Epidemioloy and control strategy of rabies

Transcription

1 OIE: Regional Training on Rabies Tokyo/Yokohama, Japan 5-8 August 2014 Epidemioloy and control strategy of rabies Satoshi INOUE, PhD DVM Laboratory of Transmission Control of Zoonosis, Department of Veterinary Science, National Institute of Infectious Diseases, Japan Key words of Rabies control Diagnosis Mangment of patients before and after death Vaccine and Imunoglobulin for humans Potency requirements Dog rabies control Prevention and control of rabies in wild animals Surveillance Rabies-free areas WHO Expert Consultation on Rabies WHO-TRS 982 1

2 Reservoirs of animal rabies Asia: Dog etc. Africa: Dog, Jackal, etc. E.Europe: Fox, Raccoon dog, etc. N.America: Raccoon, Skunk, Fox, Bat, etc. Latin America: Mangoose, Bat, etc. 2

3 The risk is linked to the age Children are more often bitten than adults Children are bitten at the head and the neck >40% of those seeking PEP and those dying of rabies are children less than 15 yrs old H. Bourhy - Rabies - Tokyo, Japan - 5/02/2013 More than 99% of the human cases are due to canine rabies Stray dogs 3

4 Key words of Rabies control Dog rabies control - Canine mass parenteral vaccination campaigns - Management of vaccination campaigns - Study of dog ecology - Vaccination and immunization coverage - Implementing and monitoring dog vaccintion campaigns - Cost-effectiveness of dog vaccination - Human dog population management - Animal birth control (ABC) WHO Expert Consultation on Rabies WHO-TRS 982 Evidence based measures has been done correctly? 4

5 Key words of Rabies control Dog rabies control - Canine mass parenteral vaccination campaigns - Management of vaccination campaigns - Study of dog ecology WHO Expert Consultation on Rabies WHO-TRS 982 Animal Rabies Dr Ronello Abila Regional Coordinator, OIE South East Asia Country Brunei Cambodia ()+ ()+ ()+ ()+ ()+ NR Indonesia Laos ()+ ()+ NR Malaysia No rabies since 1999 Myanmar Philippines () Singapore No rabies since 1953 Thailand Vietnam Workshop on Strengthening Cooperation and Sharing Information on Rabies among ASEAN Plus Three Countries 5

6 Philippines 300,000 doses (in February 2014) Afghanistan 200,000 (in January 2014) Vietnam 500,000 (in December 2013) Nepal 200,000 (in October 2013) Butan 20,000 (in September 2013) Myanmar 200,000 (in September 2013) Bangladesh 200,000 (in July 2013) Indonesia 200,000 (in July 2013) Sri Lanka 300,400 (in June 2013) Key words of Rabies control Dog rabies control - Canine mass parenteral vaccination campaigns - Management - Vaccination and immunization coverage - Implementing and monitoring dog vaccintion campaigns - Cost-effectiveness of dog vaccination - Human dog population management - Animal birth control (ABC) WHO Expert Consultation on Rabies WHO-TRS 982 6

7 Features of dog in Asia 7

8 8000 病例数

9 Key words of Rabies control Dog rabies control - Canine mass parenteral vaccination campaigns vaccination campaigns - Study of dog ecologyctiveness of dog n - Human dog population management - Animal birth control (ABC) - Animal birth contorol (ABC) WHO Expert Consultation on Rabies WHO-TRS 982 Quang Minh Nhat Thanhnien 18/06/ :35U Viet-jo.com In 2014, January to June Bite incidences = 160,000 Rabies patients = 28 National government required Vaccination of owned dogs Prohibition of dog run loose Leash a dog in public area 9

10 Key words of Rabies control Dog rabies control - Canine mass parenteral vaccination campaigns Save human life by the management of owned dogs WHO Expert Consultation on Rabies WHO-TRS

11 Features of rabies circulation in animals 11

12 Interspecific Transmission of RABV in the USA Hanlon et al, In Rabies (2nd Ed), 2007 Phylogenetic tree of Philippine RABV glycoprotein Samples collected during period of All 235 samples are dog derived Rabies status confirmed by DFA RT-PCR sequencing performed on RABV glycoprotein Saito et al. PLoS Negl Trop Dis,

13 安徽省 浙江省 江西省 13

14 Rabies cases in Taiwan 17 July - 31 Decmber in 2013 Total Positive Carnivora 1, Ferret badger Dog 1, January - 26 June in 2014 Total Positive Carnivora Ferret badger Dog Key words of Rabies control in laboratory Diagnosis Laboratory Mangment of patients before and after death Vaccine and Imunoglobulin for humans Potency requirements Dog rabies control Prevention and control of rabies in wild animals Surveillance Rabies-free areas Laboratory Laboratory Laboratory Laboratory WHO Expert Consultation on Rabies WHO-TRS

15 NO MORE RABIES Keep and expand rabies free area by the evidence of laboratory! 15