboratories About Antimicrobial Resistance Challenges Educating Clinical and Public Health Laboratories About Antimicrobial Resistance Challenges Janet Hindler, MCLS MT(ASCP) UCLA Medical Center jhindler@ucla.edu also working as a consultant with the Association

More information

levofloxacin (LVFX) LVFX LVFX LVFX Key words: Levofloxacin Escherichia coli LVFX levofloxacin (LVFX) Vol. 18 No

levofloxacin (LVFX) LVFX LVFX LVFX Key words: Levofloxacin Escherichia coli LVFX levofloxacin (LVFX) Vol. 18 No 2008 221 20 3 14 20 8 1 2001 1 2005 12 5 levofloxacin (LVFX) 5 811 125 27 LVFX (MIC: 4 mg/ml) LVFX LVFX Key words: Levofloxacin Escherichia coli 1) 2 5) 6) ( 203 0036) 2 1 2 TEL: 042 338 5111 2254 FAX:

More information

Concise Antibiogram Toolkit Background

Concise Antibiogram Toolkit Background Background This toolkit is designed to guide nursing homes in creating their own antibiograms, an important tool for guiding empiric antimicrobial therapy. Information about antibiograms and instructions

More information

Understanding the Hospital Antibiogram

Understanding the Hospital Antibiogram Understanding the Hospital Antibiogram Sharon Erdman, PharmD Clinical Professor Purdue University College of Pharmacy Infectious Diseases Clinical Pharmacist Eskenazi Health 5 Understanding the Hospital

More information

Please distribute a copy of this information to each provider in your organization.

Please distribute a copy of this information to each provider in your organization. HEALTH ADVISORY TO: Physicians and other Healthcare Providers Please distribute a copy of this information to each provider in your organization. Questions regarding this information may be directed to

More information

Antimicrobial Stewardship Strategy: Antibiograms

Antimicrobial Stewardship Strategy: Antibiograms Antimicrobial Stewardship Strategy: Antibiograms A summary of the cumulative susceptibility of bacterial isolates to formulary antibiotics in a given institution or region. Its main functions are to guide

More information

CONTAGIOUS COMMENTS Department of Epidemiology

CONTAGIOUS COMMENTS Department of Epidemiology VOLUME XXVII NUMBER 6 July 2012 CONTAGIOUS COMMENTS Department of Epidemiology Bugs and Drugs Elaine B. Dowell SM, MLS (ASCP); Sarah K. Parker, MD; James K. Todd, MD Each year the Children s Hospital Colorado

More information

Implementation and Optimization of Antibiotic Stewardship in Acute Care Hospitals: A Clinical Microbiology Laboratory Perspective

Implementation and Optimization of Antibiotic Stewardship in Acute Care Hospitals: A Clinical Microbiology Laboratory Perspective Implementation and Optimization of Antibiotic Stewardship in Acute Care Hospitals: A Clinical Microbiology Laboratory Perspective James E. Kirby, MD D(ABMM) Medical Director, Clinical Microbiology Beth

More information

Antimicrobial Susceptibility Testing: Advanced Course

Antimicrobial Susceptibility Testing: Advanced Course Antimicrobial Susceptibility Testing: Advanced Course Cascade Reporting Cascade Reporting I. Selecting Antimicrobial Agents for Testing and Reporting Selection of the most appropriate antimicrobials to

More information

a. 379 laboratories provided quantitative results, e.g (DD method) to 35.4% (MIC method) of all participants; see Table 2.

a. 379 laboratories provided quantitative results, e.g (DD method) to 35.4% (MIC method) of all participants; see Table 2. AND QUANTITATIVE PRECISION (SAMPLE UR-01, 2017) Background and Plan of Analysis Sample UR-01 (2017) was sent to API participants as a simulated urine culture for recognition of a significant pathogen colony

More information

2 0 hr. 2 hr. 4 hr. 8 hr. 10 hr. 12 hr.14 hr. 16 hr. 18 hr. 20 hr. 22 hr. 24 hr. (time)

2 0 hr. 2 hr. 4 hr. 8 hr. 10 hr. 12 hr.14 hr. 16 hr. 18 hr. 20 hr. 22 hr. 24 hr. (time) Key words I μ μ μ μ μ μ μ μ μ μ μ μ μ μ II Fig. 1. Microdilution plate. The dilution step of the antimicrobial agent is prepared in the -well microplate. Serial twofold dilution were prepared according

More information

Is Clostridium difficile infection influenced by antimicrobial use density in wards?

Is Clostridium difficile infection influenced by antimicrobial use density in wards? Apr. 2013 THE JAPANESE JOURNAL OF ANTIBIOTICS 66 2 87 29 Is Clostridium difficile infection influenced by antimicrobial use density in wards? NOBUMICHI OGAMI, JUNICHI YOSHIDA, TOSHIYUKI ISHIMARU, TETSUYA

More information

Methicillin-resistant coagulase-negative staphylococci Methicillin-resistant. spa Staphylococcus aureus

Methicillin-resistant coagulase-negative staphylococci Methicillin-resistant. spa Staphylococcus aureus 126 2005 Methicillin-resistant coagulase-negative staphylococci Methicillin-resistant Staphylococcus aureus 1) 1) 1) 1) 1) 2) 3) 4) 2) 1) MBC 2) 3) 4) 17 3 28 17 8 22 Methicillin-resistant Staphylococcus

More information

Antibiotic sensitivity of bacteria on the oral mucosa. after hematopoietic cell transplantation

Antibiotic sensitivity of bacteria on the oral mucosa. after hematopoietic cell transplantation Antibiotic sensitivity of bacteria on the oral mucosa after hematopoietic cell transplantation Yoshihiko Soga 1, Yoshinobu Maeda 2, Mitsune Tanimoto 2, Takayuki Ebinuma 3, Hiroshi Maeda 3, Shogo Takashiba

More information

Isolation of Urinary Tract Pathogens and Study of their Drug Susceptibility Patterns

Isolation of Urinary Tract Pathogens and Study of their Drug Susceptibility Patterns International Journal of Current Microbiology and Applied Sciences ISSN: 2319-7706 Volume 5 Number 4 (2016) pp. 897-903 Journal homepage: http://www.ijcmas.com Original Research Article http://dx.doi.org/10.20546/ijcmas.2016.504.101

More information

International Journal of Health Sciences and Research ISSN:

International Journal of Health Sciences and Research  ISSN: International Journal of Health Sciences and Research www.ijhsr.org ISSN: 2249-9571 Original Research Article Antibiotic Susceptibility Pattern of Pseudomonas Aeruginosa Isolated From Various Clinical

More information

THE NAC CHALLENGE PANEL OF ISOLATES FOR VERIFICATION OF ANTIBIOTIC SUSCEPTIBILITY TESTING METHODS

THE NAC CHALLENGE PANEL OF ISOLATES FOR VERIFICATION OF ANTIBIOTIC SUSCEPTIBILITY TESTING METHODS THE NAC CHALLENGE PANEL OF ISOLATES FOR VERIFICATION OF ANTIBIOTIC SUSCEPTIBILITY TESTING METHODS Stefanie Desmet University Hospitals Leuven Laboratory medicine microbiology stefanie.desmet@uzleuven.be

More information

GENERAL NOTES: 2016 site of infection type of organism location of the patient

GENERAL NOTES: 2016 site of infection type of organism location of the patient GENERAL NOTES: This is a summary of the antibiotic sensitivity profile of clinical isolates recovered at AIIMS Bhopal Hospital during the year 2016. However, for organisms in which < 30 isolates were recovered

More information

Analysis and Presentation of Cumulative Antibiograms: ANewConsensusGuidelinefromtheClinicaland Laboratory Standards Institute

Analysis and Presentation of Cumulative Antibiograms: ANewConsensusGuidelinefromtheClinicaland Laboratory Standards Institute INVITED ARTICLE MEDICAL MICROBIOLOGY L. Barth Reller and Melvin P. Weinstein, Section Editors Analysis and Presentation of Cumulative Antibiograms: ANewConsensusGuidelinefromtheClinicaland Laboratory Standards

More information

Background and Plan of Analysis

Background and Plan of Analysis ENTEROCOCCI Background and Plan of Analysis UR-11 (2017) was sent to API participants as a simulated urine culture for recognition of a significant pathogen colony count, to perform the identification

More information

Aerobic bacterial infections in a burns unit of Sassoon General Hospital, Pune

Aerobic bacterial infections in a burns unit of Sassoon General Hospital, Pune Original article Aerobic bacterial infections in a burns unit of Sassoon General Hospital, Pune Patil P, Joshi S, Bharadwaj R. Department of Microbiology, B.J. Medical College, Pune, India. Corresponding

More information

Dr Neeraj Goel Sr. Consultant Department of Clinical Microbiology. Sir Ganga Ram Hospital

Dr Neeraj Goel Sr. Consultant Department of Clinical Microbiology. Sir Ganga Ram Hospital Dr Neeraj Goel Sr. Consultant Department of Clinical Microbiology Sir Ganga Ram Hospital Resistance profile of MDROs in ICU: Quinolone: 80% Amikacin: 75% Cefaperazone sulbactum: 79% Carbapenems: 79% Super

More information

Compliance of manufacturers of AST materials and devices with EUCAST guidelines

Compliance of manufacturers of AST materials and devices with EUCAST guidelines Compliance of manufacturers of AST materials and devices with EUCAST guidelines Data are based on questionnaires to manufacturers of materials and devices for antimicrobial susceptibility testing. The

More information

Acinetobacter lwoffii h h

Acinetobacter lwoffii h h hh Acinetobacter lwoffii h h h h hh MBL Acinetobacter lwoffii MBL A. lwoffii MBL MBL Acinetobacter lwoffii hh Staphylococcus pseudintermedius Pseudomonas aeruginosa h Escherichia coli, hhh ABCD Ambler

More information

CONTAGIOUS COMMENTS Department of Epidemiology

CONTAGIOUS COMMENTS Department of Epidemiology VOLUME XXIII NUMBER 1 July 2008 CONTAGIOUS COMMENTS Department of Epidemiology Bugs and Drugs Elaine Dowell, SM (ASCP), Marti Roe SM (ASCP), Ann-Christine Nyquist MD, MSPH Are the bugs winning? The 2007

More information

Key words: Campylobacter, diarrhea, MIC, drug resistance, erythromycin

Key words: Campylobacter, diarrhea, MIC, drug resistance, erythromycin Key words: Campylobacter, diarrhea, MIC, drug resistance, erythromycin Table 1 Detection rate of Campylobacter from stool samples taken from sporadic diarrheic patients Table 2 Detection rates of Campylobacter

More information

Drive More Efficient Clinical Action by Streamlining the Interpretation of Test Results

Drive More Efficient Clinical Action by Streamlining the Interpretation of Test Results White Paper: Templated Report Comments Drive More Efficient Clinical Action by Streamlining the Interpretation of Test Results Background The availability of rapid, multiplexed technologies for the comprehensive

More information

Multidrug-Resistant Organisms: How Do We Define them? How do We Stop Them?

Multidrug-Resistant Organisms: How Do We Define them? How do We Stop Them? Multidrug-Resistant Organisms: How Do We Define them? How do We Stop Them? Roberta B. Carey, PhD Centers for Disease Control and Prevention Division of Healthcare Quality Promotion Why worry? MDROs Clinical

More information

National Surveillance of Antimicrobial Resistance in Pseudomonas aeruginosa Isolates Obtained from Intensive Care Unit Patients from 1993 to 2002

National Surveillance of Antimicrobial Resistance in Pseudomonas aeruginosa Isolates Obtained from Intensive Care Unit Patients from 1993 to 2002 ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, Dec. 2004, p. 4606 4610 Vol. 48, No. 12 0066-4804/04/$08.00 0 DOI: 10.1128/AAC.48.12.4606 4610.2004 Copyright 2004, American Society for Microbiology. All Rights

More information

SMART WORKFLOW SOLUTIONS Introducing DxM MicroScan WalkAway System* ...

SMART WORKFLOW SOLUTIONS Introducing DxM MicroScan WalkAway System* ... SMART WORKFLOW SOLUTIONS Introducing DxM MicroScan WalkAway System* The next-generation MicroScan WalkAway System combines proven technology and reliability with enhanced ease-of-use features to streamline

More information

4/3/2017 CLINICAL PEARLS: UPDATES IN THE MANAGEMENT OF NOSOCOMIAL PNEUMONIA DISCLOSURE LEARNING OBJECTIVES

4/3/2017 CLINICAL PEARLS: UPDATES IN THE MANAGEMENT OF NOSOCOMIAL PNEUMONIA DISCLOSURE LEARNING OBJECTIVES CLINICAL PEARLS: UPDATES IN THE MANAGEMENT OF NOSOCOMIAL PNEUMONIA BILLIE BARTEL, PHARMD, BCCCP APRIL 7 TH, 2017 DISCLOSURE I have had no financial relationship over the past 12 months with any commercial

More information

2016 Antibiogram. Central Zone. Alberta Health Services. including. Red Deer Regional Hospital. St. Mary s Hospital, Camrose

2016 Antibiogram. Central Zone. Alberta Health Services. including. Red Deer Regional Hospital. St. Mary s Hospital, Camrose 2016 Antibiogram Central Zone Alberta Health Services including Red Deer Regional Hospital St. Mary s Hospital, Camrose Introduction This antibiogram is a cumulative report of the antimicrobial susceptibility

More information

Regional Workshop on AMR in South East Asia Penang (Malaysia): March 2018

Regional Workshop on AMR in South East Asia Penang (Malaysia): March 2018 Regional Workshop on AMR in South East Asia Penang (Malaysia): 26-28 March 2018 Prof : Htay Htay Tin drhtayhtaytin@gmail.com DDG ( Laboratory) National Focal Point for AMR Ministry of Health and Sports

More information

RESEARCH ARTICLE ANTIBIOGRAM

RESEARCH ARTICLE ANTIBIOGRAM RESEARCH ARTICLE ANTIBIOGRAM OF ESCHERICHIA COLI, KLEBSIELLA PNEUMONIAE, AND KLEBSIELLA OXYTOCA FROM INVASIVE DISEASE CASES AT A TERTIARY CARE UNIVERSITY HOSPITAL IN THE CENTRAL REGION OF JAPAN FROM 2008

More information

EDUCATIONAL COMMENTARY CURRENT METHODS IN ANTIMICROBIAL SUSCEPTIBILITY TESTING

EDUCATIONAL COMMENTARY CURRENT METHODS IN ANTIMICROBIAL SUSCEPTIBILITY TESTING Commentary provided by: Linsey Donner, MPH, CPH, MLS (ASCP) CM Assistant Professor, Microbiology and Serology College of Allied Health Professions, Division of Medical Laboratory Science University of

More information

The Nuts and Bolts of Antibiograms in Long-Term Care Facilities

The Nuts and Bolts of Antibiograms in Long-Term Care Facilities The Nuts and Bolts of Antibiograms in Long-Term Care Facilities J. Kristie Johnson, Ph.D., D(ABMM) Professor, Department of Pathology University of Maryland School of Medicine Director, Microbiology Laboratories

More information

Antimicrobial Stewardship/Statewide Antibiogram. Felicia Matthews Senior Consultant, Pharmacy Specialty BD MedMined Services

Antimicrobial Stewardship/Statewide Antibiogram. Felicia Matthews Senior Consultant, Pharmacy Specialty BD MedMined Services Antimicrobial Stewardship/Statewide Antibiogram Felicia Matthews Senior Consultant, Pharmacy Specialty BD MedMined Services Disclosures Employee of BD Corporation MedMined Services Agenda CMS and JCAHO

More information

New Drugs for Bad Bugs- Statewide Antibiogram

New Drugs for Bad Bugs- Statewide Antibiogram New Drugs for Bad Bugs- Statewide Antibiogram Felicia Matthews, Pharm.D., BCPS Senior Consultant, Pharmacy Specialty BE MedMined Services Disclosures Employee of BD Corporation MedMined Services Agenda

More information

Annual Surveillance Summary: Methicillinresistant Staphylococcus aureus (MRSA) Infections in the Military Health System (MHS), 2017

Annual Surveillance Summary: Methicillinresistant Staphylococcus aureus (MRSA) Infections in the Military Health System (MHS), 2017 Annual Surveillance Summary: Methicillinresistant Staphylococcus aureus (MRSA) Infections in the Military Health System (MHS), 2017 Jessica R. Spencer and Uzo Chukwuma Approved for public release. Distribution

More information

Intrinsic, implied and default resistance

Intrinsic, implied and default resistance Appendix A Intrinsic, implied and default resistance Magiorakos et al. [1] and CLSI [2] are our primary sources of information on intrinsic resistance. Sanford et al. [3] and Gilbert et al. [4] have been

More information

2017 Antibiogram. Central Zone. Alberta Health Services. including. Red Deer Regional Hospital. St. Mary s Hospital, Camrose

2017 Antibiogram. Central Zone. Alberta Health Services. including. Red Deer Regional Hospital. St. Mary s Hospital, Camrose 2017 Antibiogram Central Zone Alberta Health Services including Red Deer Regional Hospital St. Mary s Hospital, Camrose Introduction This antibiogram is a cumulative report of the antimicrobial susceptibility

More information

Healthcare-associated Infections Annual Report

Healthcare-associated Infections Annual Report September 2014 Healthcare-associated Infections Annual Report 2009-2013 Summary Provincial Infection Control Newfoundland Labrador (PIC-NL) has collected data on inpatients and outpatients with healthcare-associated

More information

INFECTIOUS DISEASES DIAGNOSTIC LABORATORY NEWSLETTER

INFECTIOUS DISEASES DIAGNOSTIC LABORATORY NEWSLETTER INFECTIOUS DISEASES DIAGNOSTIC LABORATORY NEWSLETTER University of Minnesota Health University of Minnesota Medical Center University of Minnesota Masonic Children s Hospital May 2017 Printed herein are

More information

UNDERSTANDING YOUR DATA: THE ANTIBIOGRAM

UNDERSTANDING YOUR DATA: THE ANTIBIOGRAM UNDERSTANDING YOUR DATA: THE ANTIBIOGRAM April Abbott, PhD, D(ABMM) Deaconess Health System Evansville, IN April.Abbott@Deaconess.com Special thanks to Dr. Shelley Miller for UCLA data WHAT WE WILL COVER

More information

ANTIBIOTIC STEWARDSHIP

ANTIBIOTIC STEWARDSHIP ANTIBIOTIC STEWARDSHIP S.A. Dehghan Manshadi M.D. Assistant Professor of Infectious Diseases and Tropical Medicine Tehran University of Medical Sciences Issues associated with use of antibiotics were recognized

More information

Appropriate antimicrobial therapy in HAP: What does this mean?

Appropriate antimicrobial therapy in HAP: What does this mean? Appropriate antimicrobial therapy in HAP: What does this mean? Jaehee Lee, M.D. Kyungpook National University Hospital, Korea KNUH since 1907 Presentation outline Empiric antimicrobial choice: right spectrum,

More information

2015 Antibiogram. Red Deer Regional Hospital. Central Zone. Alberta Health Services

2015 Antibiogram. Red Deer Regional Hospital. Central Zone. Alberta Health Services 2015 Antibiogram Red Deer Regional Hospital Central Zone Alberta Health Services Introduction. This antibiogram is a cumulative report of the antimicrobial susceptibility rates of common microbial pathogens

More information

New Opportunities for Microbiology Labs to Add Value to Antimicrobial Stewardship Programs

New Opportunities for Microbiology Labs to Add Value to Antimicrobial Stewardship Programs New Opportunities for Microbiology Labs to Add Value to Antimicrobial Stewardship Programs Patrick R. Murray, PhD Senior Director, WW Scientific Affairs 2017 BD. BD, the BD Logo and all other trademarks

More information

Surveillance of Antimicrobial Resistance among Bacterial Pathogens Isolated from Hospitalized Patients at Chiang Mai University Hospital,

Surveillance of Antimicrobial Resistance among Bacterial Pathogens Isolated from Hospitalized Patients at Chiang Mai University Hospital, Original Article Vol. 28 No. 1 Surveillance of Antimicrobial Resistance:- Chaiwarith R, et al. 3 Surveillance of Antimicrobial Resistance among Bacterial Pathogens Isolated from Hospitalized Patients at

More information

EARS Net Report, Quarter

EARS Net Report, Quarter EARS Net Report, Quarter 4 213 March 214 Key Points for 213* Escherichia coli: The proportion of patients with invasive infections caused by E. coli producing extended spectrum β lactamases (ESBLs) increased

More information

1/30/ Division of Disease Control and Health Protection. Division of Disease Control and Health Protection

1/30/ Division of Disease Control and Health Protection. Division of Disease Control and Health Protection Surveillance, Outbreaks, and Reportable Diseases, Oh My! Assisted Living Facility, Nursing Home and Surveyor Infection Prevention Training February 2015 A.C. Burke, MA, CIC Health Care-Associated Infection

More information

Potential Conflicts of Interest. Schematic. Reporting AST. Clinically-Oriented AST Reporting & Antimicrobial Stewardship

Potential Conflicts of Interest. Schematic. Reporting AST. Clinically-Oriented AST Reporting & Antimicrobial Stewardship Potential Conflicts of Interest Clinically-Oriented AST Reporting & Antimicrobial Stewardship Hsu Li Yang 27 th September 2013 Research Funding: Pfizer Singapore AstraZeneca Janssen-Cilag Merck, Sharpe

More information

Detection and Quantitation of the Etiologic Agents of Ventilator Associated Pneumonia in Endotracheal Tube Aspirates From Patients in Iran

Detection and Quantitation of the Etiologic Agents of Ventilator Associated Pneumonia in Endotracheal Tube Aspirates From Patients in Iran Letter to the Editor Detection and Quantitation of the Etiologic Agents of Ventilator Associated Pneumonia in Endotracheal Tube Aspirates From Patients in Iran Mohammad Rahbar, PhD; Massoud Hajia, PhD

More information

Does Screening for MRSA Colonization Have A Role In Healthcare-Associated Infection Prevention Programs?

Does Screening for MRSA Colonization Have A Role In Healthcare-Associated Infection Prevention Programs? Does Screening for MRSA Colonization Have A Role In Healthcare-Associated Infection Prevention Programs? John A. Jernigan, MD, MS Division of Healthcare Quality Promotion Centers for Disease Control and

More information

Nosocomial Infections: What Are the Unmet Needs

Nosocomial Infections: What Are the Unmet Needs Nosocomial Infections: What Are the Unmet Needs Jean Chastre, MD Service de Réanimation Médicale Hôpital Pitié-Salpêtrière, AP-HP, Université Pierre et Marie Curie, Paris 6, France www.reamedpitie.com

More information

ESBL Producers An Increasing Problem: An Overview Of An Underrated Threat

ESBL Producers An Increasing Problem: An Overview Of An Underrated Threat ESBL Producers An Increasing Problem: An Overview Of An Underrated Threat Hicham Ezzat Professor of Microbiology and Immunology Cairo University Introduction 1 Since the 1980s there have been dramatic

More information

UPDATE ON ANTIMICROBIAL STEWARDSHIP REGULATIONS AND IMPLEMENTATION OF AN AMS PROGRAM

UPDATE ON ANTIMICROBIAL STEWARDSHIP REGULATIONS AND IMPLEMENTATION OF AN AMS PROGRAM UPDATE ON ANTIMICROBIAL STEWARDSHIP REGULATIONS AND IMPLEMENTATION OF AN AMS PROGRAM Diane Rhee, Pharm.D. Associate Professor of Pharmacy Practice Roseman University of Health Sciences Chair, Valley Health

More information

Workplan on Antibiotic Usage Management

Workplan on Antibiotic Usage Management IMPACT Forum: Antibiotic Guideline in Perspective Workplan on Antibiotic Usage Management Dr. Raymond Yung Consultant Microbiologist PYNEH 20 April 2002 May 2002 Dr. Raymond Yung 1 Objective 1. Heighten

More information

2016 Antibiotic Susceptibility Report

2016 Antibiotic Susceptibility Report Fairview Northland Medical Center and Elk River, Milaca, Princeton and Zimmerman Clinics 2016 Antibiotic Susceptibility Report GRAM-NEGATIVE ORGANISMS 2016 Gram-Negative Non-Urine The number of isolates

More information

What is an Antibiotic Stewardship Program?

What is an Antibiotic Stewardship Program? What is an Antibiotic Stewardship Program? Jane Rogers, R.N. Anne Messer, MPH Learning Session #4 August 15, 2017 National Nursing Home Quality Care Collaborative Change Package Change Bundle: To prevent

More information

MDR Acinetobacter baumannii. Has the post antibiotic era arrived? Dr. Michael A. Borg Infection Control Dept Mater Dei Hospital Malta

MDR Acinetobacter baumannii. Has the post antibiotic era arrived? Dr. Michael A. Borg Infection Control Dept Mater Dei Hospital Malta MDR Acinetobacter baumannii Has the post antibiotic era arrived? Dr. Michael A. Borg Infection Control Dept Mater Dei Hospital Malta 1 The Armageddon recipe Transmissible organism with prolonged environmental

More information

National MRSA Reference Laboratory

National MRSA Reference Laboratory Author: Gráinne Brennan Date: 23/02/2017 Date of Issue: 23/02/2017 National MRSA Reference Laboratory User s Manual NMRSARL Users Manual Page 1 of 12 Table of Contents Page 1. Location... 3 2. Contact

More information

Main objectives of the EURL EQAS s

Main objectives of the EURL EQAS s EQAS Enterococci, Staphylococci and E. coli EURL workshop, April, 11 Lourdes García Migura Main objectives of the EURL EQAS s To improve the comparability of antimicrobial susceptibility testing (AST)

More information

Antimicrobial susceptibility of clinical isolates from earthquake victims in Wenchuan

Antimicrobial susceptibility of clinical isolates from earthquake victims in Wenchuan ORIGINAL ARTICLE 10.1111/j.1469-0691.2008.02129.x Antimicrobial susceptibility of clinical isolates from earthquake victims in Wenchuan M. Kang 1,2, Y. Xie 1, C. Mintao 1, Z. Chen 1, H. Chen 1, H. Fan

More information

Childrens Hospital Antibiogram for 2012 (Based on data from 2011)

Childrens Hospital Antibiogram for 2012 (Based on data from 2011) Childrens Hospital Antibiogram for 2012 (Based on data from 2011) Prepared by: Department of Clinical Microbiology, Health Sciences Centre For further information contact: Andrew Walkty, MD, FRCPC Medical

More information

Detection of inducible clindamycin resistance among clinical isolates of Staphylococcus aureus in a tertiary care hospital

Detection of inducible clindamycin resistance among clinical isolates of Staphylococcus aureus in a tertiary care hospital ISSN: 2319-7706 Volume 3 Number 9 (2014) pp. 689-694 http://www.ijcmas.com Original Research Article Detection of inducible clindamycin resistance among clinical isolates of Staphylococcus aureus in a

More information

Version 1.01 (01/10/2016)

Version 1.01 (01/10/2016) CHN58: ANTIMICROBIAL SUSCEPTIBILITY TESTING (CLSI) 1.0 PURPOSE / INTRODUCTION: 1.1 Introduction Antimicrobial susceptibility tests are performed in order to determine whether a pathogen is likely to be

More information

European Committee on Antimicrobial Susceptibility Testing

European Committee on Antimicrobial Susceptibility Testing European Committee on Antimicrobial Susceptibility Testing Routine and extended internal quality control as recommended by EUCAST Version 5.0, valid from 015-01-09 This document should be cited as "The

More information

Practical approach to Antimicrobial susceptibility testing (AST) and quality control

Practical approach to Antimicrobial susceptibility testing (AST) and quality control Practical approach to Antimicrobial susceptibility testing (AST) and quality control A/Professor John Ferguson, Microbiologist & Infectious Diseases Physician, Pathology North, University of Newcastle,

More information

Evaluation of a computerized antimicrobial susceptibility system with bacteria isolated from animals

Evaluation of a computerized antimicrobial susceptibility system with bacteria isolated from animals J Vet Diagn Invest :164 168 (1998) Evaluation of a computerized antimicrobial susceptibility system with bacteria isolated from animals Susannah K. Hubert, Phouc Dinh Nguyen, Robert D. Walker Abstract.

More information

BACTERIOLOGICAL PROFILE OF OSTEOMYELITIS IN A TERTIARY CARE HOSPITAL AT VISAKHAPATNAM, ANDHRA PRADESH

BACTERIOLOGICAL PROFILE OF OSTEOMYELITIS IN A TERTIARY CARE HOSPITAL AT VISAKHAPATNAM, ANDHRA PRADESH IJCRR Vol 05 issue 20 Section: Healthcare Category: Research Received on: 07/09/13 Revised on: 02/10/13 Accepted on: 24/10/13 BACTERIOLOGICAL PROFILE OF OSTEOMYELITIS IN A TERTIARY CARE HOSPITAL AT VISAKHAPATNAM,

More information

Konsequenzen für Bevölkerung und Gesundheitssysteme. Stephan Harbarth Infection Control Program

Konsequenzen für Bevölkerung und Gesundheitssysteme. Stephan Harbarth Infection Control Program Konsequenzen für Bevölkerung und Gesundheitssysteme Stephan Harbarth Infection Control Program University of Geneva Hospitals Outline Introduction What data sources are available? AMR-associated outcomes

More information

Int.J.Curr.Microbiol.App.Sci (2017) 6(3):

Int.J.Curr.Microbiol.App.Sci (2017) 6(3): International Journal of Current Microbiology and Applied Sciences ISSN: 2319-7706 Volume 6 Number 3 (2017) pp. 891-895 Journal homepage: http://www.ijcmas.com Original Research Article https://doi.org/10.20546/ijcmas.2017.603.104

More information

CONTAGIOUS COMMENTS Department of Epidemiology

CONTAGIOUS COMMENTS Department of Epidemiology VOLUME XXIX NUMBER 3 November 2014 CONTAGIOUS COMMENTS Department of Epidemiology Bugs and Drugs Elaine Dowell SM MLS (ASCP), Marti Roe SM MLS (ASCP), Sarah Parker MD, Jason Child PharmD, and Samuel R.

More information

Lack of Change in Susceptibility of Pseudomonas aeruginosa in a Pediatric Hospital Despite Marked Changes in Antibiotic Utilization

Lack of Change in Susceptibility of Pseudomonas aeruginosa in a Pediatric Hospital Despite Marked Changes in Antibiotic Utilization Infect Dis Ther (2014) 3:55 59 DOI 10.1007/s40121-014-0028-8 BRIEF REPORT Lack of Change in Susceptibility of Pseudomonas aeruginosa in a Pediatric Hospital Despite Marked Changes in Antibiotic Utilization

More information

Antibiotic Stewardship in the LTC Setting

Antibiotic Stewardship in the LTC Setting Antibiotic Stewardship in the LTC Setting Joe Litsey, Director of Consulting Services Pharm.D., Board Certified Geriatric Pharmacist Thrifty White Pharmacy Objectives Describe the Antibiotic Stewardship

More information

Summary of the latest data on antibiotic resistance in the European Union

Summary of the latest data on antibiotic resistance in the European Union Summary of the latest data on antibiotic resistance in the European Union EARS-Net surveillance data November 2017 For most bacteria reported to the European Antimicrobial Resistance Surveillance Network

More information

Defining Extended Spectrum b-lactamases: Implications of Minimum Inhibitory Concentration- Based Screening Versus Clavulanate Confirmation Testing

Defining Extended Spectrum b-lactamases: Implications of Minimum Inhibitory Concentration- Based Screening Versus Clavulanate Confirmation Testing Infect Dis Ther (2015) 4:513 518 DOI 10.1007/s40121-015-0094-6 BRIEF REPORT Defining Extended Spectrum b-lactamases: Implications of Minimum Inhibitory Concentration- Based Screening Versus Clavulanate

More information

Update on Resistance and Epidemiology of Nosocomial Respiratory Pathogens in Asia. Po-Ren Hsueh. National Taiwan University Hospital

Update on Resistance and Epidemiology of Nosocomial Respiratory Pathogens in Asia. Po-Ren Hsueh. National Taiwan University Hospital Update on Resistance and Epidemiology of Nosocomial Respiratory Pathogens in Asia Po-Ren Hsueh National Taiwan University Hospital Ventilator-associated Pneumonia Microbiological Report Sputum from a

More information

Performance Information. Vet use only

Performance Information. Vet use only Performance Information Vet use only Performance of plates read manually was measured in three sites. Each centre tested Enterobacteriaceae, streptococci, staphylococci and pseudomonas-like organisms.

More information

Original Articles. K A M S W Gunarathne 1, M Akbar 2, K Karunarathne 3, JRS de Silva 4. Sri Lanka Journal of Child Health, 2011; 40(4):

Original Articles. K A M S W Gunarathne 1, M Akbar 2, K Karunarathne 3, JRS de Silva 4. Sri Lanka Journal of Child Health, 2011; 40(4): Original Articles Analysis of blood/tracheal culture results to assess common pathogens and pattern of antibiotic resistance at medical intensive care unit, Lady Ridgeway Hospital for Children K A M S

More information

ESCMID Online Lecture Library. by author

ESCMID Online Lecture Library. by author Expert rules in susceptibility testing EUCAST-ESGARS-EPASG Educational Workshop Linz, 16 19 September, 2014 Dr. Rafael Cantón Hospital Universitario Ramón y Cajal SERVICIO DE MICROBIOLOGÍA Y PARASITOLOGÍA

More information

Tel: Fax:

Tel: Fax: CONCISE COMMUNICATION Bactericidal activity and synergy studies of BAL,a novel pyrrolidinone--ylidenemethyl cephem,tested against streptococci, enterococci and methicillin-resistant staphylococci L. M.

More information

Antimicrobial Susceptibility Patterns

Antimicrobial Susceptibility Patterns Antimicrobial Susceptibility Patterns KNH SURGERY Department Masika M.M. Department of Medical Microbiology, UoN Medicines & Therapeutics Committee, KNH Outline Methodology Overall KNH data Surgery department

More information

Annual Surveillance Summary: Methicillin- Resistant Staphylococcus aureus (MRSA) Infections in the Military Health System (MHS), 2016

Annual Surveillance Summary: Methicillin- Resistant Staphylococcus aureus (MRSA) Infections in the Military Health System (MHS), 2016 Annual Surveillance Summary: Methicillin- Resistant Staphylococcus aureus (MRSA) Infections in the Military Health System (MHS), 2016 Jessica Spencer and Uzo Chukwuma Approved for public release. Distribution

More information

Short Report. R Boot. Keywords: Bacteria, antimicrobial susceptibility testing, quality, diagnostic laboratories, proficiency testing

Short Report. R Boot. Keywords: Bacteria, antimicrobial susceptibility testing, quality, diagnostic laboratories, proficiency testing Short Report Frequent major errors in antimicrobial susceptibility testing of bacterial strains distributed under the Deutsches Krebsforschungszentrum Quality Assurance Program R Boot Former Section of

More information

Prevalence of Metallo-Beta-Lactamase Producing Pseudomonas aeruginosa and its antibiogram in a tertiary care centre

Prevalence of Metallo-Beta-Lactamase Producing Pseudomonas aeruginosa and its antibiogram in a tertiary care centre International Journal of Current Microbiology and Applied Sciences ISSN: 2319-7706 Volume 4 Number 9 (2015) pp. 952-956 http://www.ijcmas.com Original Research Article Prevalence of Metallo-Beta-Lactamase

More information

Public Health Response to Emerging Resistance

Public Health Response to Emerging Resistance National Center for Emerging and Zoonotic Infectious Diseases Public Health Response to Emerging Resistance Alex Kallen, MD, MPH, FACP Lead Antimicrobial Resistance and Emerging Pathogens Team Prevention

More information

Compliance of manufacturers of AST materials and devices with EUCAST guidelines

Compliance of manufacturers of AST materials and devices with EUCAST guidelines Compliance of manufacturers of AST materials and devices with EUCAST guidelines Data are based on questionnaires to manufacturers of materials and devices for antimicrobial susceptibility testing. The

More information

What does multiresistance actually mean? Yohei Doi, MD, PhD University of Pittsburgh

What does multiresistance actually mean? Yohei Doi, MD, PhD University of Pittsburgh What does multiresistance actually mean? Yohei Doi, MD, PhD University of Pittsburgh Disclosures Merck Research grant Clinical context of multiresistance Resistance to more classes of agents Less options

More information

A retrospective analysis of urine culture results issued by the microbiology department, Teaching Hospital, Karapitiya

A retrospective analysis of urine culture results issued by the microbiology department, Teaching Hospital, Karapitiya A retrospective analysis of urine culture results issued by the microbiology department, Teaching Hospital, Karapitiya LU Edirisinghe 1, D Vidanagama 2 1 Senior Registrar in Medicine, 2 Consultant Microbiologist,

More information

Principles of Antimicrobial Therapy

Principles of Antimicrobial Therapy Principles of Antimicrobial Therapy Doo Ryeon Chung, MD, PhD Professor of Medicine, Division of Infectious Diseases Director, Infection Control Office SUNGKYUNKWAN UNIVERSITY SCHOOL OF MEDICINE CASE 1

More information

BBL CHROMagar MRSA Rev. 05 October 2008

BBL CHROMagar MRSA Rev. 05 October 2008 I II III IV V VI VII BBL CHROMagar MRSA 8012632 Rev. 05 October 2008 QUALITY CONTROL PROCEDURES INTRODUCTION BBL CHROMagar MRSA, supplemented with chromogens and inhibitory agents, is used for the qualitative

More information

Antimicrobial Resistance Surveillance from sentinel public hospitals, South Africa, 2013

Antimicrobial Resistance Surveillance from sentinel public hospitals, South Africa, 2013 Antimicrobial Resistance Surveillance from sentinel public s, South Africa, 213 Authors: Olga Perovic 1,2, Melony Fortuin-de Smidt 1, and Verushka Chetty 1 1 National Institute for Communicable Diseases

More information

Implementing Antibiotic Stewardship in Rural and Critical Access Hospitals

Implementing Antibiotic Stewardship in Rural and Critical Access Hospitals National Center for Emerging and Zoonotic Infectious Diseases Implementing Antibiotic Stewardship in Rural and Critical Access Hospitals Denise Cardo, MD Director, Division of Healthcare Quality Promotion,

More information

ANTIMICROBIAL SUSCEPTIBILITY DETECTION OF ELEVATED MICs TO PENICILLINS IN β- HAEMOLYTIC STREPTOCOCCI

ANTIMICROBIAL SUSCEPTIBILITY DETECTION OF ELEVATED MICs TO PENICILLINS IN β- HAEMOLYTIC STREPTOCOCCI HAEMOLYTIC STREPTOCOCCI This specimen was designated as a sample from a skin wound that was to be cultured, identified to species level and susceptibility tested [1-3]. The culture contained a Streptococcus

More information

Surveillance for Antimicrobial Resistance and Preparation of an Enhanced Antibiogram at the Local Level. janet hindler

Surveillance for Antimicrobial Resistance and Preparation of an Enhanced Antibiogram at the Local Level. janet hindler Surveillance for Antimicrobial Resistance and Preparation of an Enhanced Antibiogram at the Local Level janet hindler At the conclusion of this talk, you will be able to Describe CLSI M39-A3 recommendations

More information

Prevalence of Extended Spectrum Beta- Lactamase Producers among Various Clinical Samples in a Tertiary Care Hospital: Kurnool District, India

Prevalence of Extended Spectrum Beta- Lactamase Producers among Various Clinical Samples in a Tertiary Care Hospital: Kurnool District, India International Journal of Current Microbiology and Applied Sciences ISSN: 319-77 Volume Number (17) pp. 57-3 Journal homepage: http://www.ijcmas.com Original Research Article https://doi.org/1.5/ijcmas.17..31

More information

MICRONAUT MICRONAUT-S Detection of Resistance Mechanisms. Innovation with Integrity BMD MIC

MICRONAUT MICRONAUT-S Detection of Resistance Mechanisms. Innovation with Integrity BMD MIC MICRONAUT Detection of Resistance Mechanisms Innovation with Integrity BMD MIC Automated and Customized Susceptibility Testing For detection of resistance mechanisms and specific resistances of clinical

More information

Epidemiology and Burden of Antimicrobial-Resistant P. aeruginosa Infections

Epidemiology and Burden of Antimicrobial-Resistant P. aeruginosa Infections Epidemiology and Burden of Antimicrobial-Resistant P. aeruginosa Infections Keith S. Kaye, MD, MPH Professor of Medicine Division of Infectious Diseases Department of Internal Medicine University of Michigan

More information