OVITROL X-TEND FLEA & TICK SPOT ON FOR DOGS TECHNICAL MONOGRAPH

Transcription

1 OVITROL X-TEND FLEA & TICK SPOT ON FOR DOGS TECHNICAL MONOGRAPH TM

2 TM Dear Colleague, Fleas, ticks and other biting parasites continue to be a problem for pets. Clients look to you, their veterinary professional, for products that are not only powerful, but affordable. Veterinary Products Laboratories is continually striving to develop innovative solutions that provide veterinarians new advantages in the battle against fleas, ticks and mosquitoes. We are pleased to add Vet-Kem Ovitrol X-Tend Flea & Tick Spot On for Dogs and Ovitrol X-Tend Flea & Tick Spot On for Cats to our complete system of flea and tick control products that deliver highly efficacious formulations that are gentle on the environment with a very low acute mammalian or avian toxicity. Ovitrol X-Tend brand products contain the molecule Etofenprox, for quick and permanent knockdown of fleas, ticks, and mosquitoes that is combined with a proven IGR for extended control of flea eggs and flea larvae. Unlike traditional pyrethroids, Etofenprox is a non-ester (ether) pyrethroid chemical. As such, it is a non-organophosphate, non-carbamate proven to reduce the toxic risks to all pets (particularly cats). It provides the rapid termination of parasites that is demanded, along with the extended control that is desired. Offered exclusively to licensed, practicing veterinarians, Vet-Kem Ovitrol X-Tend Flea & Tick Spot On for Dogs and Ovitrol X-Tend Flea & Tick Spot On for Cats provide veterinary professionals with the ideal combination of efficacy for the patient and cost effectiveness for the client. With these new additions, the Vet-Kem Ovitrol X-Tend family of products makes it possible for veterinarians to prescribe a combination of products to solve each pet owner s parasite challenge on the pet, in the home and in the yard. Table of Contents Ecto-parasites Fleas Ticks Mosquitoes... 7 Active Ingredients in Ovitrol X-Tend Flea & Tick Spot On for Dogs Etofenprox Toxicity Profile Studies Application Complete System...16 Product Label Laura Petree, DVM Director of Technical Services

3 Outdoors, the larvae are more likely to be found in shady locations, often where the pet rests. The larvae feed on organic material including flea feces, flea eggshells, other flea larvae, and organic debris. After several larval stages, the larva spins a silken cocoon and pupates. FLEAS, TICKS AND MOSQUITOES The pupae can be found in the same locations as the larvae. The adult C felis can begin emerging as early as 8 days after initiation of the pupal stage or can remain in the cocoon for up to a year. Adult emergence is stimulated by vibration, mechanical pressure, increases in carbon Pupal Stage dioxide, and increases in temperature. Adults may remain quiescent in the cocoon for up to 50 weeks at cooler temperatures (11 C [51.8 F]) and when there are no appropriate environmental stimuli. FLEA life cycle Adult Flea Fleas, ticks and mosquitoes are the most common ecto-parasites of dogs and cats. They are more than just a nuisance; they can be a health risk to both dogs and their owners. Understanding their life cycles and habits can help in understanding how to combat them. Ticks Larval Stage Egg Stage Fleas Fleas are small wingless insects that are flattened laterally. The flea most commonly found on both dogs and cats in North America is Ctenocephalides felis, the cat flea. 1 The cat flea has a very wide host range and can be found on wild animals including raccoons, opossums, skunks, and foxes as well as our pets. Flea bites are very irritating to pets, but they can also lead to serious medical conditions. Heavy infestations, particularly in young animals, may lead to iron deficiency, anemia or even death. Flea allergy dermatitis, a hypersensitivity reaction to the antigens in flea saliva, is one of the most common causes of skin disease in dogs and cats. In some cases, they may act as vectors of disease. Fleas are also the intermediate host for the tapeworm Dipylidium caninum and the filarial worm Acanthocheilonema reconditum (formerly Dipetalonema reconditum). Fleas are also capable of transmitting several pathogens including Mycoplasma spp, Bartonella spp and Rickettsia spp. Some of these have zoonotic potential. In order to understand the steps needed to completely eliminate a flea infestation, it is important to understand their life cycle. Eliminating adult fleas seen on the dog or cat is one key step in controlling and preventing an infestation of this fast-multiplying parasite. It can also require a complete program that effectively kills the often unseen immature stages that are in the pet s environment. Adult fleas begin feeding immediately when on the host and must feed before mating. Egg production begins within 20 to 24 hours of females taking their first blood meal. A female flea can produce 40 to 50 eggs per day and she may live 4 to 25 days. The eggs fall off wherever the animal is, whether moving around or at rest. The eggs, pearly white ovals, fall off the host into the environment. Indoors, the eggs hatch into tiny (0.5 mm), light-colored, worm-like larvae which live deep in carpet fibers, cracks and crevices, or in bedding or furniture. Ticks are another important pest of pets and people. The majority of ticks infesting dogs and cats belong to the Ixodidae family, which include the Deer tick (Ixodes scapularis), Brown Dog tick (Rhipicephalus sanguineus), Lone Star tick (Amblyomma americanum), and American Dog tick (Dermacentor variabilis). Ixodid ticks are flattened dorsally and have a highly sclerotized dorsal shield. The dorsal shield in males covers the entire dorsal surface and in females only extends part of the way. The capitulum or head with mouthparts of ixodid ticks can be seen when ticks are examined dorsally. Ticks are identified based on various criteria such as size, body shape, location of the head, appearance of mouth parts, and ornamentation. Female adult ticks have a partial dorsal shield that allows them to expand as they feed. They may grow as much as 100 times their original weight before they detach from the host. Male adult ticks also take blood meals, but because they have a complete dorsal shield they will not increase in size as much as females and still appear flat after feeding. Ticks have 4 developmental stages: egg, larva, nymph, and adult. Ticks are obligate blood feeders with every life stage except the egg taking blood meals. Most ixodid ticks are 3-host ticks that molt off the host between their blood meals. They may or may not feed on a different host during each stage. The entire life cycle of some ticks may take 3 years to complete. Example of Ixodidae Ticks Ticks are not only voracious blood feeders, and an infestation can cause anemia, they are important vectors of disease. They transmit pathogens that cause diseases such as anaplasmosis, ehrlichiosis, cytauxzoonosis, rickettsiosis and Lyme disease. A neurotoxin produced by females of several tick species can cause tick paralysis. 1. Biology, treatment and control of flea and tick infestations. Blagburn BL, Dryden MW. VCNA 39: , 2009 Where fleas live 4 5

4 Mosquitoes Typical life cycle of 3-host tick Nymph Eggs Larva Mosquitoes require water to complete their life cycle. Some mosquitoes lay their eggs on the surface of fresh or stagnant water either singularly or in rafts. These eggs hatch within 24 to 48 hours. Other species of mosquitoes lay eggs which only hatch when flooded with water after a drying period. The legless larvae, commonly called wigglers, live in the water for 4 to 14 days depending on water temperature. The larvae grow larger, primarily feeding on algae, plankton, and fungi and molt 4 times. At the final molt, they become a pupa. The mosquito pupae, commonly called tumblers, also live in the water. The pupa floats at the surface and does not feed during this stage. The pupal stage lasts from 1 to 4 days depending upon species and temperature. The metamorphosis of the mosquito into an adult is completed within the pupal case. Adult male and female mosquitoes feed on nectar, but only female adult mosquitoes require blood meals. Acquiring a blood meal is necessary for egg production. Mosquitoes are vectors for several diseases important to companion animals and humans such as heartworm disease and West Nile Virus. Egg Stage Larval Stage Pupal Stage Adult Mosquito Adult Adult females drop off the host and lay eggs. Eggs hatch within a few weeks to a month TechMono_DOG_REV3.indd 6-7 Larvae 6-legged larvae feed on a host for several days and can live in the environment for days (6 to 90) before molting. Nymphs 8-legged nymphs feed on the host for several days and can live in the environment for days (17 to 100) before molting to adults. Adult Adult ticks may live for an extended period of time before feeding. 7 5/15/13 2:57 PM

5 Piperonyl butoxide (PBO) is an organic compound that acts as a pesticide synergist that blocks the insect s metabolism of Etofenprox. As part of their defense system, insects are able to break down some active ingredients (such as pyrethrins) to the point of making them less effective. PBO blocks a metabolic pathway in the insect, allowing Etofenprox to be more effective. ETOFENPROX Vet-Kem X-Tend branded products contain the molecule Etofenprox, for quick and permanent knockdown of fleas, ticks, and mosquitoes, in combination with an IGR to offer extended control of flea eggs and flea larvae. Unlike traditional pyrethrin-based products that have limited killing power and are potentially harmful to dogs and cats (especially cats), the Vet-Kem X-Tend products impart the rapid termination of fleas and ticks that is demanded with the extended control that is desired, all in formulations that are proven to reduce the toxic risks to all pets and the environment. Etofenprox [2-(4-ethoxyphenyl)-2-methylpropyl 3-phenoxybenzyl ether] is a pyrethroid-like insecticide. It is not a traditional pyrethroid. The molecule contains carbon, hydrogen, and oxygen and is an ether rather than an ester. All of the other commercially available pyrethroids are esters. The Environmental Protection Agency (EPA) classifies Etofenprox as a non-ester pyrethroid. Mode of action ACTIVE INGREDIENTS n Black: Carbon, C n White: Hydrogen, H n Red: Oxygen, O Etofenprox has a similar mode of action to traditional pyrethroids in that it is a sodium channel blocker. It acts on the nervous system of ecto-parasites and disturbs the function of neurons by interfering with the sodium channels. Etofenprox has a broad spectrum of activity including fleas, ticks and mosquitoes. Ovitrol X-Tend Flea & Tick Spot On for Dogs provides flea, tick, and mosquito protection for dogs and puppies over 10 weeks of age for up to 30 days. In heavy flea infestations, retreatment can occur 8 days after the initial application. Do not retreat more than once a month. This product is water resistant and remains efficacious following exposure to rainfall or swimming. TOXICITY Profile Etofenprox has been tested for safety in dogs, puppies, cats and kittens. At doses up to 3X the recommended rate, no Etofenprox-related adverse reactions were observed. Etofenprox essentially has very low toxicity in mammals by the oral, dermal or inhalation routes. The oral toxicity of Etofenprox in avian species is very low. Comparison of Acute Toxicity of Ingestion of Several Compounds Including Etofenprox Fipronil Imidacloprid Pyrethrin Dinotefuran Resmethrin Phenothrin Pyriproxyfen PBO (S)-Methoprene Etofenprox ,030 > 2,000 4,240 > 5,000 > 5,000 7,500 Acute Toxicity = LD 50 Measured in mg/kg body weight > 34, ,000 20,000 30,000 40,000 > 42,880 Etofenprox is classified in the lowest acute toxicity category by the EPA. Larger Value = Least Toxicity. LD 50 s are of active ingredient only. Source: *The Pesticide Manual 13th Edition 2003 Editor: CDS Tomlin; Publisher: British Crop Protection Council (S)-Methoprene is an insect growth regulator (IGR) that disrupts the flea life cycle. It acts by mimicking natural juvenile hormone. In the life cycle of insects, decreases in juvenile hormone levels promote the next stage to emerge. Juvenile hormone is present when flea eggs are formed, and a decrease in juvenile hormone causes a flea egg to hatch into a flea larva. Juvenile hormone must be absent for a pupa to molt to an adult. Treatment with (S)-Methoprene breaks the life cycle of the parasite, controlling potential infestations. 8 9

6 Efficacy Against Fleas and Ticks Study Design Three treatment groups of dogs were established for these evaluations. The treatment groups were treated with the label rate of Ovitrol X-Tend Flea & Tick Spot On for Dogs. For evaluations against fleas, a known number of fleas were placed on the animals at different time intervals posttreatment. After a prescribed period of time, the animals were combed to remove any fleas living or dead. studies Ticks were evaluated in a similar manner as fleas, a known number of ticks were placed on the animals and after the prescribed time period, ticks remaining on the animal were evaluated for mortality. Ovicidal efficacy was generated by collecting flea eggs from both treated and untreated groups and incubating the eggs to evaluate for egg hatch. Results Efficacy of Ovitrol X-Tend Flea & Tick Spot On for Dogs Against Cat Fleas (Ctenocephalides felis) Geometric Mean % Reduction Day 1 Day 3 Day 16 Day 23 Day 30 0 Days Post Treatment Wellmark Study 3268 Wellmark Study 3268 For all studies: The percent controls for all adult flea, tick and flea larval counts were determined based on comparative numbers of treated and control animals

7 Efficacy of Ovitrol X-Tend Flea & Tick Spot On for Dogs Against Brown Dog Tick (Rhipicephalus sanguineus) Efficacy Against Mosquitoes 100 Efficacy of Etofenprox and PBO when experimentally infested with adult Ixodes scapularis and 3 species of adult mosquitoes (Aedes aegypti, Anopheles quadrimaculatus, and Culex quinquefasciatus). Geometric Mean % Reduction Day 2 Day 3 Day 16 Day 23 Day 30 Study Design This trial was to evaluate the efficacy of Ovitrol X-Tend Flea & Tick Spot On for Dogs for control of 2 species of adult mosquitoes, Aedes aegypti and Anopheles quadrimaculatus. Two groups of animals were used in this evaluation, a treated group and a control group. The treatment group was treated with Ovitrol X-Tend Flea & Tick Spot On for Dogs at label rates. The animals were exposed to female mosquitoes and evaluations were made for mortality and blood feeding. Results 0 Days Post Treatment Geometric Mean % Mortality of Mosquitoes with Ovitrol X-Tend Flea & Tick Spot On for Dogs Wellmark Study 3268 Inhibition of Flea Larvae with Ovitrol X-Tend Flea & Tick Spot-On for Dogs % Larvae inhibition Day 40 Day 47 Day 54 Day 61 Geometric Mean % Reduction Day 0 Day 14 Day 21 Day 28 Aedes aegypti Anopheles quadrimaculatus Days post treatment Wellmark Study 3362/ Note: Anopheles quadrimaculatus mosquitoes were unavailable to infest on Day Days Post Treatment Days Post Treatment Wellmark Study

8 APPLICATION 4. APPLY: The dog/puppy should be standing for easy application. To apply, use tip to part hair and get next to dog s/puppy s skin. The formulation of Ovitrol X-Tend Flea & Tick Spot On for Dogs offers the advantages of Etofenprox and (S)-Methoprene, but also the innovative design of the X-Tender Applicator. The X-Tender Applicator is ergonomically contoured for easy handling and designed for clean, accurate dosing. The action of closing the applicator door automatically opens the tube. The tube is sealed inside, and once tube is opened, the liquid can be placed on the dog. If the applicator is laid down on a table, counter or other flat surface it will not run out or drip. The tip is used to part the hair and get next to the dog s skin. It is important for the product to be applied directly to the dog s skin for proper translocation and optimal protection against parasites. Press circle on red door once at each of four or five evenly placed spots between the shoulders and the base of the tail. Do not apply an excessive amount of the solution at any one spot that could cause some of the solution to run off the side of the dog/puppy. Do not spread this product by hand over the dog/puppy. Although the dog s/ puppy s skin and hair oils will distribute the application over the entire dog/puppy, brushing the dog/puppy hours after treatment will help to distribute the material over the skin. FOR LARGE DOGS To apply this product, use one disposable liquid tube for each application with the applicator device. 5. DISPOSE: To dispose of empty tube, open red door and drop empty tube into trash or offer for recycling, if available. Close applicator device door and store in original package. 1. OPEN: Use finger scoop to lift open red door. 6. USE RESTRICTIONS: Do not reapply product for 30 days unless retreatment is required, but not sooner than 8 days after initial treatment. Do not treat more than once per month. 2. LOAD: To load, place tube WHITE SIDE UP under the red tab. 7. RETREAT AFTER 30 DAYS: Do not reapply product for 30 days. Do not treat more than once per month. Note: Each package contains sufficient tubes for 3 applications. DO NOT USE ON CATS DO NOT USE ON CATS: Keep cats away from treated dogs/puppies for 24 hours. If applied to a cat or ingested by a cat, contact your veterinarian immediately. 3. CLOSE: Close the red door and the tube will snap open. To view application for Large Dogs, scan here. To view all application videos, please visit

9 Includes Designed to make application precise and neat. See side of package for details. Applicator Patent Pending ACTIVE INGREDIENTS: (S)-Methoprene (CAS # ) 3.6% Etofenprox (CAS # ) 40.0% OTHER INGREDIENTS: 56.4% Total 100.0% Contains a Coat Conditioner KEEP OUT OF REACH OF CHILDREN See side/back panels for additional Precautionary Statements EPA Reg. No EPA Est. No TX-1 Product code: RM# Month Supply NET CONTENTS: fl oz total (Three fl oz/1.8 cc tubes) STARTS KILLING FLEAS WITHIN 15 MINUTES KILLS Fleas Deer Ticks Flea Larvae Mosquitoes Flea Eggs total Management system to control FLEAS, TICKS and MOSQUITOES For Use Only on Cats and Kittens 5 lbs. & over & 12 weeks of age or older LARGE Ovitrol Flea & Tick Spot On for Cats A total flea and tick management program should include products for management on pets, as well as in the home and yard. The Vet-Kem X-Tend brand offers a fully-integrated Etofenprox system. The Vet-Kem X-Tend family of products provides veterinarians and pet owners a new advantage in the battle against fleas, ticks and mosquitoes. All products in the Vet-Kem X-Tend family contain the molecule Etofenprox. Classified as a non-ester pyrethroid by the EPA, Etofenprox kills fleas, ticks and mosquitoes, while offering very low toxicity for the pet. Combined with an IGR such as (S)-Methoprene, the Vet-Kem X-Tend products offer extended control of flea eggs and flea larvae. TM Get, em with the system

10 Ovitrol LARGE lbs For Use Only on Large Dogs/Puppies 10 weeks of age or older STARTS KILLING FLEAS & TICKS WITHIN 15 MINUTES KILLS Fleas Ticks Flea Eggs Flea Larvae Flea & Tick Spot On KILLS & REPELS Mosquitoes ACTIVE INGREDIENTS: Etofenprox (CAS # ) 30.0% (S)-Methoprene (CAS # ) 3.6% Piperonyl Butoxide (CAS # )* 5.0% OTHER INGREDIENTS: 61.4% Total 100.0% *(butyl carbityl) (6-propylpiperonyl) ether and related compounds PRODUCT LABEL for Dogs FOR LARGE DOGS/PUPPIES To apply this product, use one disposable liquid tube for each application with the applicator device. 1. OPEN: Use finger scoop to lift open red door. 2. LOAD: To load, place tube WHITE SIDE UP under the red tabs. 3. CLOSE: Close the red door and the tube will snap open. 4. APPLY: The dog/puppy should be standing for easy application. To apply, use tip to part hair and get next to dog s/puppy s skin. Press circle on red door once at each of four or five evenly placed spots between the shoulders and the base of the tail. Do not apply an excessive amount of the solution at any one spot that could cause some of the solution to run off the side of the dog/puppy. Do not spread this product by hand over the dog/puppy. Although the dog s/puppy s skin and hair oils will distribute the application over the entire dog/puppy, brushing the dog/puppy hours after treatment will help to distribute the material over the skin. 5. DISPOSE: To dispose of empty tube, open red door and drop empty tube into trash or offer for recycling, if available. Close applicator device door and store in original package. 6. USE RESTRICTIONS: Do not reapply product for 30 days unless retreatment is required, but not sooner than 8 days after initial treatment. Do not retreat more than once per month. NOTE: Each package contains sufficient tubes for 3 applications In case of emergency or for product information, call or contact your veterinarian if your dog is experiencing an adverse event. The powerful and affordable solution For the veterinarian and the pet owner, the Vet-Kem X-Tend system of products provides a complete portfolio of flea and tick control products that deliver highly efficacious formulations that are gentle on the environment with a very low acute mammalian or avian toxicity. OVITROL X-TEND FLEA & TICK SPOT ON FOR DOGS CAUTION KEEP OUT OF REACH OF CHILDREN READ ENTIRE LABEL BEFORE EACH USE. USE ONLY ON DOGS AND PUPPIES. DO NOT USE ON OTHER ANIMALS! IMPORTANT! DO NOT USE ON DOGS/PUPPIES LESS THAN 10 WEEKS OLD. DO NOT USE ON CATS DO NOT USE ON CATS Keep cats away from treated dogs/puppies for 24 hours. If applied to a cat or ingested by a cat, contact your veterinarian immediately. The X-Tender Applicator is specially designed to make applying flea and tick control easier and more precise than ever before. You simply insert the appropriate tube for your dog/puppy into the applicator, close it and squeeze to apply. The applicator s ergonomic, contoured shape makes it easy to grip and the built-in tip helps to spread the dog s/puppy's hair to allow the liquid to more readily reach the skin. The tube is sealed inside, so you can be confident that the liquid goes onto your dog/puppy and not your hand. Plus, if the applicator is laid down on a table, counter or other flat surface, it won t run out or drip. Vet-Kem Ovitrol X-Tend Flea & Tick Spot On for Dogs provides flea and tick protection for dogs/puppies for up to 30 days. This product is water resistant and remains efficacious following exposure to rainfall or swimming. This product is most effective when used as part of a total flea and tick management program. Use other Vet-Kem products registered for residential area control of these pests in conjunction with this treatment. Monthly treatments are required for optimal control and prevention of fleas. The successive feeding activity of fleas on dogs/puppies may elicit a hypersensitivity skin disorder known as flea allergy dermatitis (FAD). Treatment of dogs/puppies with this product rapidly kills fleas and may reduce the incidence of this condition. DIRECTIONS FOR USE: It is a violation of Federal Law to use this product in a manner inconsistent with its labeling. Read and follow all directions and precautions on this product label. USE RESTRICTIONS: Apply this product once every 30 days unless a retreatment is necessary. Do not make the retreatment sooner than 8 days after the initial treatment. Do not retreat more than once per month. Vet-Kem Ovitrol X-Tend Flea & Tick Spot On for Dogs works by application directly to the dog s/puppy s skin, not to the hair. When applying, use applicator device tip to push aside dog s/puppy s hair to allow direct application to the skin. Do not get this product in dog s/puppy s eyes or mouth. Label from Large Dog. STORAGE AND DISPOSAL: Pesticide Storage: Store in a cool area away from children and animals. Liquid Tube Disposal: If empty: Do not reuse tube. Place in trash or offer for recycling, if available. If partially filled: Call your local solid waste agency for disposal instructions. Never place unused product down any indoor or outdoor drain. PRECAUTIONARY STATEMENTS HAZARDS TO HUMANS AND DOMESTIC ANIMALS CAUTION DO NOT USE ON DOGS/PUPPIES LESS THAN 10 WEEKS OLD. For external use only. Causes moderate eye irritation. Avoid contact with eyes or clothing. Wash thoroughly with soap and water after handling and before eating, drinking, chewing gum, using tobacco, or using the toilet. Repeated exposure to etofenprox can cause skin irritation. Consult a veterinarian before using this product on debilitated, aged, pregnant, nursing, or animals on medication. Sensitivities may occur after using ANY pesticide product for pets. If signs of sensitivity occur, bathe your dog/puppy with mild soap and rinse with large amounts of water. If signs continue, consult a veterinarian immediately. Some dogs/puppies may experience hair loss or temporary skin irritation at the application site. If signs persist or become more severe, contact veterinarian immediately and report incident to company at FIRST AID: If in eyes: Hold eye open and rinse slowly and gently with water for minutes. Remove contact lenses, if present, after first 5 minutes, then continue rinsing. Call a poison control center or doctor for treatment advice. Have the product container or label with you when calling a poison control center or doctor or going for treatment. You may also contact for emergency medical treatment information. WARRANTY AND CONDITIONS OF SALE: Seller warrants that this product conforms to the chemical specifications expressed on the label. To the extent consistent with applicable law, Seller makes no other warranties, and disclaims all other warranties, express or implied, including but not limited to warranties of merchantability and fitness for the intended purpose. To the extent consistent with applicable law, Seller s liability for default, breach, or failure under this label shall be limited to the amount of the purchase price. To the extent consistent with applicable law, Seller shall have no liability for consequential damages. EPA Reg. No EPA Est. No TX-1 Product code: RM# Wellmark International 1501 East Woodfield Road 200W Schaumburg, Illinois , 2013 Veterinary Products Laboratories Product Code: Ovitrol, Spot On, Vet-Kem and the Vet-Kem design are registered trademarks of Wellmark International. All other trademarks are the property of their respective owners. Provides the veterinarian an affordable brand only offered to licensed, practicing veterinarians. Providing a proven solution that works for pets AND clients, Ovitrol X-Tend Flea & Tick Spot On for Dogs is a monthly topical flea, tick and mosquito ecto-parasiticide containing Etofenprox, (S)-Methoprene and Piperonyl Butoxide. Starts killing fleas and ticks within 15 minutes. Kills fleas, ticks, flea eggs and flea larvae. Also kills and repels mosquitoes. Powerful combination. Kills adult fleas AND flea eggs AND flea larvae with Etofenprox adulticide and (S)-Methoprene IGR. Water resistant. Remains efficacious after exposure to rain or swimming. Long-lasting. Extended protection for up to one month. Etofenprox is classified by the EPA as a non-ester pyrethroid with very low acute toxicity for mammals and birds. Environmentally friendly. Low toxicity profile. Ideal for homes with both dogs and cats. Available in 5 sizes for dogs: Toy, Small, Medium, Large and X-Large. Same price, any size 3-pack even extra-large breeds. X-Tender Applicator included with every 3-pack

11 The powerful and affordable solution for veterinary management of fleas AND ticks. Get, em with the system. For technical service support, please call Veterinary Products Laboratories Ovitrol, Spot On, Vet-Kem and Vet-Kem with design are registered trademarks of Wellmark International. All other trademarks are the property of their respective owners #